Sio Capital Management, LLC
Filing Date
Global Rank
#2,188
/ 8,623
▲ 162
· as of Mar 2026
Top Industry
Biotechnology
45.5%
3Y Alpha vs SPY
+2.3%
Period ended 4 months ago
Filed May 14, 2026 · 3mo
25 quarters · since Mar 2020
Clone Performance
Jul 2023–Jul 2026 · vs SPYHypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.
Cloned portfolio
+76.7%
SPY
+65.3%
Annualised alpha
+2.7%
Max drawdown
−38.1%
Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 91% of reported value on average across 13 quarters. Past performance does not predict future results.
Portfolio Concentration
74 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025Top Position
7.1%
−0.5 pts
Top 5
26.6%
−8.2 pts
Top 10
45.1%
−8.9 pts
HHI
301
Diversified−91
Portfolio Trend
25 quarters · across all stocks
Sector Breakdown
As of Mar 31, 2026| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 92.5% | $644,954,753 |
| Industrials | 7.1% | $49,281,682 |
| Unclassified | 0.4% | $3,060,613 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
24 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| AVR | Anteris Technologies Global Corp. | +3,508,324 | 5,382,965 | $29,875,455 | |
| WAY | Waystar Holding Corp. | +1,028,511 | 1,642,236 | $39,594,309 | |
| VIR | Vir Biotechnology, Inc. | +1,020,277 | 1,498,620 | $13,427,635 | |
| AQST | Aquestive Therapeutics, Inc. | +929,792 | 1,922,887 | $7,979,981 | |
| PMVP | PMV Pharmaceuticals, Inc. | +440,032 | 3,076,580 | $3,814,959 | |
| MMS | Maximus, Inc. | +268,521 | 768,825 | $49,281,682 | |
| TARA | Protara Therapeutics, Inc. | +254,445 | 1,969,839 | $10,262,861 | |
| RAPP | Rapport Therapeutics, Inc. | +181,544 | 366,809 | $11,477,453 | |
| ICLR | Icon PLC | +179,156 | 306,358 | $33,901,576 | |
| ANIP | Ani Pharmaceuticals Inc | +178,271 | 265,543 | $20,420,256 | |
| IBIO | iBio, Inc. | +164,268 | 904,268 | $1,718,109 | |
| HAE | Haemonetics Corp | +128,041 | 220,672 | $12,437,073 | |
| CRNX | Crinetics Pharmaceuticals, Inc. | +125,046 | 249,887 | $9,075,895 | |
| LIVN | LivaNova PLC | +99,233 | 421,615 | $26,797,849 | |
| ABVX | Abivax S.A. | +92,676 | 135,800 | $15,121,330 | |
| COR | Cencora, Inc. | +84,994 | 100,894 | $31,694,841 | |
| TYRA | Tyra Biosciences, Inc. | +79,437 | 605,439 | $23,188,313 | |
| EWTX | Edgewise Therapeutics, Inc. | +31,505 | 268,986 | $8,473,059 | |
| CCRN | Cross Country Healthcare Inc | +29,572 | 1,098,393 | $10,324,894 | |
| ORKA | Oruka Therapeutics, Inc. | +14,370 | 132,496 | $6,498,928 | |
| TFX | Teleflex Inc | +7,924 | 94,800 | $11,339,028 | |
| IRON | Disc Medicine, Inc. | +7,617 | 65,203 | $4,169,079 | |
| GPCR | Structure Therapeutics Inc. | +7,593 | 209,093 | $10,078,282 | |
| DRUG | Bright Minds Biosciences Inc. | +4,200 | 86,083 | $6,281,476 | |
| No positions match the current search. | |||||
Trimmed
Positions the filer reduced
18 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| OGN | Organon & Co. | −2,555,857 | 865,908 | $5,186,788 | |
| XLO | Xilio Therapeutics, Inc. | −1,982,073 | 152,464 | $1,282,222 | |
| HYPR | Hyperfine, Inc. | −1,000,000 | 1,000,000 | $1,080,000 | |
| MODD | Modular Medical, Inc. | −759,634 | 26,190 | $138,283 | |
| SNY | Sanofi | −732,015 | 239,671 | $11,547,348 | |
| NMTC | NEUROONE MEDICAL TECHNOLOGIES Corp | −643,426 | 496,614 | $385,869 | |
| CNTX | Context Therapeutics Inc. | −423,714 | 917,922 | $2,404,955 | |
| ZBH | Zimmer Biomet Holdings, Inc. | −323,029 | 62,613 | $5,661,467 | |
| ELTX | Elicio Therapeutics, Inc. | −285,200 | 11,700 | $125,073 | |
| CELC | Celcuity Inc. | −283,224 | 193,843 | $22,125,240 | |
| PRQR | ProQR Therapeutics N.V. | −209,466 | 1,954,715 | $3,166,638 | |
| OVID | Ovid Therapeutics Inc. | −175,114 | 1,252,381 | $2,780,285 | |
| CNC | Centene Corp | −174,350 | 100,000 | $3,274,000 | |
| DNTH | Dianthus Therapeutics, Inc. /DE/ | −104,458 | 370,045 | $31,054,176 | |
| BHVN | Biohaven Ltd. | −80,838 | 1,163,926 | $9,846,813 | |
| BMRN | Biomarin Pharmaceutical Inc | −38,462 | 194,226 | $10,971,826 | |
| SI | Shoulder Innovations, Inc. | −17,330 | 210,641 | $3,060,613 | |
| ALGS | Aligos Therapeutics, Inc. | −8,700 | 327,237 | $2,431,370 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
21 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| CORT | Corcept Therapeutics Inc | 674,759 | $27,199,535 | |
| GSK | GSK plc | 385,879 | $21,296,662 | |
| ABT | Abbott Laboratories | 186,574 | $19,155,552 | |
| EMBC | Embecta Corp. | 1,847,850 | $16,334,994 | |
| SION | Sionna Therapeutics, Inc. | 294,340 | $11,800,090 | |
| MNPR | Monopar Therapeutics | 173,506 | $9,506,393 | |
| EYPT | EyePoint, Inc. | 721,785 | $9,303,808 | |
| CMPS | COMPASS Pathways plc | 1,506,525 | $8,331,083 | |
| OCUL | Ocular Therapeutix, Inc | 968,597 | $8,204,016 | |
| RLMD | Relmada Therapeutics, Inc. | 965,000 | $6,716,400 | |
| ZBIO | Zenas BioPharma, Inc. | 331,730 | $6,485,321 | |
| QDEL | QuidelOrtho Corp | 359,011 | $5,898,550 | |
| REPL | Replimune Group, Inc. | 720,036 | $5,508,275 | |
| OKUR | OnKure Therapeutics, Inc. | 1,078,965 | $4,466,915 | |
| IMNM | Immunome Inc. | 165,110 | $3,610,955 | |
| IART | Integra Lifesciences Holdings Corp | 383,140 | $3,609,178 | |
| ANTX | AN2 Therapeutics, Inc. | 657,200 | $2,247,624 | |
| SER | Serina Therapeutics, Inc. | 1,000,000 | $1,940,000 | |
| ERAS | Erasca, Inc. | 5,000 | $80,900 | |
| OSCR | Oscar Health, Inc. | 3,000 | $34,410 | |
| SLP | Simulations Plus, Inc. | 200 | $2,364 | |
| No positions match the current search. | ||||
Sold Out
Positions the filer fully exited
12 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| CI | Cigna Group | 172,203 | $47,395,431 | |
| RYTM | Rhythm Pharmaceuticals, Inc. | 265,700 | $28,440,528 | |
| KVUE | Kenvue Inc. | 1,465,442 | $25,278,874 | |
| BTSG | BrightSpring Health Services, Inc. | 308,010 | $11,534,974 | |
| CRL | Charles River Laboratories International, Inc. | 54,985 | $10,968,407 | |
| MCK | Mckesson Corp | 6,400 | $5,249,856 | |
| FULC | Fulcrum Therapeutics, Inc. | 382,000 | $4,320,420 | |
| ALKS | Alkermes plc. | 95,353 | $2,667,976 | |
| IDYA | IDEAYA Biosciences, Inc. | 75,730 | $2,617,986 | |
| OTLK | Outlook Therapeutics, Inc. | 1,125,400 | $1,778,132 | |
| AVTX | Avalo Therapeutics, Inc. | 72,173 | $1,310,661 | |
| NXTC | NextCure, Inc. | 10,940 | $155,238 | |
| No positions match the current search. | ||||
74 tracked positions ·
$697,297,048 total
· filing declares
76 positions · $697,308,424
· as of Mar 31, 2026
Showing 1–50
of 74 positions by value
· page 1 of 2
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| MMS |
Maximus, Inc.
Industrials
|
Added | 768,825 | $49,281,682 | 7.07% | |
| WAY |
Waystar Holding Corp.
Healthcare
|
Added | 1,642,236 | $39,594,309 | 5.68% | |
| ICLR |
Icon PLC
Healthcare
|
Added | 306,358 | $33,901,576 | 4.86% | |
| COR |
Cencora, Inc.
Healthcare
|
Added | 100,894 | $31,694,841 | 4.55% | |
| DNTH |
Dianthus Therapeutics, Inc. /DE/
Healthcare
|
Reduced | 370,045 | $31,054,176 | 4.45% | |
| AVR |
Anteris Technologies Global Corp.
Healthcare
|
Added | 5,382,965 | $29,875,455 | 4.28% | |
| CORT |
Corcept Therapeutics Inc
Healthcare
|
NEW | 674,759 | $27,199,535 | 3.90% | |
| LIVN |
LivaNova PLC
Healthcare
|
Added | 421,615 | $26,797,849 | 3.84% | |
| TYRA |
Tyra Biosciences, Inc.
Healthcare
|
Added | 605,439 | $23,188,313 | 3.33% | |
| CELC |
Celcuity Inc.
Healthcare
|
Reduced | 193,843 | $22,125,240 | 3.17% | |
| GSK |
GSK plc
Healthcare
|
NEW | 385,879 | $21,296,662 | 3.05% | |
| ANIP |
Ani Pharmaceuticals Inc
Healthcare
|
Added | 265,543 | $20,420,256 | 2.93% | |
| ABT |
Abbott Laboratories
Healthcare
|
NEW | 186,574 | $19,155,552 | 2.75% | |
| EMBC |
Embecta Corp.
Healthcare
|
NEW | 1,847,850 | $16,334,994 | 2.34% | |
| ABVX |
Abivax S.A.
Healthcare
|
Added | 135,800 | $15,121,330 | 2.17% | |
| VIR |
Vir Biotechnology, Inc.
Healthcare
|
Added | 1,498,620 | $13,427,635 | 1.93% | |
| HAE |
Haemonetics Corp
Healthcare
|
Added | 220,672 | $12,437,073 | 1.78% | |
| SION |
Sionna Therapeutics, Inc.
Healthcare
|
NEW | 294,340 | $11,800,090 | 1.69% | |
| SNY |
Sanofi
Healthcare
|
Reduced | 239,671 | $11,547,348 | 1.66% | |
| RAPP |
Rapport Therapeutics, Inc.
Healthcare
|
Added | 366,809 | $11,477,453 | 1.65% | |
| TFX |
Teleflex Inc
Healthcare
|
Added | 94,800 | $11,339,028 | 1.63% | |
| BMRN |
Biomarin Pharmaceutical Inc
Healthcare
|
Reduced | 194,226 | $10,971,826 | 1.57% | |
| CCRN |
Cross Country Healthcare Inc
Healthcare
|
Added | 1,098,393 | $10,324,894 | 1.48% | |
| TARA |
Protara Therapeutics, Inc.
Healthcare
|
Added | 1,969,839 | $10,262,861 | 1.47% | |
| GPCR |
Structure Therapeutics Inc.
Healthcare
|
Added | 209,093 | $10,078,282 | 1.45% | |
| BHVN |
Biohaven Ltd.
Healthcare
|
Reduced | 1,163,926 | $9,846,813 | 1.41% | |
| MNPR |
Monopar Therapeutics
Healthcare
|
NEW | 173,506 | $9,506,393 | 1.36% | |
| EYPT |
EyePoint, Inc.
Healthcare
|
NEW | 721,785 | $9,303,808 | 1.33% | |
| CRNX |
Crinetics Pharmaceuticals, Inc.
Healthcare
|
Added | 249,887 | $9,075,895 | 1.30% | |
| EWTX |
Edgewise Therapeutics, Inc.
Healthcare
|
Added | 268,986 | $8,473,059 | 1.22% | |
| CMPS |
COMPASS Pathways plc
Healthcare
|
NEW | 1,506,525 | $8,331,083 | 1.19% | |
| OCUL |
Ocular Therapeutix, Inc
Healthcare
|
NEW | 968,597 | $8,204,016 | 1.18% | |
| AQST |
Aquestive Therapeutics, Inc.
Healthcare
|
Added | 1,922,887 | $7,979,981 | 1.14% | |
| RLMD |
Relmada Therapeutics, Inc.
Healthcare
|
NEW | 965,000 | $6,716,400 | 0.96% | |
| ORKA |
Oruka Therapeutics, Inc.
Healthcare
|
Added | 132,496 | $6,498,928 | 0.93% | |
| ZBIO |
Zenas BioPharma, Inc.
Healthcare
|
NEW | 331,730 | $6,485,321 | 0.93% | |
| DRUG |
Bright Minds Biosciences Inc.
Healthcare
|
Added | 86,083 | $6,281,476 | 0.90% | |
| QDEL |
QuidelOrtho Corp
Healthcare
|
NEW | 359,011 | $5,898,550 | 0.85% | |
| ZBH |
Zimmer Biomet Holdings, Inc.
Healthcare
|
Reduced | 62,613 | $5,661,467 | 0.81% | |
| REPL |
Replimune Group, Inc.
Healthcare
|
NEW | 720,036 | $5,508,275 | 0.79% | |
| OGN |
Organon & Co.
Healthcare
|
Reduced | 865,908 | $5,186,788 | 0.74% | |
| OKUR |
OnKure Therapeutics, Inc.
Healthcare
|
NEW | 1,078,965 | $4,466,915 | 0.64% | |
| IRON |
Disc Medicine, Inc.
Healthcare
|
Added | 65,203 | $4,169,079 | 0.60% | |
| PMVP |
PMV Pharmaceuticals, Inc.
Healthcare
|
Added | 3,076,580 | $3,814,959 | 0.55% | |
| IMNM |
Immunome Inc.
Healthcare
|
NEW | 165,110 | $3,610,955 | 0.52% | |
| IART |
Integra Lifesciences Holdings Corp
Healthcare
|
NEW | 383,140 | $3,609,178 | 0.52% | |
| SVRA |
Savara Inc
Healthcare
|
Held | 613,888 | $3,351,828 | 0.48% | |
| CNC |
Centene Corp
PUT
Healthcare
|
Reduced | 100,000 | $3,274,000 | 0.47% | |
| PRQR |
ProQR Therapeutics N.V.
Healthcare
|
Reduced | 1,954,715 | $3,166,638 | 0.45% | |
| SI |
Shoulder Innovations, Inc.
|
Reduced | 210,641 | $3,060,613 | 0.44% |
Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.