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SEPN

Septerna, Inc.
$36.40 +0.57 (+1.59%) At close · Jul 8
Market Cap
$1.64B
Shares
45,075,533

Price & Indicators

20d MA 50d MA 200d MA Earnings Filing Insider Congress Investor day
Close$36.40 Open$35.37 Day$34.75–37.26 52W$10.62–37.99 Avg vol 30d467K Short int2.7M · 5.9% float · 7.8d Short vol35% Last earningsMay 11, 2026 DataOct 2024–Jul 2026 Filing10-Q · May 11
Equibles Rating blended score · not investment advice
Overall
Buy
SellHoldBuy
Technical Buy Momentum Very Strong Sentiment Bearish Fundamentals Excellent Quant / Vol Very High
Market backdrop VIX 16.9 · calm Equity put/call 0.86
Technical
price trend
Buy
50 / 200-day cross No cross
Price vs 200-day avg +40%
above
Price vs 50-day avg +21%
above
RSI (14) 60
neutral
MACD trend Negative
52-week position 94%
near high
Volume (OBV) Confirms
volume backs price
Momentum
relative strength
Very Strong
1-month return +20%
trailing
6-month return +38%
trailing
YTD return +31%
this year
Relative strength +30%
vs S&P · 6-mo
Sentiment
smart money
Bearish
Trend (MA cross) No cross
50d $30 › 200d $26 — 50d above 200d
Institutional flow Distributing
3 of 124 funds reported for Jun 30 · net -22 sh shares
Insider flow Distributing
Net -$623.7K over 90 days · 100% sells
Short interest Rising
5.91% of float · ▲ +1.8% MoM · 7.8 days cover
Volume signal Normal
Volume near normal
Institution breadth Multi-yr high
124 holders — near 1-yr high, broad support
Squeeze score 77
high risk · 0–100
Fundamentals
Excellent
Revenue growth +4175%
Y/Y
EPS growth +85%
Y/Y
Free cash flow $109.7M
Balance sheet $120.7M
net cash
Quant / Vol
risk profile
Very High
Volatility 65%
annualized · 1-yr
Max drawdown −25%
past year
ATR 6.6%
of price · 14-day

Blended from price, momentum, positioning, fundamentals & volatility · daily-close · not investment advice. Market backdrop is context, not part of the score.

Up next
Next earnings call
Aug 9, 2026 Est · unconfirmed · in 4 wks
FQ3-26 quarter ends
~Sep 30, 2026 Est
filed May 11, 2026

Technicals

trend & momentum for long-term holders Buy
1 · 3 · 3
50 / 200-day cross
No cross Neutral
Price vs 200-day avg
+40% Bullish
Price vs 50-day avg
+21% Bullish
RSI (14)
60 Neutral
MACD trend
Negative Bearish
52-week position
94% Bullish
Volume (OBV)
Confirms Neutral
Market signals — smart money & positioning
Bearish · 3 of 6
Trend (MA cross) No cross
50d $30 › 200d $26 — 50d above 200d
Institutional flow Distributing
3 of 124 funds reported for Jun 30 · net -22 sh shares
Insider flow Distributing
Net -$623.7K over 90 days · 100% sells
Short interest Rising
5.91% of float · ▲ +1.8% MoM · 7.8 days cover
Volume signal Normal
Volume near normal
Institution breadth Multi-yr high
124 holders — near 1-yr high, broad support
Price context
position in its 52-week range
52-wk low $11 Now $36 · 94% 52-wk high $38
vs 200-day avg +40% vs 50-day avg +21%

Illustrative technical + ownership context — a signal mix, not investment advice.

Versus peers

Biotechnology — same industry group
Open screener →
Company Mkt cap YTD Rev growth Y/Y P/E Short % shares
SEPN
Septerna, Inc.
this stock
$1.64B +30.6% +4174.5% 5.9%
ONC
BeOne Medicines Ltd.
$446.53B +1.7% +22179.2% 908.7 0.1%
VRTX
Vertex Pharmaceuticals Inc / Ma
$132.55B +15.2% +46.2% 31.0 1.8%
REGN
Regeneron Pharmaceuticals, Inc.
$70.90B -12.3% +20.8% 16.5 3.2%
ARGX
Argenx SE
$57.49B +9.4% 2.4%

Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding

At a glance

key data from every section
Ownership
Institutional Holders Reducing
Holders
124
% held
101.2%
Reported
3 of 124
Top holder
RA CAPITAL MANAGEMENT, L.…
Held Float
View
Held by Funds
Fund positions
152
View
Short & Settlement
Short Interest Rising
Shares short
2.7M
Days to cover
7.8d
Change
+48.1K sh
View
Short Volume
Short vol %
35%
As of
Jul 8, 2026
Short Total
View
Fails to Deliver
FTD shares
46
Value
$1.6K
As of
Jun 12, 2026
View
Off-Exchange
Off-exchange %
52.0%
Week of
May 4, 2026
Off-exch Lit
View
Smart Money
Insider Trades Net selling
Net (90d)
-$623.7K
Buyers / Sellers
0 / 2
Buyers Sellers
View
Financials
Financials
Revenue (FY)
$46.0M
Net income (FY)
$-48.9M
EPS diluted
$-1.10
View
Filings
SEC Filings
Latest
8-K
Filed
Jun 30, 2026
This year
10
View
Proposed Sales
Value
$89.2K
Shares
2.4K
Filed
Jun 26, 2026
View
Exempt Offerings
Offering
$150.0M
Filed
Jul 13, 2023
View
Earnings & Events
Earnings Calls
Last call
May 11, 2026
View

Performance

5D 20D 120D MTD YTD
SEPN +8.7% +19.7% +38.0% +8.7% +30.6%
SPY +0.9% +1.4% +7.6% +0.1% +9.7%
vs SPY +7.8% +18.3% +30.4% +8.6% +20.9%
Key facts CIK 1984086 CUSIP 81734D104 13F (30d) 3 filings 3 filers Visit website Investor relations