RTW INVESTMENTS, LP
Filing Date
Global Rank
#432
/ 8,700
▲ 49
Top Industry
Biotechnology
81.4%
3Y Alpha vs SPY
-1.9%
Period ended 2 months ago
Filed Aug 14, 2026 · 30d
26 quarters · since Mar 2020
Clone Performance
Sep 2023–Sep 2026 · vs SPYHypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.
Cloned portfolio
+55.6%
SPY
+71.2%
Annualised alpha
-3.8%
Max drawdown
−29.9%
Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. Returns use comparable raw closes and exclude dividends. Returns are unavailable when a held security or benchmark crosses a captured split without a certified price basis; the requested window is not shortened to hide it. It tracks 100% of reported value on average across 13 quarters. Past performance does not predict future results.
Portfolio Concentration
83 tracked positions · as of Jun 30, 2026 · Δ vs Mar 31, 2026Top Position
9.1%
−1.5 pts
Top 5
30.6%
−4.2 pts
Top 10
47.7%
−3.4 pts
HHI
337
Diversified−50
Portfolio Trend
26 quarters · across all stocks
Sector Breakdown
As of Jun 30, 2026| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 100.0% | $11,712,940,263 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
25 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| RARE | Ultragenyx Pharmaceutical Inc. | +4,148,100 | 7,796,895 | $260,338,324 | |
| ERAS | Erasca, Inc. | +1,789,579 | 17,946,754 | $328,784,533 | |
| CGON | CG Oncology, Inc. | +1,529,782 | 8,514,590 | $604,961,619 | |
| MIST | Milestone Pharmaceuticals Inc. | +1,502,335 | 7,833,336 | $10,496,670 | |
| QURE | uniQure N.V. | +1,355,216 | 3,941,572 | $181,548,806 | |
| OBIO | Orchestra BioMed Holdings, Inc. | +1,250,000 | 9,556,063 | $41,234,411 | |
| ORKA | Oruka Therapeutics, Inc. | +1,080,882 | 3,139,030 | $298,741,485 | |
| LRMR | Larimar Therapeutics, Inc. | +1,065,999 | 2,565,999 | $7,826,296 | |
| CGEM | Cullinan Therapeutics, Inc. | +658,387 | 2,364,347 | $43,054,758 | |
| TNGX | Tango Therapeutics, Inc. | +600,000 | 13,900,620 | $434,533,381 | |
| RDNT | RadNet, Inc. | +561,958 | 4,846,958 | $298,911,899 | |
| IRTC | iRhythm Holdings, Inc. | +514,131 | 2,182,631 | $259,623,957 | |
| RCKT | Rocket Pharmaceuticals, Inc. | +350,000 | 18,037,772 | $60,492,180 | |
| TENX | Tenax Therapeutics, Inc. | +326,324 | 696,570 | $10,135,093 | |
| CELC | Celcuity Inc. | +265,282 | 3,304,903 | $345,758,951 | |
| NBIX | Neurocrine Biosciences Inc | +205,853 | 1,267,925 | $213,696,079 | |
| CYTK | Cytokinetics Inc | +140,845 | 2,862,003 | $243,814,035 | |
| DFTX | Definium Therapeutics, Inc. | +100,000 | 400,000 | $18,816,000 | |
| SYRE | Spyre Therapeutics, Inc. | +80,000 | 4,251,996 | $377,492,204 | |
| IMTX | Immatics N.V. | +76,836 | 12,946,176 | $131,144,762 | |
| CMPS | COMPASS Pathways plc | +68,584 | 10,700,974 | $151,418,782 | |
| VSTM | Verastem, Inc. | +59,487 | 6,635,793 | $25,348,729 | |
| REPL | Replimune Group, Inc. | +54,665 | 7,411,581 | $82,046,201 | |
| RGEN | Repligen Corp | +34,637 | 1,240,637 | $169,272,512 | |
| CSTL | Castle Biosciences Inc | +20,000 | 2,778,335 | $66,263,289 | |
| No positions match the current search. | |||||
Trimmed
Positions the filer reduced
8 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| COGT | Cogent Biosciences, Inc. | −3,149,654 | 2,309,021 | $89,359,112 | |
| HNGE | Hinge Health, Inc. | −1,430,000 | 500,000 | $41,500,000 | |
| AVTX | Avalo Therapeutics, Inc. | −681,962 | 175,000 | $3,234,000 | |
| BBNX | Beta Bionics, Inc. | −500,000 | 1,500,000 | $23,505,000 | |
| NTRA | Natera, Inc. | −250,000 | 1,000,000 | $271,450,000 | |
| XGN | Exagen Inc. | −200,231 | 195,000 | $906,750 | |
| HTFL | Heartflow, Inc. | −200,000 | 295,000 | $8,655,300 | |
| TSHA | Taysha Gene Therapies, Inc. | −119,990 | 13,560,258 | $92,345,356 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
9 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| KLRA | Kailera Therapeutics, Inc. | 10,776,820 | $237,413,344 | |
| GPCR | Structure Therapeutics Inc. | 1,607,507 | $86,274,900 | |
| AXGN | Axogen, Inc. | 1,011,576 | $46,724,695 | |
| DHR | Danaher Corp /De/ | 230,000 | $43,810,400 | |
| SLDB | Solid Biosciences Inc. | 3,892,926 | $38,890,330 | |
| IDYA | IDEAYA Biosciences, Inc. | 370,370 | $13,803,689 | |
| ALLO | Allogene Therapeutics, Inc. | 3,250,000 | $6,760,000 | |
| MAZE | Maze Therapeutics, Inc. | 212,000 | $6,326,080 | |
| ABVX | Abivax S.A. | 26,400 | $3,518,064 | |
| No positions match the current search. | ||||
Sold Out
Positions the filer fully exited
13 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| — | 2,782,097 | $234,169,104 | ||
| ISRG | Intuitive Surgical Inc | 220,000 | $101,417,800 | |
| — | 1,451,326 | $52,712,160 | ||
| WAY | Waystar Holding Corp. | 1,630,000 | $39,299,300 | |
| ARWR | Arrowhead Pharmaceuticals, Inc. | 585,682 | $36,722,261 | |
| SYK | Stryker Corp | 100,000 | $32,859,000 | |
| CMPX | Compass Therapeutics, Inc. | 4,186,599 | $22,147,108 | |
| FLGT | Fulgent Genetics, Inc. | 1,289,000 | $20,495,100 | |
| JBIO | Jade Biosciences, Inc. | 573,205 | $8,053,530 | |
| IVA | Inventiva S.A. | 1,298,702 | $7,207,796 | |
| OMDA | Omada Health, Inc. | 200,000 | $2,514,000 | |
| — | 3,685,045 | $0 | ||
| CNTA | Centessa Pharmaceuticals plc | 2,054,175 | $0 | |
| No positions match the current search. | ||||
83 tracked positions ·
$11,712,940,263 total
· filing declares
84 positions · $11,712,926,784
· as of Jun 30, 2026
Showing 1–50
of 83 positions by value
· page 1 of 2
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| MDGL |
Madrigal Pharmaceuticals, Inc.
Healthcare
|
Held | 1,993,687 | $1,070,510,234 | 9.14% | |
| ARGX |
Argenx SE
Healthcare
|
Held | 709,446 | $658,202,715 | 5.62% | |
| PTCT |
Ptc Therapeutics, Inc.
Healthcare
|
Held | 7,746,415 | $631,875,071 | 5.39% | |
| PTGX |
Protagonist Therapeutics, Inc
Healthcare
|
Added | 5,061,175 | $620,398,831 | 5.30% | |
| CGON |
CG Oncology, Inc.
Healthcare
|
Added | 8,514,590 | $604,961,619 | 5.16% | |
| INSM |
INSMED Inc
Healthcare
|
Held | 4,842,880 | $516,347,865 | 4.41% | |
| TNGX |
Tango Therapeutics, Inc.
Healthcare
|
Added | 13,900,620 | $434,533,381 | 3.71% | |
| SYRE |
Spyre Therapeutics, Inc.
Healthcare
|
Added | 4,251,996 | $377,492,204 | 3.22% | |
| CELC |
Celcuity Inc.
Healthcare
|
Added | 3,304,903 | $345,758,951 | 2.95% | |
| ERAS |
Erasca, Inc.
Healthcare
|
Added | 17,946,754 | $328,784,533 | 2.81% | |
| RDNT |
RadNet, Inc.
Healthcare
|
Added | 4,846,958 | $298,911,899 | 2.55% | |
| ORKA |
Oruka Therapeutics, Inc.
Healthcare
|
Added | 3,139,030 | $298,741,485 | 2.55% | |
| NTRA |
Natera, Inc.
Healthcare
|
Reduced | 1,000,000 | $271,450,000 | 2.32% | |
| RARE |
Ultragenyx Pharmaceutical Inc.
Healthcare
|
Added | 7,796,895 | $260,338,324 | 2.22% | |
| IRTC |
iRhythm Holdings, Inc.
Healthcare
|
Added | 2,182,631 | $259,623,957 | 2.22% | |
| CYTK |
Cytokinetics Inc
Healthcare
|
Added | 2,862,003 | $243,814,035 | 2.08% | |
| KLRA |
Kailera Therapeutics, Inc.
Healthcare
|
NEW | 10,776,820 | $237,413,344 | 2.03% | |
| ESTA |
Establishment Labs Holdings Inc.
Healthcare
|
Held | 2,655,695 | $227,885,187 | 1.95% | |
| GH |
Guardant Health, Inc.
Healthcare
|
Held | 1,481,033 | $222,199,380 | 1.90% | |
| NBIX |
Neurocrine Biosciences Inc
Healthcare
|
Added | 1,267,925 | $213,696,079 | 1.82% | |
| TARS |
Tarsus Pharmaceuticals, Inc.
Healthcare
|
Added | 3,357,059 | $211,293,293 | 1.80% | |
| STOK |
Stoke Therapeutics, Inc.
Healthcare
|
Held | 5,623,525 | $184,001,738 | 1.57% | |
| QURE |
uniQure N.V.
Healthcare
|
Added | 3,941,572 | $181,548,806 | 1.55% | |
| ACAD |
Acadia Pharmaceuticals Inc
Healthcare
|
Held | 7,144,524 | $180,756,457 | 1.54% | |
| RGEN |
Repligen Corp
Healthcare
|
Added | 1,240,637 | $169,272,512 | 1.45% | |
| URGN |
UroGen Pharma Ltd.
Healthcare
|
Held | 4,543,895 | $167,215,336 | 1.43% | |
| GHRS |
GH Research PLC
Healthcare
|
Held | 5,933,815 | $159,500,947 | 1.36% | |
| IMCR |
Immunocore Holdings plc
Healthcare
|
Held | 4,869,798 | $154,616,086 | 1.32% | |
| CMPS |
COMPASS Pathways plc
Healthcare
|
Added | 10,700,974 | $151,418,782 | 1.29% | |
| IMTX |
Immatics N.V.
Healthcare
|
Added | 12,946,176 | $131,144,762 | 1.12% | |
| ZLAB |
Zai Lab Ltd
Healthcare
|
Held | 6,574,032 | $124,906,608 | 1.07% | |
| IMVT |
Immunovant, Inc.
Healthcare
|
Held | 3,177,849 | $122,442,521 | 1.05% | |
| BLTE |
Belite Bio, Inc
Healthcare
|
Held | 715,332 | $110,150,398 | 0.94% | |
| XNCR |
Xencor Inc
Healthcare
|
Held | 6,777,461 | $109,117,122 | 0.93% | |
| TSHA |
Taysha Gene Therapies, Inc.
Healthcare
|
Reduced | 13,560,258 | $92,345,356 | 0.79% | |
| COGT |
Cogent Biosciences, Inc.
Healthcare
|
Reduced | 2,309,021 | $89,359,112 | 0.76% | |
| ALKS |
Alkermes plc.
Healthcare
|
Held | 1,672,356 | $87,631,454 | 0.75% | |
| GPCR |
Structure Therapeutics Inc.
Healthcare
|
NEW | 1,607,507 | $86,274,900 | 0.74% | |
| REPL |
Replimune Group, Inc.
Healthcare
|
Added | 7,411,581 | $82,046,201 | 0.70% | |
| CSTL |
Castle Biosciences Inc
Healthcare
|
Added | 2,778,335 | $66,263,289 | 0.57% | |
| CADL |
Candel Therapeutics, Inc.
Healthcare
|
Held | 6,422,018 | $66,146,785 | 0.56% | |
| RCKT |
Rocket Pharmaceuticals, Inc.
Healthcare
|
Added | 18,037,772 | $60,492,180 | 0.52% | |
| KOD |
Kodiak Sciences Inc.
Healthcare
|
Held | 1,487,934 | $57,969,908 | 0.49% | |
| AKTS |
Aktis Oncology, Inc.
Healthcare
|
Held | 1,592,043 | $51,311,545 | 0.44% | |
| AXGN |
Axogen, Inc.
Healthcare
|
NEW | 1,011,576 | $46,724,695 | 0.40% | |
| DHR |
Danaher Corp /De/
Healthcare
|
NEW | 230,000 | $43,810,400 | 0.37% | |
| CGEM |
Cullinan Therapeutics, Inc.
Healthcare
|
Added | 2,364,347 | $43,054,758 | 0.37% | |
| NGNE |
Neurogene Inc.
Healthcare
|
Held | 1,362,456 | $42,849,241 | 0.37% | |
| HNGE |
Hinge Health, Inc.
Healthcare
|
Reduced | 500,000 | $41,500,000 | 0.35% | |
| OBIO |
Orchestra BioMed Holdings, Inc.
Healthcare
|
Added | 9,556,063 | $41,234,411 | 0.35% |
Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.