TWO SIGMA INVESTMENTS, LP

Position in TSHA — Taysha Gene Therapies, Inc.

CIK 1179392 NEW YORK, NY

Position in TSHA

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$1,598,415

-$1,718,687 QoQ

Shares Held

234,716

-68.4% QoQ

Ownership

0.072%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

#80

of 208 holders

Holding Since

Dec 2021

12 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $7,283,390,440 across 343 Biotechnology names. TSHA ranks #179 (0.0% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,875,937	$564,713,315
2	MRNA	Moderna, Inc.	7,193,530	$503,762,905
3	IONS	Ionis Pharmaceuticals Inc	6,252,342	$495,748,197
4	REGN	Regeneron Pharmaceuticals, Inc.	656,124	$409,119,558
5	BBIO	BridgeBio Pharma, Inc.	4,722,185	$351,708,338
6	EXEL	Exelixis, Inc.	4,209,861	$229,058,537
7	INCY	Incyte Corp	2,003,559	$227,123,448
8	ARGX	Argenx SE	185,638	$172,229,367

12 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$1,598,415	234,716	-68.4%	Shares	Sole	2026-08-14
2026-03-31	$3,317,102	742,081	+111.3%	Shares	Sole	2026-05-15
2025-12-31	$1,931,193	351,126	+431.2%	Shares	Sole	2026-02-17
2025-09-30	$216,163	66,105	+102.3%	Shares	Sole	2025-11-14
2025-06-30	$75,495	32,682	+165.7%	Shares	Sole	2025-08-14
2024-12-31	$21,279	12,300	-89.9%	Shares	Sole	2025-02-14
2024-03-31	$348,753	121,517	-11.3%	Shares	Sole	2024-05-15
2023-12-31	$242,442	136,973	+215.8%	Shares	Sole	2024-02-14
2022-09-30	$83,719	43,378	-35.9%	Shares	Sole	2022-11-14
2022-06-30	$251,635	67,644	-62.8%	Shares	Sole	2022-08-15
2022-03-31	$1,186,040	181,908	+162.8%	Shares	Sole	2022-05-16
2021-12-31	$806,517	69,229	—	Shares	Sole	2022-02-14
No filing history on record for this holder in this stock.