EcoR1 Capital, LLC
CIK
1587114
Location
San Francisco, CA
Portfolio Value
Mid
$2,031,905,121
Diversification
Diversified
Filing Date
Global Rank
#1,165
/ 7,976
▲ 182
Top Industry
Biotechnology
96.3%
3Y Alpha vs SPY
-26.1%
Period ended 9 months ago
Filed Nov 14, 2025 · 7mo
23 quarters · since Mar 2020
Clone Performance
Jun 2023–Jun 2026 · vs SPYHypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.
Cloned portfolio
-15.1%
SPY
+76.3%
Annualised alpha
-26.1%
Max drawdown
−62.6%
Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.
Portfolio Concentration
26 positions · as of Sep 30, 2025 · Δ vs Jun 30, 2025Top Position
19.3%
+0.1 pts
Top 5
62.5%
−2.2 pts
Top 10
82.7%
+0.3 pts
HHI
957
Diversified−34
Portfolio Trend
23 quarters · across all stocks
Sector Breakdown
As of Sep 30, 2025| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 100.0% | $2,031,905,121 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
3 positions
Trimmed
Positions the filer reduced
4 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| APLS | Apellis Pharmaceuticals, Inc. | −8,448,652 | 3,447,156 | $78,009,140 | |
| KURA | Kura Oncology, Inc. | −3,327,500 | 872,500 | $7,721,625 | |
| VYGR | Voyager Therapeutics, Inc. | −3,247,243 | 670,303 | $3,130,315 | |
| QURE | uniQure N.V. | −135,000 | 3,988,971 | $232,836,237 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
6 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| BBOT | BridgeBio Oncology Therapeutics, Inc. | 2,823,126 | $32,691,799 | |
| AQST | Aquestive Therapeutics, Inc. | 2,625,000 | $14,673,750 | |
| CNTA | Centessa Pharmaceuticals plc | 550,000 | $13,337,500 | |
| PRME | Prime Medicine, Inc. | 1,543,326 | $8,550,026 | |
| PEPG | PepGen Inc. | 800,000 | $3,696,000 | |
| CMPS | COMPASS Pathways plc | 265,137 | $1,519,235 | |
| No positions match the current search. | ||||
Sold Out
Positions the filer fully exited
7 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| JANX | Janux Therapeutics, Inc. | 1,469,818 | $33,952,795 | |
| TECX | Tectonic Therapeutic, Inc. | 935,121 | $18,580,854 | |
| PCRX | Pacira BioSciences, Inc. | 457,471 | $10,933,556 | |
| REPL | Replimune Group, Inc. | 850,341 | $7,899,667 | |
| DAWN | Day One Biopharmaceuticals, Inc. | 862,068 | $5,603,442 | |
| WHWK | Whitehawk Therapeutics, Inc. | 1,091,417 | $2,040,949 | |
| MGNX | Macrogenics Inc | 1,602,717 | $1,939,287 | |
| No positions match the current search. | ||||
26 positions ·
$2,031,905,121 total
· as of Sep 30, 2025
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| ZYME |
Zymeworks Inc.
Healthcare
|
Held | 22,970,388 | $392,334,227 | 19.31% | |
| ANAB |
Anaptysbio, Inc
Healthcare
|
Held | 7,880,094 | $241,288,478 | 11.87% | |
| QURE |
uniQure N.V.
Healthcare
|
Reduced | 3,988,971 | $232,836,237 | 11.46% | |
| JAZZ |
Jazz Pharmaceuticals plc
Healthcare
|
Held | 1,706,469 | $224,912,614 | 11.07% | |
| CRNX |
Crinetics Pharmaceuticals, Inc.
Healthcare
|
Held | 4,288,120 | $178,600,198 | 8.79% | |
| CRSP |
CRISPR Therapeutics AG
Healthcare
|
Held | 1,389,276 | $90,038,977 | 4.43% | |
| TNGX |
Tango Therapeutics, Inc.
Healthcare
|
Held | 10,630,736 | $89,298,182 | 4.39% | |
| ORIC |
Oric Pharmaceuticals, Inc.
Healthcare
|
Added | 6,728,116 | $80,737,392 | 3.97% | |
| APLS |
Apellis Pharmaceuticals, Inc.
Healthcare
|
Reduced | 3,447,156 | $78,009,140 | 3.84% | |
| XNCR |
Xencor Inc
Healthcare
|
Held | 6,144,767 | $72,078,116 | 3.55% | |
| LKFT |
Lakefront Biotherapeutics NV
Healthcare
|
Added | 1,667,119 | $57,749,002 | 2.84% | |
| IMNM |
Immunome Inc.
Healthcare
|
Held | 4,079,415 | $47,769,949 | 2.35% | |
| ETON |
Eton Pharmaceuticals, Inc.
Healthcare
|
Held | 2,030,544 | $44,123,721 | 2.17% | |
| MBX |
MBX Biosciences, Inc.
Healthcare
|
Added | 2,123,604 | $37,163,070 | 1.83% | |
| MDGL |
Madrigal Pharmaceuticals, Inc.
Healthcare
|
Held | 75,000 | $34,399,500 | 1.69% | |
| BBOT |
BridgeBio Oncology Therapeutics, Inc.
Healthcare
|
NEW | 2,823,126 | $32,691,799 | 1.61% | |
| NGNE |
Neurogene Inc.
Healthcare
|
Held | 1,271,342 | $22,032,356 | 1.08% | |
| ALKS |
Alkermes plc.
Healthcare
|
Held | 500,000 | $15,000,000 | 0.74% | |
| AQST |
Aquestive Therapeutics, Inc.
Healthcare
|
NEW | 2,625,000 | $14,673,750 | 0.72% | |
| CNTA |
Centessa Pharmaceuticals plc
Healthcare
|
NEW | 550,000 | $13,337,500 | 0.66% | |
| PRME |
Prime Medicine, Inc.
Healthcare
|
NEW | 1,543,326 | $8,550,026 | 0.42% | |
| ATRA |
Atara Biotherapeutics, Inc.
Healthcare
|
Held | 573,183 | $8,213,712 | 0.40% | |
| KURA |
Kura Oncology, Inc.
Healthcare
|
Reduced | 872,500 | $7,721,625 | 0.38% | |
| PEPG |
PepGen Inc.
Healthcare
|
NEW | 800,000 | $3,696,000 | 0.18% | |
| VYGR |
Voyager Therapeutics, Inc.
Healthcare
|
Reduced | 670,303 | $3,130,315 | 0.15% | |
| CMPS |
COMPASS Pathways plc
Healthcare
|
NEW | 265,137 | $1,519,235 | 0.07% |