SEPN · Septerna, Inc.
$41.21
+0.69 (+1.70%)
At close · Aug 25
Market Cap
$1.89B
Shares
46.68M
Price & Indicators
20d MA
50d MA
200d MA
Earnings
Filing
Insider
Congress
Investor day
Close$40.52
Open$39.76
Day$38.96–40.90
52W close$11.96–48.19
Avg vol 30d406K
Short int2.9M · 6.2% float · 5.1d
Short vol36%
Last earningsMar 2, 2026
DataOct 2024–Aug 2026
Filing10-Q · Aug 10
Up next
FQ3-26 quarter ends
~Sep 30, 2026
Est
filed Aug 10, 2026
AI Brief
TL;DR.
Bullish
Bearish
From the call
AI-generated from the earnings call and 8-K · may contain errors · not investment advice
Ask ALVIS about this →Equibles Rating
blended score · not investment adviceOverall
Buy
SellHoldBuy
Technical
Buy
Momentum
Very Strong
Sentiment
Bullish
Fundamentals
Excellent
Quant / Vol
Very High
Market backdrop
VIX 15.5 · calm
Equity put/call 0.57
Technical
price trend
50 / 200-day cross
No cross
Price vs 200-day avg
+40%
above
Price vs 50-day avg
+10%
above
RSI (14)
53
neutral
MACD trend
Negative
52-week position
79%
mid-range
Momentum
relative strength
1-month return
+21%
trailing
6-month return
+44%
trailing
YTD return
+45%
this year
Relative strength
+32%
vs S&P · 6-mo
Sentiment
smart money
Trend (MA cross)
No cross
50d $37 › 200d $29 — 50d above 200d
Institutional flow
Accumulating
+29% holders QoQ · +51 funds added
Insider flow
Distributing
Net -$63.5M over 90 days · 100% sells
Short interest
Falling
6.16% of float · ▼ -18.1% MoM · 5.1 days cover
Volume signal
Normal
Volume near normal
Institution breadth
Multi-yr high
155 holders — near 1-yr high, broad support
Squeeze score
54
elevated · 0–100
Fundamentals
Revenue growth
+4175%
Y/Y
EPS growth
+85%
Y/Y
Free cash flow
$109.7M
Balance sheet
$120.7M
net cash
Quant / Vol
risk profile
Volatility
69%
annualized · 1-yr
Max drawdown
−25%
past year
ATR
6.3%
of price · 14-day
Blended from price, momentum, positioning, fundamentals & volatility · daily-close · not investment advice. Market backdrop is context, not part of the score.
Technicals
trend & momentum for long-term holders Buy
50 / 200-day cross
No cross
Neutral
Price vs 200-day avg
+40%
Bullish
Price vs 50-day avg
+10%
Bullish
RSI (14)
53
Neutral
MACD trend
Negative
Bearish
52-week position
79%
Neutral
Market signals — smart money & positioning
Bullish · 3 of 6
Trend (MA cross)
No cross
50d $37 › 200d $29 — 50d above 200d
Institutional flow
Accumulating
+29% holders QoQ · +51 funds added
Insider flow
Distributing
Net -$63.5M over 90 days · 100% sells
Short interest
Falling
6.16% of float · ▼ -18.1% MoM · 5.1 days cover
Volume signal
Normal
Volume near normal
Institution breadth
Multi-yr high
155 holders — near 1-yr high, broad support
Price context
position in its 52-week range
Range low $12
Now $41 · 79%
Range high $48
vs 200-day avg +40%
vs 50-day avg +10%
Illustrative technical + ownership context — a signal mix, not investment advice.
Versus peers
Biotechnology — same industry group| Company | Mkt cap | YTD | Rev growth Y/Y | P/E | Short % shares |
|---|---|---|---|---|---|
|
SEPN
this stock
Septerna, Inc.
|
$1.89B | +45.3% | +4174.5% | — | 6.2% |
|
VRTX
Vertex Pharmaceuticals Inc / Ma
|
$138.79B | +20.8% | +46.2% | 31.9 | 1.6% |
|
REGN
Regeneron Pharmaceuticals, Inc.
|
$85.30B | +7.3% | +20.8% | 20.5 | 2.3% |
|
ARGX
Argenx SE
|
$63.81B | +21.2% | — | — | 1.9% |
|
CSLLY
Csl Ltd
|
$57.97B | — | — | — | 0.0% |
Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding
At a glance
key data from every sectionOwnership
Short & Settlement
Smart Money
Financials
Filings
Earnings & Events
Performance
| 5D | 20D | 120D | MTD | YTD | |
|---|---|---|---|---|---|
| SEPN | -8.3% | +21.0% | +44.1% | +17.6% | +45.3% |
| SPY | -1.2% | +3.3% | +12.2% | +2.2% | +12.0% |
| vs SPY | -7.1% | +17.7% | +31.8% | +15.4% | +33.4% |
Key facts
CIK
1984086
CUSIP
81734D104
13F (30d)
148 filings
144 filers
Visit website
Investor relations