ACHV · Achieve Life Sciences, Inc.

$8.49 +0.18 (+2.17%) At close · Sep 4

Russell 2000 member Rebalance outlook locked

Market Cap

$873.64M

102.90M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Quarter:

Holders: 111

Total Value: $553,657,060

Total Shares: 84,786,696

Showing 1–100 of 116 holdings by value · page 1 of 2

Institutional Ownership Trend

26 quarters

Holder Concentration

Across 111 13F filers · Δ vs Mar 31, 2026

Top Holder

9.0%

−10.7 pts

Top 5

36.7%

−20.3 pts

Top 10

62.5%

−11.1 pts

HHI

485

Broadly held−437

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +29

Institutional value: +750.2%

Shares held: +282.8%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mega BlackRock, Inc.	+4,832,657	5,272,017
Large MARSHALL WACE, LLP	+2,751,032	3,770,313
Mega STATE STREET CORP	+2,691,069	2,945,526
Mega VANGUARD CAPITAL MANAGEMENT LLC	+1,936,098	4,140,812
Mega GEODE CAPITAL MANAGEMENT, LLC	+1,439,936	2,062,721

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mega TWO SIGMA INVESTMENTS, LP	−147,364	441,187
Mid Shay Capital LLC	−112,304	92,810
Mega GOLDMAN SACHS GROUP INC	−111,976	40,976
Mega RAYMOND JAMES FINANCIAL INC	−95,607	546,318
Small Alpine Global Management, LLC	−37,500	12,500

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mid Frazier Life Sciences Management, L.P.	7,614,836	$49,724,879
Mid TPG GP A, LLC	6,877,580	$44,910,597
Small venBio Partners LLC	5,914,720	$38,623,121
Mid Logos Global Management LP	5,425,000	$35,425,250
Mid Paradigm Biocapital Advisors LP	4,951,856	$32,335,619

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mega MILLENNIUM MANAGEMENT LLC	1,077,338	$3,167,373
Mid Nantahala Capital Management, LLC	648,885	$1,907,721
Mid 683 Capital Management, LLC	200,000	$588,000
Mid Foundations Investment Advisors, LLC	145,002	$426,305
Small SLT Holdings LLC	142,800	$419,832

Filter: New 47 Increased 39 Reduced 12 Sold out 18 Unchanged 13

Showing 100 of 116

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

Frazier Life Sciences Management, L.P.

$49,724,879

8.98%

7,614,836

TPG GP A, LLC

$44,910,597

8.11%

6,877,580

venBio Partners LLC

$38,623,121

6.98%

5,914,720

Logos Global Management LP

$35,425,250

6.40%

5,425,000

BlackRock, Inc.

$34,426,268

6.22%

5,272,017

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	35,990	$235,014	0.7%	Sole
BlackRock Investment Management, LLC	229,659	$1,499,673	4.4%	Sole
BLACKROCK ADVISORS LLC	169,585	$1,107,390	3.2%	Sole
BlackRock Fund Advisors	2,995,249	$19,558,975	56.8%	Sole
BlackRock Institutional Trust Company, N.A.	1,840,908	$12,021,129	34.9%	Sole
Aperio Group, LLC	626	$4,087	0.0%	Sole

FRANKLIN RESOURCES INC

$32,344,526

5.84%

4,953,220

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FRANKLIN ADVISERS INC	4,953,220	$32,344,526	100.0%	Defined

Paradigm Biocapital Advisors LP

$32,335,619

5.84%

4,951,856

VANGUARD CAPITAL MANAGEMENT LLC

$27,039,502

4.88%

4,140,812

Propel Bio Management, LLC

$26,342,137

4.76%

4,034,018

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Simplify Asset Management Inc.	4,034,018	$26,342,137	100.0%	Defined

MARSHALL WACE, LLP

$24,620,142

4.45%

3,770,313

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	3,770,313	$24,620,142	100.0%	Other

STATE STREET CORP

$19,234,284

3.47%

2,945,526

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	2,945,526	$19,234,284	100.0%	Defined

Jupiter Topco LLC

$17,964,238

3.24%

2,751,032

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS US LLC	2,751,032	$17,964,238	100.0%	Defined

Venrock Adviser, LLC

$17,964,238

3.24%

2,751,032

Vivo Capital, LLC

$17,964,238

3.24%

2,751,032

EVENTIDE ASSET MANAGEMENT, LLC

$14,496,600

2.62%

2,220,000

GEODE CAPITAL MANAGEMENT, LLC

$13,469,568

2.43%

2,062,721

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	303,153	$1,979,589	14.7%	Defined
Held directly	1,759,568	$11,489,979	85.3%	Defined

Alyeska Investment Group, L.P.

$12,574,964

2.27%

1,925,722

Simplify Asset Management Inc.

$9,351,645

1.69%

1,432,105

WELLINGTON MANAGEMENT GROUP LLP

$9,317,754

1.68%

1,426,915

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	1,392,115	$9,090,510	97.6%	Defined
Wellington Trust Company, NA joint	34,800	$227,244	2.4%	Defined

Caption Management, LLC

$7,676,015

1.39%

1,175,500

LPL Financial LLC

$5,891,725

1.06%

902,255

NORTHERN TRUST CORP

$4,856,750

0.88%

743,760

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	706,845	$4,615,696	95.0%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	24,696	$161,264	3.3%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	12,219	$79,790	1.6%	Other

Spruce Street Capital LP

$4,810,239

0.87%

736,637

VANGUARD FIDUCIARY TRUST CO

$3,877,194

0.70%

593,751

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$3,771,075

0.68%

577,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	577,500	$3,771,075	100.0%	Other

RAYMOND JAMES FINANCIAL INC

$3,567,455

0.64%

546,318

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	419,807	$2,741,339	76.8%	Defined
Raymond James Financial Services Advisors, Inc.	126,511	$826,116	23.2%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$3,510,501

0.63%

537,596

KVP Capital Advisors, LP

$3,019,178

0.55%

462,355

TWO SIGMA INVESTMENTS, LP

$2,880,951

0.52%

441,187

UBS Group AG

$2,043,916

0.37%

313,004

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS AG	281,402	$1,837,555	89.9%	Defined
UBS Switzerland AG	31,602	$206,361	10.1%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$1,515,861

0.27%

232,138

Caption Management, LLC

$1,487,096

0.27%

227,733

SILVERARC CAPITAL MANAGEMENT, LLC

$1,483,472

0.27%

227,178

Bank of New York Mellon Corp

$1,424,362

0.26%

218,126

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	45,042	$294,124	20.6%	Defined
The Bank of New York Mellon	133,027	$868,666	61.0%	Defined
Newton Investment Management North America, LLC	40,055	$261,559	18.4%	Defined
Held directly	2	$13	0.0%	Defined

JANE STREET GROUP, LLC

$1,331,467

0.24%

203,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	203,900	$1,331,467	100.0%	Defined

CITADEL ADVISORS LLC

$1,326,243

0.24%

203,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	203,100	$1,326,243	100.0%	Defined

Nuveen, LLC

$1,248,209

0.23%

191,150

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	20,500	$133,865	10.7%	Defined
TEACHERS ADVISORS, LLC joint	170,650	$1,114,344	89.3%	Defined

BANK OF AMERICA CORP /DE/

$1,208,539

0.22%

185,075

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	116,191	$758,727	62.8%	Defined
BOFA SECURITIES, INC.	68,884	$449,812	37.2%	Defined

RENAISSANCE TECHNOLOGIES LLC

$1,162,659

0.21%

178,049

WELLS FARGO & COMPANY/MN

$1,114,233

0.20%

170,633

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	71,006	$463,669	41.6%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	99,627	$650,564	58.4%	Defined

CITADEL ADVISORS LLC

$804,032

0.15%

123,129

CANTOR FITZGERALD, L. P.

$794,250

0.14%

121,631

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Cantor Fitzgerald & Co.	121,631	$794,250	100.0%	Defined

BNP PARIBAS ARBITRAGE, SA

$791,533

0.14%

121,215

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$677,161

0.12%

103,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	103,700	$677,161	100.0%	Other

Shay Capital LLC

$606,049

0.11%

92,810

XTX Topco Ltd

$587,895

0.11%

90,030

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	90,030	$587,895	100.0%	Defined

RHUMBLINE ADVISERS

$568,260

0.10%

87,023

Blue Trust, Inc.

$560,848

0.10%

85,888

Diametric Capital, LP

$530,098

0.10%

81,179

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Thakore Nainoor	81,179	$530,098	100.0%	Defined

DEUTSCHE BANK AG\

$505,976

0.09%

77,485

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	1,477	$9,644	1.9%	Defined
DWS Investments UK Ltd	76,008	$496,332	98.1%	Defined

CITIGROUP INC

$483,963

0.09%

74,114

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	74,114	$483,963	100.0%	Defined

MANCHESTER FINANCIAL INC

$438,665

0.08%

67,177

MEMBERS WEALTH LLC

$435,962

0.08%

66,763

PRICE T ROWE ASSOCIATES INC /MD/

$422,941

0.08%

64,769

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	64,769	$422,941	100.0%	Defined

MORGAN STANLEY

$387,709

0.07%

59,374

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	23	$150	0.0%	Defined
MORGAN STANLEY & CO. LLC	21,045	$137,423	35.4%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	8,926	$58,286	15.0%	Defined
MORGAN STANLEY SMITH BARNEY LLC	6,562	$42,849	11.1%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	22,818	$149,001	38.4%	Defined

Virtus Investment Advisers, LLC

$387,065

0.07%

59,275

ADAR1 Capital Management, LLC

$351,314

0.06%

53,800

JANE STREET GROUP, LLC

$329,476

0.06%

50,456

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	50,413	$329,196	99.9%	Defined
Jane Street Global Trading, LLC	43	$280	0.1%	Defined

ALLIANCEBERNSTEIN L.P.

$319,578

0.06%

48,940

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	48,940	$319,578	100.0%	Defined

MetLife Investment Management, LLC

$300,282

0.05%

45,985

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	45,985	$300,282	100.0%	Defined

OSAIC HOLDINGS, INC.

$281,540

0.05%

43,115

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
OSAIC WEALTH, INC.	43,115	$281,540	100.0%	Defined

WINTON GROUP Ltd

$277,525

0.05%

42,500

Invesco Ltd.

$276,166

0.05%

42,292

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	11,252	$73,475	26.6%	Defined
Invesco Trust Co joint	31,040	$202,691	73.4%	Defined

GOLDMAN SACHS GROUP INC

$267,573

0.05%

40,976

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	40,976	$267,573	100.0%	Defined

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$261,526

0.05%

40,050

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	35,691	$233,062	89.1%	Defined
Global X Management (AUS) Ltd joint	4,359	$28,464	10.9%	Defined

Rafferty Asset Management, LLC

$245,012

0.04%

37,521

Next Capital Management LLC

$228,517

0.04%

34,995

AMERIFLEX GROUP, INC.

$219,394

0.04%

33,598

Vanguard Global Advisers, LLC

$211,624

0.04%

32,408

JPMORGAN CHASE & CO

$210,847

0.04%

32,289

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	32,270	$210,723	99.9%	Defined
J.P. Morgan Securities plc	19	$124	0.1%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$198,329

0.04%

30,372

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	30,372	$198,329	100.0%	Other

Rockefeller Capital Management L.P.

$195,900

0.04%

30,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ROCKEFELLER FINANCIAL LLC	30,000	$195,900	100.0%	Defined

Jones Hill Capital LP

$174,742

0.03%

26,760

BCV Asset Management Inc.

$172,163

0.03%

26,365

AXQ CAPITAL, LP

$164,379

0.03%

25,173

Robertson Stephens Wealth Management, LLC

$163,250

0.03%

25,000

Keating Financial Advisory Services, Inc.

$162,668

0.03%

24,911

Police & Firemen's Retirement System of New Jersey

$149,915

0.03%

22,958

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	22,958	$149,915	100.0%	Defined

Scientech Research LLC

$143,705

0.03%

22,007

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$134,583

0.02%

20,610

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	20,610	$134,583	100.0%	Defined

SEI INVESTMENTS CO

$133,865

0.02%

20,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI TRUST CO	20,500	$133,865	100.0%	Sole

BARCLAYS PLC

$130,560

0.02%

19,994

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	10,239	$66,860	51.2%	Defined
BARCLAYS CAPITAL INC.	9,755	$63,700	48.8%	Defined

PROFUND ADVISORS LLC

$129,659

0.02%

19,856

NEW YORK STATE COMMON RETIREMENT FUND

$125,376

0.02%

19,200

nVerses Capital, LLC

$118,852

0.02%

18,201

FMR LLC

$115,625

0.02%

17,707

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	6,311	$41,210	35.6%	Defined
STRATEGIC ADVISERS LLC	11,396	$74,415	64.4%	Defined

StoneX Group Inc.

$106,713

0.02%

16,342

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STONEX FINANCIAL INC.	16,342	$106,713	100.0%	Defined

MAGNOLIA CAPITAL ADVISORS LLC

$98,603

0.02%

15,100

VOYA INVESTMENT MANAGEMENT LLC

$96,931

0.02%

14,844

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	14,844	$96,931	100.0%	Defined

SBI Securities Co., Ltd.

$96,911

0.02%

14,841

INTECH INVESTMENT MANAGEMENT LLC

$89,696

0.02%

13,736

PRUDENTIAL FINANCIAL INC

$85,151

0.02%

13,040

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PGIM Quantitative Solutions LLC	13,040	$85,151	100.0%	Defined

Alpine Global Management, LLC

$81,625

0.01%

12,500

ROYAL BANK OF CANADA

$80,815

0.01%

12,376

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC CMA LTD.	2,376	$15,515	19.2%	Defined
RBC Capital Markets, LLC	10,000	$65,300	80.8%	Defined

Windsor Capital Management, LLC

$70,635

0.01%

10,817

ProShare Advisors LLC

$66,553

0.01%

10,192

Legal & General Group Plc

$49,334

0.01%

7,555

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	7,555	$49,334	100.0%	Defined

Ameritas Investment Partners, Inc.

$46,127

0.01%

7,064

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EATON VANCE MANAGEMENT	7,064	$46,127	100.0%	Other

Russell Investments Group, Ltd.

$41,621

0.01%

6,374

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	6,374	$41,621	100.0%	Defined

Allworth Financial LP

$19,590

0.00%

3,000

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