SEPN · Septerna, Inc. · Shareholders & Ownership
$39.35
+2.97 (+8.16%)
At close · Oct 20
Return incl. dividend (before tax)
Market Cap
$1.84B
Shares
46.68M
Volume · Oct 20
418.32K
Avg daily vol (3M)
385.09K
Every disclosed holder of SEPN in one list: 13F institutions, Schedule 13D and 13G filers, insiders (Forms 3, 4 and 5) and registered funds, each from its own latest filing. Holders nest by CIK and SEC reporting links, never by name, and each is summed once.
Who Owns SEPN
13F quarter Sep 30, 2026, combined view: filers that have not filed yet carry their Jun 30, 2026 positionsNo chart: the summed disclosures exceed shares outstanding, so they are not parts of one whole.
| Holder group | Shares | % Out |
|---|---|---|
| Institutional (13F) | 47,243,551 | 101.21% |
| Insiders (Forms 3, 4, 5) | 22,148,643 | 47.45% |
| 13D/G-only blocks | 4,489,302 | 9.62% |
| Remaining | 27,204,549 | -58.28% |
| Registered funds (N-PORT, not summed) | 6,676,080 | 14.30% |
Shares outstanding: 46,676,947, the issuer's latest cover-page count restated onto today's split basis.
Remaining is negative: the summed disclosures exceed shares outstanding, as when filings are dated at different times or holders that do not disclose their links count the same shares. It is flagged, not clipped.
13D/G-only counts each filer's latest 13D or 13G that no 13F report of the listing contains, that names no 13F filer and that no counted insider files. Funds are never summed: their shares sit inside their advisers' 13F reports.
Holders of SEPN
| # | Holder | Shares | As of | Notes |
|---|---|---|---|---|
| 1 |
|
10,427,250 | ||
| 2 |
|
10,280,050 | ||
| 2.1 |
Third Rock Ventures V, L.P.
13G
CIK 1778071 · Unknown · Mar 31, 2025
Rule 13d-1(d), exempt investor, not summed
|
6,215,591 | ||
| 3 |
TRV GP V, LLC
13F
CIK 1990717 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
6,215,591 | ||
| 4 |
RA CAPITAL MANAGEMENT, L.P.
13D
CIK 1346824 · Registered investment adviser · Aug 12, 2026
Item 4 purpose: not restated by this amendment, the earlier 13D's purpose stands
not summed
|
5,525,324 | ||
| 4.1 |
RA CAPITAL MANAGEMENT, L.P.
13F
CIK 1346824 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
6,995,858 | ||
| 4.2 |
|
725,443 | ||
| 5 |
Driehaus Capital Management LLC
13F
CIK 938206 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
4,433,058 | ||
| 5.1 |
Driehaus Capital Management LLC
13G
CIK 938206 · Registered investment adviser · Jun 30, 2026
Rule 13d-1(b), qualified institution, not summed
|
4,433,058 | ||
| 5.2 |
Driehaus Small Cap Growth Fund
Fund
S000058261 · Registered fund · Jun 30, 2026
Driehaus Mutual Funds, not summed
|
417,859 | ||
| 5.3 |
Driehaus Micro Cap Growth Fund
Fund
S000042829 · Registered fund · Jun 30, 2026
Driehaus Mutual Funds, not summed
|
158,272 | ||
| 6 |
TRV GP VI, LLC
13F
CIK 1990716 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
4,211,659 | ||
| 7 |
SAMSARA BIOCAPITAL, LLC
13F
CIK 1744967 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
3,149,128 | ||
| 8 |
GOLDMAN SACHS GROUP INC
13F
CIK 886982 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
3,062,766 | ||
| 8.1 |
Goldman Sachs Absolute Return Tracker Fund
Fund
S000020314 · Registered fund · Jun 30, 2026
GOLDMAN SACHS TRUST, not summed
|
5,113 | ||
| 9 |
|
2,768,520 | ||
| 10 |
BlackRock, Inc.
13F
CIK 2012383 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,932,088 | ||
| 10.1 |
iShares Russell 2000 ETF
Fund
S000004344 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
578,523 | ||
| 10.2 |
iShares Biotechnology ETF
Fund
S000004350 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
192,645 | ||
| 10.3 |
iShares Russell 2000 Growth ETF
Fund
S000004343 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
138,834 | ||
| 10.4 |
iShares Russell 2000 Value ETF
Fund
S000004342 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
65,273 | ||
| 10.5 |
iShares U.S. Pharmaceuticals ETF
Fund
S000009417 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
59,605 | ||
| 11 |
Siren, L.L.C.
13F
CIK 2005245 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,900,000 | ||
| 12 |
BIOTECHNOLOGY VALUE FUND L P
13G
CIK 918923 · Unknown · Dec 31, 2025
Rule 13d-1(c), passive investor
|
1,720,782 | ||
| 13 |
Avoro Capital Advisors LLC
13F
CIK 1633313 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,337,500 | ||
| 14 |
Jupiter Topco LLC
13F
CIK 2146052 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,307,500 | ||
| 15 |
VANGUARD CAPITAL MANAGEMENT LLC
13F
CIK 2100119 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,221,673 | ||
| 16 |
PRIMECAP MANAGEMENT CO/CA/
13F
CIK 763212 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,167,382 | ||
| 16.1 |
PRIMECAP Odyssey Aggressive Growth Fund
Fund
S000005541 · Registered fund · Jul 31, 2026
PRIMECAP Odyssey Funds, not summed
|
824,582 | ||
| 17 |
First Light Asset Management, LLC
13F
CIK 1600004 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
963,260 | ||
| 18 |
ADAR1 Capital Management, LLC
13F
CIK 1940272 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
940,747 | ||
| 19 |
VANGUARD TOTAL STOCK MARKET INDEX FUND
Fund
S000002848 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
|
927,665 | ||
| 20 |
|
826,907 | ||
| 21 |
GEODE CAPITAL MANAGEMENT, LLC
13F
CIK 1214717 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
679,163 | ||
| 22 |
|
652,630 | ||
| 22.1 |
State Street(R) SPDR(R) S&P(R) Pharmaceuticals ETF
Fund
S000012321 · Registered fund · Jun 30, 2026
SPDR SERIES TRUST, not summed
|
126,696 | ||
| 22.2 |
STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO
Fund
S000050332 · Registered fund · Jun 30, 2026
STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
|
7,700 | ||
| 22.3 |
State Street Total Return V.I.S. Fund
Fund
S000001637 · Registered fund · Jun 30, 2026
STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed
|
559 | ||
| 22.4 |
State Street Balanced Index Fund
Fund
S000082802 · Registered fund · Jun 30, 2026
STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
|
147 | ||
| 23 |
LOOMIS SAYLES & CO L P
13F
CIK 312348 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
624,752 | ||
| 23.1 |
Loomis Sayles Small Cap Growth Fund
Fund
S000006705 · Registered fund · Jun 30, 2026
LOOMIS SAYLES FUNDS II, not summed
|
338,579 | ||
| 24 |
Casdin Capital, LLC
13F
CIK 1534261 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
553,268 | ||
| 25 |
Catalio Capital Management, LP
13F
CIK 1958125 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
536,152 | ||
| 26 |
ALGERT GLOBAL LLC
13F
CIK 1275218 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
397,487 | ||
| 27 |
Balyasny Asset Management L.P.
13F
CIK 1218710 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
350,442 | ||
| 28 |
Longaeva Partners L.P.
13F
CIK 2054122 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
298,171 | ||
| 29 |
Soleus Capital Management, L.P.
13F
CIK 1802630 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
275,000 | ||
| 30 |
VANGUARD EXTENDED MARKET INDEX FUND
Fund
S000002841 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
|
261,547 | ||
| 31 |
VANGUARD PORTFOLIO MANAGEMENT LLC
13F
CIK 2100121 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
230,184 | ||
| 32 |
Universal- Beteiligungs- und Servicegesellschaft mbH
13F
CIK 2057170 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
222,702 | ||
| 33 |
TWO SIGMA INVESTMENTS, LP
13F
CIK 1179392 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
220,885 | ||
| 34 |
NORTHERN TRUST CORP
13F
CIK 73124 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
|
201,131 | ||
| 34.1 |
Small Cap Index Fund
Fund
S000001245 · Registered fund · Jun 30, 2026
Northern Funds, not summed
|
11,053 | ||
| 34.2 |
Small Cap Core Fund
Fund
S000001244 · Registered fund · Jun 30, 2026
Northern Funds, not summed
|
4,219 | ||
| 35 |
Kalehua Capital Management LLC
13F
CIK 2106181 · Exempt reporting adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
194,544 | ||
| 36 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
13F
CIK 884546 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
187,041 | ||
| 36.1 |
Schwab U.S. Small-Cap ETF
Fund
S000026636 · Registered fund · May 31, 2026
SCHWAB STRATEGIC TRUST, not summed
|
108,128 | ||
| 36.2 |
Schwab Small-Cap Index Fund
Fund
S000005912 · Registered fund · Jul 31, 2026
SCHWAB CAPITAL TRUST, not summed
|
53,751 | ||
| 36.3 |
Schwab Total Stock Market Index Fund
Fund
S000005913 · Registered fund · Jul 31, 2026
SCHWAB CAPITAL TRUST, not summed
|
13,690 | ||
| 36.4 |
Schwab U.S. Broad Market ETF
Fund
S000026631 · Registered fund · May 31, 2026
SCHWAB STRATEGIC TRUST, not summed
|
11,580 | ||
| 37 |
Woodline Partners LP
13F
CIK 1784547 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
185,535 | ||
| 38 |
|
174,209 | ||
| 39 |
VANGUARD FIDUCIARY TRUST CO
13F
CIK 933478 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
165,656 | ||
| 40 |
MORGAN STANLEY
13F
CIK 895421 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
134,377 | ||
| 41 |
|
127,533 | ||
| 42 |
|
117,420 | ||
| 43 |
VANGUARD RUSSELL 2000 INDEX FUND
Fund
S000030003 · Registered fund · May 31, 2026
VANGUARD SCOTTSDALE FUNDS, not summed
|
109,770 | ||
| 44 |
Column Small Cap Select Fund
Fund
S000082920 · Registered fund · Aug 31, 2026
Trust for Professional Managers, not summed
|
108,704 | ||
| 45 |
SMALL CAP EQUITY FUND
Fund
S000001160 · Registered fund · Jun 30, 2026
GuideStone Funds, not summed
|
104,405 | ||
| 46 |
NORTH SQUARE DYNAMIC SMALL CAP FUND
Fund
S000063485 · Registered fund · May 31, 2026
Exchange Place Advisors Trust, not summed
|
102,301 | ||
| 47 |
JNL Multi-Manager Small Cap Growth Fund
Fund
S000001776 · Registered fund · Jun 30, 2026
JNL Series Trust, not summed
|
102,277 | ||
| 48 |
AST Small-Cap Equity Portfolio
Fund
S000001978 · Registered fund · Jun 30, 2026
Advanced Series Trust, not summed
|
101,151 | ||
| 49 |
|
96,412 | ||
| 50 |
|
89,874 |
8 more nested rows are not shown here; Every filing lists them all.
Shares are restated onto today's split basis. Change compares each row with the same holder's previous filing in the same source; a dash means there is none to compare. Nested 13D/G, insider and fund rows are not summed, since a 13F report already holds them.
Showing 1–50 of 264 holders
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