Casdin Capital, LLC

CIK

1534261

Location

New York, NY

Portfolio Value

Mid $1,320,653,767

Diversification

Diversified

Filing Date

Global Rank

#1,273 / 8,232 ▲ 361

Top Industry

Biotechnology 53.4%

3Y Alpha vs SPY

-9.9%

Period ended 2 months ago

Filed May 15, 2026 · 30d

24 quarters · since Mar 2020

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+36.5%

SPY

+76.3%

Annualised alpha

-9.9%

Max drawdown

−39.3%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

40 positions · as of Mar 31, 2026 · Δ vs Sep 30, 2025

Top Position

19.0%

−9.9 pts

Top 5

59.3%

−10.2 pts

Top 10

77.3%

−8.3 pts

HHI

903

Diversified−468

Portfolio Trend

24 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$1,320,653,767	40

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Sep 30, 2025

Added To

Positions the filer increased

9 positions

Ticker	Company	Δ Shares	Shares	Value
LAB	Standard Biotools Inc.	+11,225,000	88,783,856	$81,681,147
RLAY	Relay Therapeutics, Inc.	+3,077,193	14,418,574	$143,464,811
DNLI	Denali Therapeutics Inc.	+950,000	1,840,000	$35,328,000
HIMS	Hims & Hers Health, Inc.	+470,000	700,000	$14,532,000
GH	Guardant Health, Inc.	+215,000	315,000	$29,096,550
NGNE	Neurogene Inc.	+125,000	1,420,361	$28,634,477
GLUE	Monte Rosa Therapeutics, Inc.	+100,000	186,014	$3,059,930
ALNY	Alnylam Pharmaceuticals, Inc.	+20,000	75,000	$24,815,250
ILMN	Illumina, Inc.	+5,000	530,000	$65,327,800
No positions match the current search.

Trimmed

Positions the filer reduced

4 positions

Ticker	Company	Δ Shares	Shares	Value
BLFS	Biolife Solutions Inc	−750,000	5,957,165	$113,662,708
GPCR	Structure Therapeutics Inc.	−380,000	1,175,000	$56,635,000
BEAM	Beam Therapeutics Inc.	−250,000	1,350,000	$32,170,500
RVMD	Revolution Medicines, Inc.	−70,000	2,577,333	$250,645,634
No positions match the current search.

New Positions

Positions the filer opened this quarter

13 positions

Ticker	Company	Shares	Value
TXG	10x Genomics, Inc.	2,275,000	$48,298,250
SRRK	Scholar Rock Holding Corp	350,000	$17,206,000
AGMB	Agomab Therapeutics NV	1,550,000	$16,259,500
TSHA	Taysha Gene Therapies, Inc.	3,250,000	$14,527,500
QGEN	Qiagen N.V.	360,000	$14,414,400
GRAL	GRAIL, Inc.	230,000	$11,886,400
PSNL	Personalis, Inc.	1,600,000	$10,192,000
DGX	Quest Diagnostics Inc	50,000	$9,799,000
MLTX	MoonLake Immunotherapeutics	450,000	$8,388,000
NTLA	Intellia Therapeutics, Inc.	355,000	$4,551,100
IRON	Disc Medicine, Inc.	65,000	$4,156,100
MRNA	Moderna, Inc.	75,000	$3,810,000
ANL	Adlai Nortye Ltd.	538,461	$3,726,150
No positions match the current search.

Sold Out

Positions the filer fully exited

4 positions

Ticker	Company	Shares	Value
SPRY	ARS Pharmaceuticals, Inc.	1,600,000	$16,080,000
UNH	Unitedhealth Group Inc	25,000	$8,632,500
INCY	Incyte Corp	100,000	$8,481,000
EXAS	EXACT SCIENCES CORP	90,000	$4,923,900
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

40 positions · $1,320,653,767 total · as of Mar 31, 2026

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
RVMD	Revolution Medicines, Inc. Healthcare	Reduced	2,577,333	-70,000	$250,645,634	+102.7%	18.98%
WGS	GeneDx Holdings Corp. Healthcare	Held	3,007,164	0	$193,120,072	−40.4%	14.62%
RLAY	Relay Therapeutics, Inc. Healthcare	Added	14,418,574	+3,077,193	$143,464,811	+142.3%	10.86%
BLFS	Biolife Solutions Inc Healthcare	Reduced	5,957,165	-750,000	$113,662,708	−33.6%	8.61%
LAB	Standard Biotools Inc. Healthcare	Added	88,783,856	+11,225,000	$81,681,147	−19.0%	6.18%
ILMN	Illumina, Inc. Healthcare	Added	530,000	+5,000	$65,327,800	+31.0%	4.95%
GPCR	Structure Therapeutics Inc. Healthcare	Reduced	1,175,000	-380,000	$56,635,000	+30.1%	4.29%
TXG	10x Genomics, Inc. Healthcare	NEW	2,275,000	NEW	$48,298,250	NEW	3.66%
DNLI	Denali Therapeutics Inc. Healthcare	Added	1,840,000	+950,000	$35,328,000	+173.4%	2.68%
BEAM	Beam Therapeutics Inc. Healthcare	Reduced	1,350,000	-250,000	$32,170,500	−17.2%	2.44%
GH	Guardant Health, Inc. Healthcare	Added	315,000	+215,000	$29,096,550	+365.7%	2.20%
NGNE	Neurogene Inc. Healthcare	Added	1,420,361	+125,000	$28,634,477	+27.6%	2.17%
ALNY	Alnylam Pharmaceuticals, Inc. Healthcare	Added	75,000	+20,000	$24,815,250	−1.1%	1.88%
MAZE	Maze Therapeutics, Inc. Healthcare	Held	758,857	0	$22,651,881	+15.1%	1.72%
SRRK	Scholar Rock Holding Corp Healthcare	NEW	350,000	NEW	$17,206,000	NEW	1.30%
AGMB	Agomab Therapeutics NV Healthcare	NEW	1,550,000	NEW	$16,259,500	NEW	1.23%
HIMS	Hims & Hers Health, Inc. Healthcare	Added	700,000	+470,000	$14,532,000	+11.4%	1.10%
TSHA	Taysha Gene Therapies, Inc. Healthcare	NEW	3,250,000	NEW	$14,527,500	NEW	1.10%
QGEN	Qiagen N.V. Healthcare	NEW	360,000	NEW	$14,414,400	NEW	1.09%
TEM	Tempus AI, Inc. Healthcare	Held	294,127	0	$13,300,422	−44.0%	1.01%
SEPN	Septerna, Inc. Healthcare	Held	553,268	0	$13,295,030	+27.8%	1.01%
GRAL	GRAIL, Inc. Healthcare	NEW	230,000	NEW	$11,886,400	NEW	0.90%
PRME	Prime Medicine, Inc. Healthcare	Held	3,167,175	0	$11,021,769	−37.2%	0.83%
PSNL	Personalis, Inc. Healthcare	NEW	1,600,000	NEW	$10,192,000	NEW	0.77%
DGX	Quest Diagnostics Inc Healthcare	NEW	50,000	NEW	$9,799,000	NEW	0.74%
VCYT	Veracyte, Inc. Healthcare	Held	276,308	0	$8,899,880	−6.2%	0.67%
MLTX	MoonLake Immunotherapeutics Healthcare	NEW	450,000	NEW	$8,388,000	NEW	0.64%
NTLA	Intellia Therapeutics, Inc. Healthcare	NEW	355,000	NEW	$4,551,100	NEW	0.34%
IRON	Disc Medicine, Inc. Healthcare	NEW	65,000	NEW	$4,156,100	NEW	0.31%
MRNA	Moderna, Inc. Healthcare	NEW	75,000	NEW	$3,810,000	NEW	0.29%
ANL	Adlai Nortye Ltd. Healthcare	NEW	538,461	NEW	$3,726,150	NEW	0.28%
GLUE	Monte Rosa Therapeutics, Inc. Healthcare	Added	186,014	+100,000	$3,059,930	+380.1%	0.23%
ABSI	Absci Corp Healthcare	Held	973,260	0	$2,919,780	−1.3%	0.22%
IPSC	Century Therapeutics, Inc. Healthcare	Held	1,228,190	0	$2,775,709	+353.8%	0.21%
BBOT	BridgeBio Oncology Therapeutics, Inc. Healthcare	Held	282,312	0	$2,526,692	−22.7%	0.19%
CTNM	Contineum Therapeutics, Inc. Healthcare	Held	148,333	0	$1,937,228	+11.1%	0.15%
PACB	Pacific Biosciences Of California, Inc. Healthcare	Held	723,767	0	$955,372	+3.1%	0.07%
RXRX	Recursion Pharmaceuticals, Inc. Healthcare	Held	165,323	0	$507,541	−37.1%	0.04%
TNYA	Tenaya Therapeutics, Inc. Healthcare	Held	361,969	0	$250,482	−57.3%	0.02%
DNA	Ginkgo Bioworks Holdings, Inc. Healthcare	Held	36,493	0	$223,702	−58.0%	0.02%