TWO SIGMA INVESTMENTS, LP

Position in PRME — Prime Medicine, Inc.

CIK 1179392 NEW YORK, NY

Position in PRME

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$5,625,445

+$152,063 QoQ

Shares Held

1,524,511

-3.1% QoQ

Ownership

0.841%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

#18

of 186 holders

Holding Since

Sep 2023

12 quarters on record

Voting authority Sole 99% Shared 0% None 1%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,273,624,947 across 342 Biotechnology names. PRME ranks #111 (0.1% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE	185,638	$172,229,367

12 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$5,625,445	1,524,511	-3.1%	Shares	Sole	2026-08-14
2026-03-31	$5,473,382	1,572,811	-3.5%	Shares	Sole	2026-05-15
2025-12-31	$5,653,754	1,629,324	+264.0%	Shares	Sole	2026-02-17
2025-09-30	$2,480,075	447,667	+73.2%	Shares	Sole	2025-11-14
2025-06-30	$638,304	258,423	-0.1%	Shares	Sole	2025-08-14
2025-03-31	$514,952	258,770	+55.7%	Shares	Sole	2025-05-15
2024-12-31	$485,301	166,199	-47.8%	Shares	Sole	2025-02-14
2024-09-30	$1,232,877	318,573	-53.3%	Shares	Sole	2024-11-14
2024-06-30	$3,502,786	681,476	+34.1%	Shares	Sole	2024-08-14
2024-03-31	$3,556,546	508,078	+89.3%	Shares	Sole	2024-05-15
2023-12-31	$2,377,687	268,362	+188.6%	Shares	Sole	2024-02-14
2023-09-30	$887,153	92,993	—	Shares	Sole	2023-11-14
No filing history on record for this holder in this stock.