RTW INVESTMENTS, LP

Registered adviser

CIK

1493215

Location

NEW YORK, NY

Portfolio Value

Large $11,712,941,453

Diversification

Diversified

Filing Date

Global Rank

#486 / 8,818 ▼ 13

Top Industry

Biotechnology 81.4%

3Y Alpha vs SPY

-1.6%

Period ended 4 months ago

Filed Aug 14, 2026 · 2mo

26 quarters · since Mar 2020

Regulatory profile

From Form ADV, the SEC filer profile, 13D/13G type codes and N-CEN, never from the name.

Holder type

Registered adviser

Form ADV roster, Oct 1, 2026

Form ADV adviser

CRD 153232

Roster of Oct 1, 2026

Regulatory AUM

$14,137,925,887

Main clients

Pooled investment vehicles (100% of AUM)

Private funds

3 funds · Hedge funds

Focus by fund count, roster of Oct 1, 2026

$13,104,875,636 gross assets

LEI

54930058PPKTSERDV366

Private funds on Schedule D 7.B.(1)

As filed Mar 28, 2024; SEC's bulk Form ADV archive ends with 2024 filings.

$8,401,375,378 gross assets in 3 funds Hedge funds $8,320,296,256 (2) Private equity funds $81,079,122 (1)

Form ADV history

Monthly rosters from Dec 2019; each row is a run with the same figures, newest first.

Rosters	Regulatory AUM	Main clients
Apr 2026 to Oct 2026	$14,137,925,887	Pooled investment vehicles (100%)
Apr 2025 to Mar 2026	$9,806,112,769	Pooled investment vehicles (100%)
Apr 2024 to Mar 2025	$8,820,485,054	Pooled investment vehicles (100%)
May 2023 to Mar 2024	$7,179,756,279	Pooled investment vehicles (100%)
Apr 2023	$7,179,756,279	Pooled investment vehicles (100%)
Apr 2022 to Mar 2023	$8,730,907,156	Pooled investment vehicles (100%)

3 earlier changes not shown.

Portfolio style

Measured from the filed 13F common-share book for Jun 30, 2026, never from the firm's own description.

Style

Diversified active

Top 10 weight 47.7%, 29.6 effective positions, active share 95.3% against the Russell 2000 as of 2026-06-30; it meets none of the index-like, systematic-like or concentrated tests

Turnover

Medium turnover

31.7% over the last four quarters (30% to under 100%)

Horizon

Long horizon

Value-weighted holding period 13.4 quarters (12+), a floor since 22.8% of the book was already held when coverage starts

Closest benchmark: the Russell 2000 as of 2026-06-30, active share 95.3%; sector active share 90.9% against the combined 13F book's sector weights.

Over time 26 measured quarters

How the bands are measured

Style bands measure the filed 13F common-share book each closed quarter, tested in this order. Unknown: under $10,000,000 of valued equity or 5 stocks. Index-like (100+ stocks): active share of 20% or less against the closest benchmark, which is the S&P 500, S&P MidCap 400, S&P SmallCap 600, Russell 1000, Russell 2000, Nasdaq-100 or Dow Jones Industrial Average (weighted by an index-tracking fund's reported holdings or the index's constituents nearest the quarter end, over the names resolved to companies, and only when those are 90%+ of its weight) or every 13F filer's combined book, or index series holding 80%+ of the registered fund assets it advises (N-CEN) and equal to 50%+ of its book. Systematic-like: 500+ stocks, 100%+ annual turnover and a top 10 weight of 25% or less. Concentrated: a top 10 weight of 60%+ or 12 or fewer effective positions. Diversified active: none of these. Turnover is the smaller of buys and sells over average equity value, summed over four quarters: low under 30%, high 100%+. Horizon is the value-weighted number of quarters each position has been held: short under 4, long 12+.

Clone Performance

Build a hypothetical price-return history from this filer's public 13F holdings.

View clone backtest

Portfolio Concentration

84 tracked positions · as of Jun 30, 2026 · Δ vs Mar 31, 2026

Top Position

9.1%

−1.2 pts

Top 5

30.6%

−3.4 pts

Top 10

47.7%

−2.3 pts

HHI

337

Diversified−36

Portfolio Trend

26 quarters · across all stocks

Sector Breakdown

As of Jun 30, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$11,712,941,453	84

Last Quarter's Activity

Export CSV

Jun 30, 2026 vs Mar 31, 2026

Added To

Positions the filer increased

25 positions

Ticker	Company	Δ Shares	Shares	Value
RARE	Ultragenyx Pharmaceutical Inc.	+4,148,100	7,796,895	$260,338,324
ERAS	Erasca, Inc.	+1,789,579	17,946,754	$328,784,533
CGON	CG Oncology, Inc.	+1,529,782	8,514,590	$604,961,619
MIST	Milestone Pharmaceuticals Inc.	+1,502,335	7,833,336	$10,496,670
QURE	uniQure N.V.	+1,355,216	3,941,572	$181,548,806
OBIO	Orchestra BioMed Holdings, Inc.	+1,250,000	9,556,063	$41,234,411
ORKA	Oruka Therapeutics, Inc.	+1,080,882	3,139,030	$298,741,485
LRMR	Larimar Therapeutics, Inc.	+1,065,999	2,565,999	$7,826,296
CGEM	Cullinan Therapeutics, Inc.	+658,387	2,364,347	$43,054,758
TNGX	Tango Therapeutics, Inc.	+600,000	13,900,620	$434,533,381
RDNT	RadNet, Inc.	+561,958	4,846,958	$298,911,899
IRTC	iRhythm Holdings, Inc.	+514,131	2,182,631	$259,623,957
TENX	Tenax Therapeutics, Inc.	+326,324	696,570	$10,135,093
CELC	Celcuity Inc.	+265,282	3,304,903	$345,758,951
NBIX	Neurocrine Biosciences Inc	+205,853	1,267,925	$213,696,079
CYTK	Cytokinetics Inc	+140,845	2,862,003	$243,814,035
DFTX	Definium Therapeutics, Inc.	+100,000	400,000	$18,816,000
SYRE	Spyre Therapeutics, Inc.	+80,000	4,251,996	$377,492,204
IMTX	Immatics N.V.	+76,836	12,946,176	$131,144,762
CMPS	COMPASS Pathways plc	+68,584	10,700,974	$151,418,782
VSTM	Verastem, Inc.	+59,487	6,635,793	$25,348,729
REPL	Replimune Group, Inc.	+54,665	7,411,581	$82,046,201
RGEN	Repligen Corp	+34,637	1,240,637	$169,272,512
CSTL	Castle Biosciences Inc	+20,000	2,778,335	$66,263,289
TARS	Tarsus Pharmaceuticals, Inc.	+11,034	3,357,059	$211,293,293
No positions match the current search.

Trimmed

Positions the filer reduced

8 positions

Ticker	Company	Δ Shares	Shares	Value
COGT	Cogent Biosciences, Inc.	−3,149,654	2,309,021	$89,359,112
HNGE	Hinge Health, Inc.	−1,430,000	500,000	$41,500,000
AVTX	Avalo Therapeutics, Inc.	−681,962	175,000	$3,234,000
BBNX	Beta Bionics, Inc.	−500,000	1,500,000	$23,505,000
NTRA	Natera, Inc.	−250,000	1,000,000	$271,450,000
XGN	Exagen Inc.	−200,231	195,000	$906,750
HTFL	Heartflow, Inc.	−200,000	295,000	$8,655,300
TSHA	Taysha Gene Therapies, Inc.	−119,990	13,560,258	$92,345,356
No positions match the current search.

New Positions

Positions the filer opened this quarter

9 positions

Ticker	Company	Shares	Value
KLRA	Kailera Therapeutics, Inc.	10,776,820	$237,413,344
GPCR	Structure Therapeutics Inc.	1,607,507	$86,274,900
AXGN	Axogen, Inc.	1,011,576	$46,724,695
DHR	Danaher Corp	230,000	$43,810,400
SLDB	Solid Biosciences Inc.	3,892,926	$38,890,330
IDYA	IDEAYA Biosciences, Inc.	370,370	$13,803,689
ALLO	Allogene Therapeutics, Inc.	3,250,000	$6,760,000
MAZE	Maze Therapeutics, Inc.	212,000	$6,326,080
ABVX	Abivax S.A.	26,400	$3,518,064
No positions match the current search.

Sold Out

Positions the filer fully exited

13 positions

Ticker	Company	Shares	Value
—		2,782,097	$234,169,104
—		3,685,045	$148,249,360
ISRG	Intuitive Surgical Inc	220,000	$101,417,800
CNTA	Centessa Pharmaceuticals plc	2,054,175	$81,591,831
—		1,451,326	$52,712,160
WAY	Waystar Holding Corp.	1,630,000	$39,299,300
ARWR	Arrowhead Pharmaceuticals, Inc.	585,682	$36,722,261
SYK	Stryker Corp	100,000	$32,859,000
CMPX	Compass Therapeutics, Inc.	4,186,599	$22,147,108
FLGT	Fulgent Genetics, Inc.	1,289,000	$20,495,100
JBIO	Jade Biosciences, Inc.	573,205	$8,053,530
IVA	Inventiva S.A.	1,298,702	$7,207,796
OMDA	Omada Health, Inc.	200,000	$2,514,000
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

84 tracked positions · $11,712,941,453 total · filing declares 84 positions · $11,712,926,784 · as of Jun 30, 2026

All sectors Healthcare

Showing 1–50 of 84 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	Held (qtrs)	Est. cost/share	% of Portfolio
MDGL	Madrigal Pharmaceuticals, Inc. Healthcare	Held	1,993,687	0	$1,070,510,234	+2.6%	13	$231.65	9.14%
ARGX	Argenx SE Healthcare	Held	709,446	0	$658,202,715	+27.0%	26+	before history	5.62%
PTCT	Ptc Therapeutics, Inc. Healthcare	Held	7,746,415	0	$631,875,071	+19.7%	26+	before history	5.39%
PTGX	Protagonist Therapeutics, Inc Healthcare	Added	5,061,175	+2,122	$620,398,831	+16.3%	26+	before history	5.30%
CGON	CG Oncology, Inc. Healthcare	Added	8,514,590	+1,529,782	$604,961,619	+28.0%	10	$53.55	5.16%
INSM	INSMED Inc Healthcare	Held	4,842,880	0	$516,347,865	−34.8%	13	$85.76	4.41%
TNGX	Tango Therapeutics, Inc. Healthcare	Added	13,900,620	+600,000	$434,533,381	+56.2%	3	$13.82	3.71%
SYRE	Spyre Therapeutics, Inc. Healthcare	Added	4,251,996	+80,000	$377,492,204	+79.4%	11	$22.63	3.22%
CELC	Celcuity Inc. Healthcare	Added	3,304,903	+265,282	$345,758,951	−0.3%	3	$105.08	2.95%
ERAS	Erasca, Inc. Healthcare	Added	17,946,754	+1,789,579	$328,784,533	+25.8%	3	$11.99	2.81%
RDNT	RadNet, Inc. Healthcare	Added	4,846,958	+561,958	$298,911,899	+24.8%	11	$56.22	2.55%
ORKA	Oruka Therapeutics, Inc. Healthcare	Added	3,139,030	+1,080,882	$298,741,485	+195.9%	8	unpriced	2.55%
NTRA	Natera, Inc. Healthcare	Reduced	1,000,000	-250,000	$271,450,000	+8.6%	26+	before history	2.32%
RARE	Ultragenyx Pharmaceutical Inc. Healthcare	Added	7,796,895	+4,148,100	$260,338,324	+240.6%	19	$30.77	2.22%
IRTC	iRhythm Holdings, Inc. Healthcare	Added	2,182,631	+514,131	$259,623,957	+31.8%	3	$155.51	2.22%
CYTK	Cytokinetics Inc Healthcare	Added	2,862,003	+140,845	$243,814,035	+35.9%	24	$31.34	2.08%
KLRA	Kailera Therapeutics, Inc. Healthcare	NEW	10,776,820	NEW	$237,413,344	NEW	1	$21.98	2.03%
ESTA	Establishment Labs Holdings Inc. Healthcare	Held	2,655,695	0	$227,885,187	+51.1%	26+	before history	1.95%
GH	Guardant Health, Inc. Healthcare	Held	1,481,033	0	$222,199,380	+62.4%	5	$48.77	1.90%
NBIX	Neurocrine Biosciences Inc Healthcare	Added	1,267,925	+205,853	$213,696,079	+52.7%	5	$120.15	1.82%
TARS	Tarsus Pharmaceuticals, Inc. Healthcare	Added	3,357,059	+11,034	$211,293,293	−10.0%	23	$28.50	1.80%
STOK	Stoke Therapeutics, Inc. Healthcare	Held	5,623,525	0	$184,001,738	+0.5%	26+	before history	1.57%
QURE	uniQure N.V. Healthcare	Added	3,941,572	+1,355,216	$181,548,806	+329.3%	8	$17.52	1.55%
ACAD	Acadia Pharmaceuticals Inc Healthcare	Held	7,144,524	0	$180,756,457	+13.7%	17	$21.24	1.54%
RGEN	Repligen Corp Healthcare	Added	1,240,637	+34,637	$169,272,512	+19.1%	3	$153.75	1.45%
URGN	UroGen Pharma Ltd. Healthcare	Held	4,543,895	0	$167,215,336	+104.7%	20	$14.29	1.43%
GHRS	GH Research PLC Healthcare	Held	5,933,815	0	$159,500,947	+91.2%	21	unpriced	1.36%
IMCR	Immunocore Holdings plc Healthcare	Held	4,869,798	0	$154,616,086	+5.3%	22	$41.85	1.32%
CMPS	COMPASS Pathways plc Healthcare	Added	10,700,974	+68,584	$151,418,782	+157.5%	7	$4.76	1.29%
IMTX	Immatics N.V. Healthcare	Added	12,946,176	+76,836	$131,144,762	+3.6%	24	$10.00	1.12%
ZLAB	Zai Lab Ltd Healthcare	Held	6,574,032	0	$124,906,608	+1.0%	7	$25.69	1.07%
IMVT	Immunovant, Inc. Healthcare	Held	3,177,849	0	$122,442,521	+55.1%	3	$22.30	1.05%
BLTE	Belite Bio, Inc Healthcare	Held	715,332	0	$110,150,398	−3.4%	4	$95.37	0.94%
XNCR	Xencor Inc Healthcare	Held	6,777,461	0	$109,117,122	+33.5%	8	$13.91	0.93%
TSHA	Taysha Gene Therapies, Inc. Healthcare	Reduced	13,560,258	-119,990	$92,345,356	+51.0%	12	$1.88	0.79%
COGT	Cogent Biosciences, Inc. Healthcare	Reduced	2,309,021	-3,149,654	$89,359,112	−57.5%	4	$20.68	0.76%
ALKS	Alkermes plc. Healthcare	Held	1,672,356	0	$87,631,454	+48.2%	12	$27.15	0.75%
GPCR	Structure Therapeutics Inc. Healthcare	NEW	1,607,507	NEW	$86,274,900	NEW	1	$44.24	0.74%
REPL	Replimune Group, Inc. Healthcare	Added	7,411,581	+54,665	$82,046,201	+45.8%	9	$7.45	0.70%
CSTL	Castle Biosciences Inc Healthcare	Added	2,778,335	+20,000	$66,263,289	−2.1%	3	$32.29	0.57%
CADL	Candel Therapeutics, Inc. Healthcare	Held	6,422,018	0	$66,146,785	+110.2%	2	$5.44	0.56%
RCKT	Rocket Pharmaceuticals, Inc. Healthcare	Held	17,687,772	0	$60,492,180	−4.5%	26+	before history	0.52%
KOD	Kodiak Sciences Inc. Healthcare	Held	1,487,934	0	$57,969,908	+2.2%	3	$20.48	0.49%
AKTS	Aktis Oncology, Inc. Healthcare	Held	1,592,043	0	$51,311,545	+80.2%	2	$19.42	0.44%
AXGN	Axogen, Inc. Healthcare	NEW	1,011,576	NEW	$46,724,695	NEW	1	$40.32	0.40%
DHR	Danaher Corp Healthcare	NEW	230,000	NEW	$43,810,400	NEW	1	$181.57	0.37%
CGEM	Cullinan Therapeutics, Inc. Healthcare	Added	2,364,347	+658,387	$43,054,758	+77.6%	9	$18.52	0.37%
NGNE	Neurogene Inc. Healthcare	Held	1,362,456	0	$42,849,241	+56.0%	10	$34.49	0.37%
HNGE	Hinge Health, Inc. Healthcare	Reduced	500,000	-1,430,000	$41,500,000	−44.2%	3	$42.77	0.35%
OBIO	Orchestra BioMed Holdings, Inc. Healthcare	Added	9,556,063	+1,250,000	$41,234,411	+16.8%	14	$9.33	0.35%

Showing the top 50 of 84 positions. Create a free account to see every position, past quarters, search, filters and CSV export.

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.