Paradigm Biocapital Advisors LP

CIK

1855655

Location

NEW YORK, NY

Portfolio Value

Mid $4,894,261,596

Diversification

Diversified

Filing Date

Global Rank

#679 / 8,622 ▲ 170 · as of Mar 2026

Top Industry

Biotechnology 100.0%

3Y Alpha vs SPY

+3.6%

Period ended 4 months ago

Filed May 15, 2026 · 2mo

18 quarters · since Dec 2021

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.

Cloned portfolio

+81.1%

SPY

+67.9%

Annualised alpha

+3.0%

Max drawdown

−47.9%

Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 99% of reported value on average across 13 quarters. Past performance does not predict future results.

Portfolio Concentration

35 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

13.5%

−1.3 pts

Top 5

48.3%

−3.8 pts

Top 10

67.6%

−8.7 pts

HHI

671

Diversified−112

Portfolio Trend

18 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$4,894,261,596	35

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

13 positions

Ticker	Company	Δ Shares	Shares	Value
VRDN	Viridian Therapeutics, Inc.\DE	+1,705,791	3,148,893	$61,592,347
LXEO	Lexeo Therapeutics, Inc.	+1,420,936	6,184,134	$35,496,929
TERN	Terns Pharmaceuticals, Inc.	+1,406,213	2,216,499	$116,853,827
GMAB	Genmab A/S	+928,002	7,967,836	$213,777,039
EWTX	Edgewise Therapeutics, Inc.	+823,828	7,365,038	$231,998,697
PCVX	Vaxcyte, Inc.	+725,000	4,793,020	$278,522,392
ORKA	Oruka Therapeutics, Inc.	+610,000	2,320,316	$113,811,499
SYRE	Spyre Therapeutics, Inc.	+490,000	1,957,266	$98,724,497
OLMA	Olema Pharmaceuticals, Inc.	+476,404	8,020,576	$119,586,788
APGE	Apogee Therapeutics, Inc.	+225,000	1,348,243	$113,481,613
NUVL	Nuvalent, Inc.	+55,000	5,324,433	$545,488,160
ACLX	Arcellx, Inc.	+50,000	5,774,016	$662,972,517
RVMD	Revolution Medicines, Inc.	+11,300	6,655,703	$647,267,116
No positions match the current search.

Trimmed

Positions the filer reduced

7 positions

Ticker	Company	Δ Shares	Shares	Value
ERAS	Erasca, Inc.	−3,766,393	10,392,702	$168,153,918
URGN	UroGen Pharma Ltd.	−2,769,699	1,703,949	$30,637,003
SRRK	Scholar Rock Holding Corp	−1,836,077	1,226,080	$60,274,092
BBOT	BridgeBio Oncology Therapeutics, Inc.	−1,393,536	868,213	$7,770,506
ORIC	Oric Pharmaceuticals, Inc.	−700,000	1,701,217	$21,554,419
ABVX	Abivax S.A.	−645,000	772,473	$86,014,868
EYPT	EyePoint, Inc.	−549,038	3,142,437	$40,506,012
No positions match the current search.

New Positions

Positions the filer opened this quarter

10 positions

Ticker	Company	Shares	Value
INSM	INSMED Inc	1,254,488	$205,133,877
BLTE	Belite Bio, Inc	1,114,784	$177,741,160
CNTA	Centessa Pharmaceuticals plc	3,574,048	$141,961,186
CYTK	Cytokinetics Inc	1,480,857	$97,603,284
TNGX	Tango Therapeutics, Inc.	4,009,679	$83,882,484
MAZE	Maze Therapeutics, Inc.	2,744,399	$81,920,310
TYRA	Tyra Biosciences, Inc.	2,054,991	$78,706,155
MIRM	Mirum Pharmaceuticals, Inc.	625,000	$57,737,500
MANE	Veradermics, Inc	525,000	$33,153,750
GPCR	Structure Therapeutics Inc.	545,287	$26,282,833
No positions match the current search.

Sold Out

Positions the filer fully exited

3 positions

Ticker	Company	Shares	Value
CRNX	Crinetics Pharmaceuticals, Inc.	2,210,774	$102,911,529
BBIO	BridgeBio Pharma, Inc.	684,277	$52,340,347
OCUL	Ocular Therapeutix, Inc	2,935,284	$35,634,347
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

35 tracked positions · $4,894,261,596 total · as of Mar 31, 2026

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
ACLX	Arcellx, Inc. Healthcare	Added	5,774,016	+50,000	$662,972,517	+77.6%	13.55%
RVMD	Revolution Medicines, Inc. Healthcare	Added	6,655,703	+11,300	$647,267,116	+22.3%	13.23%
NUVL	Nuvalent, Inc. Healthcare	Added	5,324,433	+55,000	$545,488,160	+2.9%	11.15%
PCVX	Vaxcyte, Inc. Healthcare	Added	4,793,020	+725,000	$278,522,392	+48.4%	5.69%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Reduced	7,365,038	-5,717,382	$231,998,697	−28.5%	4.74%
GMAB	Genmab A/S Healthcare	Added	7,967,836	+928,002	$213,777,039	−1.4%	4.37%
INSM	INSMED Inc Healthcare	NEW	1,254,488	NEW	$205,133,877	NEW	4.19%
TARS	Tarsus Pharmaceuticals, Inc. Healthcare	Held	2,562,154	0	$179,735,103	−14.3%	3.67%
BLTE	Belite Bio, Inc Healthcare	NEW	1,114,784	NEW	$177,741,160	NEW	3.63%
ERAS	Erasca, Inc. Healthcare	Reduced	10,392,702	-3,766,393	$168,153,918	+219.2%	3.44%
CNTA	Centessa Pharmaceuticals plc Healthcare	NEW	3,574,048	NEW	$141,961,186	NEW	2.90%
OLMA	Olema Pharmaceuticals, Inc. Healthcare	Added	8,020,576	+476,404	$119,586,788	−36.6%	2.44%
TERN	Terns Pharmaceuticals, Inc. Healthcare	Added	2,216,499	+1,406,213	$116,853,827	+257.0%	2.39%
ORKA	Oruka Therapeutics, Inc. Healthcare	Added	2,320,316	+610,000	$113,811,499	+119.5%	2.33%
APGE	Apogee Therapeutics, Inc. Healthcare	Added	1,348,243	+225,000	$113,481,613	+33.9%	2.32%
SYRE	Spyre Therapeutics, Inc. Healthcare	Added	1,957,266	+490,000	$98,724,497	+105.4%	2.02%
CYTK	Cytokinetics Inc Healthcare	NEW	1,480,857	NEW	$97,603,284	NEW	1.99%
ABVX	Abivax S.A. Healthcare	Reduced	772,473	-645,000	$86,014,868	−55.0%	1.76%
TNGX	Tango Therapeutics, Inc. Healthcare	NEW	4,009,679	NEW	$83,882,484	NEW	1.71%
MAZE	Maze Therapeutics, Inc. Healthcare	NEW	2,744,399	NEW	$81,920,310	NEW	1.67%
TYRA	Tyra Biosciences, Inc. Healthcare	NEW	2,054,991	NEW	$78,706,155	NEW	1.61%
VRDN	Viridian Therapeutics, Inc.\DE Healthcare	Added	3,148,893	+1,705,791	$61,592,347	+37.1%	1.26%
SRRK	Scholar Rock Holding Corp Healthcare	Reduced	1,226,080	-1,836,077	$60,274,092	−55.3%	1.23%
MIRM	Mirum Pharmaceuticals, Inc. Healthcare	NEW	625,000	NEW	$57,737,500	NEW	1.18%
EYPT	EyePoint, Inc. Healthcare	Reduced	3,142,437	-549,038	$40,506,012	−39.9%	0.83%
LXEO	Lexeo Therapeutics, Inc. Healthcare	Added	6,184,134	+1,420,936	$35,496,929	−25.0%	0.73%
MANE	Veradermics, Inc Healthcare	NEW	525,000	NEW	$33,153,750	NEW	0.68%
VOR	Vor Biopharma Inc. Healthcare	Held	1,750,000	0	$31,220,000	+36.4%	0.64%
URGN	UroGen Pharma Ltd. Healthcare	Reduced	1,703,949	-2,769,699	$30,637,003	−70.8%	0.63%
GPCR	Structure Therapeutics Inc. Healthcare	NEW	545,287	NEW	$26,282,833	NEW	0.54%
IVA	Inventiva S.A. Healthcare	Held	4,000,000	0	$22,200,000	+19.4%	0.45%
ORIC	Oric Pharmaceuticals, Inc. Healthcare	Reduced	1,701,217	-700,000	$21,554,419	+9.7%	0.44%
ASMB	Assembly Biosciences, Inc. Healthcare	Held	665,251	0	$18,460,715	−18.4%	0.38%
BBOT	BridgeBio Oncology Therapeutics, Inc. Healthcare	Reduced	868,213	-1,393,536	$7,770,506	−72.6%	0.16%
KLRS	Kalaris Therapeutics, Inc. Healthcare	Held	700,000	0	$4,039,000	−31.6%	0.08%

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.