TYRA · Tyra Biosciences, Inc. · Shareholders & Ownership
$20.87
+0.27 (+1.31%)
At close · Oct 22
Return incl. dividend (before tax)
Market Cap
$1.26B
Shares
59.68M
Volume · Oct 22
826.16K
Avg daily vol (3M)
864.49K
Every disclosed holder of TYRA in one list: 13F institutions, Schedule 13D and 13G filers, insiders (Forms 3, 4 and 5) and registered funds, each from its own latest filing. Holders nest by CIK and SEC reporting links, never by name, and each is summed once.
Who Owns TYRA
13F quarter Sep 30, 2026, combined view: filers that have not filed yet carry their Jun 30, 2026 positionsNo chart: the summed disclosures exceed shares outstanding, so they are not parts of one whole.
| Holder group | Shares | % Out |
|---|---|---|
| Institutional (13F) | 69,355,417 | 116.22% |
| Insiders (Forms 3, 4, 5) | 9,675,079 | 16.21% |
| 13D/G-only blocks | 26,512,595 | 44.43% |
| Remaining | 45,866,152 | -76.86% |
| Registered funds (N-PORT, not summed) | 19,129,921 | 32.06% |
Shares outstanding: 59,676,939, the issuer's latest cover-page count restated onto today's split basis.
Remaining is negative: the summed disclosures exceed shares outstanding, as when filings are dated at different times or holders that do not disclose their links count the same shares. It is flagged, not clipped.
13D/G-only counts each filer's latest 13D or 13G that no 13F report of the listing contains, that names no 13F filer and that no counted insider files. Funds are never summed: their shares sit inside their advisers' 13F reports.
Holders of TYRA
| # | Holder | Shares | As of | Notes |
|---|---|---|---|---|
| 1 |
RA CAPITAL MANAGEMENT, L.P.
13D
CIK 1346824 · Registered investment adviser · Sep 15, 2026
Item 4 purpose: not restated by this amendment, the earlier 13D's purpose stands
not summed
|
14,130,492 | ||
| 1.1 |
RA CAPITAL MANAGEMENT, L.P.
13F
CIK 1346824 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
12,198,625 | ||
| 1.2 |
|
10,259,291 | ||
| 2 |
FMR LLC
13F
CIK 315066 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
8,920,513 | ||
| 2.1 |
Fidelity OTC Portfolio
Fund
S000007191 · Registered fund · Jul 31, 2026
Fidelity Securities Fund, not summed
|
3,295,446 | ||
| 2.2 |
Fidelity Advisor Equity Growth Fund
Fund
S000005121 · Registered fund · May 31, 2026
Fidelity Advisor Series I, not summed
|
678,600 | ||
| 2.3 |
VIP Growth Portfolio
Fund
S000007717 · Registered fund · Jun 30, 2026
Variable Insurance Products Fund, not summed
|
630,800 | ||
| 2.4 |
Fidelity Small Cap Index Fund
Fund
S000033638 · Registered fund · Jul 31, 2026
Fidelity Salem Street Trust, not summed
|
402,231 | ||
| 2.5 |
Fidelity Stock Selector Small Cap Fund
Fund
S000005453 · Registered fund · Jul 31, 2026
Fidelity Capital Trust, not summed
|
389,800 | ||
| 3 |
BOXER CAPITAL, LLC
13D
CIK 1465837 · Unknown · Oct 10, 2024
|
6,534,298 | ||
| 4 |
Jupiter Topco LLC
13F
CIK 2146052 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
4,352,448 | ||
| 5 |
BIOTECHNOLOGY VALUE FUND L P
13G
CIK 918923 · Unknown · Sep 14, 2026
Rule 13d-1(c), passive investor
|
4,215,886 | ||
| 6 |
|
4,144,590 | ||
| 7 |
Alta Partners Management Company, L.P.
13F
CIK 2054419 · Exempt reporting adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
3,823,425 | ||
| 8 |
|
3,823,425 | ||
| 9 |
|
3,580,818 | ||
| 10 |
Nextech Invest, Ltd.
13F
CIK 1595430 · Exempt reporting adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
3,553,585 | ||
| 11 |
|
3,553,585 | ||
| 12 |
Paradigm Biocapital Advisors LP
13G
CIK 1855655 · Registered investment adviser · Sep 10, 2026
Rule 13d-1(c), passive investor, not summed
|
3,473,453 | ||
| 12.1 |
Paradigm Biocapital Advisors LP
13F
CIK 1855655 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,828,607 | ||
| 13 |
TCG Crossover Management, LLC
13F
CIK 1839948 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
3,248,980 | ||
| 14 |
BlackRock, Inc.
13F
CIK 2012383 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
3,031,972 | ||
| 14.1 |
BlackRock, Inc.
13G
CIK 2012383 · Holding company · Jun 30, 2026
Rule 13d-1(b), qualified institution, not summed
|
2,976,228 | ||
| 14.2 |
iShares Russell 2000 ETF
Fund
S000004344 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
944,201 | ||
| 14.3 |
iShares Russell 2000 Growth ETF
Fund
S000004343 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
339,557 | ||
| 14.4 |
iShares Biotechnology ETF
Fund
S000004350 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
314,523 | ||
| 14.5 |
Master Small Cap Index Series
Fund
S000002716 · Registered fund · Jun 30, 2026
Quantitative Master Series LLC, not summed
|
68,768 | ||
| 15 |
|
2,898,103 | ||
| 16 |
PRICE T ROWE ASSOCIATES INC /MD/
13F
CIK 80255 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
2,782,567 | ||
| 16.1 |
T. Rowe Price New Horizons Fund, Inc.
Fund
S000002106 · Registered fund · Jun 30, 2026
T. ROWE PRICE NEW HORIZONS FUND, INC., not summed
|
793,140 | ||
| 16.2 |
T. Rowe Price Integrated U.S. Small-Cap Growth Equity Fund
Fund
S000002074 · Registered fund · Jun 30, 2026
T. ROWE PRICE INTEGRATED EQUITY FUNDS, INC., not summed
|
558,500 | ||
| 16.3 |
T. Rowe Price Health Sciences Fund, Inc.
Fund
S000002088 · Registered fund · Jun 30, 2026
T. ROWE PRICE HEALTH SCIENCES FUND, INC., not summed
|
303,669 | ||
| 16.4 |
T. Rowe Price Small-Mid Cap ETF
Fund
S000079837 · Registered fund · Jun 30, 2026
T. Rowe Price Exchange-Traded Funds, Inc., not summed
|
68,709 | ||
| 16.5 |
T. Rowe Price Integrated U.S. Small-Mid Cap Core Equity Fund
Fund
S000052904 · Registered fund · Jun 30, 2026
T. ROWE PRICE INTEGRATED EQUITY FUNDS, INC., not summed
|
60,843 | ||
| 17 |
Boxer Capital Management, LLC
13D
CIK 2018299 · Registered investment adviser · Dec 4, 2024
|
2,548,905 | ||
| 18 |
Vestal Point Capital, LP
13G
CIK 1974915 · Registered investment adviser · Sep 30, 2025
Rule 13d-1(b), qualified institution
|
2,425,000 | ||
| 19 |
|
2,140,368 | ||
| 19.1 |
State Street(R) SPDR(R) S&P(R) Biotech ETF
Fund
S000010018 · Registered fund · Jun 30, 2026
SPDR SERIES TRUST, not summed
|
1,392,376 | ||
| 19.2 |
STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO
Fund
S000050332 · Registered fund · Jun 30, 2026
STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
|
10,907 | ||
| 19.3 |
State Street Total Return V.I.S. Fund
Fund
S000001637 · Registered fund · Jun 30, 2026
STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed
|
929 | ||
| 19.4 |
State Street Balanced Index Fund
Fund
S000082802 · Registered fund · Jun 30, 2026
STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
|
185 | ||
| 20 |
Commodore Capital LP
13F
CIK 1831942 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,875,000 | ||
| 21 |
VANGUARD CAPITAL MANAGEMENT LLC
13F
CIK 2100119 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,508,447 | ||
| 22 |
|
1,476,196 | ||
| 23 |
|
1,438,495 | ||
| 23.1 |
|
2,913,342 | ||
| 24 |
VANGUARD TOTAL STOCK MARKET INDEX FUND
Fund
S000002848 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
|
1,135,472 | ||
| 25 |
5AM Venture Management, LLC
13F
CIK 1799883 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,029,298 | ||
| 26 |
DEERFIELD MANAGEMENT COMPANY, L.P.
13F
CIK 1009258 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,017,000 | ||
| 27 |
Hood River Capital Management LLC
13F
CIK 1578177 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,016,775 | ||
| 27.1 |
Hood River Small-Cap Growth Fund
Fund
S000012813 · Registered fund · Jun 30, 2026
Manager Directed Portfolios, not summed
|
492,217 | ||
| 27.2 |
Hood River New Opportunities Fund
Fund
S000086255 · Registered fund · Jun 30, 2026
Manager Directed Portfolios, not summed
|
81,470 | ||
| 28 |
GEODE CAPITAL MANAGEMENT, LLC
13F
CIK 1214717 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
970,734 | ||
| 29 |
Caligan Partners LP
13F
CIK 1727492 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
806,986 | ||
| 30 |
Canaan Partners XI LLC
13F
CIK 1850694 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
750,000 | ||
| 31 |
|
750,000 | ||
| 32 |
Siren, L.L.C.
13F
CIK 2005245 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
725,000 | ||
| 33 |
Sio Capital Management, LLC
13F
CIK 1482416 · Investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
695,315 | ||
| 34 |
STEMPOINT CAPITAL LP
13F
CIK 1952142 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
632,754 | ||
| 35 |
MARSHALL WACE, LLP
13F
CIK 1318757 · Exempt reporting adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
583,133 | ||
| 36 |
GOLDMAN SACHS GROUP INC
13F
CIK 886982 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
463,477 | ||
| 36.1 |
Goldman Sachs ActiveBeta(R) U.S. Small Cap Equity ETF
Fund
S000048296 · Registered fund · May 31, 2026
Goldman Sachs ETF Trust, not summed
|
7,291 | ||
| 36.2 |
Goldman Sachs Absolute Return Tracker Fund
Fund
S000020314 · Registered fund · Jun 30, 2026
GOLDMAN SACHS TRUST, not summed
|
3,192 | ||
| 37 |
JENNISON ASSOCIATES LLC
13F
CIK 53417 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
450,964 | ||
| 38 |
TWO SIGMA INVESTMENTS, LP
13F
CIK 1179392 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
449,808 | ||
| 39 |
VANGUARD PORTFOLIO MANAGEMENT LLC
13F
CIK 2100121 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
403,019 | ||
| 40 |
Defilade Capital Management, L.P.
13F
CIK 2088557 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
376,870 | ||
| 41 |
Janus Henderson Triton Fund
Fund
S000010485 · Registered fund · Jun 30, 2026
Janus Investment Fund, not summed
|
357,107 | ||
| 42 |
BANK OF AMERICA CORP /DE/
13F
CIK 70858 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
|
349,732 | ||
| 43 |
Walleye Capital LLC
13F
CIK 1758720 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
347,898 | ||
| 44 |
VANGUARD EXTENDED MARKET INDEX FUND
Fund
S000002841 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
|
340,998 | ||
| 45 |
Woodline Partners LP
13F
CIK 1784547 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
320,040 | ||
| 46 |
NORTHERN TRUST CORP
13F
CIK 73124 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
|
310,084 | ||
| 46.1 |
Small Cap Index Fund
Fund
S000001245 · Registered fund · Jun 30, 2026
Northern Funds, not summed
|
18,564 | ||
| 46.2 |
Small Cap Core Fund
Fund
S000001244 · Registered fund · Jun 30, 2026
Northern Funds, not summed
|
4,207 | ||
| 47 |
MORGAN STANLEY
13F
CIK 895421 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
300,322 | ||
| 48 |
CITADEL ADVISORS LLC
13F
CIK 1423053 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
278,307 | ||
| 49 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
13F
CIK 884546 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
267,699 | ||
| 49.1 |
Schwab U.S. Small-Cap ETF
Fund
S000026636 · Registered fund · May 31, 2026
SCHWAB STRATEGIC TRUST, not summed
|
114,471 | ||
| 49.2 |
Schwab Small-Cap Index Fund
Fund
S000005912 · Registered fund · Jul 31, 2026
SCHWAB CAPITAL TRUST, not summed
|
89,345 | ||
| 49.3 |
Schwab Total Stock Market Index Fund
Fund
S000005913 · Registered fund · Jul 31, 2026
SCHWAB CAPITAL TRUST, not summed
|
15,817 | ||
| 49.4 |
Schwab U.S. Broad Market ETF
Fund
S000026631 · Registered fund · May 31, 2026
SCHWAB STRATEGIC TRUST, not summed
|
13,115 | ||
| 50 |
Qube Research & Technologies Ltd
13F
CIK 1729829 · Exempt reporting adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
266,934 |
47 more nested rows are not shown here; Every filing lists them all.
Shares are restated onto today's split basis. Change compares each row with the same holder's previous filing in the same source; a dash means there is none to compare. Nested 13D/G, insider and fund rows are not summed, since a 13F report already holds them.
Showing 1–50 of 263 holders
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