Sio Capital Management, LLC

CIK

1482416

Location

NEW YORK, NY

Portfolio Value

Small $658,280,344

Diversification

Diversified

Filing Date

Global Rank

#2,105 / 8,420 ▲ 776

Top Industry

Biotechnology 39.5%

3Y Alpha vs SPY

-2.4%

Period ended 6 months ago

Filed Feb 17, 2026 · 4mo

24 quarters · since Mar 2020

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+66.1%

SPY

+76.3%

Annualised alpha

-2.4%

Max drawdown

−37.3%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

65 positions · as of Dec 31, 2025 · Δ vs Sep 30, 2025

Top Position

7.2%

−5.3 pts

Top 5

33.4%

−5.7 pts

Top 10

51.9%

−6.5 pts

HHI

371

Diversified−128

Portfolio Trend

24 quarters · across all stocks

Sector Breakdown

As of Dec 31, 2025

Sector	% Portfolio	Value	Positions
Healthcare	89.1%	$586,555,244	62
Industrials	6.6%	$43,186,241	1
Consumer Defensive	3.8%	$25,278,874	1
Unclassified	0.5%	$3,259,985	1

Last Quarter's Activity

Export CSV

Dec 31, 2025 vs Sep 30, 2025

Added To

Positions the filer increased

8 positions

Ticker	Company	Δ Shares	Shares	Value
KVUE	Kenvue Inc.	+621,442	1,465,442	$25,278,874
SNY	Sanofi	+408,983	971,686	$47,087,903
AVR	Anteris Technologies Global Corp.	+102,040	1,874,641	$9,354,458
PRQR	ProQR Therapeutics N.V.	+89,042	2,164,181	$4,371,645
TFX	Teleflex Inc	+46,819	86,876	$10,602,347
ANIP	Ani Pharmaceuticals Inc	+31,549	87,272	$6,889,251
TYRA	Tyra Biosciences, Inc.	+11,055	526,002	$13,828,592
BMRN	Biomarin Pharmaceutical Inc	+7,574	232,688	$13,828,647
No positions match the current search.

Trimmed

Positions the filer reduced

15 positions

Ticker	Company	Δ Shares	Shares	Value
NMTC	NEUROONE MEDICAL TECHNOLOGIES Corp	−1,220,595	1,140,040	$864,150
ALKS	Alkermes plc.	−579,487	95,353	$2,667,976
AQST	Aquestive Therapeutics, Inc.	−505,000	993,095	$6,415,393
CELC	Celcuity Inc.	−309,459	477,067	$47,582,662
IRON	Disc Medicine, Inc.	−227,201	57,586	$4,572,904
SI	Shoulder Innovations, Inc.	−122,029	227,971	$3,259,985
CNC	Centene Corp	−113,250	274,350	$11,289,502
SVRA	Savara Inc	−112,963	613,888	$3,701,744
DRUG	Bright Minds Biosciences Inc.	−108,881	81,883	$6,390,149
HAE	Haemonetics Corp	−105,404	92,631	$7,424,374
DNTH	Dianthus Therapeutics, Inc. /DE/	−103,247	474,503	$19,554,268
EWTX	Edgewise Therapeutics, Inc.	−69,700	237,481	$5,893,091
MMS	Maximus, Inc.	−57,311	500,304	$43,186,241
CRNX	Crinetics Pharmaceuticals, Inc.	−50,000	124,841	$5,811,348
IDYA	IDEAYA Biosciences, Inc.	−48,500	75,730	$2,617,986
No positions match the current search.

New Positions

Positions the filer opened this quarter

25 positions

Ticker	Company	Shares	Value
CI	Cigna Group	172,203	$47,395,431
ZBH	Zimmer Biomet Holdings, Inc.	385,642	$34,676,928
RYTM	Rhythm Pharmaceuticals, Inc.	265,700	$28,440,528
OGN	Organon & Co.	3,421,765	$24,534,055
ICLR	Icon PLC	127,202	$23,178,748
WAY	Waystar Holding Corp.	613,725	$20,099,493
LIVN	LivaNova PLC	322,382	$19,836,164
XLO	Xilio Therapeutics, Inc.	2,134,537	$19,125,451
BHVN	Biohaven Ltd.	1,244,764	$14,053,385
GPCR	Structure Therapeutics Inc.	201,500	$14,014,325
BTSG	BrightSpring Health Services, Inc.	308,010	$11,534,974
CRL	Charles River Laboratories International, Inc.	54,985	$10,968,407
TARA	Protara Therapeutics, Inc.	1,715,394	$9,143,050
CCRN	Cross Country Healthcare Inc	1,068,821	$8,657,450
ABVX	Abivax S.A.	43,124	$5,815,487
COR	Cencora, Inc.	15,900	$5,370,225
MCK	Mckesson Corp	6,400	$5,249,856
FULC	Fulcrum Therapeutics, Inc.	382,000	$4,320,420
ORKA	Oruka Therapeutics, Inc.	118,126	$3,580,399
KYMR	Kymera Therapeutics, Inc.	32,235	$2,508,205
ELTX	Elicio Therapeutics, Inc.	296,900	$2,363,324
HYPR	Hyperfine, Inc.	2,000,000	$1,958,000
OTLK	Outlook Therapeutics, Inc.	1,125,400	$1,778,132
IBIO	iBio, Inc.	740,000	$1,428,200
ADGM	Adagio Medical Holdings, Inc.	1,288,461	$1,339,999
No positions match the current search.

Sold Out

Positions the filer fully exited

9 positions

Ticker	Company	Shares	Value
MRK	Merck & Co., Inc.	177,300	$14,880,789
HSIC	Henry Schein Inc	219,207	$14,548,768
GSK	GSK plc	268,873	$11,604,558
KALV	KalVista Pharmaceuticals, Inc.	683,819	$8,328,915
NVCR	NovoCure Ltd	413,829	$5,346,670
SLP	Simulations Plus, Inc.	320,307	$4,827,026
SEPN	Septerna, Inc.	189,199	$3,558,833
ERAS	Erasca, Inc.	1,369,748	$2,986,050
APRE	Aprea Therapeutics, Inc.	112,223	$165,528
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

65 positions · $658,280,344 total · as of Dec 31, 2025

All sectors Consumer Defensive Healthcare Industrials

Showing 1–50 of 65 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
CELC	Celcuity Inc. Healthcare	Reduced	477,067	-309,459	$47,582,662	+22.5%	7.23%
CI	Cigna Group Healthcare	NEW	172,203	NEW	$47,395,431	NEW	7.20%
SNY	Sanofi Healthcare	Added	971,686	+408,983	$47,087,903	+77.3%	7.15%
MMS	Maximus, Inc. Industrials	Reduced	500,304	-57,311	$43,186,241	−15.2%	6.56%
ZBH	Zimmer Biomet Holdings, Inc. Healthcare	NEW	385,642	NEW	$34,676,928	NEW	5.27%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	NEW	265,700	NEW	$28,440,528	NEW	4.32%
KVUE	Kenvue Inc. Consumer Defensive	Added	1,465,442	+621,442	$25,278,874	+84.5%	3.84%
OGN	Organon & Co. Healthcare	NEW	3,421,765	NEW	$24,534,055	NEW	3.73%
ICLR	Icon PLC Healthcare	NEW	127,202	NEW	$23,178,748	NEW	3.52%
WAY	Waystar Holding Corp. Healthcare	NEW	613,725	NEW	$20,099,493	NEW	3.05%
LIVN	LivaNova PLC Healthcare	NEW	322,382	NEW	$19,836,164	NEW	3.01%
DNTH	Dianthus Therapeutics, Inc. /DE/ Healthcare	Reduced	474,503	-103,247	$19,554,268	−14.0%	2.97%
XLO	Xilio Therapeutics, Inc. Healthcare	NEW	2,134,537	NEW	$19,125,451	NEW	2.91%
BHVN	Biohaven Ltd. Healthcare	NEW	1,244,764	NEW	$14,053,385	NEW	2.13%
GPCR	Structure Therapeutics Inc. Healthcare	NEW	201,500	NEW	$14,014,325	NEW	2.13%
BMRN	Biomarin Pharmaceutical Inc Healthcare	Added	232,688	+7,574	$13,828,647	+13.4%	2.10%
TYRA	Tyra Biosciences, Inc. Healthcare	Added	526,002	+11,055	$13,828,592	+92.0%	2.10%
BTSG	BrightSpring Health Services, Inc. Healthcare	NEW	308,010	NEW	$11,534,974	NEW	1.75%
CNC	Centene Corp Healthcare	Reduced	274,350	-113,250	$11,289,502	−18.4%	1.71%
CRL	Charles River Laboratories International, Inc. Healthcare	NEW	54,985	NEW	$10,968,407	NEW	1.67%
TFX	Teleflex Inc Healthcare	Added	86,876	+46,819	$10,602,347	+116.3%	1.61%
AVR	Anteris Technologies Global Corp. Healthcare	Added	1,874,641	+102,040	$9,354,458	+17.3%	1.42%
TARA	Protara Therapeutics, Inc. Healthcare	NEW	1,715,394	NEW	$9,143,050	NEW	1.39%
CCRN	Cross Country Healthcare Inc Healthcare	NEW	1,068,821	NEW	$8,657,450	NEW	1.32%
MODD	Modular Medical, Inc. Healthcare	Held	785,824	0	$8,581,198	−48.0%	1.30%
HAE	Haemonetics Corp Healthcare	Reduced	92,631	-105,404	$7,424,374	−23.1%	1.13%
ANIP	Ani Pharmaceuticals Inc Healthcare	Added	87,272	+31,549	$6,889,251	+35.0%	1.05%
AQST	Aquestive Therapeutics, Inc. Healthcare	Reduced	993,095	-505,000	$6,415,393	−23.4%	0.97%
DRUG	Bright Minds Biosciences Inc. Healthcare	Reduced	81,883	-108,881	$6,390,149	−44.8%	0.97%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Reduced	237,481	-69,700	$5,893,091	+18.3%	0.90%
ABVX	Abivax S.A. Healthcare	NEW	43,124	NEW	$5,815,487	NEW	0.88%
CRNX	Crinetics Pharmaceuticals, Inc. Healthcare	Reduced	124,841	-50,000	$5,811,348	−20.2%	0.88%
RAPP	Rapport Therapeutics, Inc. Healthcare	Held	185,265	0	$5,620,940	+2.2%	0.85%
COR	Cencora, Inc. Healthcare	NEW	15,900	NEW	$5,370,225	NEW	0.82%
MCK	Mckesson Corp Healthcare	NEW	6,400	NEW	$5,249,856	NEW	0.80%
IRON	Disc Medicine, Inc. Healthcare	Reduced	57,586	-227,201	$4,572,904	−75.7%	0.69%
PRQR	ProQR Therapeutics N.V. Healthcare	Added	2,164,181	+89,042	$4,371,645	−1.1%	0.66%
FULC	Fulcrum Therapeutics, Inc. Healthcare	NEW	382,000	NEW	$4,320,420	NEW	0.66%
SVRA	Savara Inc Healthcare	Reduced	613,888	-112,963	$3,701,744	+42.7%	0.56%
ORKA	Oruka Therapeutics, Inc. Healthcare	NEW	118,126	NEW	$3,580,399	NEW	0.54%
PMVP	PMV Pharmaceuticals, Inc. Healthcare	Reduced	2,636,548	-2,636,548	$3,295,685	−55.4%	0.50%
SI	Shoulder Innovations, Inc.	Reduced	227,971	-122,029	$3,259,985	−25.8%	0.50%
ALGS	Aligos Therapeutics, Inc. Healthcare	Held	335,937	0	$3,130,932	−4.9%	0.48%
VIR	Vir Biotechnology, Inc. Healthcare	Held	478,343	0	$2,884,408	+5.6%	0.44%
ALKS	Alkermes plc. Healthcare	Reduced	95,353	-579,487	$2,667,976	−86.8%	0.41%
IDYA	IDEAYA Biosciences, Inc. Healthcare	Reduced	75,730	-48,500	$2,617,986	−22.6%	0.40%
KYMR	Kymera Therapeutics, Inc. Healthcare	NEW	32,235	NEW	$2,508,205	NEW	0.38%
ELTX	Elicio Therapeutics, Inc. Healthcare	NEW	296,900	NEW	$2,363,324	NEW	0.36%
OVID	Ovid Therapeutics Inc. Healthcare	Held	1,427,495	0	$2,326,816	+25.4%	0.35%
CNTX	Context Therapeutics Inc. Healthcare	Held	1,341,636	0	$1,972,204	+51.7%	0.30%