Sarepta expects DM1 and FSHD programs to enter registrational studies within 12 months, with potential for accelerated approval, while Huntington's proof of biologic activity is anticipated around the middle of next year.
SRPT · Sarepta Therapeutics, Inc.
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Sarepta Therapeutics raised 2026 total net product revenue guidance to $1.25 to $1.3 billion, citing stabilized Elevitus demand and strong PMO performance. The company also plans to share multiple-dose data for its DM1 and FSHD programs and prepare registrational studies.
Sarepta Therapeutics reported net product revenues of approximately $323.8 million, raised full-year product-revenue guidance to $1.25 billion to $1.3 billion, and expects SRP-1003 and SRP-1001 multiple-ascending-dose data in the fourth quarter of 2026.
Sarepta Therapeutics reported nine-month net income of $297,608 thousand versus a $301,184 thousand loss, while collaboration and other revenue reached $530,438 thousand.
Sarepta Therapeutics, Inc. entered a settlement on September 23, 2026 with REGENXBIO, UPenn and Catalent resolving patent litigation, requiring Sarepta to pay REGENXBIO $39.0 million and securing patent non-suit commitments covering ELEVIDYS and AAVrh74-based gene therapy products.
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Quarterly results
AI Brief
Q2 FY26 earnings call · Aug 5, 2026TL;DR. Sarepta delivered Q2 GAAP and non-GAAP operating profitability on $328.7M in net product revenue, narrowed 2026 net product revenue guidance to $1.2–$1.3B (toward the low end) and tightened non-GAAP opex to $800–$850M, while raising collaboration/other revenue guidance by $75M at the midpoint; FDA accepted sNDAs for Elevidys/Amondys 45 and Vyondys 53 conversion to traditional approval, and DM1/FSHD MAD readouts remain on track for 2H 2026 with Elevidys Cohort 8 full enrollment by year-end and 12-week data in Q1 2027.
- + Sarepta posted Q2 GAAP operating income of $13.3M and non-GAAP operating income of $86.5M, reflecting profitability.
- + Cash and investments grew ~$197M sequentially to ~$945M, strengthening the balance sheet.
- + Raised 2026 collaboration and other revenue guidance by $75M at the midpoint to $550–$600M.
- + Tightened 2026 non-GAAP opex guidance lower to $800–$850M, the low end of prior range.
- + FDA accepted sNDAs seeking conversion of Elevidys 45 and Vyondys 53 to traditional approval.
- + DM1 and FSHD siRNA MAD readouts remain on track for 2H 2026, with Huntington's Phase 1 dosing underway.
- − 2026 total net product revenue guidance narrowed to $1.2–$1.3B, implying results toward the low end of prior range.
- − Company expects 2H 2026 Elevidys revenue to be modestly lower than 1H, with Q3 specifically trending below Q2.
- − Future PMO franchise competition risk flagged, with potential Exon 51 skipper market entry.
AI-generated from the earnings call and 8-K · may contain errors · not investment advice
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Versus peers
Biotechnology — same industry group| Company | Mkt cap | YTD | Rev growth Y/Y | P/E | Short % shares |
|---|---|---|---|---|---|
|
SRPT
this stock
Sarepta Therapeutics, Inc.
|
$1.72B | -25.3% | +15.6% | — | 18.0% |
|
VRTX
Vertex Pharmaceuticals Inc
|
$136.56B | +18.8% | +46.2% | 34.7 | 1.9% |
|
REGN
Regeneron Pharmaceuticals, Inc.
|
$98.84B | +23.8% | +20.8% | 21.1 | 2.1% |
|
MRNA
Moderna, Inc.
|
$90.38B | +657.4% | +4.3% | — | 8.2% |
|
CSLLY
Csl Ltd
|
$66.05B | — | — | — | 0.0% |
Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding
At a glance
key data from every section- Filed
- Nov 9, 2026
- This year
- 21
Sarepta expects DM1 and FSHD programs to enter registrational studies within 12 months, with potential for accelerated approval, while Huntington's proof of biologic activity is anticipated around the middle of next year.
ViewPerformance
| 5D | 20D | 120D | MTD | YTD | |
|---|---|---|---|---|---|
| SRPT | -9.8% | -6.0% | -3.6% | -13.7% | -25.3% |
| SPY | +2.6% | -1.2% | +0.5% | -0.2% | +10.6% |
| vs SPY | -12.4% | -4.9% | -4.1% | -13.5% | -36.0% |
Capital returns
Dividends per share over the trailing 365 days by ex-date · buyback figures as last reported in SEC filings ("spent" derived as authorized − remaining; when several programs run concurrently, authorized is their combined total per the newest filing) · components shown separately — trailing-year buyback spend isn't tracked, so no combined shareholder yield is derived.