D. E. Shaw & Co., Inc.

Position in TSHA — Taysha Gene Therapies, Inc.

CIK 1009207 New York, NY

Position in TSHA

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$29,954,819

+$10,164,785 QoQ

Shares Held

4,398,652

-0.6% QoQ

Ownership

1.35%

of shares outstanding

% of Portfolio

0.02%

of 13F equity value

Holder Rank

#16

of 208 holders

Holding Since

Jun 2021

9 quarters on record

Voting authority Sole 99% Shared 0% None 1%

Healthcare · as of Jun 30, 2026

D. E. Shaw & Co., Inc. holds $5,139,216,221 across 216 Biotechnology names. TSHA ranks #38 (0.6% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	INSM	INSMED Inc	5,877,959	$626,707,987
2	ALNY	Alnylam Pharmaceuticals, Inc.	1,104,109	$332,369,932
3	EXEL	Exelixis, Inc.	5,551,747	$302,070,554
4	BBIO	BridgeBio Pharma, Inc.	3,633,007	$270,586,360
5	TGTX	Tg Therapeutics, Inc.	3,400,808	$186,840,390
6	HALO	Halozyme Therapeutics, Inc.	2,006,479	$157,047,110
7	AXSM	Axsome Therapeutics, Inc.	604,753	$148,025,391
8	PTCT	Ptc Therapeutics, Inc.	1,548,919	$126,345,322

9 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$29,954,819	4,398,652	-0.6%	Shares	Defined	2026-08-14
2026-03-31	$19,790,034	4,427,301	+10.3%	Shares	Defined	2026-05-15
2025-12-31	$22,074,992	4,013,635	+48.3%	Shares	Defined	2026-02-17
2025-09-30	$8,850,039	2,706,434	+574.1%	Shares	Defined	2025-11-14
2025-06-30	$927,485	401,509	+274.3%	Shares	Defined	2025-08-14
2022-09-30	$207,038	107,274	-20.3%	Shares	Defined	2022-11-14
2022-06-30	$500,656	134,585	+80.1%	Shares	Defined	2022-08-15
2022-03-31	$487,265	74,734	+552.8%	Shares	Defined	2022-05-16
2021-06-30	$242,697	11,448	—	Shares	Defined	2021-08-16
No filing history on record for this holder in this stock.