ALNY · Alnylam Pharmaceuticals, Inc. · Holdings

$233.29 +1.46 (+0.63%) At close · Oct 19

Nasdaq-100 member Russell 1000 member Rebalance outlook locked

Market Cap

$31.34B

133.81M

Volume · Oct 19 1.35M Avg daily vol (3M) 1.72M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Some SEC filings for this period have not finished importing. Holder totals and changes may be incomplete; these filings remain queued for recovery.

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 798

Total Value: $40,690,402,761

Total Shares: 135,258,067

Showing 1–100 of 829 holdings by value · page 1 of 9

Institutional Ownership Trend

27 quarters

Superinvestors Holding ALNY

All superinvestors →

Ray Dalio $29,977,771 Joel Greenblatt $12,658,612

Holder Concentration

Across 800 13F filers

Top Holder

11.1%

of institutional value

Top 5

39.4%

of institutional value

Top 10

55.4%

of institutional value

HHI

419

Broadly held

Who Holds ALNY

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 794 filers, like-for-like change +0.8%; actively managed books +0.1%; index-like books +3.5%.

Holder type	Share	Filers	Change	New	Exited
Registered adviser	25.5%	402	+1.8%	45	42
Exempt adviser	1.0%	12	-39.0%	4	1
Adviser	26.5%	19	+8.8%	2	0
Bank	8.5%	33	-22.4%	1	0
Insurer	0.1%	4	+1.9%	0	0
Broker-dealer	0.0%	2	-21.2%	0	1
Registered fund	0.0%	1	+46.9%	0	0
Benefit plan	0.1%	5	-4.4%	0	0
Non-US	2.2%	7	+6.7%	0	1
Unknown	36.1%	309	+3.5%	28	33

Style	Share	Filers	Change	New	Exited
Index-like	20.6%	20	+3.5%	0	0
Systematic-like	4.3%	37	-16.8%	12	5
Concentrated	0.9%	136	+85.2%	20	25
Diversified active	74.2%	600	+0.7%	48	47
Unknown	0.0%	1	-99.9%	0	1
Not measured	0.0%	0	—	0	0

Turnover	Share	Filers	Change	New	Exited
Low turnover	56.4%	451	-2.2%	30	38
Medium turnover	25.3%	196	+11.4%	13	19
High turnover	5.2%	78	-12.3%	27	10
Unknown	13.1%	69	+1.3%	10	11
Not measured	0.0%	0	—	0	0

Holding horizon	Share	Filers	Change	New	Exited
Short horizon	11.6%	92	+1.7%	26	18
Medium horizon	15.5%	163	+12.5%	18	20
Long horizon	67.9%	490	-1.2%	27	38
Unknown	4.9%	49	-6.4%	9	2
Not measured	0.0%	0	—	0	0

13F book size	Share	Filers	Change	New	Exited
Under $1B	0.5%	216	+50.3%	42	39
$1B to $10B	3.0%	272	+33.2%	30	29
$10B to $100B	10.7%	217	-0.9%	7	9
$100B or more	85.8%	89	-0.1%	1	1
Not measured	0.0%	0	—	0	0

Client base	Share	Filers	Change	New	Exited
Individuals and high net worth	1.0%	247	-4.0%	25	35
Pooled investment vehicles	4.1%	56	+11.1%	13	4
Registered funds and BDCs	15.6%	40	-1.3%	2	1
Pension and profit sharing plans	0.3%	4	+44.1%	0	0
Insurance companies	0.1%	5	-16.5%	0	0
Charitable organizations	0.0%	2	+15.4%	0	0
Governments and sovereign funds	0.4%	10	+26.4%	1	0
Corporations	0.0%	1	0.0%	0	0
Other investment advisers	0.0%	10	-11.5%	1	0
Other	0.1%	1	-1.4%	0	1
Diversified	3.8%	26	+4.2%	3	1
Unknown	74.5%	392	+0.4%	35	36

Private funds	Share	Filers	Change	New	Exited
Hedge funds	7.6%	77	+0.6%	19	9
Private equity funds	0.3%	23	-10.1%	1	0
Venture capital funds	0.0%	1	+237.9%	0	1
Real estate funds	0.0%	4	-13.8%	0	0
Liquidity funds	0.0%	1	+12.3%	0	0
Other private funds	2.4%	28	-1.1%	4	2
Mixed private funds	1.9%	15	-10.7%	0	0
Private funds, type not stated	0.4%	10	-12.8%	1	1
No private funds	13.9%	255	+0.8%	24	30
Unknown	73.6%	380	+1.3%	31	35

Location	Share	Filers	Change	New	Exited
United States	83.9%	592	+0.4%	66	68
Outside the US	16.1%	202	+2.7%	14	9
Unknown	0.0%	0	-100.0%	0	1

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type, client base and private funds come from each filer's current regulatory profile. Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Excluded 5 holders with no observed 2026-03-31 13F and 7 holders with no observed 2026-06-30 13F. Compared across CIK changes: 4 filers continue as Evelyn Partners Group Ltd; JANUS HENDERSON GROUP PLC continues as Jupiter Topco LLC.

Holder type: Registered adviser 406 Exempt adviser 11 Adviser 19 Bank 33 Insurer 4 Broker-dealer 3 Registered fund 1 Benefit plan 5 Non-US 7 Unknown 309

Showing 100 of 829

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

FMR LLC

$4,522,663,276

11.11%

15,023,962

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC joint	10,325,698	$3,108,344,868	68.7%	Defined
FIDELITY MANAGEMENT TRUST CO	2,380,552	$716,617,568	15.8%	Defined
STRATEGIC ADVISERS LLC	756,165	$227,628,349	5.0%	Defined
Fidelity Institutional Asset Management Trust Co	102,664	$30,904,943	0.7%	Defined
FIAM LLC	1,457,197	$438,660,012	9.7%	Defined
Fidelity Diversifying Solutions LLC	1,686	$507,536	0.0%	Defined

Capital World Investors

$3,354,932,991

8.25%

11,144,846

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	11,144,846	$3,354,932,991	100.0%	Defined

BlackRock, Inc.

$3,283,537,392

8.07%

10,907,675

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	341,519	$102,807,464	3.1%	Sole
BlackRock Investment Management (Australia) Ltd	91,954	$27,680,912	0.8%	Sole
BlackRock Asset Management Canada Ltd	117,758	$35,448,690	1.1%	Sole
BLACKROCK (SINGAPORE) LTD.	9,715	$2,924,506	0.1%	Sole
BlackRock Asset Management North Asia Ltd	17,497	$5,267,121	0.2%	Sole
BlackRock Investment Management, LLC	167,576	$50,445,403	1.5%	Sole
BLACKROCK ADVISORS LLC	303,580	$91,386,687	2.8%	Sole
BlackRock Fund Advisors	4,171,597	$1,255,775,844	38.2%	Sole
BlackRock Institutional Trust Company, N.A.	3,428,111	$1,031,964,254	31.4%	Sole
BlackRock Japan Co. Ltd	138,832	$41,792,596	1.3%	Sole
BlackRock Fund Managers Ltd.	149,228	$44,922,104	1.4%	Sole
BlackRock Investment Management (UK) Ltd.	426,523	$128,396,218	3.9%	Sole
BlackRock (Netherlands) B.V.	230,932	$69,517,459	2.1%	Sole
BlackRock International, Ltd.	146	$43,950	0.0%	Sole
BlackRock Asset Management Ireland Ltd	999,406	$300,851,188	9.2%	Sole
BlackRock Advisors (UK) Ltd	6,941	$2,089,449	0.1%	Sole
BlackRock Asset Management Deutschland AG	36,024	$10,844,304	0.3%	Sole
BlackRock (Luxembourg) S.A.	108,675	$32,714,435	1.0%	Sole
BlackRock Life Ltd	34,397	$10,354,528	0.3%	Sole
BlackRock Asset Management Schweiz AG	5,011	$1,508,461	0.0%	Sole
Aperio Group, LLC	116,696	$35,128,996	1.1%	Sole
SpiderRock Advisors, LLC	5,557	$1,672,823	0.1%	Sole

Capital Research Global Investors

$2,935,252,919

7.21%

9,750,699

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	9,750,699	$2,935,252,919	100.0%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$1,968,251,541

4.84%

6,538,390

VANGUARD CAPITAL MANAGEMENT LLC

$1,815,053,762

4.46%

6,029,478

T. Rowe Price Investment Management, Inc.

$1,698,463,338

4.17%

5,642,173

Invesco Ltd.

$1,130,162,341

2.78%

3,754,318

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	44,188	$13,301,911	1.2%	Defined
Invesco Trust Co joint	54,395	$16,374,526	1.4%	Defined
Invesco Management S.A.	4,244	$1,277,571	0.1%	Defined
Invesco Taiwan Ltd	220	$66,226	0.0%	Defined
Invesco Asset Management (Japan) Limited	2,988	$899,477	0.1%	Defined
Invesco Investment Advisers LLC	865	$260,390	0.0%	Defined
Invesco Capital Management LLC	3,647,418	$1,097,982,240	97.2%	Defined

STATE STREET CORP

$1,070,369,059

2.63%

3,555,689

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS (JAPAN) CO., LTD. joint	3,555,689	$1,070,369,059	100.0%	Defined

JPMORGAN CHASE & CO

$805,410,876

1.98%

2,675,517

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	199	$59,904	0.0%	Other
JPMorgan Chase Bank, N.A.	99,676	$30,005,466	3.7%	Defined
J.P. Morgan Investment Management Inc.	2,237,814	$673,649,148	83.6%	Other
J.P. Morgan Securities LLC	74,040	$22,288,260	2.8%	Defined
JPMorgan Asset Management (UK) Ltd	152,972	$46,049,161	5.7%	Defined
JPMorgan Asset Management (Canada) Inc.	913	$274,840	0.0%	Defined
JPMorgan Asset Management (Asia Pacific) Ltd	3,785	$1,139,398	0.1%	Defined
JPMorgan Asset Management (Japan) Ltd	33,023	$9,940,913	1.2%	Defined
JPMorgan Asset Management (Taiwan) Ltd	3,500	$1,053,605	0.1%	Defined
55I, LLC	59	$17,760	0.0%	Other
J.P. Morgan SE	9,516	$2,864,601	0.4%	Defined
J.P. MORGAN MANSART MANAGEMENT Ltd	60,020	$18,067,820	2.2%	Defined

GEODE CAPITAL MANAGEMENT, LLC

$793,466,914

1.95%

2,635,840

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	347,115	$104,492,028	13.2%	Defined
Held directly	2,288,725	$688,974,886	86.8%	Defined

BAILLIE GIFFORD & CO

$734,479,783

1.81%

2,439,889

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BAILLIE GIFFORD & CO LTD	550,940	$165,849,468	22.6%	Defined
BAILLIE GIFFORD OVERSEAS LTD	852,262	$256,556,429	34.9%	Defined
Baillie Gifford Investment Management (Europe) Ltd	247,199	$74,414,314	10.1%	Defined
Held directly	789,488	$237,659,572	32.4%	Sole

NORGES BANK

$683,883,867

1.68%

2,271,813

WELLINGTON MANAGEMENT GROUP LLP

$635,295,816

1.56%

2,110,407

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	2,042,733	$614,923,914	96.8%	Defined
Wellington Managment Canada LLC	1,344	$404,584	0.1%	Defined
Wellington Management Japan Pte Ltd	719	$216,440	0.0%	Defined
Wellington Management Singapore Pte. Ltd.	14,339	$4,316,469	0.7%	Defined
Wellington Management International Ltd	19,225	$5,787,301	0.9%	Defined
Wellington Trust Company, NA joint	26,634	$8,017,633	1.3%	Defined
Wellington Management Australia Pty Ltd	5,413	$1,629,475	0.3%	Defined

Orbis Allan Gray Ltd

$598,269,128

1.47%

1,987,407

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ORBIS INVESTMENT MANAGEMENT LTD	1,984,586	$597,419,923	99.9%	Defined
Held directly	2,821	$849,205	0.1%	Defined

Dodge & Cox

$588,631,954

1.45%

1,955,393

TWO SIGMA INVESTMENTS, LP

$564,713,315

1.39%

1,875,937

AMERICAN CENTURY COMPANIES INC

$558,096,374

1.37%

1,853,956

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	1,853,956	$558,096,374	100.0%	Defined

Clearbridge Investments, LLC

$379,142,167

0.93%

1,259,483

PRICE T ROWE ASSOCIATES INC /MD/

$345,943,976

0.85%

1,149,201

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	139,541	$42,006,027	12.1%	Defined
Held directly	1,009,660	$303,937,949	87.9%	Sole

D. E. Shaw & Co., Inc.

$332,369,932

0.82%

1,104,109

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	794,407	$239,140,339	72.0%	Defined
D. E. Shaw Investment Management, L.L.C. joint	309,702	$93,229,593	28.0%	Defined

MORGAN STANLEY

$310,708,106

0.76%

1,032,150

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	994	$299,223	0.1%	Defined
MORGAN STANLEY & CO. LLC	137,251	$41,316,668	13.3%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	308,083	$92,742,225	29.8%	Defined
MORGAN STANLEY AIP GP LP	138	$41,541	0.0%	Defined
MORGAN STANLEY INVESTMENT MANAGEMENT INC	8,412	$2,532,263	0.8%	Defined
MORGAN STANLEY SMITH BARNEY LLC	182,492	$54,935,566	17.7%	Defined
Morgan Stanley Strategic Investments, Inc	1	$301	0.0%	Defined
Parametric Sas	110	$33,113	0.0%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	340,402	$102,471,213	33.0%	Defined
EATON VANCE MANAGEMENT	11,509	$3,464,554	1.1%	Defined
Calvert Research & Management	26,003	$7,827,682	2.5%	Defined
BOSTON MANAGEMENT & RESEARCH	16,755	$5,043,757	1.6%	Defined

BANK OF AMERICA CORP /DE/

$299,367,107

0.74%

994,476

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	586,016	$176,408,396	58.9%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	20,420	$6,147,032	2.1%	Defined
BOFA SECURITIES, INC.	140,417	$42,269,729	14.1%	Defined
MERRILL LYNCH INTERNATIONAL	16,614	$5,001,312	1.7%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	223,952	$67,416,270	22.5%	Defined
BofA Securities Europe SA	7,057	$2,124,368	0.7%	Defined

Legal & General Group Plc

$278,320,596

0.68%

924,561

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	323,780	$97,467,493	35.0%	Defined
Legal & General Investment Management Ltd joint	600,781	$180,853,103	65.0%	Defined

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$269,059,108

0.66%

893,795

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	893,795	$269,059,108	100.0%	Defined

NORTHERN TRUST CORP

$266,983,504

0.66%

886,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	687,322	$206,904,540	77.5%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	177,360	$53,390,680	20.0%	Defined
Northern Trust Asset Management Australia Pty Ltd	7,881	$2,372,417	0.9%	Defined
Northern Trust Co of Hong Kong Ltd	14,337	$4,315,867	1.6%	Defined

ROYAL BANK OF CANADA

$263,659,830

0.65%

875,859

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC Global Asset Management Inc.	514,893	$154,998,239	58.8%	Defined
RBC CMA LTD.	2,226	$670,092	0.3%	Defined
RBC Capital Markets, LLC	61,059	$18,380,590	7.0%	Defined
RBC Dominion Securities Inc.	31,703	$9,543,554	3.6%	Defined
RBC Phillips, Hager & North Investment Counsel Inc.	93	$27,995	0.0%	Defined
RBC Private Counsel (USA) Inc.	559	$168,275	0.1%	Defined
RBC Trust Co (Delaware) Ltd	138	$41,542	0.0%	Defined
CITY NATIONAL BANK	580	$174,597	0.1%	Defined
RBC Rochdale, LLC	1,803	$542,757	0.2%	Defined
Held directly	262,805	$79,112,189	30.0%	Sole

VANGUARD FIDUCIARY TRUST CO

$259,723,265

0.64%

862,782

Deep Track Capital, LP

$248,349,750

0.61%

825,000

DEUTSCHE BANK AG\

$245,459,858

0.60%

815,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deutsche Bank Trust Co Americas	3	$903	0.0%	Defined
DWS Investment GmbH	58,287	$17,546,135	7.1%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC	18,782	$5,653,945	2.3%	Defined
DWS Investments UK Ltd	360,796	$108,610,419	44.2%	Defined
DBX Advisors LLC	5,660	$1,703,829	0.7%	Defined
DWS Investments Hong Kong Ltd	6,507	$1,958,802	0.8%	Defined
DWS International GmbH	66,893	$20,136,799	8.2%	Defined
Held directly	298,472	$89,849,026	36.6%	Sole

Qube Research & Technologies Ltd

$240,437,176

0.59%

798,715

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$227,391,137

0.56%

755,377

LOS ANGELES CAPITAL MANAGEMENT LLC

$219,642,024

0.54%

729,635

AQR CAPITAL MANAGEMENT LLC

$219,161,577

0.54%

728,039

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
KEB ASSET MANAGEMENT, LLC	12	$3,612	0.0%	Other
RF&L WEALTH MANAGEMENT, LLC	1	$301	0.0%	Other
Prism Planning Partners LLC	96	$28,898	0.0%	Other
Compound Planning, Inc.	6	$1,806	0.0%	Other
Arax Advisory Partners	575	$173,092	0.1%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	1,761	$530,113	0.2%	Other
Stokes Family Office, LLC	737	$221,859	0.1%	Other
NATIONAL MUTUAL FUNDS MANAGEMENT LTD	4,544	$1,367,880	0.6%	Other
Held directly	720,307	$216,834,016	98.9%	Defined

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$219,104,078

0.54%

727,848

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	80,464	$24,222,077	11.1%	Defined
UBS Asset Management Switzerland AG	285,400	$85,913,961	39.2%	Defined
UBS Asset Management (UK) Ltd.	275,156	$82,830,209	37.8%	Defined
UBS Asset Management Life Ltd.	5,715	$1,720,386	0.8%	Defined
Held directly	81,113	$24,417,445	11.1%	Defined

FEDERATED HERMES, INC.

$216,713,000

0.53%

719,905

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED EQUITY MANAGEMENT CO OF PENNSYLVANIA	3,664	$1,102,973	0.5%	Defined
FEDERATED MDTA LLC	708,065	$213,148,806	98.4%	Defined
HERMES INVESTMENT MANAGEMENT LTD	8,176	$2,461,221	1.1%	Defined

UBS Group AG

$188,747,012

0.46%

627,004

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	46,272	$13,929,260	7.4%	Defined
UBS AG	223,582	$67,304,889	35.7%	Defined
UBS Switzerland AG	355,617	$107,051,385	56.7%	Defined
UBS Securities LLC	1,533	$461,478	0.2%	Defined

Amundi

$185,877,294

0.46%

617,471

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Amundi Asset Management joint	611,030	$183,938,360	99.0%	Defined
CPR Asset Management	6,441	$1,938,934	1.0%	Defined

LOOMIS SAYLES & CO L P

$174,653,692

0.43%

580,187

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
LOOMIS SAYLES TRUST COMPANY, LLC	13,943	$4,197,261	2.4%	Defined
Held directly	566,244	$170,456,431	97.6%	Defined

GOLDMAN SACHS GROUP INC

$173,019,098

0.43%

574,757

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	123,010	$37,029,700	21.4%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	445,738	$134,180,510	77.6%	Defined
GOLDMAN SACHS INTERNATIONAL	3,508	$1,056,013	0.6%	Defined
GOLDMAN SACHS BANK AG	865	$260,390	0.2%	Defined
Goldman Sachs Trust Company, N.A.	1,636	$492,485	0.3%	Defined

Bank of New York Mellon Corp

$148,128,128

0.36%

492,071

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNY Mellon Trust of Delaware	75	$22,577	0.0%	Defined
Mellon Investments Corporation joint	345,788	$104,092,561	70.3%	Defined
BNY Mellon Securities Corporation	31	$9,331	0.0%	Defined
The Bank of New York Mellon	114,641	$34,510,380	23.3%	Defined
BNY Mellon, NA joint	10,920	$3,287,246	2.2%	Defined
BNY Mellon Advisors, Inc. joint	15,359	$4,623,519	3.1%	Defined
Newton Investment Management North America, LLC joint	5,256	$1,582,213	1.1%	Defined
Held directly	1	$301	0.0%	Defined

Polar Capital Holdings Plc

$145,322,533

0.36%

482,751

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	482,751	$145,322,533	100.0%	Defined

Paradigm Biocapital Advisors LP

$144,494,400

0.36%

480,000

FRANKLIN RESOURCES INC

$134,770,826

0.33%

447,699

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brandywine Global Investment Management, LLC	136	$40,940	0.0%	Defined
FIDUCIARY TRUST CO INTERNATIONAL	368	$110,779	0.1%	Defined
Fiduciary Trust Co International of Pennsylvania	800	$240,824	0.2%	Defined
Fiduciary Trust International of the South	127	$38,230	0.0%	Defined
FIDUCIARY TRUST INTERNATIONAL LLC	2,125	$639,688	0.5%	Defined
FRANKLIN ADVISERS INC	369,655	$111,277,244	82.6%	Defined
FRANKLIN ADVISORY SERVICES LLC	54,860	$16,514,505	12.3%	Defined
PUTNAM INVESTMENT MANAGEMENT LLC	19,628	$5,908,616	4.4%	Defined

D. E. Shaw & Co., Inc.

$129,533,209

0.32%

430,300

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	430,300	$129,533,209	100.0%	Defined

FIRST TRUST ADVISORS LP

$126,894,380

0.31%

421,534

RAYMOND JAMES FINANCIAL INC

$118,244,281

0.29%

392,799

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	81,925	$24,661,882	20.9%	Defined
Raymond James Financial Services Advisors, Inc.	4,911	$1,478,358	1.3%	Defined
ClariVest Asset Management LLC joint	6	$1,806	0.0%	Defined
EAGLE ASSET MANAGEMENT INC joint	304,904	$91,785,251	77.6%	Defined
RAYMOND JAMES TRUST N.A.	1,053	$316,984	0.3%	Defined

DIMENSIONAL FUND ADVISORS LP

$118,010,380

0.29%

392,022

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	6,308	$1,898,897	1.6%	Defined
DFA Australia Ltd.	33,295	$10,022,793	8.5%	Defined
Dimensional Fund Advisors Pte. Ltd.	1,763	$530,715	0.4%	Defined
Dimensional Ireland Ltd	36,110	$10,870,193	9.2%	Defined
Held directly	314,546	$94,687,782	80.2%	Sole

Swiss National Bank

$112,609,302

0.28%

374,080

WELLS FARGO & COMPANY/MN

$111,381,100

0.27%

370,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	370,000	$111,381,100	100.0%	Defined

MASSACHUSETTS FINANCIAL SERVICES CO /MA/

$105,529,075

0.26%

350,560

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MFS Institutional Advisors, Inc.	36,368	$10,947,859	10.4%	Defined
MFS Investment Management CO (LUX) S.A.R.L.	2,073	$624,035	0.6%	Defined
MFS Investment Management K.K.	2,012	$605,672	0.6%	Defined
MFS Heritage Trust CO	55,689	$16,764,059	15.9%	Defined
MFS INVESTMENT MANAGEMENT CANADA LTD	581	$174,898	0.2%	Defined
Held directly	253,837	$76,412,552	72.4%	Sole

CANADA PENSION PLAN INVESTMENT BOARD

$100,618,073

0.25%

334,246

Sumitomo Mitsui Trust Group, Inc.

$97,948,840

0.24%

325,379

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUMITOMO MITSUI TRUST BANK Ltd joint	325,379	$97,948,840	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$97,804,647

0.24%

324,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	324,900	$97,804,647	100.0%	Other

MILLENNIUM MANAGEMENT LLC

$95,125,781

0.23%

316,001

Nuveen, LLC

$95,014,096

0.23%

315,630

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	29,148	$8,774,421	9.2%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	15,565	$4,685,531	4.9%	Defined
TEACHERS ADVISORS, LLC joint	270,917	$81,554,144	85.8%	Defined

Candriam S.C.A.

$94,677,547

0.23%

314,512

WELLS FARGO & COMPANY/MN

$93,333,446

0.23%

310,047

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	126,661	$38,128,760	40.9%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	51,357	$15,459,997	16.6%	Defined
WELLS FARGO CLEARING SERVICES, LLC	117,443	$35,353,866	37.9%	Defined
Wells Fargo Securities, LLC	9,945	$2,993,743	3.2%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	4,641	$1,397,080	1.5%	Defined

NOMURA ASSET MANAGEMENT INTERNATIONAL INC.

$90,367,098

0.22%

300,193

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA HOLDINGS INC joint	300,193	$90,367,098	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$88,641,293

0.22%

294,460

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	294,460	$88,641,293	100.0%	Other

Pictet Asset Management Holding SA

$83,870,871

0.21%

278,613

BNP PARIBAS ARBITRAGE, SA

$81,586,053

0.20%

271,023

GILDER GAGNON HOWE & CO LLC

$80,992,422

0.20%

269,051

MARSHALL WACE, LLP

$78,207,292

0.19%

259,799

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	259,799	$78,207,292	100.0%	Other

VANGUARD ASSET MANAGEMENT, Ltd

$77,578,441

0.19%

257,710

California Public Employees Retirement System

$76,477,574

0.19%

254,053

WESTFIELD CAPITAL MANAGEMENT CO LP

$75,974,854

0.19%

252,383

Korea Investment CORP

$74,553,089

0.18%

247,660

Woodline Partners LP

$74,138,270

0.18%

246,282

Squarepoint Ops LLC

$70,440,718

0.17%

233,999

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	233,999	$70,440,718	100.0%	Defined

TD Asset Management Inc

$70,349,506

0.17%

233,696

CITIGROUP INC

$68,570,419

0.17%

227,786

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citibank, N.A. joint	22,902	$6,894,189	10.1%	Defined
Citigroup Financial Products Inc. joint	204,884	$61,676,230	89.9%	Defined

ROYAL LONDON ASSET MANAGEMENT LTD

$64,296,696

0.16%

213,589

AMERIPRISE FINANCIAL INC

$61,591,036

0.15%

204,601

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	93,649	$28,191,158	45.8%	Defined
Threadneedle Asset Management Holdings LTD	590	$177,607	0.3%	Defined
Ameriprise Financial Services, LLC	14,230	$4,283,656	7.0%	Defined
Ameriprise Bank, FSB	167	$50,272	0.1%	Defined
Columbia Threadneedle Management Ltd	95,965	$28,888,343	46.9%	Defined

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

$60,164,156

0.15%

199,861

National Pension Service

$59,692,743

0.15%

198,295

PINEBRIDGE INVESTMENTS LLC

$58,914,280

0.14%

195,709

CITADEL ADVISORS LLC

$57,505,458

0.14%

191,029

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	177,597	$53,462,024	93.0%	Defined
Held directly	13,432	$4,043,434	7.0%	Defined

Robeco Institutional Asset Management B.V.

$56,618,926

0.14%

188,084

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$53,824,164

0.13%

178,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	178,800	$53,824,164	100.0%	Other

VICTORY CAPITAL MANAGEMENT INC

$52,030,627

0.13%

172,842

Man Group plc

$51,448,133

0.13%

170,907

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AHL Partners LLP	51,988	$15,649,947	30.4%	Defined
Numeric Investors LLC	118,919	$35,798,186	69.6%	Defined

Mitsubishi UFJ Asset Management Co., Ltd.

$50,772,923

0.12%

168,664

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MITSUBISHI UFJ FINANCIAL GROUP INC	168,664	$50,772,923	100.0%	Defined

RHUMBLINE ADVISERS

$49,844,246

0.12%

165,579

Life Cycle Investment Partners Ltd

$49,797,586

0.12%

165,424

CIBC Bancorp USA Inc.

$49,288,543

0.12%

163,733

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CIBC Private Wealth Advisors, Inc.	92,541	$27,857,617	56.5%	Defined
CIBC National Trust Co	64,062	$19,284,583	39.1%	Defined
CIBC WORLD MARKETS CORP	7,130	$2,146,343	4.4%	Defined

ANTIPODES PARTNERS Ltd

$49,228,338

0.12%

163,533

BNP PARIBAS ASSET MANAGEMENT Holding S.A.

$48,698,525

0.12%

161,773

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	96,408	$29,021,700	59.6%	Defined
AXA INVESTMENT MANAGERS UK LIMITED	65,365	$19,676,825	40.4%	Defined

Russell Investments Group, Ltd.

$47,631,369

0.12%

158,228

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management Limited	8,837	$2,660,202	5.6%	Defined
Russell Investment Management, LLC joint	60,058	$18,079,258	38.0%	Defined
Russell Investments Canada Limited	38,017	$11,444,257	24.0%	Defined
Russell Investments Capital, LLC	1,104	$332,337	0.7%	Defined
Russell Investments Implementation Services, LLC	3,473	$1,045,477	2.2%	Defined
Russell Investments Limited joint	44,437	$13,376,868	28.1%	Other
Russell Investments Trust Company joint	2,302	$692,970	1.5%	Other

Universal- Beteiligungs- und Servicegesellschaft mbH

$47,328,839

0.12%

157,223

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Universal-Investment-Gesellschaft mbH joint	157,223	$47,328,839	100.0%	Defined

CAPITAL FUND MANAGEMENT S.A.

$46,931,781

0.12%

155,904

Vinva Investment Management Ltd

$46,651,221

0.11%

154,972

Hudson Bay Capital Management LP

$44,769,181

0.11%

148,720

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Hudson Bay Capital UK LLP	8,520	$2,564,775	5.7%	Defined
Held directly	140,200	$42,204,406	94.3%	Sole

Assenagon Asset Management S.A.

$41,531,276

0.10%

168,320

ENVESTNET ASSET MANAGEMENT INC

$41,058,986

0.10%

136,395

Jupiter Topco LLC

$40,803,110

0.10%

135,545

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	9,392	$2,827,273	6.9%	Defined
JANUS HENDERSON INVESTORS US LLC	120,453	$36,259,966	88.9%	Defined
Held directly	5,700	$1,715,871	4.2%	Defined

BARCLAYS PLC

$40,794,982

0.10%

135,518

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	92,945	$27,979,233	68.6%	Defined
BARCLAYS CAPITAL INC.	3,818	$1,149,332	2.8%	Defined
BARCLAYS CAPITAL SECURITIES LTD	38,755	$11,666,417	28.6%	Defined

LMR Partners LLP

$40,402,439

0.10%

134,214

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wabon Partners, L.P.	119,196	$35,881,571	88.8%	Sole
Held directly joint	15,018	$4,520,868	11.2%	Other

ProShare Advisors LLC

$38,686,569

0.10%

128,514

SEI INVESTMENTS CO

$36,713,618

0.09%

121,960

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	19,279	$5,803,557	15.8%	Sole
SEI TRUST CO	102,681	$30,910,061	84.2%	Sole

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Key facts CIK 1178670 CUSIP 02043Q107 13F (30d) 85 filings 79 filers Visit website Investor relations