Caligan Partners LP

CIK

1727492

Location

NEW YORK, NY

Portfolio Value

Mid $1,503,599,991

Diversification

Diversified

Filing Date

Global Rank

#1,400 / 8,622 ▲ 240 · as of Mar 2026

Top Industry

Biotechnology 78.2%

3Y Alpha vs SPY

+47.9%

Period ended 4 months ago

Filed May 15, 2026 · 2mo

14 quarters · since Dec 2022

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.

Cloned portfolio

+362.9%

SPY

+67.9%

Annualised alpha

+47.8%

Max drawdown

−23.1%

Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 98% of reported value on average across 13 quarters. Past performance does not predict future results.

Portfolio Concentration

26 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

20.4%

−3.1 pts

Top 5

56.7%

−13.6 pts

Top 10

76.8%

−13.9 pts

HHI

904

Diversified−368

Portfolio Trend

14 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$1,503,599,991	26

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

10 positions

Ticker	Company	Δ Shares	Shares	Value
IVA	Inventiva S.A.	+2,974,906	4,974,906	$27,610,728
ADMA	Adma Biologics, Inc.	+2,044,003	5,056,511	$45,559,164
VOR	Vor Biopharma Inc.	+999,999	1,925,066	$34,343,177
AVTX	Avalo Therapeutics, Inc.	+753,490	1,635,023	$24,410,893
RVMD	Revolution Medicines, Inc.	+597,808	1,881,708	$182,996,103
PCVX	Vaxcyte, Inc.	+355,904	2,060,719	$119,748,381
TYRA	Tyra Biosciences, Inc.	+332,711	1,276,968	$48,907,874
XENE	Xenon Pharmaceuticals Inc.	+293,662	1,393,027	$81,004,520
MAZE	Maze Therapeutics, Inc.	+64,771	614,962	$18,356,615
ABVX	Abivax S.A.	+10,000	1,461,924	$162,785,237
No positions match the current search.

Trimmed

Positions the filer reduced

2 positions

Ticker	Company	Δ Shares	Shares	Value
MLYS	Mineralys Therapeutics, Inc.	−2,298,400	2,772,654	$75,111,196
TNGX	Tango Therapeutics, Inc.	−1,321,097	2,408,798	$50,392,054
No positions match the current search.

New Positions

Positions the filer opened this quarter

9 positions

Ticker	Company	Shares	Value
CGON	CG Oncology, Inc.	900,000	$60,912,000
SYRE	Spyre Therapeutics, Inc.	878,127	$44,292,725
LBRX	Lb Pharmaceuticals Inc	1,438,070	$35,462,806
SABS	SAB Biotherapeutics, Inc.	7,967,207	$30,514,402
IRD	Opus Genetics, Inc.	6,075,028	$27,641,377
MBX	MBX Biosciences, Inc.	848,590	$25,330,411
FTH	Faeth Therapeutics, Inc.	126,002	$3,971,583
AURA	Aura Biosciences, Inc.	229,864	$1,537,790
XLO	Xilio Therapeutics, Inc.	112,128	$942,996
No positions match the current search.

Sold Out

Positions the filer fully exited

3 positions

Ticker	Company	Shares	Value
INBX	Inhibrx Biosciences, Inc.	473,565	$37,411,635
SPRB	Spruce Biosciences, Inc.	20,514	$1,786,974
ELDN	Eledon Pharmaceuticals, Inc.	555,978	$839,526
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

26 tracked positions · $1,503,599,991 total · as of Mar 31, 2026

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
LQDA	Liquidia Corp Healthcare	Held	8,118,892	0	$306,406,984	+9.4%	20.38%
RVMD	Revolution Medicines, Inc. CALL + SHARES Healthcare	Added	1,881,708	+597,808	$182,996,103	+78.9%	12.17%
ABVX	Abivax S.A. Healthcare	Added	1,461,924	+10,000	$162,785,237	−16.9%	10.83%
PCVX	Vaxcyte, Inc. Healthcare	Added	2,060,719	+355,904	$119,748,381	+52.2%	7.96%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Added	1,393,027	+293,662	$81,004,520	+64.4%	5.39%
MLYS	Mineralys Therapeutics, Inc. Healthcare	Reduced	2,772,654	-2,298,400	$75,111,196	−59.2%	5.00%
EXEL	Exelixis, Inc. Healthcare	Held	1,553,262	0	$66,619,407	−2.1%	4.43%
CGON	CG Oncology, Inc. CALL Healthcare	NEW	900,000	NEW	$60,912,000	NEW	4.05%
TNGX	Tango Therapeutics, Inc. Healthcare	Reduced	2,408,798	-1,321,097	$50,392,054	+52.5%	3.35%
TYRA	Tyra Biosciences, Inc. Healthcare	Added	1,276,968	+332,711	$48,907,874	+97.0%	3.25%
ADMA	Adma Biologics, Inc. CALL + SHARES Healthcare	Added	5,056,511	+2,044,003	$45,559,164	−17.1%	3.03%
SYRE	Spyre Therapeutics, Inc. Healthcare	NEW	878,127	NEW	$44,292,725	NEW	2.95%
LBRX	Lb Pharmaceuticals Inc Healthcare	NEW	1,438,070	NEW	$35,462,806	NEW	2.36%
VOR	Vor Biopharma Inc. Healthcare	Added	1,925,066	+999,999	$34,343,177	+183.8%	2.28%
SABS	SAB Biotherapeutics, Inc. Healthcare	NEW	7,967,207	NEW	$30,514,402	NEW	2.03%
IRD	Opus Genetics, Inc. Healthcare	NEW	6,075,028	NEW	$27,641,377	NEW	1.84%
IVA	Inventiva S.A. Healthcare	Added	4,974,906	+2,974,906	$27,610,728	+196.9%	1.84%
MBX	MBX Biosciences, Inc. Healthcare	NEW	848,590	NEW	$25,330,411	NEW	1.68%
AVTX	Avalo Therapeutics, Inc. Healthcare	Added	1,635,023	+753,490	$24,410,893	+52.5%	1.62%
ANIK	Anika Therapeutics, Inc. Healthcare	Held	1,435,130	0	$20,809,385	+50.9%	1.38%
MAZE	Maze Therapeutics, Inc. Healthcare	Added	614,962	+64,771	$18,356,615	−19.5%	1.22%
VRCA	Verrica Pharmaceuticals Inc. Healthcare	Held	923,910	0	$4,887,483	−36.3%	0.33%
FTH	Faeth Therapeutics, Inc. Healthcare	NEW	126,002	NEW	$3,971,583	NEW	0.26%
AGIO	Agios Pharmaceuticals, Inc. CALL Healthcare	Held	90,000	0	$3,044,700	+24.3%	0.20%
AURA	Aura Biosciences, Inc. Healthcare	NEW	229,864	NEW	$1,537,790	NEW	0.10%
XLO	Xilio Therapeutics, Inc. Healthcare	NEW	112,128	NEW	$942,996	NEW	0.06%

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.