ZYME · Zymeworks Inc. · Shareholders & Ownership

$28.63 +0.26 (+0.92%)

Russell 2000 member Rebalance outlook locked

Market Cap

$1.99B

70.96M

Volume · Oct 27 260.57K Avg daily vol (3M) 881.53K

Every disclosed holder of ZYME in one list: 13F institutions, Schedule 13D and 13G filers, insiders (Forms 3, 4 and 5) and registered funds, each from its own latest filing. Holders nest by CIK and SEC reporting links, never by name, and each is summed once.

How the holder list picks a filing →

Who Owns ZYME

13F quarter Sep 30, 2026, combined view: filers that have not filed yet carry their Jun 30, 2026 positions

No chart: the summed disclosures exceed shares outstanding, so they are not parts of one whole.

Holder group	Holders	Shares	% Out	Summed
Institutional (13F)	203	68,556,251	96.61%	Yes
Insiders (Forms 3, 4, 5)	7	953,063	1.34%	Yes
13D/G-only blocks	2	3,965,641	5.59%	Yes
Remaining	—	2,515,714	-3.55%	Negative
Registered funds (N-PORT, not summed)	176	9,577,615	13.50%	No

Shares outstanding: 70,959,241, the issuer's latest cover-page count restated onto today's split basis.

Remaining is negative: the summed disclosures exceed shares outstanding, as when filings are dated at different times or holders that do not disclose their links count the same shares. It is flagged, not clipped.

13D/G-only counts each filer's latest 13D or 13G that no 13F report of the listing contains, that names no 13F filer and that no counted insider files. Funds are never summed: their shares sit inside their advisers' 13F reports.

Holders of ZYME

One row per holder Every filing By ultimate parent

All 13F Funds Insiders 13D/G Non-US

#	Holder	Shares	% Out	Change	As of	Notes
1	EcoR1 Capital, LLC 13F CIK 1587114 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	22,970,388	32.37%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
1.1	EcoR1 Capital, LLC Insider CIK 1587114 · Jun 26, 2025 Director, 10% Owner, issuer-wide, not summed	22,970,388	32.37%	—	Jun 26, 2025	Director, 10% Owner, issuer-wide, not summed
2	NODELMAN OLEG Insider CIK 1454385 · Feb 17, 2025 Director, 10% Owner, issuer-wide, not summed	15,720,161	22.15%	—	Feb 17, 2025	Director, 10% Owner, issuer-wide, not summed
3	Rubric Capital Management LP 13F CIK 1687509 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	7,000,000	9.86%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
4	BlackRock, Inc. 13F CIK 2012383 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	4,251,030	5.99%	-302,858	Jun 30, 2026	carried, not yet filed for the newest quarter
4.1	iShares Russell 2000 ETF Fund S000004344 · Registered fund · Jun 30, 2026 iShares Trust, not summed	1,207,865	1.70%	-10,358	Jun 30, 2026	iShares Trust, not summed
4.2	iShares Biotechnology ETF Fund S000004350 · Registered fund · Jun 30, 2026 iShares Trust, not summed	500,560	0.71%	-29,421	Jun 30, 2026	iShares Trust, not summed
4.3	iShares Russell 2000 Growth ETF Fund S000004343 · Registered fund · Jun 30, 2026 iShares Trust, not summed	434,367	0.61%	+28,336	Jun 30, 2026	iShares Trust, not summed
4.4	BlackRock Advantage Small Cap Core Fund Fund S000039982 · Registered fund · Aug 31, 2026 BlackRock Funds, not summed	239,659	0.34%	+20,713	Aug 31, 2026	BlackRock Funds, not summed
4.5	Master Small Cap Index Series Fund S000002716 · Registered fund · Jun 30, 2026 Quantitative Master Series LLC, not summed	84,656	0.12%	+4,835	Jun 30, 2026	Quantitative Master Series LLC, not summed
5	PERCEPTIVE ADVISORS LLC 13F CIK 1224962 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	4,182,953	5.89%	+672,875	Jun 30, 2026	carried, not yet filed for the newest quarter
6	BIOTECHNOLOGY VALUE FUND L P 13G CIK 918923 · Unknown · Sep 30, 2025 Rule 13d-1(c), passive investor	3,938,641	5.55%	-669,294	Sep 30, 2025	Rule 13d-1(c), passive investor
7	BVF INC/IL 13F CIK 1056807 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	3,649,142	5.14%	-85,000	Jun 30, 2026	carried, not yet filed for the newest quarter
8	MORGAN STANLEY 13F CIK 895421 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	2,231,260	3.14%	-249,308	Jun 30, 2026	carried, not yet filed for the newest quarter
8.1	E*TRADE No Fee Total Market Index Fund Fund S000090722 · Registered fund · Jul 31, 2026 E Trade Trust, not summed	151	0.00%	0	Jul 31, 2026	E Trade Trust, not summed
9	BNP PARIBAS ASSET MANAGEMENT Holding S.A. 13F CIK 1520354 · Non-US institution · Jun 30, 2026 carried, not yet filed for the newest quarter	1,781,116	2.51%	-126,923	Jun 30, 2026	carried, not yet filed for the newest quarter
10	VANGUARD CAPITAL MANAGEMENT LLC 13F CIK 2100119 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,558,998	2.20%	-146,582	Jun 30, 2026	carried, not yet filed for the newest quarter
11	VANGUARD TOTAL STOCK MARKET INDEX FUND Fund S000002848 · Registered fund · Jun 30, 2026 VANGUARD INDEX FUNDS, not summed	1,508,613	2.13%	-142,700	Jun 30, 2026	VANGUARD INDEX FUNDS, not summed
12	Assenagon Asset Management S.A. 13F CIK 1546007 · Unknown · Sep 30, 2026	1,508,069	2.13%	+256,042	Sep 30, 2026
13	Nextech Invest, Ltd. 13F CIK 1595430 · Exempt reporting adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,113,946	1.57%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
14	STATE STREET CORP 13F CIK 93751 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	1,088,216	1.53%	+76,439	Jun 30, 2026	carried, not yet filed for the newest quarter
14.1	State Street(R) SPDR(R) Portfolio Developed World ex-US ETF Fund S000014038 · Registered fund · Jun 30, 2026 SPDR INDEX SHARES FUNDS, not summed	79,798	0.11%	-80	Jun 30, 2026	SPDR INDEX SHARES FUNDS, not summed
14.2	State Street(R) SPDR(R) S&P(R) International Small Cap ETF Fund S000014039 · Registered fund · Jun 30, 2026 SPDR INDEX SHARES FUNDS, not summed	42,050	0.06%	+434	Jun 30, 2026	SPDR INDEX SHARES FUNDS, not summed
14.3	STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO Fund S000050332 · Registered fund · Jun 30, 2026 STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed	17,700	0.02%	+700	Jun 30, 2026	STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
14.4	State Street(R) SPDR(R) US Small Cap Low Volatility Index ETF Fund S000039795 · Registered fund · Jun 30, 2026 SPDR SERIES TRUST, not summed	6,892	0.01%	—	Jun 30, 2026	SPDR SERIES TRUST, not summed
14.5	State Street Total Return V.I.S. Fund Fund S000001637 · Registered fund · Jun 30, 2026 STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed	1,151	0.00%	-20	Jun 30, 2026	STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed
15	DIMENSIONAL FUND ADVISORS LP 13F CIK 354204 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	994,955	1.40%	-144,180	Jun 30, 2026	carried, not yet filed for the newest quarter
15.1	U.S. SMALL CAP PORTFOLIO Fund S000000971 · Registered fund · Jul 31, 2026 DFA INVESTMENT DIMENSIONS GROUP INC, not summed	194,463	0.27%	-55,476	Jul 31, 2026	DFA INVESTMENT DIMENSIONS GROUP INC, not summed
15.2	Dimensional U.S. Small Cap ETF Fund S000070906 · Registered fund · Jul 31, 2026 Dimensional ETF Trust, not summed	189,632	0.27%	-234	Jul 31, 2026	Dimensional ETF Trust, not summed
15.3	U.S. MICRO CAP PORTFOLIO Fund S000000948 · Registered fund · Jul 31, 2026 DFA INVESTMENT DIMENSIONS GROUP INC, not summed	166,863	0.24%	-4,775	Jul 31, 2026	DFA INVESTMENT DIMENSIONS GROUP INC, not summed
15.4	Dimensional U.S. Core Equity 2 ETF Fund S000070903 · Registered fund · Jul 31, 2026 Dimensional ETF Trust, not summed	70,572	0.10%	-2,330	Jul 31, 2026	Dimensional ETF Trust, not summed
15.5	U.S. CORE EQUITY 2 PORTFOLIO Fund S000000980 · Registered fund · Jul 31, 2026 DFA INVESTMENT DIMENSIONS GROUP INC, not summed	59,341	0.08%	-1,817	Jul 31, 2026	DFA INVESTMENT DIMENSIONS GROUP INC, not summed
16	CITADEL ADVISORS LLC 13F CIK 1423053 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	914,136	1.29%	-235,882	Jun 30, 2026	carried, not yet filed for the newest quarter
17	NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 13F CIK 921739 · Investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	889,802	1.25%	+889,802	Jun 30, 2026	carried, not yet filed for the newest quarter
17.1	Nomura Small Cap Growth Fund Fund S000006286 · Registered fund · Jun 30, 2026 IVY FUNDS, not summed	600,846	0.85%	—	Jun 30, 2026	IVY FUNDS, not summed
17.2	Nomura VIP Small Cap Growth Series Fund S000006233 · Registered fund · Jun 30, 2026 Ivy Variable Insurance Portfolios, not summed	117,152	0.17%	—	Jun 30, 2026	Ivy Variable Insurance Portfolios, not summed
18	FMR LLC 13F CIK 315066 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	702,568	0.99%	+35,415	Jun 30, 2026	carried, not yet filed for the newest quarter
18.1	Fidelity Small Cap Index Fund Fund S000033638 · Registered fund · Jul 31, 2026 Fidelity Salem Street Trust, not summed	512,747	0.72%	+20,194	Jul 31, 2026	Fidelity Salem Street Trust, not summed
18.2	Fidelity Small Cap Growth Fund Fund S000007193 · Registered fund · Jul 31, 2026 Fidelity Securities Fund, not summed	369,100	0.52%	0	Jul 31, 2026	Fidelity Securities Fund, not summed
18.3	Fidelity Small Cap Growth K6 Fund Fund S000057285 · Registered fund · Jul 31, 2026 Fidelity Securities Fund, not summed	184,050	0.26%	0	Jul 31, 2026	Fidelity Securities Fund, not summed
18.4	Select Biotechnology Portfolio Fund S000007486 · Registered fund · Aug 31, 2026 Fidelity Select Portfolios, not summed	112,773	0.16%	+64,900	Aug 31, 2026	Fidelity Select Portfolios, not summed
18.5	Fidelity Enhanced Small Cap Core ETF Fund S000081807 · Registered fund · Jun 30, 2026 Fidelity Covington Trust, not summed	78,711	0.11%	+35,270	Jun 30, 2026	Fidelity Covington Trust, not summed
19	GEODE CAPITAL MANAGEMENT, LLC 13F CIK 1214717 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	692,410	0.98%	+32,470	Jun 30, 2026	carried, not yet filed for the newest quarter
20	Prosight Management, LP 13F CIK 1617201 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	674,434	0.95%	+135,385	Jun 30, 2026	carried, not yet filed for the newest quarter
21	Qube Research & Technologies Ltd 13F CIK 1729829 · Exempt reporting adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	593,590	0.84%	+81,653	Jun 30, 2026	carried, not yet filed for the newest quarter
22	VANGUARD PORTFOLIO MANAGEMENT LLC 13F CIK 2100121 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	510,032	0.72%	+10,157	Jun 30, 2026	carried, not yet filed for the newest quarter
23	Ciongoli Gregory Austin Insider CIK 2023732 · Aug 12, 2025 Director, issuer-wide	493,500	0.70%	+415,000	Aug 12, 2025	Director, issuer-wide
24	Redmile Group, LLC 13F CIK 1425738 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	491,654	0.69%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
25	Capricorn Fund Managers Ltd 13F CIK 1901361 · Exempt reporting adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	486,529	0.69%	-520,681	Jun 30, 2026	carried, not yet filed for the newest quarter
26	GOLDMAN SACHS GROUP INC 13F CIK 886982 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	470,822	0.66%	-128,664	Jun 30, 2026	carried, not yet filed for the newest quarter
26.1	Goldman Sachs ActiveBeta(R) U.S. Small Cap Equity ETF Fund S000048296 · Registered fund · May 31, 2026 Goldman Sachs ETF Trust, not summed	10,887	0.02%	-3,265	May 31, 2026	Goldman Sachs ETF Trust, not summed
26.2	Goldman Sachs Absolute Return Tracker Fund Fund S000020314 · Registered fund · Aug 31, 2026 GOLDMAN SACHS TRUST, not summed	8,045	0.01%	-2,535	Aug 31, 2026	GOLDMAN SACHS TRUST, not summed
26.3	Goldman Sachs Small Cap Growth Insights Fund Fund S000014930 · Registered fund · Jul 31, 2026 Goldman Sachs Trust, not summed	2,314	0.00%	-2,223	Jul 31, 2026	Goldman Sachs Trust, not summed
27	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 13F CIK 1164508 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	418,497	0.59%	-325,401	Jun 30, 2026	carried, not yet filed for the newest quarter
28	DEUTSCHE BANK AG\ 13F CIK 948046 · Non-US institution · Jun 30, 2026 carried, not yet filed for the newest quarter	397,190	0.56%	-524,060	Jun 30, 2026	carried, not yet filed for the newest quarter
28.1	DWS Small Cap Index VIP Fund S000006223 · Registered fund · Jun 30, 2026 DEUTSCHE DWS INVESTMENTS VIT FUNDS, not summed	7,391	0.01%	+420	Jun 30, 2026	DEUTSCHE DWS INVESTMENTS VIT FUNDS, not summed
29	Hillsdale Investment Management Inc. 13F CIK 1368465 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	382,922	0.54%	+37,300	Jun 30, 2026	carried, not yet filed for the newest quarter
30	FIRST TRUST ADVISORS LP 13F CIK 1125816 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	340,363	0.48%	+340,363	Jun 30, 2026	carried, not yet filed for the newest quarter
30.1	First Trust Small Cap Growth AlphaDEX Fund Fund S000031806 · Registered fund · Jul 31, 2026 First Trust Exchange-Traded AlphaDEX Fund, not summed	65,877	0.09%	-120,370	Jul 31, 2026	First Trust Exchange-Traded AlphaDEX Fund, not summed
30.2	First Trust Multi Cap Growth AlphaDEX Fund Fund S000017343 · Registered fund · Jul 31, 2026 First Trust Exchange-Traded AlphaDEX Fund, not summed	5,969	0.01%	-11,424	Jul 31, 2026	First Trust Exchange-Traded AlphaDEX Fund, not summed
31	Granahan Investment Management, LLC 13F CIK 1026710 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	336,157	0.47%	+85,384	Jun 30, 2026	carried, not yet filed for the newest quarter
32	NORTHERN TRUST CORP 13F CIK 73124 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	321,073	0.45%	+863	Jun 30, 2026	carried, not yet filed for the newest quarter
32.1	Small Cap Index Fund Fund S000001245 · Registered fund · Jun 30, 2026 Northern Funds, not summed	23,649	0.03%	+205	Jun 30, 2026	Northern Funds, not summed
32.2	FlexShares Morningstar US Market Factor Tilt Index Fund Fund S000033312 · Registered fund · Jul 31, 2026 FlexShares Trust, not summed	5,508	0.01%	+272	Jul 31, 2026	FlexShares Trust, not summed
32.3	Small Cap Core Fund Fund S000001244 · Registered fund · Jun 30, 2026 Northern Funds, not summed	4,478	0.01%	-193	Jun 30, 2026	Northern Funds, not summed
33	Pictet Asset Management Holding SA 13F CIK 1993888 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	308,187	0.43%	+298,931	Jun 30, 2026	carried, not yet filed for the newest quarter
34	PICTON MAHONEY ASSET MANAGEMENT 13F CIK 1539041 · Non-US institution · Jun 30, 2026 carried, not yet filed for the newest quarter	271,343	0.38%	+14,653	Jun 30, 2026	carried, not yet filed for the newest quarter
35	VANGUARD RUSSELL 2000 INDEX FUND Fund S000030003 · Registered fund · May 31, 2026 VANGUARD SCOTTSDALE FUNDS, not summed	256,110	0.36%	+9,187	May 31, 2026	VANGUARD SCOTTSDALE FUNDS, not summed
36	Galbraith Kenneth Insider CIK 1567045 · Jan 12, 2026 Director, Chair & CEO, issuer-wide	226,842	0.32%	+33,576	Jan 12, 2026	Director, Chair & CEO, issuer-wide
37	SILVERCREST ASSET MANAGEMENT GROUP LLC 13F CIK 1232395 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	223,766	0.32%	+60,117	Jun 30, 2026	carried, not yet filed for the newest quarter
38	BANK OF AMERICA CORP /DE/ 13F CIK 70858 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	219,071	0.31%	-17,683	Jun 30, 2026	carried, not yet filed for the newest quarter
39	WELLS FARGO & COMPANY/MN 13F CIK 72971 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	217,199	0.31%	+27,563	Jun 30, 2026	carried, not yet filed for the newest quarter
40	SummitTX Capital, L.P. 13F CIK 2052310 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	210,802	0.30%	-110,625	Jun 30, 2026	carried, not yet filed for the newest quarter
41	Man Group plc 13F CIK 1637460 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	210,779	0.30%	+20,889	Jun 30, 2026	carried, not yet filed for the newest quarter
42	FEDERATED HERMES, INC. 13F CIK 1056288 · Investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	187,995	0.26%	+5,585	Jun 30, 2026	carried, not yet filed for the newest quarter
43	RAYMOND JAMES FINANCIAL INC 13F CIK 720005 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	166,416	0.23%	-9,995	Jun 30, 2026	carried, not yet filed for the newest quarter
44	Federated Hermes MDT Small Cap Core Fund Fund S000012972 · Registered fund · Jul 31, 2026 Federated Hermes MDT Series, not summed	156,803	0.22%	0	Jul 31, 2026	Federated Hermes MDT Series, not summed
45	STATE OF WISCONSIN INVESTMENT BOARD 13F CIK 854157 · Pension or benefit plan · Jun 30, 2026 carried, not yet filed for the newest quarter	155,579	0.22%	+89,473	Jun 30, 2026	carried, not yet filed for the newest quarter
46	CHARLES SCHWAB INVESTMENT MANAGEMENT INC 13F CIK 884546 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	152,416	0.21%	-32,708	Jun 30, 2026	carried, not yet filed for the newest quarter
46.1	Schwab Small-Cap Index Fund Fund S000005912 · Registered fund · Jul 31, 2026 SCHWAB CAPITAL TRUST, not summed	114,401	0.16%	+5,098	Jul 31, 2026	SCHWAB CAPITAL TRUST, not summed
46.2	Schwab Small-Cap Equity Fund Fund S000005516 · Registered fund · Jul 31, 2026 SCHWAB CAPITAL TRUST, not summed	25,477	0.04%	-39,612	Jul 31, 2026	SCHWAB CAPITAL TRUST, not summed
47	KENNEDY CAPITAL MANAGEMENT LLC 13F CIK 884589 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	145,386	0.20%	-2,840	Jun 30, 2026	carried, not yet filed for the newest quarter
48	D. E. Shaw & Co., Inc. 13F CIK 1009207 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	144,807	0.20%	-90,814	Jun 30, 2026	carried, not yet filed for the newest quarter
49	DIADEMA PARTNERS LP 13F CIK 2026172 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	142,132	0.20%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
50	Hollywood Mark Insider CIK 2104446 · Jul 6, 2026 EVP & Chief Operating Officer, issuer-wide	133,852	0.19%	+939	Jul 6, 2026	EVP & Chief Operating Officer, issuer-wide

25 more nested rows are not shown here; Every filing lists them all.

Shares are restated onto today's split basis. Change compares each row with the same holder's previous filing in the same source; a dash means there is none to compare. Nested 13D/G, insider and fund rows are not summed, since a 13F report already holds them.

Showing 1–50 of 290 holders

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Key facts CIK 1937653 CUSIP 98985Y108 13F (30d) 24 filings 24 filers Visit website Investor relations