PERCEPTIVE ADVISORS LLC

CIK

1224962

Location

NEW YORK, NY

Portfolio Value

Mid $5,100,117,995

Diversification

Diversified

Filing Date

Global Rank

#659 / 8,622 ▲ 4 · as of Mar 2026

Top Industry

Biotechnology 90.9%

3Y Alpha vs SPY

+4.0%

Period ended 4 months ago

Filed May 29, 2026 · 2mo

25 quarters · since Mar 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.

Cloned portfolio

+79.3%

SPY

+67.9%

Annualised alpha

+2.6%

Max drawdown

−46.0%

Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 99% of reported value on average across 13 quarters. Past performance does not predict future results.

Portfolio Concentration

91 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

12.9%

+1.8 pts

Top 5

35.3%

+5.5 pts

Top 10

51.6%

+7.8 pts

HHI

413

Diversified+93

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$5,100,117,995	91

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

23 positions

Ticker	Company	Δ Shares	Shares	Value
RLAY	Relay Therapeutics, Inc.	+7,847,896	9,751,141	$97,023,852
SABS	SAB Biotherapeutics, Inc.	+5,628,533	6,431,743	$24,633,575
BCRX	Biocryst Pharmaceuticals Inc	+4,271,504	7,434,033	$70,771,994
CNTA	Centessa Pharmaceuticals plc	+2,341,269	5,258,903	$208,883,627
AVR	Anteris Technologies Global Corp.	+1,750,000	3,425,476	$19,011,391
CRVS	Corvus Pharmaceuticals, Inc.	+1,600,000	2,292,441	$33,538,411
DYN	Dyne Therapeutics, Inc.	+1,189,895	4,668,839	$84,646,051
TENX	Tenax Therapeutics, Inc.	+1,008,640	1,447,782	$23,150,034
SYRE	Spyre Therapeutics, Inc.	+714,000	3,783,225	$190,825,869
ASND	Ascendis Pharma A/S	+450,000	1,531,421	$350,281,925
XFOR	X4 Pharmaceuticals, Inc	+423,196	6,737,648	$27,826,486
CTMX	CytomX Therapeutics, Inc.	+418,639	10,098,824	$47,464,472
ROIV	Roivant Sciences Ltd.	+300,000	8,285,461	$229,507,269
TNGX	Tango Therapeutics, Inc.	+295,118	808,153	$16,906,560
ZYME	Zymeworks Inc.	+248,228	3,510,078	$87,892,353
BBNX	Beta Bionics, Inc.	+240,000	842,944	$8,446,298
ANRO	Alto Neuroscience, Inc.	+225,500	2,009,893	$45,182,394
NRIX	Nurix Therapeutics, Inc.	+155,000	3,710,877	$57,518,593
GH	Guardant Health, Inc.	+140,000	300,000	$27,711,000
SLDB	Solid Biosciences Inc.	+73,107	11,906,646	$85,727,851
PRAX	Praxis Precision Medicines, Inc.	+40,000	2,035,986	$655,974,329
BLLN	BillionToOne, Inc.	+19,000	91,812	$7,247,639
AXSM	Axsome Therapeutics, Inc.	+1,050	149,950	$25,344,549
No positions match the current search.

Trimmed

Positions the filer reduced

25 positions

Ticker	Company	Δ Shares	Shares	Value
PALI	Palisade Bio, Inc.	−3,121,851	8,928,149	$15,624,260
IKT	Inhibikase Therapeutics, Inc.	−3,106,568	2,315,000	$3,889,200
IRD	Opus Genetics, Inc.	−2,489,158	1,835,842	$8,353,081
VRDN	Viridian Therapeutics, Inc.\DE	−1,871,874	1,170,829	$22,901,415
OMDA	Omada Health, Inc.	−1,610,000	786,330	$9,884,168
IVVD	Invivyd, Inc.	−925,863	20,859,303	$27,117,093
APGE	Apogee Therapeutics, Inc.	−790,267	1,540,384	$129,654,121
SION	Sionna Therapeutics, Inc.	−520,659	658,439	$26,396,819
ADMA	Adma Biologics, Inc.	−416,235	467,233	$4,209,769
IMVT	Immunovant, Inc.	−397,507	1,597,383	$39,678,993
NBIX	Neurocrine Biosciences Inc	−266,000	65,050	$8,569,687
BLTE	Belite Bio, Inc	−262,260	151,979	$24,231,531
CBIO	Crescent Biopharma, Inc.	−246,744	206,942	$3,801,524
CTNM	Contineum Therapeutics, Inc.	−209,000	1,255,592	$16,398,031
RYTM	Rhythm Pharmaceuticals, Inc.	−172,596	2,373,795	$206,448,951
CPIX	Cumberland Pharmaceuticals Inc	−144,109	196,978	$640,178
TVTX	Travere Therapeutics, Inc.	−135,629	4,142,551	$123,075,190
ABVX	Abivax S.A.	−129,459	328,884	$36,621,233
PTGX	Protagonist Therapeutics, Inc	−119,546	1,230,879	$129,734,646
OBIO	Orchestra BioMed Holdings, Inc.	−89,350	5,037,906	$21,411,100
AXGN	Axogen, Inc.	−86,828	697,312	$23,101,946
AORT	Artivion, Inc.	−85,000	1,637,290	$59,957,559
NUVL	Nuvalent, Inc.	−84,600	1,580,505	$161,922,737
ORKA	Oruka Therapeutics, Inc.	−81,000	1,395,501	$68,449,324
DRUG	Bright Minds Biosciences Inc.	−71,746	377,544	$27,549,385
No positions match the current search.

New Positions

Positions the filer opened this quarter

20 positions

Ticker	Company	Shares	Value
MRNA	Moderna, Inc.	1,000,000	$50,800,000
IONS	Ionis Pharmaceuticals Inc	504,000	$37,845,360
DAWN	Day One Biopharmaceuticals, Inc.	1,755,799	$37,644,330
DMRA	Damora Therapeutics, Inc.	1,223,000	$31,675,700
RVMD	Revolution Medicines, Inc.	258,600	$25,148,850
DBVT	DBV Technologies S.A.	964,391	$20,146,127
STRO	Sutro Biopharma, Inc.	715,307	$17,818,297
EVMN	Evommune, Inc.	448,350	$10,307,566
PHAT	Phathom Pharmaceuticals, Inc.	925,000	$10,276,750
NMRA	Neumora Therapeutics, Inc.	5,104,097	$9,952,989
TWST	Twist Bioscience Corp	150,000	$7,128,000
SRZN	Surrozen, Inc./DE	229,393	$6,682,218
AGMB	Agomab Therapeutics NV	600,000	$6,294,000
EOLS	Evolus, Inc.	1,286,862	$5,289,002
OCUL	Ocular Therapeutix, Inc	500,000	$4,235,000
APLS	Apellis Pharmaceuticals, Inc.	80,956	$3,256,859
EDSA	Edesa Biotech, Inc.	563,239	$2,945,739
CORT	Corcept Therapeutics Inc	50,000	$2,015,500
ADPT	Adaptive Biotechnologies Corp	152,500	$529,175
XGN	Exagen Inc.	114,893	$344,679
No positions match the current search.

Sold Out

Positions the filer fully exited

25 positions

Ticker	Company	Shares	Value
EXAS	EXACT SCIENCES CORP	1,200,487	$121,921,459
ACLX	Arcellx, Inc.	1,466,071	$95,587,829
BSX	Boston Scientific Corp	979,000	$93,347,650
FOLD	AMICUS THERAPEUTICS, INC.	6,370,851	$90,720,918
DHR	Danaher Corp /De/	200,000	$45,784,000
IRON	Disc Medicine, Inc.	450,743	$35,793,501
PEN	Penumbra Inc	110,529	$34,364,571
CAI	Caris Life Sciences, Inc.	1,136,206	$30,654,837
PVLA	Palvella Therapeutics, Inc.	266,287	$27,872,260
KOD	Kodiak Sciences Inc.	848,900	$23,735,244
BIIB	Biogen Inc.	124,000	$21,822,760
ALDX	Aldeyra Therapeutics, Inc.	4,185,632	$21,681,573
MIRM	Mirum Pharmaceuticals, Inc.	259,545	$20,501,459
GRAL	GRAIL, Inc.	237,342	$20,314,101
CVS	CVS HEALTH Corp	220,000	$17,459,200
GKOS	GLAUKOS Corp	140,000	$15,807,400
DXCM	Dexcom Inc	225,758	$14,983,558
SVRA	Savara Inc	2,400,000	$14,472,000
SEPN	Septerna, Inc.	433,160	$12,076,500
GOSS	Gossamer Bio, Inc.	3,139,669	$9,732,973
MPLT	MapLight Therapeutics, Inc.	550,000	$9,660,750
XENE	Xenon Pharmaceuticals Inc.	200,791	$8,999,452
KMTS	Kestra Medical Technologies, Ltd.	285,000	$7,558,200
CAPR	Capricor Therapeutics, Inc.	242,100	$6,987,006
BHVN	Biohaven Ltd.	500,000	$5,645,000
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

91 tracked positions · $5,100,117,995 total · as of Mar 31, 2026

All sectors Healthcare

Showing 1–50 of 91 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
PRAX	Praxis Precision Medicines, Inc. Healthcare	Added	2,035,986	+40,000	$655,974,329	+11.5%	12.86%
CELC	Celcuity Inc. Healthcare	Reduced	3,127,200	-33,000	$356,938,608	+13.2%	7.00%
ASND	Ascendis Pharma A/S Healthcare	Added	1,531,421	+450,000	$350,281,925	+51.9%	6.87%
ROIV	Roivant Sciences Ltd. Healthcare	Added	8,285,461	+300,000	$229,507,269	+32.4%	4.50%
CNTA	Centessa Pharmaceuticals plc Healthcare	Added	5,258,903	+2,341,269	$208,883,627	+186.3%	4.10%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	Reduced	2,373,795	-172,596	$206,448,951	−24.3%	4.05%
SYRE	Spyre Therapeutics, Inc. Healthcare	Added	3,783,225	+714,000	$190,825,869	+89.8%	3.74%
NUVL	Nuvalent, Inc. Healthcare	Reduced	1,580,505	-84,600	$161,922,737	−3.3%	3.17%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Reduced	4,423,974	-34,000	$139,355,181	+26.0%	2.73%
PTGX	Protagonist Therapeutics, Inc Healthcare	Reduced	1,230,879	-119,546	$129,734,646	+10.0%	2.54%
APGE	Apogee Therapeutics, Inc. Healthcare	Reduced	1,540,384	-790,267	$129,654,121	−26.3%	2.54%
TVTX	Travere Therapeutics, Inc. Healthcare	Reduced	4,142,551	-135,629	$123,075,190	−24.7%	2.41%
AMLX	Amylyx Pharmaceuticals, Inc. Healthcare	Held	8,284,882	0	$115,159,859	+15.1%	2.26%
IMTX	Immatics N.V. Healthcare	Held	10,383,456	0	$102,173,207	−6.3%	2.00%
RLAY	Relay Therapeutics, Inc. Healthcare	Added	9,751,141	+7,847,896	$97,023,852	+502.6%	1.90%
INBX	Inhibrx Biosciences, Inc. Healthcare	Reduced	1,442,707	-10,000	$96,993,191	−15.5%	1.90%
MGTX	MeiraGTx Holdings plc Healthcare	Held	10,326,103	0	$89,424,051	+8.9%	1.75%
ZYME	Zymeworks Inc. Healthcare	Added	3,510,078	+248,228	$87,892,353	+2.3%	1.72%
SLDB	Solid Biosciences Inc. Healthcare	Added	11,906,646	+73,107	$85,727,851	+28.4%	1.68%
DYN	Dyne Therapeutics, Inc. Healthcare	Added	4,668,839	+1,189,895	$84,646,051	+24.4%	1.66%
BCRX	Biocryst Pharmaceuticals Inc Healthcare	Added	7,434,033	+4,271,504	$70,771,994	+186.9%	1.39%
ORKA	Oruka Therapeutics, Inc. Healthcare	Reduced	1,395,501	-81,000	$68,449,324	+53.0%	1.34%
AORT	Artivion, Inc. Healthcare	Reduced	1,637,290	-85,000	$59,957,559	−23.7%	1.18%
NRIX	Nurix Therapeutics, Inc. Healthcare	Added	3,710,877	+155,000	$57,518,593	−14.7%	1.13%
MRNA	Moderna, Inc. PUT Healthcare	NEW	1,000,000	NEW	$50,800,000	NEW	1.00%
NAUT	Nautilus Biotechnology, Inc. Healthcare	Held	12,594,211	0	$48,865,538	+99.0%	0.96%
CTMX	CytomX Therapeutics, Inc. Healthcare	Added	10,098,824	+418,639	$47,464,472	+15.1%	0.93%
ANRO	Alto Neuroscience, Inc. Healthcare	Added	2,009,893	+225,500	$45,182,394	+42.3%	0.89%
ENGN	enGene Therapeutics Inc. Healthcare	Reduced	5,827,506	-41,570	$39,685,315	−25.1%	0.78%
IMVT	Immunovant, Inc. Healthcare	Reduced	1,597,383	-397,507	$39,678,993	−21.8%	0.78%
ISRG	Intuitive Surgical Inc Healthcare	Reduced	85,419	-2,500	$39,377,304	−20.9%	0.77%
IONS	Ionis Pharmaceuticals Inc Healthcare	NEW	504,000	NEW	$37,845,360	NEW	0.74%
DAWN	Day One Biopharmaceuticals, Inc. Healthcare	NEW	1,755,799	NEW	$37,644,330	NEW	0.74%
ABVX	Abivax S.A. Healthcare	Reduced	328,884	-129,459	$36,621,233	−40.8%	0.72%
CRVS	Corvus Pharmaceuticals, Inc. Healthcare	Added	2,292,441	+1,600,000	$33,538,411	+529.0%	0.66%
RGEN	Repligen Corp Healthcare	Reduced	280,541	-35,000	$33,053,340	−36.1%	0.65%
JAZZ	Jazz Pharmaceuticals plc Healthcare	Held	170,000	0	$32,138,500	+11.2%	0.63%
DMRA	Damora Therapeutics, Inc. Healthcare	NEW	1,223,000	NEW	$31,675,700	NEW	0.62%
XFOR	X4 Pharmaceuticals, Inc Healthcare	Added	6,737,648	+423,196	$27,826,486	+10.2%	0.55%
GH	Guardant Health, Inc. Healthcare	Added	300,000	+140,000	$27,711,000	+69.6%	0.54%
DRUG	Bright Minds Biosciences Inc. Healthcare	Reduced	377,544	-71,746	$27,549,385	−21.4%	0.54%
IVVD	Invivyd, Inc. Healthcare	Reduced	20,859,303	-925,863	$27,117,093	−49.6%	0.53%
SION	Sionna Therapeutics, Inc. Healthcare	Reduced	658,439	-520,659	$26,396,819	−45.6%	0.52%
AXSM	Axsome Therapeutics, Inc. Healthcare	Added	149,950	+1,050	$25,344,549	−6.8%	0.50%
RVMD	Revolution Medicines, Inc. Healthcare	NEW	258,600	NEW	$25,148,850	NEW	0.49%
SABS	SAB Biotherapeutics, Inc. Healthcare	Added	6,431,743	+5,628,533	$24,633,575	+720.0%	0.48%
BLTE	Belite Bio, Inc Healthcare	Reduced	151,979	-262,260	$24,231,531	−63.4%	0.48%
TENX	Tenax Therapeutics, Inc. Healthcare	Added	1,447,782	+439,332	$23,150,034	+88.3%	0.45%
AXGN	Axogen, Inc. Healthcare	Reduced	697,312	-86,828	$23,101,946	−10.0%	0.45%
VRDN	Viridian Therapeutics, Inc.\DE Healthcare	Reduced	1,170,829	-1,871,874	$22,901,415	−75.8%	0.45%

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.