D. E. Shaw & Co., Inc.

Position in TSHA — Taysha Gene Therapies, Inc.

CIK 1009207 New York, NY

Position in TSHA

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$19,790,034

-$2,284,958 QoQ

Shares Held

4,427,301

+10.3% QoQ

Ownership

1.54%

of shares outstanding

% of Portfolio

0.02%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Jun 2021

8 quarters on record

Voting authority Sole 99.36981921942962.ToString("F0")% Shared 0.ToString("F0")% None 0.6301807805703746.ToString("F0")%

Healthcare · as of Mar 31, 2026

D. E. Shaw & Co., Inc. holds $4,371,472,260 across 180 Biotechnology names. TSHA ranks #41 (0.5% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	INSM	INSMED Inc	5,625,825	$919,934,903
2	ALNY	Alnylam Pharmaceuticals, Inc.	1,059,062	$350,411,843
3	BBIO	BridgeBio Pharma, Inc.	2,545,486	$189,027,789
4	PCVX	Vaxcyte, Inc.	2,865,318	$166,503,628
5	EXEL	Exelixis, Inc.	3,603,063	$154,535,371
6	HALO	Halozyme Therapeutics, Inc.	1,868,708	$120,774,597
7	PTCT	Ptc Therapeutics, Inc.	1,640,381	$111,759,157
8	VRTX	Vertex Pharmaceuticals Inc / Ma	248,960	$111,170,598

8 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$19,790,034	4,427,301	+10.3%	Shares	Defined	2026-05-15
2025-12-31	$22,074,992	4,013,635	+48.3%	Shares	Defined	2026-02-17
2025-09-30	$8,850,039	2,706,434	+574.1%	Shares	Defined	2025-11-14
2025-06-30	$927,485	401,509	+274.3%	Shares	Defined	2025-08-14
2022-09-30	$207,038	107,274	-20.3%	Shares	Defined	2022-11-14
2022-06-30	$500,656	134,585	+80.1%	Shares	Defined	2022-08-15
2022-03-31	$487,265	74,734	+552.8%	Shares	Defined	2022-05-16
2021-06-30	$242,697	11,448	—	Shares	Defined	2021-08-16
No filing history on record for this holder in this stock.