IRD · Opus Genetics, Inc.

$4.05 -0.07 (-1.70%) At close · Aug 21

Market Cap

$354.83M

83.20M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Quarter:

Holders: 102

Total Value: $236,403,476

Total Shares: 57,531,791

Institutional Ownership Trend

23 quarters

Holder Concentration

Across 102 13F filers · Δ vs Mar 31, 2026

Top Holder

10.6%

−2.8 pts

Top 5

38.2%

−8.2 pts

Top 10

62.4%

−7.5 pts

HHI

511

Broadly held−143

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +23

Institutional value: +14.1%

Shares held: +26.3%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mega BlackRock, Inc.	+2,968,747	3,116,487
Small Trails Edge Capital Partners, LP	+2,243,658	2,743,658
Small GREAT POINT PARTNERS LLC	+1,645,847	1,970,187
Mid Nantahala Capital Management, LLC	+1,380,029	3,061,359
Mega GOLDMAN SACHS GROUP INC	+1,200,420	1,527,229

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP	−707,886	196,897
Small Mink Brook Asset Management LLC	−429,347	161,205
Large MARSHALL WACE, LLP	−367,771	1,945,609
Mega MILLENNIUM MANAGEMENT LLC	−328,331	2,302,101
Mid ADAR1 Capital Management, LLC	−65,223	1,783,781

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mid SummitTX Capital, L.P.	1,007,351	$4,140,212
Mega VANGUARD PORTFOLIO MANAGEMENT LLC	371,950	$1,528,714
Large Squarepoint Ops LLC	330,783	$1,359,518
Mid AWM Investment Company, Inc.	232,590	$955,944
Mega Bank of New York Mellon Corp	122,479	$503,387

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mid PERCEPTIVE ADVISORS LLC	1,835,842	$8,353,081
Large FARALLON CAPITAL MANAGEMENT LLC	1,000,000	$4,550,000
Mega AMERIPRISE FINANCIAL INC	388,491	$1,767,633
Mid Voleon Capital Management LP	143,796	$654,271
Large RENAISSANCE TECHNOLOGIES LLC	73,209	$333,100

Filter: New 39 Increased 34 Reduced 12 Sold out 16 Unchanged 17

Showing 100 of 103

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

Caligan Partners LP

$24,976,815

10.57%

6,077,084

ADAGE CAPITAL PARTNERS GP, L.L.C.

$24,782,375

10.48%

6,029,775

BIOS Capital Management, LP

$15,138,893

6.40%

3,683,429

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Steelhead Capital Management, LLC	3,683,429	$15,138,893	100.0%	Other

BlackRock, Inc.

$12,808,759

5.42%

3,116,487

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	18,663	$76,704	0.6%	Sole
BlackRock Investment Management, LLC	159,654	$656,177	5.1%	Sole
BLACKROCK ADVISORS LLC	117,224	$481,790	3.8%	Sole
BlackRock Fund Advisors	2,037,482	$8,374,051	65.4%	Sole
BlackRock Institutional Trust Company, N.A.	783,464	$3,220,037	25.1%	Sole

Balyasny Asset Management L.P.

$12,691,129

5.37%

3,087,866

Nantahala Capital Management, LLC

$12,582,185

5.32%

3,061,359

VANGUARD CAPITAL MANAGEMENT LLC

$12,160,187

5.14%

2,958,683

Boxer Capital Management, LLC

$11,569,650

4.89%

2,815,000

Trails Edge Capital Partners, LP

$11,276,434

4.77%

2,743,658

MILLENNIUM MANAGEMENT LLC

$9,461,635

4.00%

2,302,101

GREAT POINT PARTNERS LLC

$8,097,468

3.43%

1,970,187

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JAY JEFFREY R joint	1,970,187	$8,097,468	100.0%	Defined

MARSHALL WACE, LLP

$7,996,452

3.38%

1,945,609

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	1,945,609	$7,996,452	100.0%	Other

ADAR1 Capital Management, LLC

$7,331,339

3.10%

1,783,781

GOLDMAN SACHS GROUP INC

$6,276,910

2.66%

1,527,229

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	1,428,579	$5,871,459	93.5%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	98,650	$405,451	6.5%	Defined

Woodline Partners LP

$5,896,670

2.49%

1,434,713

GEODE CAPITAL MANAGEMENT, LLC

$5,621,295

2.38%

1,367,712

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	217,234	$892,831	15.9%	Defined
Held directly	1,150,478	$4,728,464	84.1%	Defined

BOOTHBAY FUND MANAGEMENT, LLC

$4,888,906

2.07%

1,189,515

Opaleye Management Inc.

$4,623,750

1.96%

1,125,000

SummitTX Capital, L.P.

$4,140,212

1.75%

1,007,351

STATE STREET CORP

$3,247,458

1.37%

790,136

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SSGA FUNDS MANAGEMENT, INC. joint	790,136	$3,247,458	100.0%	Defined

Bleichroeder LP

$3,028,420

1.28%

736,842

UBS Group AG

$2,810,808

1.19%

683,895

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS AG	671,521	$2,759,951	98.2%	Defined
UBS Switzerland AG	12,374	$50,857	1.8%	Defined

CITADEL ADVISORS LLC

$2,735,870

1.16%

665,662

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	90,910	$373,640	13.7%	Defined
Held directly	574,752	$2,362,230	86.3%	Defined

MORGAN STANLEY

$1,910,737

0.81%

464,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	58	$238	0.0%	Defined
MORGAN STANLEY & CO. LLC	14,400	$59,184	3.1%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	414,639	$1,704,166	89.2%	Defined
MORGAN STANLEY SMITH BARNEY LLC	33,177	$136,357	7.1%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	2,626	$10,792	0.6%	Defined

NORTHERN TRUST CORP

$1,817,252

0.77%

442,154

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	433,734	$1,782,646	98.1%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	8,420	$34,606	1.9%	Other

VANGUARD FIDUCIARY TRUST CO

$1,686,641

0.71%

410,375

VANGUARD PORTFOLIO MANAGEMENT LLC

$1,528,714

0.65%

371,950

Squarepoint Ops LLC

$1,359,518

0.58%

330,783

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	330,783	$1,359,518	100.0%	Defined

TWO SIGMA INVESTMENTS, LP

$1,043,783

0.44%

253,962

AWM Investment Company, Inc.

$955,944

0.40%

232,590

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$809,246

0.34%

196,897

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	196,897	$809,246	100.0%	Other

JANE STREET GROUP, LLC

$776,740

0.33%

188,988

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	188,988	$776,740	100.0%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$678,367

0.29%

165,053

Mink Brook Asset Management LLC

$662,552

0.28%

161,205

XTX Topco Ltd

$592,230

0.25%

144,095

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	144,095	$592,230	100.0%	Defined

Seven Fleet Capital Management LP

$588,293

0.25%

143,137

Creative Planning

$527,584

0.22%

128,366

Texas Capital Bank Wealth Management Services Inc

$503,594

0.21%

122,529

Bank of New York Mellon Corp

$503,387

0.21%

122,479

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	31,036	$127,557	25.3%	Defined
The Bank of New York Mellon	91,442	$375,826	74.7%	Defined
Held directly	1	$4	0.0%	Defined

Stonepine Capital Management, LLC

$413,950

0.18%

100,718

Jump Financial, LLC

$389,710

0.16%

94,820

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Leap GP LLC joint	94,820	$389,710	100.0%	Defined

Nuveen, LLC

$293,219

0.12%

71,343

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TEACHERS ADVISORS, LLC joint	71,343	$293,219	100.0%	Defined

Palogic Value Management, L.P.

$267,511

0.11%

65,088

Aureus Asset Management, LLC

$239,202

0.10%

58,200

Regency Capital Management Inc.\DE

$238,380

0.10%

58,000

BANK OF AMERICA CORP /DE/

$226,070

0.10%

55,005

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	30,950	$127,204	56.3%	Defined
BOFA SECURITIES, INC.	24,055	$98,866	43.7%	Defined

DEUTSCHE BANK AG\

$219,111

0.09%

53,312

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	1,071	$4,401	2.0%	Defined
DWS Investments UK Ltd	52,241	$214,710	98.0%	Defined

Invesco Ltd.

$218,778

0.09%

53,231

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	7,740	$31,811	14.5%	Defined
Invesco Trust Co joint	21,353	$87,760	40.1%	Defined
Invesco Capital Management LLC	24,138	$99,207	45.3%	Defined

WELLS FARGO & COMPANY/MN

$216,321

0.09%

52,633

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	48,848	$200,765	92.8%	Defined
WELLS FARGO CLEARING SERVICES, LLC	3,785	$15,556	7.2%	Defined

RHUMBLINE ADVISERS

$211,517

0.09%

51,464

EntryPoint Capital, LLC

$209,129

0.09%

50,883

Quadrature Capital Ltd

$190,658

0.08%

46,389

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Quadrature US Inc.	46,389	$190,658	100.0%	Other

PRICE T ROWE ASSOCIATES INC /MD/

$180,581

0.08%

43,937

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	43,937	$180,581	100.0%	Defined

Empowered Funds, LLC

$172,887

0.07%

42,065

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Bridgeway Capital Management, LLC	42,065	$172,887	100.0%	Other

BRIDGEWAY CAPITAL MANAGEMENT, LLC

$172,887

0.07%

42,065

MANGROVE PARTNERS IM, LLC

$171,456

0.07%

41,717

MetLife Investment Management, LLC

$132,374

0.06%

32,208

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	32,208	$132,374	100.0%	Defined

CAPTRUST FINANCIAL ADVISORS

$131,520

0.06%

32,000

CITIGROUP INC

$123,677

0.05%

30,092

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	30,092	$123,677	100.0%	Defined

Miller Financial Services LLC

$110,970

0.05%

27,000

SIMPLEX TRADING, LLC

$105,022

0.04%

25,553

ALLIANCEBERNSTEIN L.P.

$104,311

0.04%

25,380

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	25,380	$104,311	100.0%	Defined

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$101,340

0.04%

24,657

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	24,657	$101,340	100.0%	Defined

JPMORGAN CHASE & CO

$91,237

0.04%

22,199

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	22,199	$91,237	100.0%	Defined

JANE STREET GROUP, LLC

$84,666

0.04%

20,600

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	20,600	$84,666	100.0%	Defined

Point72 Asset Management, L.P.

$77,769

0.03%

18,922

NewEdge Advisors, LLC

$67,256

0.03%

16,364

JAMES INVESTMENT RESEARCH, INC.

$67,256

0.03%

16,364

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$65,550

0.03%

15,949

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	15,949	$65,550	100.0%	Defined

State of Wyoming

$65,365

0.03%

15,904

Police & Firemen's Retirement System of New Jersey

$64,909

0.03%

15,793

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	15,793	$64,909	100.0%	Defined

RAYMOND JAMES FINANCIAL INC

$61,682

0.03%

15,008

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	15,008	$61,682	100.0%	Defined

NEW YORK STATE COMMON RETIREMENT FUND

$59,595

0.03%

14,500

Vanguard Global Advisers, LLC

$58,945

0.02%

14,342

OSAIC HOLDINGS, INC.

$57,129

0.02%

13,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
OSAIC WEALTH, INC.	13,900	$57,129	100.0%	Defined

BARCLAYS PLC

$54,897

0.02%

13,357

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	9,066	$37,261	67.9%	Defined
BARCLAYS CAPITAL INC.	4,291	$17,636	32.1%	Defined

KESTRA PRIVATE WEALTH SERVICES, LLC

$52,608

0.02%

12,800

Stokes Family Office, LLC

$49,813

0.02%

12,120

Engineers Gate Manager LP

$49,578

0.02%

12,063

First City Capital Management, Inc.

$48,645

0.02%

11,836

INTECH INVESTMENT MANAGEMENT LLC

$47,536

0.02%

11,566

VOYA INVESTMENT MANAGEMENT LLC

$45,279

0.02%

11,017

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	11,017	$45,279	100.0%	Defined

STRS OHIO

$43,155

0.02%

10,500

Carolina Wealth Management Inc

$41,100

0.02%

10,000

Annandale Capital, LLC

$41,100

0.02%

10,000

BNP PARIBAS ARBITRAGE, SA

$33,623

0.01%

8,181

Legal & General Group Plc

$21,384

0.01%

5,203

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	5,203	$21,384	100.0%	Defined

Ameritas Investment Partners, Inc.

$19,974

0.01%

4,860

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EATON VANCE MANAGEMENT	4,860	$19,974	100.0%	Other

Hilton Head Capital Partners, LLC

$18,379

0.01%

4,472

Russell Investments Group, Ltd.

$17,599

0.01%

4,282

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	4,282	$17,599	100.0%	Defined

Farther Finance Advisors, LLC

$14,343

0.01%

3,490

Tower Research Capital LLC (TRC)

$13,053

0.01%

3,176

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Latour Trading LLC (Latour)	3,176	$13,053	100.0%	Defined

TD Waterhouse Canada Inc.

$12,330

0.01%

3,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TORONTO DOMINION BANK	3,000	$12,330	100.0%	Defined

ROYAL BANK OF CANADA

$8,608

0.00%

2,095

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC CMA LTD.	1,754	$7,208	83.7%	Defined
RBC Capital Markets, LLC	336	$1,380	16.0%	Defined
RBC Dominion Securities Inc.	5	$20	0.2%	Defined

NATIONAL BANK OF CANADA /FI/

$8,277

0.00%

2,014

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
National Bank Financial Inc.	2,014	$8,277	100.0%	Defined

GGM Financial LLC

$4,130

0.00%

1,005

INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC

$2,141

0.00%

521

Quarry LP

$2,063

0.00%

502

SBI Securities Co., Ltd.

$2,059

0.00%

501

Sterling Capital Management LLC

$772

0.00%

188

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	142	$583	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	386,621	$1,759,125	99.5%	Defined
Ameriprise Financial Services, LLC	1,870	$8,508	0.5%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brevan Howard US Investment Management, LP	32,813	$149,299	53.5%	Defined
Brevan Howard (Hong Kong) Ltd	28,500	$129,675	46.5%	Defined

Key facts CIK 1228627 CUSIP 67577R102 13F (30d) 99 filings 97 filers Visit website Investor relations