Equibles

ZYME

Zymeworks Inc.

Company with tickers: ZYME

CIK
1937653
CUSIP
98985Y108
Shares Outstanding
73,023,061
13F Activity (30d)
185 filings 179 filers
Holders: 214
Total Value: $1,772,403,150
Total Shares: 70,782,879
Showing 1–100 of 221 holdings by value · page 1 of 3

Institutional Ownership Trend

15 quarters

Holder Concentration

Across 214 13F filers · Δ vs Dec 31, 2025
Top Holder
32.5%
Jun 2023 → Mar 2026 · range 19.7% – 32.5%
+0.6 pts
Top 5
59.0%
Jun 2023 → Mar 2026 · range 48.2% – 59.0%
+2.9 pts
Top 10
71.0%
Jun 2023 → Mar 2026 · range 66.9% – 71.9%
+1.0 pts
HHI
1,295
Jun 2023 → Mar 2026 · range 704 – 1,295
Broadly held +69

Quarterly Activity

vs Dec 31, 2025
New
39
Increased
77
Decreased
61
Sold Out
36
Unchanged
37
Holder count: +3
Institutional value: -6.8%
Shares held: -2.0%

Top Buyers

vs Dec 31, 2025
Institution Added Now Holds Open
Mid Rubric Capital Management LP +1,250,000 7,000,000
Mega CITADEL ADVISORS LLC +950,267 1,250,518
Mid PERCEPTIVE ADVISORS LLC +248,228 3,510,078
Mega GOLDMAN SACHS GROUP INC +179,279 599,486
Mega JANE STREET GROUP, LLC +156,522 226,967

Top Sellers

vs Dec 31, 2025
Institution Sold Now Holds Open
Mega DEUTSCHE BANK AG\ −674,583 921,250
Mega MILLENNIUM MANAGEMENT LLC −331,621 50,000
Mid BVF INC/IL −204,499 3,734,142
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP −184,867 274,921
Mega Invesco Ltd. −131,950 125,630

Top New Positions

vs Dec 31, 2025
Institution Acquired Value (USD) Open
Mega VANGUARD CAPITAL MANAGEMENT LLC 1,705,580 $42,707,723
Mid MPM BIOIMPACT LLC 565,249 $14,153,834
Mega VANGUARD PORTFOLIO MANAGEMENT LLC 499,875 $12,516,870
Mid ROYCE & ASSOCIATES LP 299,202 $7,492,018
Large Tidal Investments LLC 104,931 $2,627,472

Top Sold-Out Positions

vs Dec 31, 2025
Institution Previously Held Last Value (USD) Open
Mega VANGUARD GROUP INC 2,328,727 $61,315,379
Mid Siren, L.L.C. 1,680,121 $44,237,585
Mid Vestal Point Capital, LP 865,000 $22,775,450
Large ADAGE CAPITAL PARTNERS GP, L.L.C. 663,546 $17,471,166
Mid ALGERT GLOBAL LLC 423,646 $11,154,599
Filter: New 39 Increased 77 Reduced 61 Sold out 36 Unchanged 37
Showing 100 of 221
All Common Calls Puts
Export CSV
Holder Value (USD) % of 13F Shares Open
Mid EcoR1 Capital, LLC $575,178,515 32.45% 22,970,388
Mid Rubric Capital Management LP $175,280,000 9.89% 7,000,000
Mega BlackRock, Inc. $114,029,348 6.43% 4,553,888
Mid BVF INC/IL $93,502,915 5.28% 3,734,142
Mid PERCEPTIVE ADVISORS LLC $87,892,353 4.96% 3,510,078
Mega MORGAN STANLEY $62,113,421 3.50% 2,480,568
Large BNP PARIBAS ASSET MANAGEMENT Holding S.A. $47,777,295 2.70% 1,908,039
Mega VANGUARD CAPITAL MANAGEMENT LLC $42,707,723 2.41% 1,705,580
Mega CITADEL ADVISORS LLC $28,796,449 1.62% 1,150,018
Mega DIMENSIONAL FUND ADVISORS LP $28,523,938 1.61% 1,139,135
Mid Nextech Invest, Ltd. $27,893,207 1.57% 1,113,946
Mega STATE STREET CORP $25,334,896 1.43% 1,011,777
Small Capricorn Fund Managers Ltd $25,220,538 1.42% 1,007,210
Mega DEUTSCHE BANK AG\ Bank $23,068,099 1.30% 921,250
Mega ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $18,627,205 1.05% 743,898
Large Assenagon Asset Management S.A. $18,228,769 1.03% 727,986
Mega FMR LLC $16,705,511 0.94% 667,153
Mega GEODE CAPITAL MANAGEMENT, LLC $16,524,897 0.93% 659,940
Mega Nuveen, LLC $16,317,615 0.92% 651,662
Mega GOLDMAN SACHS GROUP INC $15,011,128 0.85% 599,486
Mid MPM BIOIMPACT LLC $14,153,834 0.80% 565,249
Small Prosight Management, LP $13,497,786 0.76% 539,049
Large Qube Research & Technologies Ltd $12,818,902 0.72% 511,937
Mega VANGUARD PORTFOLIO MANAGEMENT LLC $12,516,870 0.71% 499,875
Mid Redmile Group, LLC $12,311,016 0.69% 491,654
Mid Hillsdale Investment Management Inc. $8,654,374 0.49% 345,622
Mid SummitTX Capital, L.P. $8,048,532 0.45% 321,427
Mega NORTHERN TRUST CORP Bank $8,018,056 0.45% 320,210
Mega UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $7,997,398 0.45% 319,385
Mid ROYCE & ASSOCIATES LP $7,492,018 0.42% 299,202
Mid PICTON MAHONEY ASSET MANAGEMENT $6,427,517 0.36% 256,690
Mid Granahan Investment Management, LLC $6,279,355 0.35% 250,773
Large HRT FINANCIAL LP $5,956,740 0.34% 237,889
Mega BANK OF AMERICA CORP /DE/ Bank $5,928,319 0.33% 236,754
Mega D. E. Shaw & Co., Inc. $5,899,949 0.33% 235,621
Mega JANE STREET GROUP, LLC $5,683,253 0.32% 226,967
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $5,418,656 0.31% 216,400
Large PANAGORA ASSET MANAGEMENT INC $5,179,624 0.29% 206,854
Large Man Group plc $4,754,845 0.27% 189,890
Mega WELLS FARGO & COMPANY/MN $4,748,483 0.27% 189,636
Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC $4,635,504 0.26% 185,124
Large FEDERATED HERMES, INC. $4,567,545 0.26% 182,410
Mega RAYMOND JAMES FINANCIAL INC $4,417,331 0.25% 176,411
Mega UBS Group AG $4,301,345 0.24% 171,779
Large SILVERCREST ASSET MANAGEMENT GROUP LLC $4,097,770 0.23% 163,649
Mid KENNEDY CAPITAL MANAGEMENT LLC $3,711,579 0.21% 148,226
Mid XTX Topco Ltd $3,602,805 0.20% 143,882
Small DIADEMA PARTNERS LP $3,558,985 0.20% 142,132
Mega WELLINGTON MANAGEMENT GROUP LLP $3,472,796 0.20% 138,690
Mega Invesco Ltd. $3,145,773 0.18% 125,630
Mega Bank of New York Mellon Corp Bank $3,107,587 0.18% 124,105
Mega CITIGROUP INC $2,862,747 0.16% 114,327
Mega JPMORGAN CHASE & CO $2,856,362 0.16% 114,072
Small PLATINUM INVESTMENT MANAGEMENT LTD $2,633,807 0.15% 105,184
Mid Tema ETFs LLC Mutual Fund $2,627,472 0.15% 104,931
Large Tidal Investments LLC $2,627,472 0.15% 104,931
Mega Fisher Asset Management, LLC $2,540,032 0.14% 101,439
Mid Susquehanna Portfolio Strategies, LLC $2,498,866 0.14% 99,795
Mega AQR CAPITAL MANAGEMENT LLC $2,270,348 0.13% 90,669
Mid KORNITZER CAPITAL MANAGEMENT INC /KS $2,223,552 0.13% 88,800
Mega CITADEL ADVISORS LLC $2,180,984 0.12% 87,100
Mega VANGUARD FIDUCIARY TRUST CO Bank $2,113,451 0.12% 84,403
Large Squarepoint Ops LLC $2,081,975 0.12% 83,146
Large MACKENZIE FINANCIAL CORP $2,071,459 0.12% 82,726
Micro Verdad Advisers, LP $2,070,757 0.12% 82,698
Mega PRINCIPAL FINANCIAL GROUP INC $1,966,816 0.11% 78,547
Mega FRANKLIN RESOURCES INC $1,944,579 0.11% 77,659
Large STIFEL FINANCIAL CORP $1,921,970 0.11% 76,756
Mega RHUMBLINE ADVISERS $1,887,990 0.11% 75,399
Large CREDIT AGRICOLE S A $1,878,000 0.11% 75,000
Mega AMERIPRISE FINANCIAL INC $1,858,517 0.10% 74,222
Mega Swiss National Bank Bank $1,857,968 0.10% 74,200
Mega AMERICAN CENTURY COMPANIES INC $1,774,109 0.10% 70,851
Large STATE OF WISCONSIN INVESTMENT BOARD $1,655,294 0.09% 66,106
Mid Dana Investment Advisors, Inc. $1,404,919 0.08% 56,107
Mega ALLIANCEBERNSTEIN L.P. $1,399,635 0.08% 55,896
Mid Campbell & CO Investment Adviser LLC $1,374,270 0.08% 54,883
Small DLD Asset Management, LP $1,327,120 0.07% 53,000
Mega MILLENNIUM MANAGEMENT LLC $1,252,000 0.07% 50,000
Large Russell Investments Group, Ltd. $1,188,145 0.07% 47,450
Mega ROYAL BANK OF CANADA Bank $1,185,894 0.07% 47,360
Small North Growth Management Ltd. $1,151,840 0.06% 46,000
Mid SEGALL BRYANT & HAMILL, LLC $1,144,979 0.06% 45,726
Large JACOBS LEVY EQUITY MANAGEMENT, INC $1,071,361 0.06% 42,786
Mega VICTORY CAPITAL MANAGEMENT INC $1,061,796 0.06% 42,404
Mega ENVESTNET ASSET MANAGEMENT INC $1,012,091 0.06% 40,419
Small Manatuck Hill Partners, LLC $1,001,600 0.06% 40,000
Large LOS ANGELES CAPITAL MANAGEMENT LLC $995,340 0.06% 39,750
Large Quantinno Capital Management LP $992,585 0.06% 39,640
Large Zurcher Kantonalbank (Zurich Cantonalbank) Bank $985,449 0.06% 39,355
Large Connor, Clark & Lunn Investment Management Ltd. $949,491 0.05% 37,919
Mega HSBC HOLDINGS PLC $945,935 0.05% 37,777
Large CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM Pension $936,220 0.05% 37,389
Large O'SHAUGHNESSY ASSET MANAGEMENT, LLC $929,710 0.05% 37,129
Large TUDOR INVESTMENT CORP ET AL $923,350 0.05% 36,875
Large HighTower Advisors, LLC $908,000 0.05% 36,262
Small Persistent Asset Partners Ltd $899,812 0.05% 35,935
Mega PRICE T ROWE ASSOCIATES INC /MD/ $888,594 0.05% 35,487
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $853,864 0.05% 34,100
Small HighVista Strategies LLC $853,488 0.05% 34,085
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