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PRME · Prime Medicine, Inc.

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$3.24 -0.30 (-8.47%) At close · Aug 20
Going-concern doubt — flagged Aug 6, 2026

Substantial doubt about the company's ability to continue as a going concern.

“the Company evaluated whether there are conditions and events, considered in the aggregate, that raise substantial doubt about the Company's ability to continue as a going concern within one year after the date on which this Quarterly Report on Form 10-Q is filed. Based on the Company's cash, cash equivalents, and short-term investments as of June 30, 2026, the Company's current and forecasted level of operations, and its forecasted cash flows, the Company's ability to continue as a going concern is dependent upon its ability to obtain the necessary financing to meet its obligations and repay its liabilities arising from normal business operations when they come due. Management plans to provide for the Company's capital requirements through financing or other transactions, and selling shares under the Company's "at the market offering" program. There can be no assurance that the Company will be able to raise additional capital to fund operations with terms acceptable to the Company, or at all.”
View the 10-Q filed Aug 6, 2026
Market Cap
$642.07M
Shares
181.38M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Holders: 187
Total Value: $397,187,541
Total Shares: 107,638,933

Institutional Ownership Trend

15 quarters

Holder Concentration

Across 187 13F filers · Δ vs Mar 31, 2026
Top Holder
15.4%
Sep 2023 → Jun 2026 · range 15.4% – 25.5%
−1.2 pts
Top 5
44.0%
Sep 2023 → Jun 2026 · range 43.3% – 56.5%
+0.6 pts
Top 10
60.8%
Sep 2023 → Jun 2026 · range 60.8% – 80.2%
−0.3 pts
HHI
557
Sep 2023 → Jun 2026 · range 557 – 992
Broadly held−20

Quarterly Activity

vs Mar 31, 2026
New
23
Increased
64
Decreased
67
Sold Out
29
Unchanged
33
Holder count: -6
Institutional value: +14.6%
Shares held: +8.1%

Top Buyers

vs Mar 31, 2026
Institution Added Now Holds Open
GOLDMAN SACHS GROUP INC +2,460,093 3,430,518
ARK Investment Management LLC +2,101,919 8,348,746
CITADEL ADVISORS LLC +1,755,385 2,353,443
STATE STREET CORP +1,231,335 7,576,460
BlackRock, Inc. +1,100,333 9,602,041

Top Sellers

vs Mar 31, 2026
Institution Sold Now Holds Open
D. E. Shaw & Co., Inc. −744,681 648,940
RENAISSANCE TECHNOLOGIES LLC −623,627 117,412
Amova Asset Management Americas, Inc. −533,775 2,407,018
Sumitomo Mitsui Trust Group, Inc. −527,809 2,412,984
HRT FINANCIAL LP −451,259 161,510

Top New Positions

vs Mar 31, 2026
Institution Acquired Value (USD) Open
Jump Financial, LLC 1,240,429 $4,577,182
Point72 Asset Management, L.P. 533,553 $1,968,810
MILLENNIUM MANAGEMENT LLC 427,097 $1,575,987
Jain Global LLC 215,218 $794,154
JUPITER ASSET MANAGEMENT LTD 209,490 $773,018

Top Sold-Out Positions

vs Mar 31, 2026
Institution Previously Held Last Value (USD) Open
Elevate Capital Advisors, LLC 151,069 $525,720
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 86,473 $300,926
TUDOR INVESTMENT CORP ET AL 61,546 $214,180
JANUS HENDERSON GROUP PLC 60,900 $211,932
Aquatic Capital Management LLC 54,230 $188,720
Filter: New 23 Increased 64 Reduced 67 Sold out 29 Unchanged 33
Showing 100 of 192
All Common Calls Puts
Export CSV
Holder Value (USD) % of 13F Shares Open
Alphabet Inc. $61,115,617 15.39% 16,562,498
BlackRock, Inc. $35,431,526 8.92% 9,602,041
ARK Investment Management LLC $30,806,872 7.76% 8,348,746
STATE STREET CORP $27,957,137 7.04% 7,576,460
T. Rowe Price Investment Management, Inc. $19,325,755 4.87% 5,237,332
VANGUARD CAPITAL MANAGEMENT LLC $16,688,541 4.20% 4,522,640
Balyasny Asset Management L.P. $14,645,912 3.69% 3,969,082
GOLDMAN SACHS GROUP INC $12,658,609 3.19% 3,430,518
Casdin Capital, LLC $11,686,875 2.94% 3,167,175
Woodline Partners LP $11,084,405 2.79% 3,003,904
UBS Group AG $10,312,400 2.60% 2,794,689
GEODE CAPITAL MANAGEMENT, LLC $10,008,925 2.52% 2,712,446
Sumitomo Mitsui Trust Group, Inc. $8,903,910 2.24% 2,412,984
Amova Asset Management Americas, Inc. $8,881,896 2.24% 2,407,018
CITADEL ADVISORS LLC $7,581,263 1.91% 2,054,543
ADAR1 Capital Management, LLC $7,370,966 1.86% 1,997,552
FMR LLC $6,501,350 1.64% 1,761,884
TWO SIGMA INVESTMENTS, LP $5,625,445 1.42% 1,524,511
Redmile Group, LLC $5,127,742 1.29% 1,389,632
FARALLON CAPITAL MANAGEMENT LLC $4,578,710 1.15% 1,240,843
Jump Financial, LLC $4,577,182 1.15% 1,240,429
BANK OF AMERICA CORP /DE/ $3,621,125 0.91% 981,335
VANGUARD PORTFOLIO MANAGEMENT LLC $3,549,137 0.89% 961,826
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $3,422,615 0.86% 927,538
NORTHERN TRUST CORP $3,367,481 0.85% 912,597
JPMORGAN CHASE & CO $2,989,248 0.75% 810,095
Greenwich Wealth Management LLC $2,833,923 0.71% 768,001
VANGUARD FIDUCIARY TRUST CO $2,821,495 0.71% 764,633
MORGAN STANLEY $2,616,068 0.66% 708,963
Alessandra Capital Management, LLC $2,459,765 0.62% 666,603
D. E. Shaw & Co., Inc. $2,394,588 0.60% 648,940
SUSQUEHANNA INTERNATIONAL GROUP, LLP $2,392,887 0.60% 648,479
Point72 Asset Management, L.P. $1,968,810 0.50% 533,553
MOORE CAPITAL MANAGEMENT, LP $1,845,000 0.46% 500,000
CHELSEA COUNSEL CO $1,657,031 0.42% 449,060
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1,635,039 0.41% 443,100
MILLENNIUM MANAGEMENT LLC $1,575,987 0.40% 427,097
HighTower Advisors, LLC $1,255,946 0.32% 340,365
DIMENSIONAL FUND ADVISORS LP $1,124,260 0.28% 304,678
WELLINGTON MANAGEMENT GROUP LLP $1,123,397 0.28% 304,444
Nuveen, LLC $1,018,185 0.26% 275,931
WELLS FARGO & COMPANY/MN $928,945 0.23% 251,747
Bank of New York Mellon Corp $909,007 0.23% 246,344
IQ EQ FUND MANAGEMENT (IRELAND) Ltd $833,198 0.21% 225,799
MARSHALL WACE, LLP $800,143 0.20% 216,841
XTX Topco Ltd $795,962 0.20% 215,708
Jain Global LLC $794,154 0.20% 215,218
JUPITER ASSET MANAGEMENT LTD $773,018 0.19% 209,490
Swiss National Bank $768,627 0.19% 208,300
PEAK6 LLC $767,730 0.19% 208,057
CITIGROUP INC $721,999 0.18% 195,664
JANE STREET GROUP, LLC $718,074 0.18% 194,600
Green Alpha Advisors, LLC $682,734 0.17% 185,023
Keystone Financial Group $614,421 0.15% 166,510
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $599,026 0.15% 162,338
PRICE T ROWE ASSOCIATES INC /MD/ $598,979 0.15% 162,325
HRT FINANCIAL LP $595,971 0.15% 161,510
CITADEL ADVISORS LLC $591,138 0.15% 160,200
Bollard Group LLC $557,691 0.14% 151,136
ALLIANCEBERNSTEIN L.P. $554,607 0.14% 150,300
Rafferty Asset Management, LLC $536,064 0.13% 145,275
Invesco Ltd. $517,735 0.13% 140,308
CITADEL ADVISORS LLC $511,803 0.13% 138,700
SUSQUEHANNA INTERNATIONAL GROUP, LLP $495,198 0.12% 134,200
Concurrent Investment Advisors, LLC $486,053 0.12% 131,722
ExodusPoint Capital Management, LP $437,132 0.11% 118,464
AQR CAPITAL MANAGEMENT LLC $435,408 0.11% 117,998
Virtus Investment Advisers, LLC $435,084 0.11% 117,909
RENAISSANCE TECHNOLOGIES LLC $433,250 0.11% 117,412
RHUMBLINE ADVISERS $430,822 0.11% 116,754
FIL Ltd $425,110 0.11% 115,206
DEUTSCHE BANK AG\ $422,400 0.11% 114,472
Steward Partners Investment Advisory, LLC $399,590 0.10% 108,290
Palumbo Wealth Management LLC $383,025 0.10% 103,801
MILESTONE ASSET MANAGEMENT, LLC $369,129 0.09% 100,035
TD Asset Management Inc $347,406 0.09% 94,148
LPL Financial LLC $340,122 0.09% 92,174
Rockefeller Capital Management L.P. $334,810 0.08% 90,735
BARCLAYS PLC $324,933 0.08% 88,058
Squarepoint Ops LLC $324,827 0.08% 88,029
COMMONWEALTH EQUITY SERVICES, LLC $322,173 0.08% 87,310
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $314,757 0.08% 85,300
LOS ANGELES CAPITAL MANAGEMENT LLC $303,705 0.08% 82,305
JANE STREET GROUP, LLC $285,606 0.07% 77,400
PROFUND ADVISORS LLC $267,982 0.07% 72,624
Legal & General Group Plc $245,177 0.06% 66,444
BNP PARIBAS ARBITRAGE, SA $243,912 0.06% 66,101
BRIDGEWAY CAPITAL MANAGEMENT, LLC $239,112 0.06% 64,800
Jupiter Topco LLC $224,721 0.06% 60,900
Engineers Gate Manager LP $218,200 0.05% 59,133
VANGUARD ASSET MANAGEMENT, Ltd $217,787 0.05% 59,021
SG Americas Securities, LLC $217,422 0.05% 58,922
&PARTNERS $212,027 0.05% 57,460
MetLife Investment Management, LLC $207,348 0.05% 56,192
Russell Investments Group, Ltd. $188,167 0.05% 50,994
AMERIPRISE FINANCIAL INC $184,282 0.05% 49,941
Mutual Advisors, LLC $166,050 0.04% 45,000
Vanguard Global Advisers, LLC $163,352 0.04% 44,269
Quadrature Capital Ltd $161,116 0.04% 43,663
IvyRock Asset Management (HK) Ltd $154,242 0.04% 41,800
Key facts CIK 1894562 CUSIP 74168J101 13F (30d) 175 filings 175 filers Visit website Investor relations

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