TWO SIGMA INVESTMENTS, LP

Position in TSHA — Taysha Gene Therapies, Inc.

CIK 1179392 NEW YORK, NY

Position in TSHA

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$3,317,102

+$1,385,909 QoQ

Shares Held

742,081

+111.3% QoQ

Ownership

0.258%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Dec 2021

11 quarters on record

Voting authority Sole 99.52835337382308.ToString("F0")% Shared 0.ToString("F0")% None 0.47164662617692676.ToString("F0")%

Healthcare · as of Mar 31, 2026

TWO SIGMA INVESTMENTS, LP holds $5,506,832,621 across 316 Biotechnology names. TSHA ranks #128 (0.1% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,992,577	$659,283,951
2	REGN	Regeneron Pharmaceuticals, Inc.	812,236	$627,566,023
3	MRNA	Moderna, Inc.	9,086,404	$461,589,323
4	IONS	Ionis Pharmaceuticals Inc	5,857,629	$439,849,361
5	BBIO	BridgeBio Pharma, Inc.	3,120,631	$231,738,058
6	VRTX	Vertex Pharmaceuticals Inc / Ma	378,146	$168,857,314
7	RVMD	Revolution Medicines, Inc.	1,558,807	$151,593,980
8	VKTX	Viking Therapeutics, Inc.	4,432,142	$144,221,900

11 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$3,317,102	742,081	+111.3%	Shares	Sole	2026-05-15
2025-12-31	$1,931,193	351,126	+431.2%	Shares	Sole	2026-02-17
2025-09-30	$216,163	66,105	+102.3%	Shares	Sole	2025-11-14
2025-06-30	$75,495	32,682	+165.7%	Shares	Sole	2025-08-14
2024-12-31	$21,279	12,300	-89.9%	Shares	Sole	2025-02-14
2024-03-31	$348,753	121,517	-11.3%	Shares	Sole	2024-05-15
2023-12-31	$242,442	136,973	+215.8%	Shares	Sole	2024-02-14
2022-09-30	$83,719	43,378	-35.9%	Shares	Sole	2022-11-14
2022-06-30	$251,635	67,644	-62.8%	Shares	Sole	2022-08-15
2022-03-31	$1,186,040	181,908	+162.8%	Shares	Sole	2022-05-16
2021-12-31	$806,517	69,229	—	Shares	Sole	2022-02-14
No filing history on record for this holder in this stock.