Sio Capital Management, LLC

Adviser

CIK

1482416

Location

NEW YORK, NY

Portfolio Value

Small $604,294,806

Diversification

Diversified

Filing Date

Global Rank

#3,436 / 8,818 ▼ 528

Top Industry

Biotechnology 40.2%

Period ended 4 months ago

Filed Aug 14, 2026 · 2mo

26 quarters · since Mar 2020

Regulatory profile

From Form ADV, the SEC filer profile, 13D/13G type codes and N-CEN, never from the name.

Holder type

Adviser

Schedule 13G, Jul 28, 2026

Portfolio style

Measured from the filed 13F common-share book for Jun 30, 2026, never from the firm's own description.

Style

Diversified active

Top 10 weight 50.1%, 25.9 effective positions, active share 98.6% against the Russell 2000 as of 2026-06-30; it meets none of the index-like, systematic-like or concentrated tests

Turnover

High turnover

134.0% over the last four quarters (100%+)

Horizon

Short horizon

Value-weighted holding period 3.8 quarters (under 4)

Closest benchmark: the Russell 2000 as of 2026-06-30, active share 98.6%; sector active share 84.3% against the combined 13F book's sector weights.

Over time 26 measured quarters

How the bands are measured

Style bands measure the filed 13F common-share book each closed quarter, tested in this order. Unknown: under $10,000,000 of valued equity or 5 stocks. Index-like (100+ stocks): active share of 20% or less against the closest benchmark, which is the S&P 500, S&P MidCap 400, S&P SmallCap 600, Russell 1000, Russell 2000, Nasdaq-100 or Dow Jones Industrial Average (weighted by an index-tracking fund's reported holdings or the index's constituents nearest the quarter end, over the names resolved to companies, and only when those are 90%+ of its weight) or every 13F filer's combined book, or index series holding 80%+ of the registered fund assets it advises (N-CEN) and equal to 50%+ of its book. Systematic-like: 500+ stocks, 100%+ annual turnover and a top 10 weight of 25% or less. Concentrated: a top 10 weight of 60%+ or 12 or fewer effective positions. Diversified active: none of these. Turnover is the smaller of buys and sells over average equity value, summed over four quarters: low under 30%, high 100%+. Horizon is the value-weighted number of quarters each position has been held: short under 4, long 12+.

Clone Performance

Build a hypothetical price-return history from this filer's public 13F holdings.

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Portfolio Concentration

59 tracked positions · as of Jun 30, 2026 · Δ vs Mar 31, 2026

Top Position

9.0%

+2.0 pts

Top 5

32.1%

+5.5 pts

Top 10

48.6%

+3.5 pts

HHI

369

Diversified+69

Portfolio Trend

26 quarters · across all stocks

Sector Breakdown

As of Jun 30, 2026

Sector	% Portfolio	Value	Positions
Healthcare	93.6%	$565,842,053	58
Industrials	6.4%	$38,452,753	1

Last Quarter's Activity

Export CSV

Jun 30, 2026 vs Mar 31, 2026

Added To

Positions the filer increased

10 positions

Ticker	Company	Δ Shares	Shares	Value
SENS	Senseonics Holdings, Inc.	+1,476,908	1,592,692	$9,046,490
AVR	Anteris Technologies Global Corp.	+163,019	5,545,984	$54,627,942
SNY	Sanofi	+124,529	364,200	$15,536,772
TYRA	Tyra Biosciences, Inc.	+89,876	695,315	$22,208,361
COR	Cencora, Inc.	+72,694	173,588	$49,121,932
ZBH	Zimmer Biomet Holdings, Inc.	+68,832	131,445	$11,316,100
GSK	GSK plc	+50,821	436,700	$22,891,814
ORKA	Oruka Therapeutics, Inc.	+44,622	177,118	$16,856,320
RLMD	Relmada Therapeutics, Inc.	+38,562	1,003,562	$6,944,649
SVRA	Savara Inc	+3,787	617,675	$3,804,878
No positions match the current search.

Trimmed

Positions the filer reduced

22 positions

Ticker	Company	Δ Shares	Shares	Value
WAY	Waystar Holding Corp.	−716,402	925,834	$19,007,372
ADGM	Adagio Medical Holdings, Inc.	−589,472	698,989	$455,740
PMVP	PMV Pharmaceuticals, Inc.	−442,443	2,634,137	$3,529,743
AQST	Aquestive Therapeutics, Inc.	−436,712	1,486,175	$6,182,488
OCUL	Ocular Therapeutix, Inc	−429,104	539,493	$5,297,821
VIR	Vir Biotechnology, Inc.	−423,346	1,075,274	$10,957,042
NMTC	NEUROONE MEDICAL TECHNOLOGIES Corp	−413,847	82,767	$251,611
DNTH	Dianthus Therapeutics, Inc.	−310,791	59,254	$5,776,079
OVID	Ovid Therapeutics Inc.	−247,047	1,005,334	$2,704,348
ICLR	Icon PLC	−218,172	88,186	$15,318,790
ANIP	Ani Pharmaceuticals Inc	−168,238	97,305	$8,054,907
SION	Sionna Therapeutics, Inc.	−166,532	127,808	$5,622,273
ANTX	AN2 Therapeutics, Inc.	−127,267	529,933	$2,564,875
ZBIO	Zenas BioPharma, Inc.	−123,173	208,557	$5,293,176
EYPT	EyePoint, Inc.	−98,655	623,130	$8,910,759
CELC	Celcuity Inc.	−83,821	110,022	$11,510,501
RAPP	Rapport Therapeutics, Inc.	−59,152	307,657	$12,820,067
ABT	Abbott Laboratories	−57,918	128,656	$11,674,245
MMS	Maximus, Inc.	−53,558	715,267	$38,452,753
TARA	Protara Therapeutics, Inc.	−47,967	1,921,872	$7,341,551
IMNM	Immunome Inc.	−40,942	124,168	$2,631,119
DRUG	Bright Minds Biosciences Inc.	−12,131	73,952	$5,191,430
No positions match the current search.

New Positions

Positions the filer opened this quarter

14 positions

Ticker	Company	Shares	Value
ALLO	Allogene Therapeutics, Inc.	13,323,431	$27,712,736
GMED	Globus Medical Inc	301,816	$23,846,482
IDYA	IDEAYA Biosciences, Inc.	480,383	$17,903,874
CI	Cigna Group	57,750	$15,920,520
VTRS	Viatris Inc	954,299	$15,154,268
REGN	Regeneron Pharmaceuticals, Inc.	18,000	$11,223,720
BMY	Bristol Myers Squibb Co	193,500	$11,149,470
MDT	Medtronic plc	142,500	$11,147,775
HELP	Helus Pharma Inc.	1,300,000	$8,593,000
TNGX	Tango Therapeutics, Inc.	208,500	$6,517,710
AVAH	Aveanna Healthcare Holdings, Inc.	369,036	$3,162,638
AORT	Artivion, Inc.	48,481	$1,089,368
ENVB	Enveric Biosciences, Inc.	180,000	$248,400
QTI	Qt Imaging Holdings, Inc.	15,236	$62,010
No positions match the current search.

Sold Out

Positions the filer fully exited

25 positions

Ticker	Company	Shares	Value
CORT	Corcept Therapeutics Inc	674,759	$27,199,535
LIVN	LivaNova PLC	421,615	$26,797,849
EMBC	Embecta Corp.	1,847,850	$16,334,994
ABVX	Abivax S.A.	135,800	$15,121,330
HAE	Haemonetics Corp	220,672	$12,437,073
TFX	Teleflex Inc	94,800	$11,339,028
BMRN	Biomarin Pharmaceutical Inc	194,226	$10,971,826
GPCR	Structure Therapeutics Inc.	209,093	$10,078,282
BHVN	Biohaven Ltd.	1,163,926	$9,846,813
MNPR	Monopar Therapeutics	173,506	$9,506,393
—		249,887	$9,075,895
EWTX	Edgewise Therapeutics, Inc.	268,986	$8,473,059
CMPS	COMPASS Pathways plc	1,506,525	$8,331,083
QDEL	QuidelOrtho Corp	359,011	$5,898,550
REPL	Replimune Group, Inc.	720,036	$5,508,275
OGN	Organon & Co.	865,908	$5,186,788
IRON	Disc Medicine, Inc.	65,203	$4,169,079
IART	Integra Lifesciences Holdings Corp	383,140	$3,609,178
PRQR	ProQR Therapeutics N.V.	1,954,715	$3,166,638
SI	Shoulder Innovations, Inc.	210,641	$3,060,613
KYMR	Kymera Therapeutics, Inc.	32,235	$2,684,853
CNTX	Context Therapeutics Inc.	917,922	$2,404,955
HYPR	Hyperfine, Inc.	1,000,000	$1,080,000
FHTX	Foghorn Therapeutics Inc.	122,889	$587,409
—		10,100	$532,472
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

59 tracked positions · $604,294,806 total · filing declares 59 positions · $604,294,540 · as of Jun 30, 2026

All sectors Healthcare Industrials

Showing 1–50 of 59 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	Held (qtrs)	Est. cost/share	% of Portfolio
AVR	Anteris Technologies Global Corp. Healthcare	Added	5,545,984	+163,019	$54,627,942	+82.9%	7	unpriced	9.04%
COR	Cencora, Inc. Healthcare	Added	173,588	+72,694	$49,121,932	+55.0%	3	$322.89	8.13%
MMS	Maximus, Inc. Industrials	Reduced	715,267	-53,558	$38,452,753	−22.0%	8	$80.75	6.36%
ALLO	Allogene Therapeutics, Inc. Healthcare	NEW	13,323,431	NEW	$27,712,736	NEW	1	$2.20	4.59%
GMED	Globus Medical Inc Healthcare	NEW	301,816	NEW	$23,846,482	NEW	1	$85.00	3.95%
GSK	GSK plc Healthcare	Added	436,700	+50,821	$22,891,814	+7.5%	2	$54.04	3.79%
TYRA	Tyra Biosciences, Inc. Healthcare	Added	695,315	+89,876	$22,208,361	−4.2%	10	$17.39	3.68%
WAY	Waystar Holding Corp. Healthcare	Reduced	925,834	-716,402	$19,007,372	−52.0%	3	$29.94	3.15%
SLS	SELLAS Life Sciences Group, Inc. PUT Healthcare	NEW	1,230,700	NEW	$18,165,132	NEW	—	—	3.01%
IDYA	IDEAYA Biosciences, Inc. Healthcare	NEW	480,383	NEW	$17,903,874	NEW	1	$30.61	2.96%
ORKA	Oruka Therapeutics, Inc. Healthcare	Added	177,118	+44,622	$16,856,320	+159.4%	3	$38.19	2.79%
CI	Cigna Group Healthcare	NEW	57,750	NEW	$15,920,520	NEW	1	$282.51	2.63%
SNY	Sanofi Healthcare	Added	364,200	+124,529	$15,536,772	+34.5%	5	$47.76	2.57%
ICLR	Icon PLC Healthcare	Reduced	88,186	-218,172	$15,318,790	−54.8%	3	$153.82	2.53%
VTRS	Viatris Inc Healthcare	NEW	954,299	NEW	$15,154,268	NEW	1	$15.50	2.51%
		Held	1,098,393	0	$14,509,772	+40.5%	3	unpriced	2.40%
RAPP	Rapport Therapeutics, Inc. Healthcare	Reduced	307,657	-59,152	$12,820,067	+11.7%	4	$22.93	2.12%
ABT	Abbott Laboratories Healthcare	Reduced	128,656	-57,918	$11,674,245	−39.1%	2	$112.91	1.93%
CELC	Celcuity Inc. Healthcare	Reduced	110,022	-83,821	$11,510,501	−48.0%	4	$40.03	1.90%
ZBH	Zimmer Biomet Holdings, Inc. Healthcare	Added	131,445	+68,832	$11,316,100	+99.9%	3	$91.08	1.87%
REGN	Regeneron Pharmaceuticals, Inc. Healthcare	NEW	18,000	NEW	$11,223,720	NEW	1	$680.68	1.86%
BMY	Bristol Myers Squibb Co Healthcare	NEW	193,500	NEW	$11,149,470	NEW	1	$57.42	1.85%
MDT	Medtronic plc Healthcare	NEW	142,500	NEW	$11,147,775	NEW	1	$80.67	1.84%
VIR	Vir Biotechnology, Inc. Healthcare	Reduced	1,075,274	-423,346	$10,957,042	−18.4%	7	$7.93	1.81%
SENS	Senseonics Holdings, Inc. Healthcare	Added	1,592,692	+1,476,908	$9,046,490	+1073.2%	5	$6.79	1.50%
EYPT	EyePoint, Inc. Healthcare	Reduced	623,130	-98,655	$8,910,759	−4.2%	2	$14.95	1.47%
HELP	Helus Pharma Inc. Healthcare	NEW	1,300,000	NEW	$8,593,000	NEW	1	$5.00	1.42%
ANIP	Ani Pharmaceuticals Inc Healthcare	Reduced	97,305	-168,238	$8,054,907	−60.6%	7	$75.10	1.33%
TARA	Protara Therapeutics, Inc. Healthcare	Reduced	1,921,872	-47,967	$7,341,551	−28.5%	3	$5.61	1.21%
RLMD	Relmada Therapeutics, Inc. Healthcare	Added	1,003,562	+38,562	$6,944,649	+3.4%	2	$4.82	1.15%
TNGX	Tango Therapeutics, Inc. Healthcare	NEW	208,500	NEW	$6,517,710	NEW	1	$24.72	1.08%
AQST	Aquestive Therapeutics, Inc. Healthcare	Reduced	1,486,175	-436,712	$6,182,488	−22.5%	6	$3.74	1.02%
DNTH	Dianthus Therapeutics, Inc. Healthcare	Reduced	59,254	-310,791	$5,776,079	−81.4%	6	$23.44	0.96%
SION	Sionna Therapeutics, Inc. Healthcare	Reduced	127,808	-166,532	$5,622,273	−52.4%	2	$38.16	0.93%
OCUL	Ocular Therapeutix, Inc Healthcare	Reduced	539,493	-429,104	$5,297,821	−35.4%	2	$9.53	0.88%
ZBIO	Zenas BioPharma, Inc. Healthcare	Reduced	208,557	-123,173	$5,293,176	−18.4%	2	$22.45	0.88%
DRUG	Bright Minds Biosciences Inc. Healthcare	Reduced	73,952	-12,131	$5,191,430	−17.4%	7	$37.50	0.86%
OKUR	OnKure Therapeutics, Inc. Healthcare	Held	1,078,965	0	$4,920,080	+10.1%	2	$3.09	0.81%
SVRA	Savara Inc Healthcare	Added	617,675	+3,787	$3,804,878	+13.5%	7	$2.78	0.63%
PMVP	PMV Pharmaceuticals, Inc. Healthcare	Reduced	2,634,137	-442,443	$3,529,743	−7.5%	9	$1.66	0.58%
AVAH	Aveanna Healthcare Holdings, Inc. Healthcare	NEW	369,036	NEW	$3,162,638	NEW	1	$7.05	0.52%
OVID	Ovid Therapeutics Inc. Healthcare	Reduced	1,005,334	-247,047	$2,704,348	−2.7%	7	$0.84	0.45%
IMNM	Immunome Inc. Healthcare	Reduced	124,168	-40,942	$2,631,119	−27.1%	2	$22.26	0.44%
HIMS	Hims & Hers Health, Inc. CALL Healthcare	NEW	75,000	NEW	$2,600,250	NEW	—	—	0.43%
ANTX	AN2 Therapeutics, Inc. Healthcare	Reduced	529,933	-127,267	$2,564,875	+14.1%	2	$2.06	0.42%
SER	Serina Therapeutics, Inc. Healthcare	Held	1,000,000	0	$1,940,000	0.0%	2	$2.20	0.32%
ALGS	Aligos Therapeutics, Inc. Healthcare	Held	327,237	0	$1,888,157	−22.3%	6	$14.55	0.31%
IBIO	iBio, Inc. Healthcare	Held	904,268	0	$1,582,469	−7.9%	3	$1.54	0.26%
XLO	Xilio Therapeutics, Inc. Healthcare	Held	152,464	0	$1,460,605	+13.9%	3	$10.51	0.24%
AORT	Artivion, Inc. Healthcare	NEW	48,481	NEW	$1,089,368	NEW	1	$27.97	0.18%

Showing the top 50 of 59 positions. Create a free account to see every position, past quarters, search, filters and CSV export.

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.