Equibles

SEPN

Septerna, Inc.

Company with tickers: SEPN

CIK
1984086
CUSIP
81734D104
Shares Outstanding
45,075,533
13F Activity (30d)
109 filings 109 filers
Holders: 125
Total Value: $1,100,445,798
Total Shares: 45,794,668
Showing 1–100 of 125 holdings by value · page 1 of 2

Institutional Ownership Trend

6 quarters

Holder Concentration

Across 125 13F filers · Δ vs Dec 31, 2025
Top Holder
15.3%
Dec 2024 → Mar 2026 · range 15.3% – 15.8%
+0.0 pts
Top 5
54.5%
Dec 2024 → Mar 2026 · range 49.2% – 58.2%
−0.8 pts
Top 10
75.1%
Dec 2024 → Mar 2026 · range 71.6% – 79.8%
−1.5 pts
HHI
767
Dec 2024 → Mar 2026 · range 722 – 840
Broadly held −14

Quarterly Activity

vs Dec 31, 2025
New
28
Increased
43
Decreased
31
Sold Out
26
Unchanged
23
Holder count: +2
Institutional value: -13.9%
Shares held: -0.1%

Top Buyers

vs Dec 31, 2025
Institution Added Now Holds Open
Mega PRIMECAP MANAGEMENT CO/CA/ +502,734 1,048,834
Large Balyasny Asset Management L.P. +233,108 236,679
Mega GOLDMAN SACHS GROUP INC +191,298 2,906,427
Mid First Light Asset Management, LLC +112,049 732,860
Mega STATE STREET CORP +91,419 631,447

Top Sellers

vs Dec 31, 2025
Institution Sold Now Holds Open
Large Driehaus Capital Management LLC −413,898 4,395,572
Mid BVF INC/IL −367,533 1,353,249
Large MARSHALL WACE, LLP −187,061 39,840
Mid Soleus Capital Management, L.P. −108,368 275,000
Mid Venrock Adviser, LLC −104,752 506,056

Top New Positions

vs Dec 31, 2025
Institution Acquired Value (USD) Open
Mega VANGUARD CAPITAL MANAGEMENT LLC 1,196,962 $28,762,996
Mega JANUS HENDERSON GROUP PLC 890,754 $21,404,818
Mega VANGUARD PORTFOLIO MANAGEMENT LLC 195,043 $4,686,883
Mega VANGUARD FIDUCIARY TRUST CO 154,484 $3,712,250
Small HUSSMAN STRATEGIC ADVISORS, INC. 105,000 $2,523,150

Top Sold-Out Positions

vs Dec 31, 2025
Institution Previously Held Last Value (USD) Open
Mega VANGUARD GROUP INC 1,508,195 $42,048,476
Mid PERCEPTIVE ADVISORS LLC 433,160 $12,076,500
Large Woodline Partners LP 385,310 $10,742,442
Mega JANE STREET GROUP, LLC 124,270 $3,464,647
Mega CITADEL ADVISORS LLC 87,845 $2,449,118
Filter: New 28 Increased 43 Reduced 31 Sold out 26 Unchanged 23
Showing 100 of 125
All Common Calls Puts
Export CSV
Holder Value (USD) % of 13F Shares Open
Mid RA CAPITAL MANAGEMENT, L.P. $168,110,467 15.28% 6,995,858
Small TRV GP V, LLC $149,360,651 13.57% 6,215,591
Large Driehaus Capital Management LLC $105,625,595 9.60% 4,395,572
Small TRV GP VI, LLC $101,206,165 9.20% 4,211,659
Mid SAMSARA BIOCAPITAL, LLC $75,673,545 6.88% 3,149,128
Mega GOLDMAN SACHS GROUP INC $69,841,440 6.35% 2,906,427
Mid Siren, L.L.C. $48,060,000 4.37% 2,000,000
Mega BlackRock, Inc. $43,786,838 3.98% 1,822,174
Mid BVF INC/IL $32,518,573 2.96% 1,353,249
Large Avoro Capital Advisors LLC $32,140,125 2.92% 1,337,500
Mega VANGUARD CAPITAL MANAGEMENT LLC $28,762,996 2.61% 1,196,962
Mid ADAR1 Capital Management, LLC $26,188,326 2.38% 1,089,818
Mega PRIMECAP MANAGEMENT CO/CA/ $25,203,481 2.29% 1,048,834
Mega JANUS HENDERSON GROUP PLC $21,404,818 1.95% 890,754
Mid First Light Asset Management, LLC $17,610,625 1.60% 732,860
Mega GEODE CAPITAL MANAGEMENT, LLC $15,502,858 1.41% 645,146
Mega STATE STREET CORP $15,173,671 1.38% 631,447
Mid Casdin Capital, LLC $13,295,030 1.21% 553,268
Mid Venrock Adviser, LLC $12,160,525 1.11% 506,056
Small Catalio Capital Management, LP $7,073,470 0.64% 294,360
Mid Soleus Capital Management, L.P. $6,608,250 0.60% 275,000
Large Balyasny Asset Management L.P. $5,687,396 0.52% 236,679
Large Universal- Beteiligungs- und Servicegesellschaft mbH $5,382,599 0.49% 223,995
Mega VANGUARD PORTFOLIO MANAGEMENT LLC $4,686,883 0.43% 195,043
Small Kalehua Capital Management LLC $4,674,892 0.42% 194,544
Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC $4,363,367 0.40% 181,580
Mega NORTHERN TRUST CORP Bank $3,953,653 0.36% 164,530
Mega VANGUARD FIDUCIARY TRUST CO Bank $3,712,250 0.34% 154,484
Mega MILLENNIUM MANAGEMENT LLC $2,982,147 0.27% 124,101
Mega UBS Group AG $2,811,005 0.26% 116,979
Mega MORGAN STANLEY $2,656,033 0.24% 110,530
Small HUSSMAN STRATEGIC ADVISORS, INC. $2,523,150 0.23% 105,000
Small Checkpoint Capital L.P. $2,410,209 0.22% 100,300
Large FEDERATED HERMES, INC. $2,145,901 0.20% 89,301
Mega JPMORGAN CHASE & CO $2,034,714 0.18% 84,674
Mega Invesco Ltd. $1,991,316 0.18% 82,868
Mega TWO SIGMA INVESTMENTS, LP $1,811,069 0.16% 75,367
Mid Longaeva Partners L.P. $1,791,845 0.16% 74,567
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $1,754,190 0.16% 73,000
Mega AMERICAN CENTURY COMPANIES INC $1,472,798 0.13% 61,290
Mega Bank of New York Mellon Corp Bank $1,410,775 0.13% 58,709
Mid Jump Financial, LLC $1,273,854 0.12% 53,011
Mid Sofinnova Investments, Inc. $1,141,569 0.10% 47,506
Large MARSHALL WACE, LLP $957,355 0.09% 39,840
Small Rangeley Capital, LLC $956,394 0.09% 39,800
Large RENAISSANCE TECHNOLOGIES LLC $905,931 0.08% 37,700
Mid XTX Topco Ltd $882,453 0.08% 36,723
Large Trexquant Investment LP $848,283 0.08% 35,301
Large Alyeska Investment Group, L.P. $841,050 0.08% 35,000
Large ACADIAN ASSET MANAGEMENT LLC $744,401 0.07% 30,978
Mega Nuveen, LLC $701,098 0.06% 29,176
Large JACOBS LEVY EQUITY MANAGEMENT, INC $683,317 0.06% 28,436
Mega PRICE T ROWE ASSOCIATES INC /MD/ $674,666 0.06% 28,076
Mega RHUMBLINE ADVISERS $639,294 0.06% 26,604
Mega BANK OF AMERICA CORP /DE/ Bank $624,131 0.06% 25,973
Mid Y-Intercept (Hong Kong) Ltd $619,253 0.06% 25,770
Large ADAGE CAPITAL PARTNERS GP, L.L.C. $576,720 0.05% 24,000
Mid Logos Global Management LP $565,858 0.05% 23,548
Mega FMR LLC $563,407 0.05% 23,446
Mega BARCLAYS PLC $545,816 0.05% 22,714
Mega Swiss National Bank Bank $531,063 0.05% 22,100
Mid ALGERT GLOBAL LLC $505,471 0.05% 21,035
Mega ALLIANCEBERNSTEIN L.P. $470,988 0.04% 19,600
Large Squarepoint Ops LLC $434,534 0.04% 18,083
Large STRS OHIO $413,316 0.04% 17,200
Mega DEUTSCHE BANK AG\ Bank $404,737 0.04% 16,843
Small VARCOV Co. $402,550 0.04% 16,752
Mid Engineers Gate Manager LP $397,167 0.04% 16,528
Mega Vanguard Global Advisers, LLC $390,415 0.04% 16,247
Mega AQR CAPITAL MANAGEMENT LLC $369,459 0.03% 15,375
Small Numerai GP LLC $362,420 0.03% 15,082
Large LOS ANGELES CAPITAL MANAGEMENT LLC $341,562 0.03% 14,214
Large MetLife Investment Management, LLC $328,850 0.03% 13,685
Small EntryPoint Capital, LLC $307,007 0.03% 12,776
Large OSAIC HOLDINGS, INC. $305,132 0.03% 12,698
Large Verition Fund Management LLC $296,602 0.03% 12,343
Mid China Universal Asset Management Co., Ltd. $287,062 0.03% 11,946
Large Man Group plc $284,947 0.03% 11,858
Large Russell Investments Group, Ltd. $276,701 0.03% 11,515
Small Seven Fleet Capital Management LP $275,023 0.02% 11,445
Small Virtus Investment Advisers, LLC $257,577 0.02% 10,719
Mega MASSACHUSETTS FINANCIAL SERVICES CO /MA/ $249,478 0.02% 10,382
Large MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. Mutual Fund $240,804 0.02% 10,021
Mega WELLS FARGO & COMPANY/MN $237,151 0.02% 9,869
Mega CITIGROUP INC $220,955 0.02% 9,195
Mid WINTON GROUP Ltd $212,473 0.02% 8,842
Mega VANGUARD ASSET MANAGEMENT, Ltd $178,302 0.02% 7,420
Mega Legal & General Group Plc $137,811 0.01% 5,735
Large NEW YORK STATE COMMON RETIREMENT FUND Pension $134,568 0.01% 5,600
Mega BNP PARIBAS ARBITRAGE, SA $128,824 0.01% 5,361
Large Police & Firemen's Retirement System of New Jersey Pension $124,355 0.01% 5,175
Large Vanguard Investments Australia, Ltd. $93,596 0.01% 3,895
Large PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO Pension $81,077 0.01% 3,374
Large KLP KAPITALFORVALTNING AS $60,075 0.01% 2,500
Large Mirae Asset Global Investments Co., Ltd. $56,110 0.01% 2,335
Small Covestor Ltd $54,307 0.00% 2,260
Mid Ameritas Investment Partners, Inc. $46,714 0.00% 1,944
Large CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM Pension $27,802 0.00% 1,157
Mid GAMMA Investing LLC $26,673 0.00% 1,110
Mid GF FUND MANAGEMENT CO. LTD. $24,174 0.00% 1,006
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