RTW INVESTMENTS, LP
Filing Date
Global Rank
#415
/ 8,623
▲ 14
· as of Mar 2026
Top Industry
Biotechnology
82.2%
3Y Alpha vs SPY
-5.1%
Period ended 4 months ago
Filed May 15, 2026 · 3mo
25 quarters · since Mar 2020
Clone Performance
Jul 2023–Jul 2026 · vs SPYHypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.
Cloned portfolio
+49.1%
SPY
+67.9%
Annualised alpha
-4.6%
Max drawdown
−28.6%
Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 100% of reported value on average across 13 quarters. Past performance does not predict future results.
Portfolio Concentration
87 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025Top Position
10.4%
−1.3 pts
Top 5
34.0%
−2.3 pts
Top 10
50.0%
−0.8 pts
HHI
373
Diversified−27
Portfolio Trend
25 quarters · across all stocks
Sector Breakdown
As of Mar 31, 2026| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 100.0% | $10,049,745,359 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
25 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| ERAS | Erasca, Inc. | +16,010,524 | 16,157,175 | $261,423,091 | |
| TNGX | Tango Therapeutics, Inc. | +11,809,392 | 13,300,620 | $278,248,970 | |
| CGON | CG Oncology, Inc. | +4,972,681 | 6,984,808 | $472,731,805 | |
| MIST | Milestone Pharmaceuticals Inc. | +3,824,899 | 6,331,001 | $7,533,891 | |
| CELC | Celcuity Inc. | +2,489,461 | 3,039,621 | $346,942,340 | |
| CMPS | COMPASS Pathways plc | +1,875,000 | 10,632,390 | $58,797,116 | |
| CMPX | Compass Therapeutics, Inc. | +1,686,599 | 4,186,599 | $22,147,108 | |
| HNGE | Hinge Health, Inc. | +1,576,500 | 1,930,000 | $74,420,800 | |
| IMTX | Immatics N.V. | +1,435,986 | 12,869,340 | $126,634,305 | |
| AQST | Aquestive Therapeutics, Inc. | +1,176,471 | 7,426,471 | $30,819,854 | |
| RARE | Ultragenyx Pharmaceutical Inc. | +648,656 | 3,648,795 | $76,442,255 | |
| CSTL | Castle Biosciences Inc | +643,098 | 2,758,335 | $67,717,124 | |
| FLGT | Fulgent Genetics, Inc. | +583,973 | 1,289,000 | $20,495,100 | |
| IRTC | iRhythm Holdings, Inc. | +486,510 | 1,668,500 | $196,916,370 | |
| RDNT | RadNet, Inc. | +346,500 | 4,285,000 | $239,488,650 | |
| CNTA | Centessa Pharmaceuticals plc | +263,338 | 2,054,175 | $81,591,831 | |
| EVMN | Evommune, Inc. | +218,564 | 1,502,235 | $34,536,382 | |
| REPL | Replimune Group, Inc. | +216,564 | 7,356,916 | $56,280,407 | |
| RGEN | Repligen Corp | +142,000 | 1,206,000 | $142,090,920 | |
| ISRG | Intuitive Surgical Inc | +118,772 | 220,000 | $101,417,800 | |
| CRNX | Crinetics Pharmaceuticals, Inc. | +100,000 | 1,451,326 | $52,712,160 | |
| STOK | Stoke Therapeutics, Inc. | +76,669 | 5,623,525 | $183,101,974 | |
| APGE | Apogee Therapeutics, Inc. | +70,000 | 2,782,097 | $234,169,104 | |
| ESTA | Establishment Labs Holdings Inc. | +66,864 | 2,655,695 | $150,790,362 | |
| ARGX | Argenx SE | +35,949 | 709,446 | $518,072,941 | |
| No positions match the current search. | |||||
Trimmed
Positions the filer reduced
13 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| APLS | Apellis Pharmaceuticals, Inc. | −3,981,719 | 3,685,045 | $148,249,360 | |
| TSHA | Taysha Gene Therapies, Inc. | −2,718,049 | 13,680,248 | $61,150,708 | |
| COGT | Cogent Biosciences, Inc. | −2,133,566 | 5,458,675 | $210,104,400 | |
| LRMR | Larimar Therapeutics, Inc. | −1,625,000 | 1,500,000 | $6,750,000 | |
| QURE | uniQure N.V. | −1,125,106 | 2,586,356 | $42,286,920 | |
| JBIO | Jade Biosciences, Inc. | −876,068 | 573,205 | $8,053,530 | |
| BBNX | Beta Bionics, Inc. | −500,000 | 2,000,000 | $20,040,000 | |
| XGN | Exagen Inc. | −395,231 | 395,231 | $1,185,693 | |
| ZLAB | Zai Lab Ltd | −385,000 | 6,574,032 | $123,657,541 | |
| NTRA | Natera, Inc. | −250,000 | 1,250,000 | $249,987,500 | |
| SYK | Stryker Corp | −145,000 | 100,000 | $32,859,000 | |
| TENX | Tenax Therapeutics, Inc. | −8,100 | 370,246 | $5,920,233 | |
| IMVT | Immunovant, Inc. | −1 | 3,177,849 | $78,937,769 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
9 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| WAY | Waystar Holding Corp. | 1,630,000 | $39,299,300 | |
| CADL | Candel Therapeutics, Inc. | 6,422,018 | $31,467,888 | |
| AKTS | Aktis Oncology, Inc. | 1,592,043 | $28,481,649 | |
| DNTH | Dianthus Therapeutics, Inc. /DE/ | 248,063 | $20,817,446 | |
| IPSC | Century Therapeutics, Inc. | 8,695,652 | $19,652,173 | |
| AVTX | Avalo Therapeutics, Inc. | 856,962 | $12,794,442 | |
| OCGN | Ocugen, Inc. | 6,666,666 | $12,066,665 | |
| ATAI | AtaiBeckley Inc. | 2,000,000 | $7,080,000 | |
| DFTX | Definium Therapeutics, Inc. | 300,000 | $5,670,000 | |
| No positions match the current search. | ||||
Sold Out
Positions the filer fully exited
9 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| PEN | Penumbra Inc | 866,499 | $269,403,204 | |
| AXSM | Axsome Therapeutics, Inc. | 888,001 | $162,184,502 | |
| PODD | Insulet Corp | 324,600 | $92,264,304 | |
| MASI | Masimo Corp | 683,294 | $88,869,217 | |
| TEM | Tempus AI, Inc. | 200,000 | $11,810,000 | |
| IQV | Iqvia Holdings Inc. | 46,000 | $10,368,860 | |
| ALURD | Allurion Technologies, Inc. | 5,891,430 | $7,246,458 | |
| GPCR | Structure Therapeutics Inc. | 100,000 | $6,955,000 | |
| CRVS | Corvus Pharmaceuticals, Inc. | 447,607 | $3,446,573 | |
| No positions match the current search. | ||||
87 tracked positions ·
$10,049,745,359 total
· filing declares
88 positions · $10,049,752,600
· as of Mar 31, 2026
Showing 1–50
of 87 positions by value
· page 1 of 2
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| MDGL |
Madrigal Pharmaceuticals, Inc.
Healthcare
|
Held | 1,993,687 | $1,043,635,333 | 10.38% | |
| INSM |
INSMED Inc
Healthcare
|
Added | 4,842,880 | $791,907,737 | 7.88% | |
| PTGX |
Protagonist Therapeutics, Inc
Healthcare
|
Held | 5,059,053 | $533,224,186 | 5.31% | |
| PTCT |
Ptc Therapeutics, Inc.
Healthcare
|
Held | 7,746,415 | $527,763,253 | 5.25% | |
| ARGX |
Argenx SE
Healthcare
|
Added | 709,446 | $518,072,941 | 5.16% | |
| CGON |
CG Oncology, Inc.
Healthcare
|
Added | 6,984,808 | $472,731,805 | 4.70% | |
| CELC |
Celcuity Inc.
Healthcare
|
Added | 3,039,621 | $346,942,340 | 3.45% | |
| TNGX |
Tango Therapeutics, Inc.
Healthcare
|
Added | 13,300,620 | $278,248,970 | 2.77% | |
| ERAS |
Erasca, Inc.
Healthcare
|
Added | 16,157,175 | $261,423,091 | 2.60% | |
| NTRA |
Natera, Inc.
Healthcare
|
Reduced | 1,250,000 | $249,987,500 | 2.49% | |
| RDNT |
RadNet, Inc.
Healthcare
|
Added | 4,285,000 | $239,488,650 | 2.38% | |
| TARS |
Tarsus Pharmaceuticals, Inc.
Healthcare
|
Added | 3,346,025 | $234,723,653 | 2.34% | |
| APGE |
Apogee Therapeutics, Inc.
Healthcare
|
Added | 2,782,097 | $234,169,104 | 2.33% | |
| SYRE |
Spyre Therapeutics, Inc.
Healthcare
|
Held | 4,171,996 | $210,435,478 | 2.09% | |
| COGT |
Cogent Biosciences, Inc.
Healthcare
|
Reduced | 5,458,675 | $210,104,400 | 2.09% | |
| IRTC |
iRhythm Holdings, Inc.
Healthcare
|
Added | 1,668,500 | $196,916,370 | 1.96% | |
| STOK |
Stoke Therapeutics, Inc.
Healthcare
|
Added | 5,623,525 | $183,101,974 | 1.82% | |
| CYTK |
Cytokinetics Inc
Healthcare
|
Held | 2,721,158 | $179,351,523 | 1.78% | |
| ACAD |
Acadia Pharmaceuticals Inc
Healthcare
|
Held | 7,144,524 | $159,037,104 | 1.58% | |
| ESTA |
Establishment Labs Holdings Inc.
Healthcare
|
Added | 2,655,695 | $150,790,362 | 1.50% | |
| APLS |
Apellis Pharmaceuticals, Inc.
Healthcare
|
Reduced | 3,685,045 | $148,249,360 | 1.48% | |
| IMCR |
Immunocore Holdings plc
Healthcare
|
Held | 4,869,798 | $146,824,409 | 1.46% | |
| RGEN |
Repligen Corp
Healthcare
|
Added | 1,206,000 | $142,090,920 | 1.41% | |
| NBIX |
Neurocrine Biosciences Inc
Healthcare
|
Held | 1,062,072 | $139,917,365 | 1.39% | |
| GH |
Guardant Health, Inc.
Healthcare
|
Held | 1,481,033 | $136,803,018 | 1.36% | |
| IMTX |
Immatics N.V.
Healthcare
|
Added | 12,869,340 | $126,634,305 | 1.26% | |
| ZLAB |
Zai Lab Ltd
Healthcare
|
Reduced | 6,574,032 | $123,657,541 | 1.23% | |
| BLTE |
Belite Bio, Inc
Healthcare
|
Held | 715,332 | $114,052,534 | 1.13% | |
| ISRG |
Intuitive Surgical Inc
Healthcare
|
Added | 220,000 | $101,417,800 | 1.01% | |
| ORKA |
Oruka Therapeutics, Inc.
Healthcare
|
Held | 2,058,148 | $100,952,159 | 1.00% | |
| GHRS |
GH Research PLC
Healthcare
|
Held | 5,933,815 | $83,429,438 | 0.83% | |
| XNCR |
Xencor Inc
Healthcare
|
Held | 6,777,461 | $81,736,179 | 0.81% | |
| URGN |
UroGen Pharma Ltd.
Healthcare
|
Held | 4,543,895 | $81,699,232 | 0.81% | |
| CNTA |
Centessa Pharmaceuticals plc
Healthcare
|
Added | 2,054,175 | $81,591,831 | 0.81% | |
| IMVT |
Immunovant, Inc.
Healthcare
|
Reduced | 3,177,849 | $78,937,769 | 0.79% | |
| RARE |
Ultragenyx Pharmaceutical Inc.
Healthcare
|
Added | 3,648,795 | $76,442,255 | 0.76% | |
| HNGE |
Hinge Health, Inc.
Healthcare
|
Added | 1,930,000 | $74,420,800 | 0.74% | |
| CSTL |
Castle Biosciences Inc
Healthcare
|
Added | 2,758,335 | $67,717,124 | 0.67% | |
| RCKT |
Rocket Pharmaceuticals, Inc.
Healthcare
|
Held | 17,687,772 | $63,322,223 | 0.63% | |
| TSHA |
Taysha Gene Therapies, Inc.
Healthcare
|
Reduced | 13,680,248 | $61,150,708 | 0.61% | |
| ALKS |
Alkermes plc.
Healthcare
|
Held | 1,672,356 | $59,134,508 | 0.59% | |
| CMPS |
COMPASS Pathways plc
Healthcare
|
Added | 10,632,390 | $58,797,116 | 0.59% | |
| KOD |
Kodiak Sciences Inc.
Healthcare
|
Added | 1,487,934 | $56,720,044 | 0.56% | |
| REPL |
Replimune Group, Inc.
Healthcare
|
Added | 7,356,916 | $56,280,407 | 0.56% | |
| CRNX |
Crinetics Pharmaceuticals, Inc.
Healthcare
|
Added | 1,451,326 | $52,712,160 | 0.52% | |
| QURE |
uniQure N.V.
Healthcare
|
Reduced | 2,586,356 | $42,286,920 | 0.42% | |
| WAY |
Waystar Holding Corp.
Healthcare
|
NEW | 1,630,000 | $39,299,300 | 0.39% | |
| ARWR |
Arrowhead Pharmaceuticals, Inc.
Healthcare
|
Added | 585,682 | $36,722,261 | 0.37% | |
| OBIO |
Orchestra BioMed Holdings, Inc.
Healthcare
|
Held | 8,306,063 | $35,300,767 | 0.35% | |
| VSTM |
Verastem, Inc.
Healthcare
|
Held | 6,576,306 | $34,854,421 | 0.35% |
Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.