DSGN · Design Therapeutics, Inc. · Holdings

$14.63 -0.17 (-1.15%) At close · Sep 11

Russell 2000 member Rebalance outlook locked

Market Cap

$915.57M

62.58M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Quarter:

Holders: 136

Total Value: $649,053,611

Total Shares: 44,855,128

Showing 1–100 of 139 holdings by value · page 1 of 2

Institutional Ownership Trend

22 quarters

Holder Concentration

Across 136 13F filers · Δ vs Mar 31, 2026

Top Holder

14.6%

−2.6 pts

Top 5

39.1%

−5.5 pts

Top 10

62.3%

−3.9 pts

HHI

526

Broadly held−97

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +11

Institutional value: +60.6%

Shares held: +18.1%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Large Caption Management, LLC	+2,531,390	2,618,098
Small Trails Edge Capital Partners, LP	+1,149,269	2,001,282
Mid Logos Global Management LP	+1,050,000	3,000,000
Large Driehaus Capital Management LLC	+916,128	2,661,115
Mega BlackRock, Inc.	+526,260	2,660,024

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Small Almitas Capital LLC	−503,442	1,026,893
Large Point72 Asset Management, L.P.	−356,301	2,366,453
Mega D. E. Shaw & Co., Inc.	−274,625	195,645
Large Woodline Partners LP	−261,147	700,354
Mega CITADEL ADVISORS LLC	−135,642	95,871

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mid Frazier Life Sciences Management, L.P.	1,809,854	$26,188,587
Mid Sofinnova Investments, Inc.	865,135	$12,518,503
Mid Siren, L.L.C.	523,212	$7,570,877
Mid Eversept Partners, LP	190,000	$2,749,300
Small KVP Capital Advisors, LP	185,000	$2,676,950

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Large RA CAPITAL MANAGEMENT, L.P.	2,972,973	$31,632,432
Mid Kynam Capital Management, LP	784,606	$8,348,207
Large MARSHALL WACE, LLP	151,008	$1,606,725
Small Lynx1 Capital Management LP	119,516	$1,271,650
Mega JANE STREET GROUP, LLC	103,902	$1,105,516

Filter: New 28 Increased 61 Reduced 32 Sold out 17 Unchanged 15

Showing 100 of 139

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

SR One Capital Management, LP

$94,438,107

14.55%

6,526,476

Logos Global Management LP

$43,410,000

6.69%

3,000,000

BAKER BROS. ADVISORS LP

$38,756,882

5.97%

2,678,430

Driehaus Capital Management LLC

$38,506,334

5.93%

2,661,115

BlackRock, Inc.

$38,490,543

5.93%

2,660,024

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	14,667	$212,231	0.6%	Sole
BlackRock Asset Management Canada Ltd	2,821	$40,819	0.1%	Sole
BlackRock Investment Management, LLC	92,521	$1,338,778	3.5%	Sole
BLACKROCK ADVISORS LLC	70,700	$1,023,029	2.7%	Sole
BlackRock Fund Advisors	1,584,313	$22,925,009	59.6%	Sole
BlackRock Institutional Trust Company, N.A.	765,193	$11,072,342	28.8%	Sole
BlackRock Asset Management Ireland Ltd	48,320	$699,190	1.8%	Sole
Aperio Group, LLC	54,489	$788,455	2.0%	Sole
SpiderRock Advisors, LLC	27,000	$390,690	1.0%	Sole

Point72 Asset Management, L.P.

$34,242,574

5.28%

2,366,453

Trails Edge Capital Partners, LP

$28,958,550

4.46%

2,001,282

Frazier Life Sciences Management, L.P.

$26,188,587

4.03%

1,809,854

Vivo Capital, LLC

$23,338,706

3.60%

1,612,903

VANGUARD CAPITAL MANAGEMENT LLC

$22,732,688

3.50%

1,571,022

Caption Management, LLC

$21,705,000

3.34%

1,500,000

Caption Management, LLC

$16,178,878

2.49%

1,118,098

Almitas Capital LLC

$14,859,141

2.29%

1,026,893

GEODE CAPITAL MANAGEMENT, LLC

$13,868,293

2.14%

958,417

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	120,219	$1,739,568	12.5%	Defined
Held directly	838,198	$12,128,725	87.5%	Defined

Sofinnova Investments, Inc.

$12,518,503

1.93%

865,135

FMR LLC

$11,235,405

1.73%

776,462

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	776,364	$11,233,987	100.0%	Defined
STRATEGIC ADVISERS LLC	98	$1,418	0.0%	Defined

MORGAN STANLEY

$11,075,697

1.71%

765,425

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	7,923	$114,645	1.0%	Defined
MORGAN STANLEY & CO. LLC	31,784	$459,914	4.2%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	636,575	$9,211,240	83.2%	Defined
MORGAN STANLEY SMITH BARNEY LLC	18	$260	0.0%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	89,125	$1,289,638	11.6%	Defined

STATE STREET CORP

$10,653,117

1.64%

736,221

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	736,221	$10,653,117	100.0%	Defined

Woodline Partners LP

$10,134,122

1.56%

700,354

DIMENSIONAL FUND ADVISORS LP

$10,052,929

1.55%

694,743

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	4,923	$71,235	0.7%	Defined
DFA Australia Ltd.	21,093	$305,215	3.0%	Defined
Dimensional Ireland Ltd	54,578	$789,743	7.9%	Defined
Held directly	614,149	$8,886,736	88.4%	Sole

GOLDMAN SACHS GROUP INC

$9,500,769

1.46%

656,584

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	465,168	$6,730,980	70.8%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	191,416	$2,769,789	29.2%	Defined

JACOBS LEVY EQUITY MANAGEMENT, INC

$8,184,188

1.26%

565,597

ACADIAN ASSET MANAGEMENT LLC

$7,777,321

1.20%

537,479

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	537,479	$7,777,321	100.0%	Defined

Siren, L.L.C.

$7,570,877

1.17%

523,212

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	523,212	$7,570,877	100.0%	Defined

Qube Research & Technologies Ltd

$6,324,533

0.97%

437,079

RENAISSANCE TECHNOLOGIES LLC

$5,613,101

0.86%

387,913

KENNEDY CAPITAL MANAGEMENT LLC

$5,557,000

0.86%

384,036

NORTHERN TRUST CORP

$5,110,758

0.79%

353,197

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	299,469	$4,333,315	84.8%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	48,897	$707,539	13.8%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	4,831	$69,904	1.4%	Other

ALGERT GLOBAL LLC

$4,284,349

0.66%

296,085

ACUTA CAPITAL PARTNERS, LLC

$4,088,701

0.63%

282,564

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$3,925,190

0.60%

271,264

VANGUARD PORTFOLIO MANAGEMENT LLC

$3,638,365

0.56%

251,442

VANGUARD FIDUCIARY TRUST CO

$3,331,022

0.51%

230,202

PRUDENTIAL FINANCIAL INC

$3,243,739

0.50%

224,170

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PGIM Quantitative Solutions LLC	171,370	$2,479,723	76.4%	Defined
Prudential Trust Co	52,800	$764,016	23.6%	Defined

D. E. Shaw & Co., Inc.

$2,830,983

0.44%

195,645

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	184,630	$2,671,596	94.4%	Defined
D. E. Shaw Investment Management, L.L.C. joint	11,015	$159,387	5.6%	Defined

Eversept Partners, LP

$2,749,300

0.42%

190,000

KVP Capital Advisors, LP

$2,676,950

0.41%

185,000

J. Goldman & Co LP

$2,557,861

0.39%

176,770

MILLENNIUM MANAGEMENT LLC

$2,137,421

0.33%

147,714

RAYMOND JAMES FINANCIAL INC

$2,004,398

0.31%

138,521

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	98	$1,418	0.1%	Defined
ClariVest Asset Management LLC joint	138,423	$2,002,980	99.9%	Defined

Balyasny Asset Management L.P.

$1,607,660

0.25%

111,103

Elmind Capital, LP

$1,561,313

0.24%

107,900

Nuveen, LLC

$1,515,499

0.23%

104,734

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	4,617	$66,807	4.4%	Defined
TEACHERS ADVISORS, LLC joint	100,117	$1,448,692	95.6%	Defined

DAFNA Capital Management LLC

$1,484,622

0.23%

102,600

Bank of New York Mellon Corp

$1,332,237

0.21%

92,069

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	41,424	$599,405	45.0%	Defined
The Bank of New York Mellon	50,644	$732,818	55.0%	Defined
Held directly	1	$14	0.0%	Defined

China Universal Asset Management Co., Ltd.

$1,301,431

0.20%

89,940

CITADEL ADVISORS LLC

$1,186,120

0.18%

81,971

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	81,971	$1,186,120	100.0%	Defined

SummitTX Capital, L.P.

$1,167,193

0.18%

80,663

AMERICAN CENTURY COMPANIES INC

$1,111,657

0.17%

76,825

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	76,825	$1,111,657	100.0%	Defined

Palumbo Wealth Management LLC

$1,038,135

0.16%

71,744

AQR CAPITAL MANAGEMENT LLC

$1,029,016

0.16%

71,114

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RF&L WEALTH MANAGEMENT, LLC	17	$245	0.0%	Other
Compound Planning, Inc.	3	$43	0.0%	Other
Arax Advisory Partners	85	$1,229	0.1%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	98	$1,418	0.1%	Other
Stokes Family Office, LLC	4	$57	0.0%	Other
Held directly	70,907	$1,026,024	99.7%	Defined

AMERIPRISE FINANCIAL INC

$978,143

0.15%

67,598

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	67,598	$978,143	100.0%	Defined

Russell Investments Group, Ltd.

$967,447

0.15%

66,859

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC joint	30,939	$447,686	46.3%	Defined
Russell Investments Capital, LLC joint	23,131	$334,705	34.6%	Other
Russell Investments Trust Company joint	12,789	$185,056	19.1%	Other

ALPS ADVISORS INC

$917,267

0.14%

63,391

STATE OF WISCONSIN INVESTMENT BOARD

$857,333

0.13%

59,249

STRS OHIO

$730,735

0.11%

50,500

Verdad Advisers, LP

$688,149

0.11%

47,557

BANK OF AMERICA CORP /DE/

$632,743

0.10%

43,728

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	23,875	$345,471	54.6%	Defined
BOFA SECURITIES, INC.	19,853	$287,272	45.4%	Defined

ALLIANCEBERNSTEIN L.P.

$625,538

0.10%

43,230

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	43,230	$625,538	100.0%	Defined

ExodusPoint Capital Management, LP

$597,408

0.09%

41,286

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$578,800

0.09%

40,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	40,000	$578,800	100.0%	Other

RHUMBLINE ADVISERS

$551,770

0.09%

38,132

Vanguard Global Advisers, LLC

$514,176

0.08%

35,534

UBS Group AG

$502,990

0.08%

34,761

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	78	$1,128	0.2%	Defined
UBS AG	33,415	$483,515	96.1%	Defined
UBS Switzerland AG	1,262	$18,261	3.6%	Defined
UBS Securities LLC	6	$86	0.0%	Defined

Susquehanna Portfolio Strategies, LLC

$482,936

0.07%

33,375

TWO SIGMA INVESTMENTS, LP

$476,424

0.07%

32,925

CANADA PENSION PLAN INVESTMENT BOARD

$471,722

0.07%

32,600

OPPENHEIMER & CO INC

$464,298

0.07%

32,087

DEUTSCHE BANK AG\

$442,970

0.07%

30,613

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	583	$8,436	1.9%	Defined
DWS Investments UK Ltd	30,030	$434,534	98.1%	Defined

Virtus Investment Advisers, LLC

$431,596

0.07%

29,827

Squarepoint Ops LLC

$428,746

0.07%

29,630

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	29,630	$428,746	100.0%	Defined

Trexquant Investment LP

$407,330

0.06%

28,150

WELLS FARGO & COMPANY/MN

$406,201

0.06%

28,072

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	28,072	$406,201	100.0%	Defined

Corient Private Wealth LLC

$393,135

0.06%

27,169

BRIDGEWAY CAPITAL MANAGEMENT, LLC

$390,690

0.06%

27,000

Quantinno Capital Management LP

$389,257

0.06%

26,901

PRICE T ROWE ASSOCIATES INC /MD/

$370,518

0.06%

25,606

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	25,606	$370,518	100.0%	Defined

SEI INVESTMENTS CO

$329,047

0.05%

22,740

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	48	$694	0.2%	Sole
SEI TRUST CO	22,692	$328,353	99.8%	Sole

XTX Topco Ltd

$323,882

0.05%

22,383

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	22,383	$323,882	100.0%	Defined

AlphaCentric Advisors LLC

$311,640

0.05%

21,537

Invesco Ltd.

$310,076

0.05%

21,429

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	4,553	$65,881	21.2%	Defined
Invesco Trust Co joint	12,165	$176,027	56.8%	Defined
Invesco Capital Management LLC	4,711	$68,168	22.0%	Defined

PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO

$299,529

0.05%

20,700

MetLife Investment Management, LLC

$298,212

0.05%

20,609

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	20,609	$298,212	100.0%	Defined

WELLINGTON MANAGEMENT GROUP LLP

$280,718

0.04%

19,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	6,200	$89,714	32.0%	Defined
Wellington Trust Company, NA joint	13,200	$191,004	68.0%	Defined

JPMORGAN CHASE & CO

$244,599

0.04%

16,904

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	12,758	$184,608	75.5%	Defined
J.P. Morgan Investment Management Inc.	234	$3,385	1.4%	Defined
J.P. Morgan Securities plc	3,912	$56,606	23.1%	Defined

CITIGROUP INC

$229,782

0.04%

15,880

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	15,880	$229,782	100.0%	Defined

Creative Planning

$229,262

0.04%

15,844

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$226,455

0.03%

15,650

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	15,650	$226,455	100.0%	Other

NISA INVESTMENT ADVISORS, LLC

$214,503

0.03%

14,824

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$205,054

0.03%

14,171

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	14,171	$205,054	100.0%	Defined

CITADEL ADVISORS LLC

$201,133

0.03%

13,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	13,900	$201,133	100.0%	Defined

Y-Intercept (Hong Kong) Ltd

$186,807

0.03%

12,910

SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC

$181,641

0.03%

12,553

ROYAL BANK OF CANADA

$177,314

0.03%

12,254

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC CMA LTD.	933	$13,500	7.6%	Defined
RBC Capital Markets, LLC	11,321	$163,814	92.4%	Defined

BARCLAYS PLC

$169,400

0.03%

11,707

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	8,362	$120,998	71.4%	Defined
BARCLAYS CAPITAL INC.	3,345	$48,402	28.6%	Defined

NEW YORK STATE COMMON RETIREMENT FUND

$156,652

0.02%

10,826

GSA CAPITAL PARTNERS LLP

$149,446

0.02%

10,328

Police & Firemen's Retirement System of New Jersey

$142,515

0.02%

9,849

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	9,849	$142,515	100.0%	Defined

BNP PARIBAS ARBITRAGE, SA

$83,216

0.01%

5,751

Clearstead Advisors, LLC

$81,176

0.01%

5,610

Key facts CIK 1807120 CUSIP 25056L103 13F (30d) 80 filings 80 filers Visit website Investor relations