FULC · Fulcrum Therapeutics, Inc. · Holdings

$3.75 +0.08 (+2.18%) At close · Oct 8

Russell 2000 member Rebalance outlook locked

Market Cap

$286.50M

76.30M

Volume · Oct 8 2.63M Avg daily vol (3M) 1.55M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Some SEC filings for this period have not finished importing. Holder totals and changes may be incomplete; these filings remain queued for recovery.

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 156

Total Value: $292,986,567

Total Shares: 80,050,964

Showing 1–100 of 163 holdings by value · page 1 of 2

Institutional Ownership Trend

27 quarters

Holder Concentration

Across 154 13F filers

Top Holder

11.0%

of institutional value

Top 5

38.8%

of institutional value

Top 10

55.0%

of institutional value

HHI

436

Broadly held

Showing 100 of 163

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

BlackRock, Inc.

$32,296,784

11.02%

8,824,259

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	684,363	$2,504,768	7.8%	Sole
BlackRock Investment Management, LLC	336,416	$1,231,282	3.8%	Sole
BLACKROCK ADVISORS LLC	1,714,126	$6,273,701	19.4%	Sole
BlackRock Fund Advisors	2,923,423	$10,699,728	33.1%	Sole
BlackRock Institutional Trust Company, N.A.	2,967,471	$10,860,943	33.6%	Sole
BlackRock Japan Co. Ltd	18,130	$66,355	0.2%	Sole
BlackRock Investment Management (UK) Ltd.	112,394	$411,362	1.3%	Sole
BlackRock Asset Management Ireland Ltd	50,740	$185,708	0.6%	Sole
Aperio Group, LLC	17,196	$62,937	0.2%	Sole

EcoR1 Capital, LLC

$23,972,509

8.18%

6,549,866

TANG CAPITAL MANAGEMENT LLC

$23,868,367

8.15%

6,521,412

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TANG KEVIN	6,521,412	$23,868,367	100.0%	Other

Nantahala Capital Management, LLC

$20,038,646

6.84%

5,475,040

SUVRETTA CAPITAL MANAGEMENT, LLC

$13,472,170

4.60%

3,680,921

D. E. Shaw & Co., Inc.

$11,142,448

3.80%

3,044,385

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	2,212,873	$8,099,115	72.7%	Defined
D. E. Shaw Investment Management, L.L.C. joint	831,512	$3,043,333	27.3%	Defined

CITADEL ADVISORS LLC

$9,898,488

3.38%

2,704,505

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	2,704,505	$9,898,488	100.0%	Defined

VANGUARD CAPITAL MANAGEMENT LLC

$9,871,810

3.37%

2,697,216

JANE STREET GROUP, LLC

$8,116,041

2.77%

2,217,498

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	1,194,353	$4,371,331	53.9%	Defined
Jane Street Global Trading, LLC	1,023,145	$3,744,710	46.1%	Defined

STATE STREET CORP

$7,455,511

2.54%

2,037,025

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	2,037,025	$7,455,511	100.0%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$7,320,000

2.50%

2,000,000

GSK plc

$6,535,713

2.23%

1,785,714

Qube Research & Technologies Ltd

$6,399,389

2.18%

1,748,467

RENAISSANCE TECHNOLOGIES LLC

$6,030,948

2.06%

1,647,800

ADAR1 Capital Management, LLC

$5,728,006

1.96%

1,565,029

MILLENNIUM MANAGEMENT LLC

$5,438,038

1.86%

1,485,803

GEODE CAPITAL MANAGEMENT, LLC

$5,241,605

1.79%

1,432,133

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	198,406	$726,165	13.9%	Defined
Held directly	1,233,727	$4,515,440	86.1%	Defined

MARSHALL WACE, LLP

$4,971,828

1.70%

1,358,423

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	1,358,423	$4,971,828	100.0%	Other

UBS Group AG

$4,589,306

1.57%

1,253,909

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	1,250	$4,575	0.1%	Defined
UBS AG	1,244,207	$4,553,797	99.2%	Defined
UBS Securities LLC	8,452	$30,934	0.7%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$4,322,262

1.48%

1,180,946

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	1,180,946	$4,322,262	100.0%	Other

AQR CAPITAL MANAGEMENT LLC

$4,037,933

1.38%

1,103,261

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Prism Planning Partners LLC	256	$936	0.0%	Other
Compound Planning, Inc.	5	$18	0.0%	Other
Arax Advisory Partners	1,376	$5,036	0.1%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	1,126	$4,121	0.1%	Other
Stokes Family Office, LLC	91	$333	0.0%	Other
Held directly	1,100,407	$4,027,489	99.7%	Defined

GOLDMAN SACHS GROUP INC

$4,005,595

1.37%

1,094,425

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	864,314	$3,163,389	79.0%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	230,111	$842,206	21.0%	Defined

Ikarian Capital, LLC

$3,839,929

1.31%

1,049,161

BANK OF AMERICA CORP /DE/

$3,817,485

1.30%

1,043,029

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	1,028,657	$3,764,884	98.6%	Defined
BOFA SECURITIES, INC.	14,372	$52,601	1.4%	Defined

ACADIAN ASSET MANAGEMENT LLC

$3,801,997

1.30%

1,038,797

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	1,038,797	$3,801,997	100.0%	Defined

Jump Financial, LLC

$3,678,300

1.26%

1,005,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Leap GP LLC joint	1,005,000	$3,678,300	100.0%	Defined

DIMENSIONAL FUND ADVISORS LP

$3,515,601

1.20%

960,547

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	5,335	$19,526	0.6%	Defined
DFA Australia Ltd.	8,119	$29,715	0.8%	Defined
Dimensional Ireland Ltd	46,285	$169,403	4.8%	Defined
Held directly	900,808	$3,296,957	93.8%	Sole

Assenagon Asset Management S.A.

$3,056,846

1.04%

835,204

TWO SIGMA INVESTMENTS, LP

$2,974,723

1.02%

812,766

VANGUARD PORTFOLIO MANAGEMENT LLC

$2,862,647

0.98%

782,144

Connor, Clark & Lunn Investment Management Ltd.

$2,727,860

0.93%

745,317

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	745,317	$2,727,860	100.0%	Sole

Balyasny Asset Management L.P.

$2,534,081

0.86%

692,372

Y-Intercept (Hong Kong) Ltd

$2,495,505

0.85%

681,832

Point72 Asset Management, L.P.

$2,384,222

0.81%

651,427

NORTHERN TRUST CORP

$1,785,600

0.61%

487,869

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	479,528	$1,755,072	98.3%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	8,341	$30,528	1.7%	Other

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$1,585,585

0.54%

433,220

VANGUARD FIDUCIARY TRUST CO

$1,265,071

0.43%

345,648

BOOTHBAY FUND MANAGEMENT, LLC

$1,112,596

0.38%

303,988

BESSEMER GROUP INC

$1,050,375

0.36%

286,988

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BESSEMER TRUST Co NATIONAL ASSOCIATION	285,714	$1,045,713	99.6%	Defined
Bessemer Trust CO of Delaware, N.A.	1,274	$4,662	0.4%	Other

Peapod Lane Capital LLC

$1,046,020

0.36%

285,798

WELLINGTON MANAGEMENT GROUP LLP

$1,043,406

0.36%

285,084

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	85,801	$314,031	30.1%	Defined
Wellington Trust Company, NA joint	182,748	$668,857	64.1%	Defined
Wellington Management Australia Pty Ltd	16,535	$60,518	5.8%	Defined

Engineers Gate Manager LP

$885,720

0.30%

242,000

Hennion & Walsh Asset Management, Inc.

$855,894

0.29%

233,851

EntryPoint Capital, LLC

$794,948

0.27%

217,199

XTX Topco Ltd

$765,844

0.26%

209,247

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	209,247	$765,844	100.0%	Defined

CITADEL ADVISORS LLC

$743,712

0.25%

203,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	203,200	$743,712	100.0%	Defined

Quadrature Capital Ltd

$692,175

0.24%

189,119

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Quadrature US Inc.	189,119	$692,175	100.0%	Other

MORGAN STANLEY

$674,139

0.23%

184,192

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	101	$369	0.1%	Defined
MORGAN STANLEY & CO. LLC	28,387	$103,896	15.4%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	104,671	$383,095	56.8%	Defined
MORGAN STANLEY SMITH BARNEY LLC	1,051	$3,846	0.6%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	49,982	$182,933	27.1%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$641,964

0.22%

175,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	175,400	$641,964	100.0%	Other

AMERICAN CENTURY COMPANIES INC

$570,476

0.19%

155,868

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	155,868	$570,476	100.0%	Defined

Nuveen, LLC

$566,826

0.19%

154,871

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	25,253	$92,425	16.3%	Defined
TEACHERS ADVISORS, LLC joint	129,618	$474,401	83.7%	Defined

Bank of New York Mellon Corp

$565,515

0.19%

154,513

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	51,737	$189,357	33.5%	Defined
The Bank of New York Mellon	93,760	$343,161	60.7%	Defined
BNY Mellon, NA joint	9,015	$32,994	5.8%	Defined
Held directly	1	$3	0.0%	Defined

Simplify Asset Management Inc.

$562,886

0.19%

153,794

GSA CAPITAL PARTNERS LLP

$526,714

0.18%

143,911

Fiduciary Trust Co

$499,791

0.17%

136,555

Squarepoint Ops LLC

$463,202

0.16%

126,558

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	126,558	$463,202	100.0%	Defined

Verdad Advisers, LP

$458,319

0.16%

125,224

BNP PARIBAS ARBITRAGE, SA

$435,679

0.15%

119,038

Rangeley Capital, LLC

$420,497

0.14%

114,890

Invesco Ltd.

$414,746

0.14%

113,319

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	7,212	$26,395	6.4%	Defined
Invesco Trust Co joint	20,400	$74,664	18.0%	Defined
Invesco Capital Management LLC	85,707	$313,687	75.6%	Defined

HSBC HOLDINGS PLC

$400,231

0.14%

109,353

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
HSBC BANK PLC	109,353	$400,231	100.0%	Defined

Russell Investments Group, Ltd.

$381,366

0.13%

104,199

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	63,959	$234,089	61.4%	Defined
Russell Investments Capital, LLC	15,279	$55,921	14.7%	Defined
Russell Investments France SAS	9,703	$35,512	9.3%	Defined
Russell Investments Trust Company	15,258	$55,844	14.6%	Defined

CANADA PENSION PLAN INVESTMENT BOARD

$374,784

0.13%

102,400

ALGERT GLOBAL LLC

$370,977

0.13%

101,360

PANAGORA ASSET MANAGEMENT INC

$349,606

0.12%

95,521

PRICE T ROWE ASSOCIATES INC /MD/

$344,900

0.12%

94,235

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	94,235	$344,900	100.0%	Defined

FMR LLC

$337,916

0.12%

92,327

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	92,327	$337,916	100.0%	Defined

Headlands Technologies LLC

$328,386

0.11%

89,723

Susquehanna Portfolio Strategies, LLC

$313,222

0.11%

85,580

BARCLAYS PLC

$305,144

0.10%

83,373

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	82,174	$300,756	98.6%	Defined
BARCLAYS CAPITAL INC.	1,199	$4,388	1.4%	Defined

ALLIANCEBERNSTEIN L.P.

$305,134

0.10%

83,370

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	83,370	$305,134	100.0%	Defined

AXQ CAPITAL, LP

$298,227

0.10%

81,483

RHUMBLINE ADVISERS

$268,801

0.09%

73,443

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$263,520

0.09%

72,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	72,000	$263,520	100.0%	Other

RBF Capital, LLC

$256,200

0.09%

70,000

PRELUDE CAPITAL MANAGEMENT, LLC

$248,356

0.08%

67,857

ALPS ADVISORS INC

$247,533

0.08%

67,632

CITIGROUP INC

$229,752

0.08%

62,774

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	62,774	$229,752	100.0%	Defined

FOX RUN MANAGEMENT, L.L.C.

$206,592

0.07%

56,446

DEUTSCHE BANK AG\

$191,714

0.07%

52,381

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investments UK Ltd	52,381	$191,714	100.0%	Defined

WELLS FARGO & COMPANY/MN

$181,887

0.06%

49,696

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	49,696	$181,887	100.0%	Defined

STRS OHIO

$169,092

0.06%

46,200

JANE STREET GROUP, LLC

$161,772

0.06%

44,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	44,200	$161,772	100.0%	Defined

JPMORGAN CHASE & CO

$151,416

0.05%

41,371

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	28,301	$103,581	68.4%	Defined
J.P. Morgan Investment Management Inc.	17	$62	0.0%	Defined
J.P. Morgan Securities LLC	6,990	$25,583	16.9%	Defined
J.P. Morgan Securities plc	6,063	$22,190	14.7%	Defined

COMMONWEALTH EQUITY SERVICES, LLC

$146,400

0.05%

40,000

Marquette Asset Management, LLC

$141,100

0.05%

38,552

MetLife Investment Management, LLC

$124,729

0.04%

34,079

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	34,079	$124,729	100.0%	Defined

FRANKLIN RESOURCES INC

$124,669

0.04%

34,063

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST INTERNATIONAL LLC	24,821	$90,844	72.9%	Defined
FRANKLIN ADVISERS INC	9,242	$33,825	27.1%	Defined

CITADEL ADVISORS LLC

$124,440

0.04%

34,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	34,000	$124,440	100.0%	Defined

PROFUND ADVISORS LLC

$119,001

0.04%

32,514

State of Alaska, Department of Revenue

$113,460

0.04%

31,000

SEI INVESTMENTS CO

$112,292

0.04%

30,681

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI TRUST CO	30,681	$112,292	100.0%	Sole

COUNTRY TRUST BANK

$109,950

0.04%

30,041

LMR Partners LLP

$109,800

0.04%

30,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wabon Partners, L.P.	30,000	$109,800	100.0%	Sole

Aigen Investment Management, LP

$108,013

0.04%

29,512

Scientech Research LLC

$104,617

0.04%

28,584

Mariner, LLC

$102,860

0.04%

28,104

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$100,009

0.03%

27,325

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	27,325	$100,009	100.0%	Defined

Graham Capital Management, L.P.

$91,745

0.03%

25,067

STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM

$91,690

0.03%

25,052

Key facts CIK 1680581 CUSIP 359616109 13F (30d) 5 filings 5 filers Visit website Investor relations