SEPN
Septerna, Inc.
$34.54
+0.18 (+0.52%)
At close · Jul 14
Market Cap
$1.54B
Shares
45,075,533
Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.
The Jun 30, 2026 filing window is
still open — showing the latest known positions. Funds that have not filed yet
carry their prior-quarter positions; a fund that filed without this stock counts
as sold out.
Holders: 123
Total Value: $1,095,153,171
Total Shares: 45,573,833
Showing 1–100
of 123 holdings by value
· page 1 of 2
Institutional Ownership Trend
7 quarters
Holder Concentration
Across 124 13F filersTop Holder
15.3%
of institutional value
Top 5
54.8%
of institutional value
Top 10
75.4%
of institutional value
HHI
774
Broadly held
| Holder | Value (USD) | % of 13F | Shares | Type | Discretion | Filed | Open | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Mid RA CAPITAL MANAGEMENT, L.P. | $168,110,467 | 15.35% | 6,995,858 | Shares | Sole | 2026-05-15 | ||||
| Small TRV GP V, LLC | $149,360,651 | 13.64% | 6,215,591 | Shares | Sole | 2026-05-07 | ||||
| Large Driehaus Capital Management LLC | $105,625,595 | 9.64% | 4,395,572 | Shares | Sole | 2026-05-15 | ||||
| Small TRV GP VI, LLC | $101,206,165 | 9.24% | 4,211,659 | Shares | Sole | 2026-05-07 | ||||
| Mid SAMSARA BIOCAPITAL, LLC | $75,673,545 | 6.91% | 3,149,128 | Shares | Sole | 2026-05-15 | ||||
| Mega GOLDMAN SACHS GROUP INC | $69,841,440 | 6.38% | 2,906,427 | Shares | Defined | 2026-05-15 | ||||
| Mid Siren, L.L.C. | $48,060,000 | 4.39% | 2,000,000 | Shares | Defined | 2026-05-14 | ||||
| Mega BlackRock, Inc. | $43,786,838 | 4.00% | 1,822,174 | Shares | Sole | 2026-05-13 | ||||
| Mid BVF INC/IL | $32,518,573 | 2.97% | 1,353,249 | Shares | Defined | 2026-05-15 | ||||
| Large Avoro Capital Advisors LLC | $32,140,125 | 2.93% | 1,337,500 | Shares | Sole | 2026-05-15 | ||||
| Mega VANGUARD CAPITAL MANAGEMENT LLC | $28,762,996 | 2.63% | 1,196,962 | Shares | Defined | 2026-05-15 | ||||
| Mid ADAR1 Capital Management, LLC | $26,188,326 | 2.39% | 1,089,818 | Shares | Sole | 2026-05-18 | ||||
| Mega PRIMECAP MANAGEMENT CO/CA/ | $25,203,481 | 2.30% | 1,048,834 | Shares | Sole | 2026-05-11 | ||||
| Mega JANUS HENDERSON GROUP PLC | $21,404,818 | 1.95% | 890,754 | Shares | Defined | 2026-05-18 | ||||
| Mid First Light Asset Management, LLC | $17,610,625 | 1.61% | 732,860 | Shares | Sole | 2026-05-15 | ||||
| Mega GEODE CAPITAL MANAGEMENT, LLC | $15,502,858 | 1.42% | 645,146 | Shares | Defined | 2026-05-15 | ||||
| Mega STATE STREET CORP | $15,173,671 | 1.39% | 631,447 | Shares | Defined | 2026-05-15 | ||||
| Mid Casdin Capital, LLC | $13,295,030 | 1.21% | 553,268 | Shares | Sole | 2026-05-15 | ||||
| Mid Venrock Adviser, LLC | $12,160,525 | 1.11% | 506,056 | Shares | Sole | 2026-05-15 | ||||
| Small Catalio Capital Management, LP | $7,073,470 | 0.65% | 294,360 | Shares | Sole | 2026-05-15 | ||||
| Mid Soleus Capital Management, L.P. | $6,608,250 | 0.60% | 275,000 | Shares | Sole | 2026-05-14 | ||||
| Large Balyasny Asset Management L.P. | $5,687,396 | 0.52% | 236,679 | Shares | Sole | 2026-05-15 | ||||
| Large Universal- Beteiligungs- und Servicegesellschaft mbH | $5,382,599 | 0.49% | 223,995 | Shares | Defined | 2026-05-11 | ||||
| Small Kalehua Capital Management LLC | $4,674,892 | 0.43% | 194,544 | Shares | Sole | 2026-05-15 | ||||
| Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $4,363,367 | 0.40% | 181,580 | Shares | Sole | 2026-05-15 | ||||
| Mega NORTHERN TRUST CORP Bank | $3,953,653 | 0.36% | 164,530 | Shares | Defined | 2026-05-14 | ||||
| Mega VANGUARD FIDUCIARY TRUST CO Bank | $3,712,250 | 0.34% | 154,484 | Shares | Defined | 2026-05-08 | ||||
| Mega MILLENNIUM MANAGEMENT LLC | $2,982,147 | 0.27% | 124,101 | Shares | Sole | 2026-05-15 | ||||
| Mega UBS Group AG | $2,811,005 | 0.26% | 116,979 | Shares | Defined | 2026-05-05 | ||||
| Mega MORGAN STANLEY | $2,656,033 | 0.24% | 110,530 | Shares | Defined | 2026-05-15 | ||||
| Small HUSSMAN STRATEGIC ADVISORS, INC. | $2,523,150 | 0.23% | 105,000 | Shares | Sole | 2026-05-11 | ||||
| Small Checkpoint Capital L.P. | $2,410,209 | 0.22% | 100,300 | Shares | Sole | 2026-05-15 | ||||
| Large FEDERATED HERMES, INC. | $2,145,901 | 0.20% | 89,301 | Shares | Defined | 2026-05-11 | ||||
| Mega JPMORGAN CHASE & CO | $2,034,714 | 0.19% | 84,674 | Shares | Defined | 2026-05-13 | ||||
| Mega Invesco Ltd. | $1,991,316 | 0.18% | 82,868 | Shares | Defined | 2026-05-12 | ||||
| Mega TWO SIGMA INVESTMENTS, LP | $1,811,069 | 0.17% | 75,367 | Shares | Sole | 2026-05-15 | ||||
| Mid Longaeva Partners L.P. | $1,791,845 | 0.16% | 74,567 | Shares | Other | 2026-05-15 | ||||
| Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1,754,190 | 0.16% | 73,000 | Call | Other | 2026-05-15 | ||||
| Mega AMERICAN CENTURY COMPANIES INC | $1,472,798 | 0.13% | 61,290 | Shares | Defined | 2026-05-15 | ||||
| Mega Bank of New York Mellon Corp Bank | $1,410,775 | 0.13% | 58,709 | Shares | Defined | 2026-05-05 | ||||
| Mid Jump Financial, LLC | $1,273,854 | 0.12% | 53,011 | Shares | Defined | 2026-05-14 | ||||
| Mid Sofinnova Investments, Inc. | $1,141,569 | 0.10% | 47,506 | Shares | Sole | 2026-05-15 | ||||
| Large MARSHALL WACE, LLP | $957,355 | 0.09% | 39,840 | Shares | Other | 2026-05-15 | ||||
| Small Rangeley Capital, LLC | $956,394 | 0.09% | 39,800 | Shares | Sole | 2026-05-15 | ||||
| Large RENAISSANCE TECHNOLOGIES LLC | $905,931 | 0.08% | 37,700 | Shares | Sole | 2026-05-14 | ||||
| Mid XTX Topco Ltd | $882,453 | 0.08% | 36,723 | Shares | Defined | 2026-05-15 | ||||
| Large Trexquant Investment LP | $848,283 | 0.08% | 35,301 | Shares | Sole | 2026-05-15 | ||||
| Large Alyeska Investment Group, L.P. | $841,050 | 0.08% | 35,000 | Shares | Sole | 2026-05-15 | ||||
| Large ACADIAN ASSET MANAGEMENT LLC | $744,401 | 0.07% | 30,978 | Shares | Defined | 2026-05-13 | ||||
| Mega Nuveen, LLC | $701,098 | 0.06% | 29,176 | Shares | Defined | 2026-04-30 | ||||
| Large JACOBS LEVY EQUITY MANAGEMENT, INC | $683,317 | 0.06% | 28,436 | Shares | Sole | 2026-05-15 | ||||
| Mega PRICE T ROWE ASSOCIATES INC /MD/ | $674,666 | 0.06% | 28,076 | Shares | Defined | 2026-05-15 | ||||
| Mega RHUMBLINE ADVISERS | $639,294 | 0.06% | 26,604 | Shares | Sole | 2026-05-12 | ||||
| Mega BANK OF AMERICA CORP /DE/ Bank | $624,131 | 0.06% | 25,973 | Shares | Defined | 2026-05-18 | ||||
| Large ADAGE CAPITAL PARTNERS GP, L.L.C. | $576,720 | 0.05% | 24,000 | Shares | Sole | 2026-05-15 | ||||
| Mid Logos Global Management LP | $565,858 | 0.05% | 23,548 | Shares | Sole | 2026-05-15 | ||||
| Mega FMR LLC | $563,407 | 0.05% | 23,446 | Shares | Defined | 2026-05-15 | ||||
| Mega BARCLAYS PLC | $545,816 | 0.05% | 22,714 | Shares | Defined | 2026-05-15 | ||||
| Mega Swiss National Bank Bank | $531,063 | 0.05% | 22,100 | Shares | Sole | 2026-05-07 | ||||
| Mid ALGERT GLOBAL LLC | $505,471 | 0.05% | 21,035 | Shares | Sole | 2026-05-14 | ||||
| Mega ALLIANCEBERNSTEIN L.P. | $470,988 | 0.04% | 19,600 | Shares | Defined | 2026-05-15 | ||||
| Large Squarepoint Ops LLC | $434,534 | 0.04% | 18,083 | Shares | Defined | 2026-05-15 | ||||
| Large STRS OHIO | $413,316 | 0.04% | 17,200 | Shares | Sole | 2026-04-24 | ||||
| Mega DEUTSCHE BANK AG\ Bank | $404,737 | 0.04% | 16,843 | Shares | Defined | 2026-05-06 | ||||
| Small VARCOV Co. | $402,550 | 0.04% | 16,752 | Shares | Sole | 2026-05-15 | ||||
| Mid Engineers Gate Manager LP | $397,167 | 0.04% | 16,528 | Shares | Sole | 2026-05-15 | ||||
| Mega Vanguard Global Advisers, LLC | $390,415 | 0.04% | 16,247 | Shares | Defined | 2026-05-08 | ||||
| Mega AQR CAPITAL MANAGEMENT LLC | $369,459 | 0.03% | 15,375 | Shares | Defined | 2026-05-15 | ||||
| Small Numerai GP LLC | $362,420 | 0.03% | 15,082 | Shares | Sole | 2026-05-15 | ||||
| Large LOS ANGELES CAPITAL MANAGEMENT LLC | $341,562 | 0.03% | 14,214 | Shares | Sole | 2026-05-08 | ||||
| Large MetLife Investment Management, LLC | $328,850 | 0.03% | 13,685 | Shares | Defined | 2026-05-14 | ||||
| Small EntryPoint Capital, LLC | $307,007 | 0.03% | 12,776 | Shares | Sole | 2026-05-14 | ||||
| Large OSAIC HOLDINGS, INC. | $305,132 | 0.03% | 12,698 | Shares | Defined | 2026-05-15 | ||||
| Large Verition Fund Management LLC | $296,602 | 0.03% | 12,343 | Shares | Sole | 2026-05-15 | ||||
| Mid China Universal Asset Management Co., Ltd. | $287,062 | 0.03% | 11,946 | Shares | Sole | 2026-04-28 | ||||
| Large Man Group plc | $284,947 | 0.03% | 11,858 | Shares | Defined | 2026-05-15 | ||||
| Large Russell Investments Group, Ltd. | $276,701 | 0.03% | 11,515 | Shares | Defined | 2026-05-08 | ||||
| Small Seven Fleet Capital Management LP | $275,023 | 0.03% | 11,445 | Shares | Sole | 2026-05-15 | ||||
| Small Virtus Investment Advisers, LLC | $257,577 | 0.02% | 10,719 | Shares | Other | 2026-05-14 | ||||
| Mega MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $249,478 | 0.02% | 10,382 | Shares | Sole | 2026-05-14 | ||||
| Large MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. Mutual Fund | $240,804 | 0.02% | 10,021 | Shares | Defined | 2026-05-15 | ||||
| Mega WELLS FARGO & COMPANY/MN | $237,151 | 0.02% | 9,869 | Shares | Defined | 2026-05-11 | ||||
| Mega CITIGROUP INC | $220,955 | 0.02% | 9,195 | Shares | Defined | 2026-05-11 | ||||
| Mid WINTON GROUP Ltd | $212,473 | 0.02% | 8,842 | Shares | Sole | 2026-05-12 | ||||
| Mega VANGUARD ASSET MANAGEMENT, Ltd | $178,302 | 0.02% | 7,420 | Shares | Defined | 2026-05-08 | ||||
| Mega Legal & General Group Plc | $137,811 | 0.01% | 5,735 | Shares | Defined | 2026-05-08 | ||||
| Large NEW YORK STATE COMMON RETIREMENT FUND Pension | $134,568 | 0.01% | 5,600 | Shares | Sole | 2026-05-06 | ||||
| Mega BNP PARIBAS ARBITRAGE, SA | $128,824 | 0.01% | 5,361 | Shares | Defined | 2026-05-12 | ||||
| Large Police & Firemen's Retirement System of New Jersey Pension | $124,355 | 0.01% | 5,175 | Shares | Defined | 2026-04-29 | ||||
| Large Vanguard Investments Australia, Ltd. | $93,596 | 0.01% | 3,895 | Shares | Defined | 2026-05-08 | ||||
| Large PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO Pension | $81,077 | 0.01% | 3,374 | Shares | Sole | 2026-05-14 | ||||
| Large KLP KAPITALFORVALTNING AS | $60,075 | 0.01% | 2,500 | Shares | Sole | 2026-04-29 | ||||
| Large Mirae Asset Global Investments Co., Ltd. | $56,110 | 0.01% | 2,335 | Shares | Sole | 2026-05-04 | ||||
| Small Covestor Ltd | $54,307 | 0.00% | 2,260 | Shares | Sole | 2026-05-05 | ||||
| Mid Ameritas Investment Partners, Inc. | $46,714 | 0.00% | 1,944 | Shares | Other | 2026-05-13 | ||||
| Mid GAMMA Investing LLC | $37,475 | 0.00% | 1,119 | Shares | Defined | 2026-07-07 | ||||
| Large CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM Pension | $27,802 | 0.00% | 1,157 | Shares | Sole | 2026-05-18 | ||||
| Mid GF FUND MANAGEMENT CO. LTD. | $24,174 | 0.00% | 1,006 | Shares | Sole | 2026-04-15 | ||||
| Mid SIGNATUREFD, LLC | $23,212 | 0.00% | 966 | Shares | Sole | 2026-04-07 | ||||
| Large CWM, LLC | $21,482 | 0.00% | 894 | Shares | Sole | 2026-05-14 | ||||
| No holders match your search. | ||||||||||