SEPN · Septerna, Inc.

$38.91 -1.56 (-3.85%) At close · Aug 28

Russell 2000 member Rebalance outlook locked

Market Cap

$1.82B

46.68M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Quarter:

Holders: 157

Total Value: $1,630,227,189

Total Shares: 48,678,032

Showing 1–100 of 164 holdings by value · page 1 of 2

Institutional Ownership Trend

7 quarters

Superinvestors Holding SEPN

All superinvestors →

Joel Greenblatt $312,193

Holder Concentration

Across 157 13F filers · Δ vs Mar 31, 2026

Top Holder

14.4%

−0.9 pts

Top 5

51.4%

−3.2 pts

Top 10

71.0%

−4.1 pts

HHI

689

Broadly held−79

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +32

Institutional value: +48.1%

Shares held: +6.3%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mid ALGERT GLOBAL LLC	+376,452	397,487
Small Catalio Capital Management, LP	+241,792	536,152
Mid First Light Asset Management, LLC	+230,400	963,260
Mid Longaeva Partners L.P.	+223,604	298,171
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP	+222,900	295,900

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mid ADAR1 Capital Management, LLC	−149,071	940,747
Mid Siren, L.L.C.	−100,000	1,900,000
Mega MILLENNIUM MANAGEMENT LLC	−73,539	50,562
Mega Invesco Ltd.	−58,774	24,094
Small HUSSMAN STRATEGIC ADVISORS, INC.	−42,000	63,000

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega Jupiter Topco LLC	1,307,500	$43,788,175
Large Caption Management, LLC	678,006	$22,706,420
Large LOOMIS SAYLES & CO L P	624,752	$20,922,944
Large TUDOR INVESTMENT CORP ET AL	328,966	$11,017,071
Large Woodline Partners LP	185,535	$6,213,567

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mid BVF INC/IL	1,353,249	$32,518,573
Mega JANUS HENDERSON GROUP PLC	890,754	$21,404,818
Mid Venrock Adviser, LLC	506,056	$12,160,525
Small Checkpoint Capital L.P.	100,300	$2,410,209
Large MARSHALL WACE, LLP	39,840	$957,355

Filter: New 49 Increased 51 Reduced 32 Sold out 17 Unchanged 25

Showing 100 of 164

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

RA CAPITAL MANAGEMENT, L.P.

$234,291,284

14.37%

6,995,858

TRV GP V, LLC

$208,160,142

12.77%

6,215,591

Driehaus Capital Management LLC

$148,463,112

9.11%

4,433,058

TRV GP VI, LLC

$141,048,459

8.65%

4,211,659

SAMSARA BIOCAPITAL, LLC

$105,464,296

6.47%

3,149,128

GOLDMAN SACHS GROUP INC

$102,572,032

6.29%

3,062,766

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	1,718,862	$57,564,688	56.1%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	1,343,904	$45,007,344	43.9%	Defined

BlackRock, Inc.

$64,705,621

3.97%

1,932,088

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	17,397	$582,625	0.9%	Sole
BlackRock Asset Management Canada Ltd	202	$6,764	0.0%	Sole
BlackRock Investment Management, LLC	60,649	$2,031,135	3.1%	Sole
BLACKROCK ADVISORS LLC	50,346	$1,686,087	2.6%	Sole
BlackRock Fund Advisors	1,087,608	$36,423,991	56.3%	Sole
BlackRock Institutional Trust Company, N.A.	635,825	$21,293,779	32.9%	Sole
BlackRock Fund Managers Ltd.	2,840	$95,111	0.1%	Sole
BlackRock (Netherlands) B.V.	6,579	$220,330	0.3%	Sole
BlackRock Asset Management Ireland Ltd	38,163	$1,278,078	2.0%	Sole
Aperio Group, LLC	32,479	$1,087,721	1.7%	Sole

Siren, L.L.C.

$63,631,000

3.90%

1,900,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	1,900,000	$63,631,000	100.0%	Defined

Avoro Capital Advisors LLC

$44,792,875

2.75%

1,337,500

Jupiter Topco LLC

$43,788,175

2.69%

1,307,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS US LLC	1,307,500	$43,788,175	100.0%	Defined

VANGUARD CAPITAL MANAGEMENT LLC

$40,913,828

2.51%

1,221,673

PRIMECAP MANAGEMENT CO/CA/

$39,095,623

2.40%

1,167,382

First Light Asset Management, LLC

$32,259,577

1.98%

963,260

ADAR1 Capital Management, LLC

$31,505,617

1.93%

940,747

GEODE CAPITAL MANAGEMENT, LLC

$22,745,168

1.40%

679,163

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	83,817	$2,807,031	12.3%	Defined
Held directly	595,346	$19,938,137	87.7%	Defined

STATE STREET CORP

$21,856,578

1.34%

652,630

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	652,630	$21,856,578	100.0%	Defined

LOOMIS SAYLES & CO L P

$20,922,944

1.28%

624,752

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
LOOMIS SAYLES TRUST COMPANY, LLC	104,711	$3,506,771	16.8%	Defined
Held directly	520,041	$17,416,173	83.2%	Defined

Casdin Capital, LLC

$18,528,945

1.14%

553,268

Catalio Capital Management, LP

$17,955,730

1.10%

536,152

Caption Management, LLC

$14,735,600

0.90%

440,000

ALGERT GLOBAL LLC

$13,311,839

0.82%

397,487

Balyasny Asset Management L.P.

$11,736,302

0.72%

350,442

Longaeva Partners L.P.

$9,985,746

0.61%

298,171

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Balyasny Asset Management L.P.	298,171	$9,985,746	100.0%	Other

Soleus Capital Management, L.P.

$9,209,750

0.56%

275,000

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$8,774,380

0.54%

262,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	262,000	$8,774,380	100.0%	Other

VANGUARD PORTFOLIO MANAGEMENT LLC

$7,708,862

0.47%

230,184

Universal- Beteiligungs- und Servicegesellschaft mbH

$7,458,289

0.46%

222,702

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UI BVK Kapitalverwaltungsgesellschaft mbH	222,702	$7,458,289	100.0%	Defined

TWO SIGMA INVESTMENTS, LP

$7,397,438

0.45%

220,885

NORTHERN TRUST CORP

$6,735,875

0.41%

201,131

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	191,445	$6,411,492	95.2%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	6,207	$207,872	3.1%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	3,479	$116,511	1.7%	Other

TUDOR INVESTMENT CORP ET AL

$6,698,000

0.41%

200,000

Caption Management, LLC

$6,698,000

0.41%

200,000

Kalehua Capital Management LLC

$6,515,278

0.40%

194,544

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$6,264,003

0.38%

187,041

Woodline Partners LP

$6,213,567

0.38%

185,535

VANGUARD FIDUCIARY TRUST CO

$5,547,819

0.34%

165,656

MORGAN STANLEY

$4,500,282

0.28%

134,377

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	106	$3,549	0.1%	Defined
MORGAN STANLEY & CO. LLC	6,103	$204,389	4.5%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	111,992	$3,750,612	83.3%	Defined
MORGAN STANLEY SMITH BARNEY LLC	9,869	$330,512	7.3%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	6,307	$211,220	4.7%	Defined

TUDOR INVESTMENT CORP ET AL

$3,349,000

0.21%

100,000

UBS Group AG

$3,009,880

0.18%

89,874

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS AG	76,174	$2,551,067	84.8%	Defined
UBS Europe SE	13,700	$458,813	15.2%	Defined

FEDERATED HERMES, INC.

$2,905,357

0.18%

86,753

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED EQUITY MANAGEMENT CO OF PENNSYLVANIA	10,990	$368,055	12.7%	Defined
FEDERATED GLOBAL INVESTMENT MANAGEMENT CORP	2,481	$83,088	2.9%	Defined
FEDERATED MDTA LLC	73,282	$2,454,214	84.5%	Defined

JPMORGAN CHASE & CO

$2,856,728

0.18%

85,301

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	11,320	$379,106	13.3%	Defined
J.P. Morgan Investment Management Inc.	62,358	$2,088,369	73.1%	Defined
J.P. Morgan Securities plc	3,438	$115,138	4.0%	Defined
JPMorgan Asset Management (UK) Ltd	8,185	$274,115	9.6%	Defined

CITADEL ADVISORS LLC

$2,739,482

0.17%

81,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	81,800	$2,739,482	100.0%	Defined

LAZARD ASSET MANAGEMENT LLC

$2,525,983

0.15%

75,425

DIMENSIONAL FUND ADVISORS LP

$2,522,096

0.15%

75,309

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	685	$22,940	0.9%	Defined
DFA Australia Ltd.	1,807	$60,516	2.4%	Defined
Dimensional Ireland Ltd	4,608	$154,321	6.1%	Defined
Held directly	68,209	$2,284,319	90.6%	Sole

ARROWSTREET CAPITAL, LIMITED PARTNERSHIP

$2,499,995

0.15%

74,649

JACOBS LEVY EQUITY MANAGEMENT, INC

$2,283,348

0.14%

68,180

HUSSMAN STRATEGIC ADVISORS, INC.

$2,109,870

0.13%

63,000

AMERICAN CENTURY COMPANIES INC

$2,041,985

0.13%

60,973

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	60,973	$2,041,985	100.0%	Defined

DIADEMA PARTNERS LP

$1,999,353

0.12%

59,700

JANE STREET GROUP, LLC

$1,915,628

0.12%

57,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	57,200	$1,915,628	100.0%	Defined

Bank of New York Mellon Corp

$1,881,332

0.12%

56,176

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	15,427	$516,650	27.5%	Defined
The Bank of New York Mellon	38,088	$1,275,567	67.8%	Defined
BNY Mellon, NA joint	2,660	$89,082	4.7%	Defined
Held directly	1	$33	0.0%	Defined

XTX Topco Ltd

$1,824,836

0.11%

54,489

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	54,489	$1,824,836	100.0%	Defined

MILLENNIUM MANAGEMENT LLC

$1,693,321

0.10%

50,562

BARCLAYS PLC

$1,668,504

0.10%

49,821

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	49,195	$1,647,540	98.7%	Defined
BARCLAYS CAPITAL INC.	626	$20,964	1.3%	Defined

Elmind Capital, LP

$1,655,879

0.10%

49,444

Nuveen, LLC

$1,615,188

0.10%

48,229

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	3,378	$113,129	7.0%	Defined
TEACHERS ADVISORS, LLC joint	44,851	$1,502,059	93.0%	Defined

Sofinnova Investments, Inc.

$1,590,975

0.10%

47,506

D. E. Shaw & Co., Inc.

$1,556,715

0.10%

46,483

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. Shaw Investment Management, L.L.C. joint	46,483	$1,556,715	100.0%	Defined

JANE STREET GROUP, LLC

$1,525,535

0.09%

45,552

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	26,036	$871,945	57.2%	Defined
Jane Street Global Trading, LLC	19,516	$653,590	42.8%	Defined

Voleon Capital Management LP

$1,488,128

0.09%

44,435

HRT FINANCIAL LP

$1,407,316

0.09%

42,022

RENAISSANCE TECHNOLOGIES LLC

$1,387,122

0.09%

41,419

Russell Investments Group, Ltd.

$1,346,597

0.08%

40,209

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC joint	14,527	$486,509	36.1%	Defined
Russell Investments Capital, LLC joint	24,672	$826,264	61.4%	Defined
Russell Investments Trust Company joint	1,010	$33,824	2.5%	Other

Caption Management, LLC

$1,272,820

0.08%

38,006

BANK OF AMERICA CORP /DE/

$1,201,453

0.07%

35,875

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	35,875	$1,201,453	100.0%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$1,182,967

0.07%

35,323

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	35,323	$1,182,967	100.0%	Defined

Alyeska Investment Group, L.P.

$1,172,150

0.07%

35,000

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$1,135,311

0.07%

33,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	33,900	$1,135,311	100.0%	Other

ALLIANCEBERNSTEIN L.P.

$1,001,351

0.06%

29,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	29,900	$1,001,351	100.0%	Defined

Brevan Howard Capital Management LP

$986,347

0.06%

29,452

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brevan Howard US Investment Management, LP	29,452	$986,347	100.0%	Defined

HighVista Strategies LLC

$982,496

0.06%

29,337

TUDOR INVESTMENT CORP ET AL

$970,071

0.06%

28,966

RHUMBLINE ADVISERS

$925,529

0.06%

27,636

Trexquant Investment LP

$858,851

0.05%

25,645

Invesco Ltd.

$806,906

0.05%

24,094

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	3,144	$105,292	13.0%	Defined
Invesco Trust Co joint	8,532	$285,736	35.4%	Defined
Invesco Capital Management LLC	12,418	$415,878	51.5%	Defined

Logos Global Management LP

$788,622

0.05%

23,548

FMR LLC

$778,307

0.05%

23,240

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	23,240	$778,307	100.0%	Defined

FOX RUN MANAGEMENT, L.L.C.

$738,052

0.05%

22,038

DEUTSCHE BANK AG\

$732,526

0.04%

21,873

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	279	$9,343	1.3%	Defined
DWS Investments UK Ltd	21,594	$723,183	98.7%	Defined

Squarepoint Ops LLC

$710,624

0.04%

21,219

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	21,219	$710,624	100.0%	Defined

STRS OHIO

$703,290

0.04%

21,000

ACADIAN ASSET MANAGEMENT LLC

$703,156

0.04%

20,996

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	20,996	$703,156	100.0%	Defined

FRED ALGER MANAGEMENT, LLC

$701,883

0.04%

20,958

Jump Financial, LLC

$676,498

0.04%

20,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Leap GP LLC joint	20,200	$676,498	100.0%	Defined

Swiss National Bank

$663,102

0.04%

19,800

WELLS FARGO & COMPANY/MN

$659,216

0.04%

19,684

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	19,638	$657,676	99.8%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	46	$1,540	0.2%	Defined

FRANKLIN RESOURCES INC

$623,148

0.04%

18,607

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST INTERNATIONAL LLC	160	$5,358	0.9%	Defined
FRANKLIN ADVISERS INC	18,447	$617,790	99.1%	Defined

CITIGROUP INC

$596,389

0.04%

17,808

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	17,808	$596,389	100.0%	Defined

Aquatic Capital Management LLC

$583,630

0.04%

17,427

Engineers Gate Manager LP

$581,051

0.04%

17,350

BNP PARIBAS ARBITRAGE, SA

$567,521

0.03%

16,946

LOS ANGELES CAPITAL MANAGEMENT LLC

$555,833

0.03%

16,597

State of Wyoming

$548,532

0.03%

16,379

Vanguard Global Advisers, LLC

$544,112

0.03%

16,247

AQR CAPITAL MANAGEMENT LLC

$515,643

0.03%

15,397

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Arax Advisory Partners	51	$1,707	0.3%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	91	$3,047	0.6%	Other
Stokes Family Office, LLC	14	$468	0.1%	Other
Held directly	15,241	$510,421	99.0%	Defined

VIRGINIA RETIREMENT SYSTEMS ET Al

$445,417

0.03%

13,300

Verdad Advisers, LP

$434,365

0.03%

12,970

MetLife Investment Management, LLC

$431,351

0.03%

12,880

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	12,880	$431,351	100.0%	Defined

OSAIC HOLDINGS, INC.

$421,772

0.03%

12,594

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
OSAIC WEALTH, INC.	236	$7,903	1.9%	Defined
CW Advisors, LLC	12,358	$413,869	98.1%	Sole

Man Group plc

$384,096

0.02%

11,469

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Numeric Investors LLC	11,469	$384,096	100.0%	Defined

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

$363,902

0.02%

10,866

Key facts CIK 1984086 CUSIP 81734D104 13F (30d) 146 filings 142 filers Visit website Investor relations