Octagon Capital Advisors LP

CIK

1839435

Location

NEW YORK, NY

Portfolio Value

Small $576,533,778

Diversification

Diversified

Filing Date

Global Rank

#2,389 / 7,976 ▲ 513

Top Industry

Biotechnology 100.0%

3Y Alpha vs SPY

-8.6%

Period ended 9 months ago

Filed Nov 14, 2025 · 7mo

20 quarters · since Dec 2020

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+41.2%

SPY

+76.3%

Annualised alpha

-8.6%

Max drawdown

−55.4%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

22 positions · as of Sep 30, 2025 · Δ vs Jun 30, 2025

Top Position

19.5%

+7.8 pts

Top 5

57.3%

+13.9 pts

Top 10

79.3%

+9.7 pts

HHI

952

Diversified+319

Portfolio Trend

20 quarters · across all stocks

Sector Breakdown

As of Sep 30, 2025

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$576,533,778	22

Last Quarter's Activity

Export CSV

Sep 30, 2025 vs Jun 30, 2025

Added To

Positions the filer increased

7 positions

Ticker	Company	Δ Shares	Shares	Value
OCUL	Ocular Therapeutix, Inc	+199,000	2,624,000	$30,674,560
COGT	Cogent Biosciences, Inc.	+111,111	2,874,111	$41,272,233
KYMR	Kymera Therapeutics, Inc.	+94,000	360,000	$20,376,000
DNTH	Dianthus Therapeutics, Inc. /DE/	+75,000	2,416,667	$95,095,846
ABVX	Abivax S.A.	+58,000	1,325,000	$112,492,500
PHVS	Pharvaris N.V.	+50,000	722,595	$18,028,745
AVBP	ArriVent BioPharma, Inc.	+25,000	1,971,054	$36,365,946
No positions match the current search.

Trimmed

Positions the filer reduced

6 positions

Ticker	Company	Δ Shares	Shares	Value
NUVB	Nuvation Bio Inc.	−5,058,000	2,633,334	$9,743,335
TSHA	Taysha Gene Therapies, Inc.	−3,525,000	9,067,500	$29,650,725
GOSS	Gossamer Bio, Inc.	−1,300,000	17,050,000	$44,841,500
TRVI	Trevi Therapeutics, Inc.	−857,000	2,815,000	$25,757,250
CNTA	Centessa Pharmaceuticals plc	−200,000	830,000	$20,127,500
NGNE	Neurogene Inc.	−51,000	252,000	$4,367,160
No positions match the current search.

New Positions

Positions the filer opened this quarter

3 positions

Ticker	Company	Shares	Value
BBOT	BridgeBio Oncology Therapeutics, Inc.	1,043,110	$12,079,213
PEPG	PepGen Inc.	700,000	$3,234,000
GPCR	Structure Therapeutics Inc.	115,000	$3,220,000
No positions match the current search.

Sold Out

Positions the filer fully exited

5 positions

Ticker	Company	Shares	Value
SPRY	ARS Pharmaceuticals, Inc.	1,350,000	$23,557,500
ATYR	aTYR PHARMA INC	3,820,000	$19,367,400
MLTX	MoonLake Immunotherapeutics	148,000	$6,985,600
KLRS	Kalaris Therapeutics, Inc.	360,000	$961,200
ERAS	Erasca, Inc.	700,000	$889,000
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

22 positions · $576,533,778 total · as of Sep 30, 2025

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
ABVX	Abivax S.A. Healthcare	Added	1,325,000	+58,000	$112,492,500	+1060.6%	19.51%
DNTH	Dianthus Therapeutics, Inc. /DE/ Healthcare	Added	2,416,667	+75,000	$95,095,846	+118.0%	16.49%
GOSS	Gossamer Bio, Inc. Healthcare	Reduced	17,050,000	-1,300,000	$44,841,500	+98.7%	7.78%
COGT	Cogent Biosciences, Inc. Healthcare	Added	2,874,111	+111,111	$41,272,233	+108.0%	7.16%
AVBP	ArriVent BioPharma, Inc. Healthcare	Added	1,971,054	+25,000	$36,365,946	−14.2%	6.31%
OCUL	Ocular Therapeutix, Inc Healthcare	Added	2,624,000	+199,000	$30,674,560	+36.3%	5.32%
TSHA	Taysha Gene Therapies, Inc. Healthcare	Reduced	9,067,500	-3,525,000	$29,650,725	+1.9%	5.14%
TRVI	Trevi Therapeutics, Inc. Healthcare	Reduced	2,815,000	-857,000	$25,757,250	+28.2%	4.47%
APLS	Apellis Pharmaceuticals, Inc. Healthcare	Held	903,500	0	$20,446,205	+30.7%	3.55%
KYMR	Kymera Therapeutics, Inc. Healthcare	Added	360,000	+94,000	$20,376,000	+75.5%	3.53%
CNTA	Centessa Pharmaceuticals plc Healthcare	Reduced	830,000	-200,000	$20,127,500	+48.7%	3.49%
PHVS	Pharvaris N.V. Healthcare	Added	722,595	+50,000	$18,028,745	+52.3%	3.13%
KALV	KalVista Pharmaceuticals, Inc. Healthcare	Held	1,273,333	0	$15,509,195	+7.7%	2.69%
CRBP	Corbus Pharmaceuticals Holdings, Inc. Healthcare	Held	1,115,000	0	$14,104,750	+83.3%	2.45%
BBOT	BridgeBio Oncology Therapeutics, Inc. Healthcare	NEW	1,043,110	NEW	$12,079,213	NEW	2.10%
DBVT	DBV Technologies S.A. Healthcare	Held	1,018,021	0	$10,180,210	+9.2%	1.77%
NUVB	Nuvation Bio Inc. Healthcare	Reduced	2,633,334	-5,058,000	$9,743,335	−35.0%	1.69%
MAZE	Maze Therapeutics, Inc. Healthcare	Held	177,667	0	$4,606,905	+111.3%	0.80%
NGNE	Neurogene Inc. Healthcare	Reduced	252,000	-51,000	$4,367,160	−3.6%	0.76%
UNCY	Unicycive Therapeutics, Inc. Healthcare	Reduced	1,000,000	-1,000,000	$4,360,000	−54.3%	0.76%
PEPG	PepGen Inc. Healthcare	NEW	700,000	NEW	$3,234,000	NEW	0.56%
GPCR	Structure Therapeutics Inc. Healthcare	NEW	115,000	NEW	$3,220,000	NEW	0.56%