Paradigm Biocapital Advisors LP

CIK

1855655

Location

NEW YORK, NY

Portfolio Value

Mid $2,883,920,399

Diversification

Diversified

Filing Date

Global Rank

#950 / 7,976 ▲ 157

Top Industry

Biotechnology 97.3%

3Y Alpha vs SPY

-3.4%

Period ended 9 months ago

Filed Nov 14, 2025 · 7mo

16 quarters · since Dec 2021

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+61.7%

SPY

+76.3%

Annualised alpha

-3.4%

Max drawdown

−47.9%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

31 positions · as of Sep 30, 2025 · Δ vs Jun 30, 2025

Top Position

15.8%

−3.4 pts

Top 5

49.3%

−6.1 pts

Top 10

69.2%

−4.1 pts

HHI

714

Diversified−157

Portfolio Trend

16 quarters · across all stocks

Sector Breakdown

As of Sep 30, 2025

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$2,883,920,399	31

Last Quarter's Activity

Export CSV

Sep 30, 2025 vs Jun 30, 2025

Added To

Positions the filer increased

12 positions

Ticker	Company	Δ Shares	Shares	Value
AGIO	Agios Pharmaceuticals, Inc.	+1,731,044	2,873,555	$115,344,497
ERAS	Erasca, Inc.	+1,652,835	13,560,017	$29,560,837
PHVS	Pharvaris N.V.	+772,583	1,835,494	$45,795,575
APGE	Apogee Therapeutics, Inc.	+563,127	1,521,757	$60,459,405
PCVX	Vaxcyte, Inc.	+411,918	3,784,755	$136,326,875
SRRK	Scholar Rock Holding Corp	+409,191	2,009,745	$74,842,903
ALKS	Alkermes plc.	+343,765	1,719,334	$51,580,020
CRNX	Crinetics Pharmaceuticals, Inc.	+207,221	2,550,774	$106,239,737
RVMD	Revolution Medicines, Inc.	+130,000	6,223,291	$290,627,689
OCUL	Ocular Therapeutix, Inc	+76,967	3,497,307	$40,883,518
OLMA	Olema Pharmaceuticals, Inc.	+30,000	6,794,172	$66,514,943
EWTX	Edgewise Therapeutics, Inc.	+27,787	6,170,131	$100,079,524
No positions match the current search.

Trimmed

Positions the filer reduced

7 positions

Ticker	Company	Δ Shares	Shares	Value
COGT	Cogent Biosciences, Inc.	−7,196,051	3,156,398	$45,325,875
IRON	Disc Medicine, Inc.	−963,255	247,716	$16,369,073
LENZ	LENZ Therapeutics, Inc.	−643,605	1,073,461	$50,001,813
SYRE	Spyre Therapeutics, Inc.	−403,179	1,467,266	$24,591,378
TARS	Tarsus Pharmaceuticals, Inc.	−310,401	2,665,698	$158,422,432
BBIO	BridgeBio Pharma, Inc.	−281,487	684,277	$35,541,347
VRDN	Viridian Therapeutics, Inc.DE	−132,223	2,609,353	$56,309,837
No positions match the current search.

New Positions

Positions the filer opened this quarter

9 positions

Ticker	Company	Shares	Value
ABVX	Abivax S.A.	1,564,196	$132,800,240
GMAB	Genmab A/S	3,816,851	$117,062,820
URGN	UroGen Pharma Ltd.	4,216,084	$84,110,875
EYPT	EyePoint, Inc.	2,005,365	$28,556,397
TNGX	Tango Therapeutics, Inc.	3,086,184	$25,923,945
AMLX	Amylyx Pharmaceuticals, Inc.	1,900,000	$25,821,000
DYN	Dyne Therapeutics, Inc.	1,898,950	$24,021,717
BBOT	BridgeBio Oncology Therapeutics, Inc.	1,866,141	$21,609,912
GPCR	Structure Therapeutics Inc.	372,869	$10,440,332
No positions match the current search.

Sold Out

Positions the filer fully exited

4 positions

Ticker	Company	Shares	Value
ONC	BeOne Medicines Ltd.	347,787	$84,188,799
MLTX	MoonLake Immunotherapeutics	878,323	$41,456,845
IMTX	Immatics N.V.	3,144,157	$16,915,564
CBIO	Crescent Biopharma, Inc.	642,721	$10,373,516
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

31 positions · $2,883,920,399 total · as of Sep 30, 2025

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
NUVL	Nuvalent, Inc. Healthcare	Held	5,269,433	0	$455,700,565	+13.3%	15.80%
ACLX	Arcellx, Inc. Healthcare	Held	4,649,016	0	$381,684,213	+24.7%	13.23%
RVMD	Revolution Medicines, Inc. Healthcare	Added	6,223,291	+130,000	$290,627,689	+29.6%	10.08%
TARS	Tarsus Pharmaceuticals, Inc. Healthcare	Reduced	2,665,698	-310,401	$158,422,432	+31.4%	5.49%
PCVX	Vaxcyte, Inc. Healthcare	Added	3,784,755	+411,918	$136,326,875	+24.3%	4.73%
ABVX	Abivax S.A. Healthcare	NEW	1,564,196	NEW	$132,800,240	NEW	4.60%
GMAB	Genmab A/S Healthcare	NEW	3,816,851	NEW	$117,062,820	NEW	4.06%
AGIO	Agios Pharmaceuticals, Inc. Healthcare	Added	2,873,555	+1,731,044	$115,344,497	+203.5%	4.00%
CRNX	Crinetics Pharmaceuticals, Inc. Healthcare	Added	2,550,774	+207,221	$106,239,737	+57.6%	3.68%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Added	6,170,131	+27,787	$100,079,524	+24.3%	3.47%
URGN	UroGen Pharma Ltd. Healthcare	NEW	4,216,084	NEW	$84,110,875	NEW	2.92%
SRRK	Scholar Rock Holding Corp Healthcare	Added	2,009,745	+409,191	$74,842,903	+32.0%	2.60%
JANX	Janux Therapeutics, Inc. Healthcare	Held	2,920,258	0	$71,371,105	+5.8%	2.47%
OLMA	Olema Pharmaceuticals, Inc. Healthcare	Added	6,794,172	+30,000	$66,514,943	+130.8%	2.31%
APGE	Apogee Therapeutics, Inc. Healthcare	Added	1,521,757	+563,127	$60,459,405	+45.2%	2.10%
VRDN	Viridian Therapeutics, Inc.DE Healthcare	Reduced	2,609,353	-132,223	$56,309,837	+46.9%	1.95%
ALKS	Alkermes plc. Healthcare	Added	1,719,334	+343,765	$51,580,020	+31.1%	1.79%
LENZ	LENZ Therapeutics, Inc. Healthcare	Reduced	1,073,461	-643,605	$50,001,813	−0.6%	1.73%
PHVS	Pharvaris N.V. Healthcare	Added	1,835,494	+772,583	$45,795,575	+144.8%	1.59%
COGT	Cogent Biosciences, Inc. Healthcare	Reduced	3,156,398	-17,548,500	$45,325,875	−69.5%	1.57%
OCUL	Ocular Therapeutix, Inc Healthcare	Added	3,497,307	+76,967	$40,883,518	+28.8%	1.42%
BBIO	BridgeBio Pharma, Inc. Healthcare	Reduced	684,277	-281,487	$35,541,347	−14.8%	1.23%
ERAS	Erasca, Inc. Healthcare	Added	13,560,017	+1,652,835	$29,560,837	+95.5%	1.03%
EYPT	EyePoint, Inc. Healthcare	NEW	2,005,365	NEW	$28,556,397	NEW	0.99%
TNGX	Tango Therapeutics, Inc. Healthcare	NEW	3,086,184	NEW	$25,923,945	NEW	0.90%
AMLX	Amylyx Pharmaceuticals, Inc. Healthcare	NEW	1,900,000	NEW	$25,821,000	NEW	0.90%
SYRE	Spyre Therapeutics, Inc. Healthcare	Reduced	1,467,266	-403,179	$24,591,378	−12.2%	0.85%
DYN	Dyne Therapeutics, Inc. Healthcare	NEW	1,898,950	NEW	$24,021,717	NEW	0.83%
BBOT	BridgeBio Oncology Therapeutics, Inc. Healthcare	NEW	1,866,141	NEW	$21,609,912	NEW	0.75%
IRON	Disc Medicine, Inc. Healthcare	Reduced	247,716	-963,255	$16,369,073	−74.5%	0.57%
GPCR	Structure Therapeutics Inc. Healthcare	NEW	372,869	NEW	$10,440,332	NEW	0.36%