SEPN · Septerna, Inc.

Track SEPN — free

$38.37 +1.47 (+3.98%) At close · Oct 9

Russell 2000 member Rebalance outlook locked

Market Cap

$1.79B

46.68M

Volume · Oct 9 349.48K Avg daily vol (3M) 389.91K

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Latest filing: 10-Q

filed Aug 10, 2026

Q4 2025 earnings call transcript

call held Mar 2, 2026

Metrics snapshot

Useful current figures from the complete screener profile.

View all 115 metrics

Revenue (TTM)

$98.88M

Trailing 12 months

Net income (TTM)

−$24.24M

Trailing 12 months

Revenue growth YoY

+22,375.6%

Year over year

Operating margin

-44.0%

Trailing 12 months

P / E (TTM)

—

Trailing earnings

FCF yield

6.1%

TTM · current market cap

Return on invested capital

—

Trailing 12 months

Net cash

$372.32M

Latest balance sheet

Dividend yield

—

Trailing 12 months

Shares change YoY

+2.0%

Year over year · more shares

Price change (1Y)

+64.1%

Trailing year

Short interest

6.6%

Latest settlement · 8.8 days to cover

View all 115 metrics

Equibles Rating

blended score · not investment advice

Overall

Buy

SellHoldBuy

Technical Neutral Momentum Very Strong Sentiment Neutral Fundamentals Excellent Quant / Vol Very High

Market backdrop VIX 14.8 · calm Equity put/call 0.56

Technical

price trend

Neutral

50 / 200-day cross No cross

Price vs 200-day avg +23%

above

Price vs 50-day avg −3%

below

RSI (14) 51

neutral

MACD trend Negative

52-week position 67%

mid-range

Momentum

relative strength

Very Strong

1-month return 0%

trailing

6-month return +43%

trailing

YTD return +38%

this year

Relative strength +33%

vs S&P · 6-mo

Sentiment

smart money

Neutral

Trend (MA cross) No cross

50d $39 › 200d $31 — 50d above 200d

Institutional flow Accumulating

4 of 156 funds reported for Sep 30 · net +261 sh shares · +1 new

Insider flow Distributing

Net -$63.5M over 90 days · 100% sells

Short interest Rising

6.63% of float · ▲ +7.0% MoM · 8.8 days cover

Volume signal Normal

Volume near normal

Institution breadth Multi-yr high

156 holders — near 1-yr high, broad support

Squeeze score 66

elevated · 0–100

Fundamentals

Excellent

Revenue growth +4175%

Y/Y

EPS growth +85%

Y/Y

Free cash flow $109.7M

Quant / Vol

risk profile

Very High

Volatility 67%

annualized · 1-yr

Max drawdown −26%

past year

ATR 5.4%

of price · 14-day

Blended from price, momentum, positioning, fundamentals & volatility · daily-close · not investment advice. Market backdrop is context, not part of the score.

Technicals

trend & momentum for long-term holders Neutral

1 · 4 · 1

50 / 200-day cross

No cross Neutral

Price vs 200-day avg

+23% Bullish

Price vs 50-day avg

−3% Neutral

RSI (14)

51 Neutral

MACD trend

Negative Bearish

52-week position

67% Neutral

Market signals — smart money & positioning

Mixed

Trend (MA cross) No cross

50d $39 › 200d $31 — 50d above 200d

Institutional flow Accumulating

4 of 156 funds reported for Sep 30 · net +261 sh shares · +1 new

Insider flow Distributing

Net -$63.5M over 90 days · 100% sells

Short interest Rising

6.63% of float · ▲ +7.0% MoM · 8.8 days cover

Volume signal Normal

Volume near normal

Institution breadth Multi-yr high

156 holders — near 1-yr high, broad support

Price context

position in its 52-week range

Range low $18 Now $38 · 67% Range high $48

vs 200-day avg +23% vs 50-day avg -3%

Illustrative technical + ownership context — a signal mix, not investment advice.

Key metrics

Earlier KPI extraction records exist, but do not meet the current evidence-completeness requirements. No current verified series is available. Earlier figures remain withheld until revalidated; this is not evidence that the company reports no KPIs.

Versus peers

Biotechnology — same industry group

Open screener →

Company	Mkt cap	YTD	Rev growth Y/Y	P/E	Short % shares
SEPN Septerna, Inc. this stock	$1.79B	+37.6%	+4174.5%	—	6.6%
VRTX Vertex Pharmaceuticals Inc / Ma	$127.55B	+12.5%	+46.2%	29.3	1.8%
MRNA Moderna, Inc.	$89.83B	+663.0%	+4.3%	—	7.7%
REGN Regeneron Pharmaceuticals, Inc.	$76.86B	-3.3%	+20.8%	18.5	2.1%
CSLLY Csl Ltd	$61.58B	—	—	—	0.0%

Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding

At a glance

key data from every section

Ownership

Institutional Holders Accumulating

Holders

157

% held: 104.3%
Reported: 4 of 156
Top holder: RA CAPITAL MANAGEMENT, L.…

Held Float

View

Held by Funds

Fund positions

176

View

Short & Settlement

Short Interest Rising

Shares short

3.1M

Days to cover: 8.8d
Change: +202.2K sh

View

Short Volume

Short vol %

58%

As of: Oct 9, 2026

Short Total

View

Fails to Deliver

FTD shares

Value: $1.1K
As of: Aug 27, 2026

View

Off-Exchange

Off-exchange %

38.4%

Week of: Aug 31, 2026

Off-exch Lit

View

Smart Money

Insider Trades Net selling

Net (90d)

-$63.5M

Buyers / Sellers: 0 / 1

Buyers Sellers

View

Financials

Revenue (FY)

$46.0M

Net income (FY): $-48.9M
EPS diluted: $-1.10

View

Filings

SEC Filings

Latest

Investor Event Transcript

Filed: Sep 8, 2026
This year: 14

View

Proposed Sales

Value

$391.3K

Shares: 10.0K
Filed: Oct 1, 2026

View

Exempt Offerings

Offering

$150.0M

Filed: Jul 13, 2023

View

Earnings & Events

Webcasts

Last webcast

Sep 8, 2026

View

Performance

	5D	20D	120D	MTD	YTD
SEPN	+1.8%	-0.4%	+42.9%	-1.9%	+37.6%
SPY	+1.2%	+1.9%	+9.9%	+2.1%	+14.2%
vs SPY	+0.6%	-2.2%	+33.0%	-4.0%	+23.5%

Key facts CIK 1984086 CUSIP 81734D104 13F (30d) 5 filings 5 filers Visit website Investor relations

SEPN · Septerna, Inc.

Price & Indicators

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Metrics snapshot

Equibles Rating

Technicals

Key metrics

Versus peers

At a glance

Performance