PRLD · Prelude Therapeutics Inc · Shareholders & Ownership

$3.88 +0.18 (+4.86%) At close · Oct 27 Q3 2025 earnings call transcript

Russell 2000 member Rebalance outlook locked

Market Cap

$295.27M

79.80M

Volume · Oct 27 277.22K Avg daily vol (3M) 518.04K

Every disclosed holder of PRLD in one list: 13F institutions, Schedule 13D and 13G filers, insiders (Forms 3, 4 and 5) and registered funds, each from its own latest filing. Holders nest by CIK and SEC reporting links, never by name, and each is summed once.

How the holder list picks a filing →

Who Owns PRLD

13F quarter Sep 30, 2026, combined view: filers that have not filed yet carry their Jun 30, 2026 positions

Holder group	Holders	Shares	% Out	Summed
Institutional (13F)	78	49,613,606	62.17%	Yes
Insiders (Forms 3, 4, 5)	0	0	0.00%	No
13D/G-only blocks	3	14,496,149	18.16%	Yes
Remaining	—	15,693,730	19.67%	Rest
Registered funds (N-PORT, not summed)	70	4,429,077	5.55%	No

Shares outstanding: 79,803,485, the issuer's latest cover-page count restated onto today's split basis.

Insiders are listed but not summed: the issuer has more than one class of common stock and Forms 3, 4 and 5 report one issuer-wide balance across them.

13D/G-only counts each filer's latest 13D or 13G that no 13F report of the listing contains, that names no 13F filer and that no counted insider files. Funds are never summed: their shares sit inside their advisers' 13F reports.

Holders of PRLD

One row per holder Every filing By ultimate parent

All 13F Funds Insiders 13D/G Non-US

#	Holder	Shares	% Out	Change	As of	Notes
1	ORBIMED ADVISORS LLC 13F CIK 1055951 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	13,724,571	17.20%	+2,815,315	Jun 30, 2026	carried, not yet filed for the newest quarter
1.1	ORBIMED ADVISORS LLC Insider CIK 1055951 · Apr 21, 2026 10% Owner, issuer-wide, not summed	13,461,371	16.87%	+2,815,315	Apr 21, 2026	10% Owner, issuer-wide, not summed
2	Bonita David P Insider CIK 1572451 · Apr 21, 2026 Director, 10% Owner, issuer-wide, not summed	13,461,371	16.87%	+2,815,315	Apr 21, 2026	Director, 10% Owner, issuer-wide, not summed
3	BAKER BROS. ADVISORS LP 13F CIK 1263508 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	10,123,824	12.69%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
4	Vaddi Krishna 13G CIK 1824633 · Unknown · Dec 31, 2025 Rule 13d-1(d), exempt investor	6,745,647	8.45%	+347,808	Dec 31, 2025	Rule 13d-1(d), exempt investor
4.1	Vaddi Krishna Insider CIK 1824633 · Mar 25, 2025 Director, CEO, issuer-wide, not summed	3,669,054	4.60%	+675,000	Mar 25, 2025	Director, CEO, issuer-wide, not summed
5	RA CAPITAL MANAGEMENT, L.P. 13F CIK 1346824 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	6,475,882	8.11%	+6,475,882	Jun 30, 2026	carried, not yet filed for the newest quarter
5.1	RA CAPITAL MANAGEMENT, L.P. Insider CIK 1346824 · Apr 27, 2026 Director, issuer-wide, not summed	6,475,882	8.11%	-1,407,000	Apr 27, 2026	Director, issuer-wide, not summed
6	INCYTE CORP 13G CIK 879169 · Unknown · Nov 3, 2025 Rule 13d-1(c), passive investor	4,372,124	5.48%	—	Nov 3, 2025	Rule 13d-1(c), passive investor
7	Soleus Capital Management, L.P. 13F CIK 1802630 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	3,378,378	4.23%	+3,378,378	Jun 30, 2026	carried, not yet filed for the newest quarter
8	Soleus Capital Management, L.P. 13G CIK 1955982 · Unknown · Apr 21, 2026 Rule 13d-1(c), passive investor	3,378,378	4.23%	—	Apr 21, 2026	Rule 13d-1(c), passive investor
9	Kynam Capital Management, LP 13F CIK 1907884 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	2,415,087	3.03%	+822,536	Jun 30, 2026	carried, not yet filed for the newest quarter
10	VANGUARD CAPITAL MANAGEMENT LLC 13F CIK 2100119 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	2,009,445	2.52%	+779,039	Jun 30, 2026	carried, not yet filed for the newest quarter
11	BlackRock, Inc. 13F CIK 2012383 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	1,797,501	2.25%	+1,475,615	Jun 30, 2026	carried, not yet filed for the newest quarter
11.1	iShares Russell 2000 ETF Fund S000004344 · Registered fund · Jun 30, 2026 iShares Trust, not summed	657,987	0.82%	—	Jun 30, 2026	iShares Trust, not summed
11.2	iShares Russell 2000 Growth ETF Fund S000004343 · Registered fund · Jun 30, 2026 iShares Trust, not summed	260,735	0.33%	—	Jun 30, 2026	iShares Trust, not summed
11.3	iShares Micro-Cap ETF Fund S000004439 · Registered fund · Jun 30, 2026 iShares Trust, not summed	93,079	0.12%	—	Jun 30, 2026	iShares Trust, not summed
11.4	Master Small Cap Index Series Fund S000002716 · Registered fund · Jun 30, 2026 Quantitative Master Series LLC, not summed	51,899	0.07%	—	Jun 30, 2026	Quantitative Master Series LLC, not summed
11.5	BlackRock Small Cap Index V.I. Fund Fund S000059910 · Registered fund · Jun 30, 2026 BlackRock Variable Series Funds, Inc., not summed	3,769	0.00%	—	Jun 30, 2026	BlackRock Variable Series Funds, Inc., not summed
12	VANGUARD TOTAL STOCK MARKET INDEX FUND Fund S000002848 · Registered fund · Jun 30, 2026 VANGUARD INDEX FUNDS, not summed	1,513,825	1.90%	+577,824	Jun 30, 2026	VANGUARD INDEX FUNDS, not summed
13	SPHERA FUNDS MANAGEMENT LTD. 13F CIK 1496201 · Exempt reporting adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,019,832	1.28%	+461,493	Jun 30, 2026	carried, not yet filed for the newest quarter
14	TWO SIGMA INVESTMENTS, LP 13F CIK 1179392 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	993,369	1.24%	+69,743	Jun 30, 2026	carried, not yet filed for the newest quarter
15	ADAR1 Capital Management, LLC 13F CIK 1940272 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	900,900	1.13%	+748,075	Jun 30, 2026	carried, not yet filed for the newest quarter
16	MILLENNIUM MANAGEMENT LLC 13F CIK 1273087 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	844,993	1.06%	+462,256	Jun 30, 2026	carried, not yet filed for the newest quarter
17	GEODE CAPITAL MANAGEMENT, LLC 13F CIK 1214717 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	841,862	1.05%	+539,404	Jun 30, 2026	carried, not yet filed for the newest quarter
18	ADAGE CAPITAL PARTNERS GP, L.L.C. 13F CIK 1165408 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	766,095	0.96%	+766,095	Jun 30, 2026	carried, not yet filed for the newest quarter
19	ACADIAN ASSET MANAGEMENT LLC 13F CIK 916542 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	611,359	0.77%	+99,840	Jun 30, 2026	carried, not yet filed for the newest quarter
20	MORGAN STANLEY 13F CIK 895421 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	503,860	0.63%	+181,699	Jun 30, 2026	carried, not yet filed for the newest quarter
21	Combs Andrew Insider CIK 1825005 · Mar 25, 2025 Chief Chemistry Officer, issuer-wide, not summed	480,123	0.60%	+102,500	Mar 25, 2025	Chief Chemistry Officer, issuer-wide, not summed
22	VANGUARD EXTENDED MARKET INDEX FUND Fund S000002841 · Registered fund · Jun 30, 2026 VANGUARD INDEX FUNDS, not summed	458,355	0.57%	+195,199	Jun 30, 2026	VANGUARD INDEX FUNDS, not summed
23	STATE STREET CORP 13F CIK 93751 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	428,787	0.54%	+290,556	Jun 30, 2026	carried, not yet filed for the newest quarter
23.1	STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO Fund S000050332 · Registered fund · Jun 30, 2026 STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed	13,300	0.02%	—	Jun 30, 2026	STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
23.2	State Street Total Return V.I.S. Fund Fund S000001637 · Registered fund · Jun 30, 2026 STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed	701	0.00%	—	Jun 30, 2026	STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed
24	UBS Group AG 13F CIK 1610520 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	318,797	0.40%	+254,292	Jun 30, 2026	carried, not yet filed for the newest quarter
25	VANGUARD FIDUCIARY TRUST CO 13F CIK 933478 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	284,886	0.36%	+127,506	Jun 30, 2026	carried, not yet filed for the newest quarter
26	RENAISSANCE TECHNOLOGIES LLC 13F CIK 1037389 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	281,200	0.35%	+6,000	Jun 30, 2026	carried, not yet filed for the newest quarter
27	NORTHERN TRUST CORP 13F CIK 73124 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	240,599	0.30%	+190,479	Jun 30, 2026	carried, not yet filed for the newest quarter
27.1	Small Cap Index Fund Fund S000001245 · Registered fund · Jun 30, 2026 Northern Funds, not summed	12,318	0.02%	—	Jun 30, 2026	Northern Funds, not summed
28	VANGUARD PORTFOLIO MANAGEMENT LLC 13F CIK 2100121 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	193,920	0.24%	+193,920	Jun 30, 2026	carried, not yet filed for the newest quarter
29	MARSHALL WACE, LLP 13F CIK 1318757 · Exempt reporting adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	190,692	0.24%	-168,214	Jun 30, 2026	carried, not yet filed for the newest quarter
30	SIMT Tax-Managed Small/Mid Cap Fund Fund S000006677 · Registered fund · Jun 30, 2026 SEI INSTITUTIONAL MANAGED TRUST, not summed	182,119	0.23%	—	Jun 30, 2026	SEI INSTITUTIONAL MANAGED TRUST, not summed
31	Connor, Clark & Lunn Investment Management Ltd. 13F CIK 1596800 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	125,606	0.16%	+16,521	Jun 30, 2026	carried, not yet filed for the newest quarter
32	GOLDMAN SACHS GROUP INC 13F CIK 886982 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	120,834	0.15%	-115,635	Jun 30, 2026	carried, not yet filed for the newest quarter
32.1	Goldman Sachs Small Cap Growth Insights Fund Fund S000014930 · Registered fund · Jul 31, 2026 Goldman Sachs Trust, not summed	25,913	0.03%	—	Jul 31, 2026	Goldman Sachs Trust, not summed
32.2	Goldman Sachs Absolute Return Tracker Fund Fund S000020314 · Registered fund · Aug 31, 2026 GOLDMAN SACHS TRUST, not summed	39	0.00%	—	Aug 31, 2026	GOLDMAN SACHS TRUST, not summed
33	Brusky Sean P. Insider CIK 1884733 · Mar 5, 2026 Chief Business Officer, issuer-wide, not summed	100,000	0.13%	—	Mar 5, 2026	Chief Business Officer, issuer-wide, not summed
34	Huang Jane Insider CIK 1683913 · Oct 4, 2025 CMO, Hematology, issuer-wide, not summed	86,917	0.11%	+6,020	Oct 4, 2025	CMO, Hematology, issuer-wide, not summed
35	SIIT SMALL CAP II FUND Fund S000036633 · Registered fund · May 31, 2026 SEI INSTITUTIONAL INVESTMENTS TRUST, not summed	82,100	0.10%	—	May 31, 2026	SEI INSTITUTIONAL INVESTMENTS TRUST, not summed
36	Hillsdale Investment Management Inc. 13F CIK 1368465 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	81,400	0.10%	+81,400	Jun 30, 2026	carried, not yet filed for the newest quarter
37	Bank of New York Mellon Corp 13F CIK 1390777 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	68,187	0.09%	+68,187	Jun 30, 2026	carried, not yet filed for the newest quarter
38	CHARLES SCHWAB INVESTMENT MANAGEMENT INC 13F CIK 884546 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	67,622	0.08%	+67,622	Jun 30, 2026	carried, not yet filed for the newest quarter
38.1	Schwab Small-Cap Index Fund Fund S000005912 · Registered fund · Jul 31, 2026 SCHWAB CAPITAL TRUST, not summed	67,622	0.08%	—	Jul 31, 2026	SCHWAB CAPITAL TRUST, not summed
39	BRIDGEWAY CAPITAL MANAGEMENT, LLC 13F CIK 1107261 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	64,500	0.08%	+11,000	Jun 30, 2026	carried, not yet filed for the newest quarter
39.1	Ultra-Small Company Market Fund Fund S000004424 · Registered fund · Jun 30, 2026 Bridgeway Funds, Inc., not summed	61,000	0.08%	+11,000	Jun 30, 2026	Bridgeway Funds, Inc., not summed
40	Squarepoint Ops LLC 13F CIK 1642575 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	59,540	0.07%	+59,540	Jun 30, 2026	carried, not yet filed for the newest quarter
41	PANAGORA ASSET MANAGEMENT INC 13F CIK 883677 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	47,574	0.06%	+47,574	Jun 30, 2026	carried, not yet filed for the newest quarter
42	Mariner, LLC 13F CIK 1373442 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	45,261	0.06%	+45,261	Jun 30, 2026	carried, not yet filed for the newest quarter
43	Nuveen, LLC 13F CIK 1871926 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	37,023	0.05%	+37,023	Jun 30, 2026	carried, not yet filed for the newest quarter
43.1	Nuveen Small Cap Blend Index Fund Fund S000005367 · Registered fund · Jul 31, 2026 TIAA-CREF Funds, not summed	37,023	0.05%	—	Jul 31, 2026	TIAA-CREF Funds, not summed
44	DIMENSIONAL FUND ADVISORS LP 13F CIK 354204 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	35,210	0.04%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
44.1	U.S. MICRO CAP PORTFOLIO Fund S000000948 · Registered fund · Jul 31, 2026 DFA INVESTMENT DIMENSIONS GROUP INC, not summed	8,690	0.01%	0	Jul 31, 2026	DFA INVESTMENT DIMENSIONS GROUP INC, not summed
44.2	Dimensional U.S. Small Cap ETF Fund S000070906 · Registered fund · Jul 31, 2026 Dimensional ETF Trust, not summed	7,414	0.01%	0	Jul 31, 2026	Dimensional ETF Trust, not summed
44.3	U.S. CORE EQUITY 1 PORTFOLIO Fund S000000979 · Registered fund · Jul 31, 2026 DFA INVESTMENT DIMENSIONS GROUP INC, not summed	4,982	0.01%	0	Jul 31, 2026	DFA INVESTMENT DIMENSIONS GROUP INC, not summed
44.4	U.S. SMALL CAP PORTFOLIO Fund S000000971 · Registered fund · Jul 31, 2026 DFA INVESTMENT DIMENSIONS GROUP INC, not summed	3,449	0.00%	0	Jul 31, 2026	DFA INVESTMENT DIMENSIONS GROUP INC, not summed
44.5	Dimensional US Sustainability Core 1 ETF Fund S000076639 · Registered fund · Jul 31, 2026 Dimensional ETF Trust, not summed	3,323	0.00%	0	Jul 31, 2026	Dimensional ETF Trust, not summed
45	Invesco Ltd. 13F CIK 914208 · Investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	34,742	0.04%	+34,742	Jun 30, 2026	carried, not yet filed for the newest quarter
46	Cerity Partners LLC 13F CIK 1566475 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	32,875	0.04%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
47	State of Wyoming 13F CIK 1821626 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	32,862	0.04%	+32,862	Jun 30, 2026	carried, not yet filed for the newest quarter
48	Graham Capital Management, L.P. 13F CIK 1315421 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	29,770	0.04%	+18,427	Jun 30, 2026	carried, not yet filed for the newest quarter
49	EQ/2000 Managed Volatility Portfolio Fund S000025800 · Registered fund · Jun 30, 2026 EQ Advisors Trust, not summed	29,511	0.04%	—	Jun 30, 2026	EQ Advisors Trust, not summed
50	DEUTSCHE BANK AG\ 13F CIK 948046 · Non-US institution · Jun 30, 2026 carried, not yet filed for the newest quarter	27,824	0.03%	+27,824	Jun 30, 2026	carried, not yet filed for the newest quarter
50.1	DWS Small Cap Index VIP Fund S000006223 · Registered fund · Jun 30, 2026 DEUTSCHE DWS INVESTMENTS VIT FUNDS, not summed	4,344	0.01%	—	Jun 30, 2026	DEUTSCHE DWS INVESTMENTS VIT FUNDS, not summed

2 more nested rows are not shown here; Every filing lists them all.

Shares are restated onto today's split basis. Change compares each row with the same holder's previous filing in the same source; a dash means there is none to compare. Nested 13D/G, insider and fund rows are not summed, since a 13F report already holds them.

Showing 1–50 of 127 holders

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Key facts CIK 1678660 CUSIP 74065P101 13F (30d) 7 filings 7 filers Visit website Investor relations