TCG Crossover Management, LLC

CIK

1839948

Location

PALO ALTO, CA

Portfolio Value

Mid $3,501,388,578

Diversification

Diversified

Filing Date

Global Rank

#669 / 8,232 ▲ 159

Top Industry

Biotechnology 93.1%

3Y Alpha vs SPY

+19.8%

Period ended 2 months ago

Filed May 15, 2026 · 30d

18 quarters · since Dec 2021

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+178.2%

SPY

+76.3%

Annualised alpha

+19.8%

Max drawdown

−57.4%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

49 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

20.6%

−12.1 pts

Top 5

44.3%

−8.2 pts

Top 10

60.9%

−4.9 pts

HHI

688

Diversified−578

Portfolio Trend

18 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$3,501,388,578	49

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

8 positions

Ticker	Company	Δ Shares	Shares	Value
IMVT	Immunovant, Inc.	+2,797,055	4,457,988	$110,736,421
RLAY	Relay Therapeutics, Inc.	+1,053,170	4,273,356	$42,519,892
MIRM	Mirum Pharmaceuticals, Inc.	+1,000,000	1,062,049	$98,112,086
TYRA	Tyra Biosciences, Inc.	+350,877	3,248,980	$124,435,934
AVTX	Avalo Therapeutics, Inc.	+255,383	738,383	$11,024,058
TRDA	Entrada Therapeutics, Inc.	+199,108	2,287,500	$28,868,250
RVMD	Revolution Medicines, Inc.	+140,000	576,473	$56,061,999
LBRX	Lb Pharmaceuticals Inc	+94,474	1,839,489	$45,361,798
No positions match the current search.

Trimmed

Positions the filer reduced

10 positions

Ticker	Company	Δ Shares	Shares	Value
OCUL	Ocular Therapeutix, Inc	−4,092,479	1,647,752	$13,956,459
TNGX	Tango Therapeutics, Inc.	−2,231,023	10,531,071	$220,310,005
LQDA	Liquidia Corp	−1,307,036	403,048	$15,211,031
COGT	Cogent Biosciences, Inc.	−921,268	4,946,894	$190,405,950
GPCR	Structure Therapeutics Inc.	−780,446	140,411	$6,767,810
ABVX	Abivax S.A.	−630,511	6,481,085	$721,668,814
UPB	Upstream Bio, Inc.	−562,823	181,063	$1,629,567
URGN	UroGen Pharma Ltd.	−311,982	405,365	$7,288,462
ARVN	Arvinas, Inc.	−278,755	2,387,461	$25,307,086
MNPR	Monopar Therapeutics	−9,812	132,103	$7,237,923
No positions match the current search.

New Positions

Positions the filer opened this quarter

11 positions

Ticker	Company	Shares	Value
BCRX	Biocryst Pharmaceuticals Inc	11,020,968	$104,919,615
VOR	Vor Biopharma Inc.	5,673,078	$101,207,711
IRON	Disc Medicine, Inc.	1,341,862	$85,798,656
SRZN	Surrozen, Inc./DE	1,473,101	$42,911,432
IPSC	Century Therapeutics, Inc.	17,754,430	$40,125,011
TECX	Tectonic Therapeutic, Inc.	1,204,891	$37,243,180
CATX	Perspective Therapeutics, Inc.	7,915,567	$33,007,914
ALXO	Alx Oncology Holdings Inc	13,011,849	$26,088,757
AGMB	Agomab Therapeutics NV	2,053,233	$21,538,414
CNTX	Context Therapeutics Inc.	2,682,696	$7,028,663
CGEM	Cullinan Therapeutics, Inc.	406,786	$5,780,429
No positions match the current search.

Sold Out

Positions the filer fully exited

3 positions

Ticker	Company	Shares	Value
EYPT	EyePoint, Inc.	3,572,335	$65,266,560
AGIO	Agios Pharmaceuticals, Inc.	1,181,841	$32,169,712
MAZE	Maze Therapeutics, Inc.	173,816	$7,201,196
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

49 positions · $3,501,388,578 total · as of Mar 31, 2026

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
ABVX	Abivax S.A. Healthcare	Reduced	6,481,085	-630,511	$721,668,814	−24.8%	20.61%
CGON	CG Oncology, Inc. Healthcare	Held	3,670,206	0	$248,399,542	+63.0%	7.09%
TNGX	Tango Therapeutics, Inc. Healthcare	Reduced	10,531,071	-2,231,023	$220,310,005	+94.8%	6.29%
COGT	Cogent Biosciences, Inc. Healthcare	Reduced	4,946,894	-921,268	$190,405,950	−8.7%	5.44%
CNTA	Centessa Pharmaceuticals plc Healthcare	Held	4,286,480	0	$170,258,985	+58.8%	4.86%
DNTH	Dianthus Therapeutics, Inc. /DE/ Healthcare	Held	1,676,624	0	$140,702,286	+103.6%	4.02%
TYRA	Tyra Biosciences, Inc. Healthcare	Added	3,248,980	+350,877	$124,435,934	+63.3%	3.55%
IMVT	Immunovant, Inc. Healthcare	Added	4,457,988	+2,797,055	$110,736,421	+162.3%	3.16%
BCRX	Biocryst Pharmaceuticals Inc Healthcare	NEW	11,020,968	NEW	$104,919,615	NEW	3.00%
VOR	Vor Biopharma Inc. Healthcare	NEW	5,673,078	NEW	$101,207,711	NEW	2.89%
MIRM	Mirum Pharmaceuticals, Inc. Healthcare	Added	1,062,049	+1,000,000	$98,112,086	+1901.8%	2.80%
SYRE	Spyre Therapeutics, Inc. Healthcare	Held	1,900,582	0	$95,865,356	+54.0%	2.74%
AMLX	Amylyx Pharmaceuticals, Inc. Healthcare	Held	6,243,812	0	$86,788,986	+15.1%	2.48%
IRON	Disc Medicine, Inc. Healthcare	NEW	1,341,862	NEW	$85,798,656	NEW	2.45%
DYN	Dyne Therapeutics, Inc. Healthcare	Held	4,615,144	0	$83,672,560	−7.3%	2.39%
GLUE	Monte Rosa Therapeutics, Inc. Healthcare	Held	4,622,151	0	$76,034,383	+4.9%	2.17%
SVRA	Savara Inc Healthcare	Held	12,362,205	0	$67,497,639	−9.5%	1.93%
RVMD	Revolution Medicines, Inc. Healthcare	Added	576,473	+140,000	$56,061,999	+61.3%	1.60%
KOD	Kodiak Sciences Inc. Healthcare	Held	1,445,538	0	$55,103,908	+36.3%	1.57%
LBRX	Lb Pharmaceuticals Inc Healthcare	Added	1,839,489	+94,474	$45,361,798	+16.8%	1.30%
SRZN	Surrozen, Inc./DE Healthcare	NEW	1,473,101	NEW	$42,911,432	NEW	1.23%
ADCT	ADC Therapeutics SA Healthcare	Held	11,390,175	0	$42,713,156	+6.2%	1.22%
RLAY	Relay Therapeutics, Inc. Healthcare	Added	4,273,356	+1,053,170	$42,519,892	+56.1%	1.21%
FULC	Fulcrum Therapeutics, Inc. Healthcare	Held	5,250,000	0	$40,267,500	−32.2%	1.15%
IPSC	Century Therapeutics, Inc. Healthcare	NEW	17,754,430	NEW	$40,125,011	NEW	1.15%
BHVN	Biohaven Ltd. Healthcare	Held	4,631,317	0	$39,180,941	−25.1%	1.12%
TECX	Tectonic Therapeutic, Inc. Healthcare	NEW	1,204,891	NEW	$37,243,180	NEW	1.06%
CATX	Perspective Therapeutics, Inc. Healthcare	NEW	7,915,567	NEW	$33,007,914	NEW	0.94%
XNCR	Xencor Inc Healthcare	Held	2,452,138	0	$29,572,784	−21.2%	0.84%
TRDA	Entrada Therapeutics, Inc. Healthcare	Added	2,287,500	+199,108	$28,868,250	+34.5%	0.82%
ALXO	Alx Oncology Holdings Inc Healthcare	NEW	13,011,849	NEW	$26,088,757	NEW	0.75%
ARVN	Arvinas, Inc. Healthcare	Reduced	2,387,461	-278,755	$25,307,086	−20.0%	0.72%
JANX	Janux Therapeutics, Inc. Healthcare	Held	1,789,617	0	$24,875,676	+0.7%	0.71%
AGMB	Agomab Therapeutics NV Healthcare	NEW	2,053,233	NEW	$21,538,414	NEW	0.62%
ALEC	Alector, Inc. Healthcare	Held	10,000,000	0	$21,500,000	+37.8%	0.61%
MBX	MBX Biosciences, Inc. Healthcare	Held	650,000	0	$19,402,500	−5.4%	0.55%
SLN	Silence Therapeutics plc Healthcare	Held	3,033,560	0	$15,986,861	−13.3%	0.46%
LQDA	Liquidia Corp Healthcare	Reduced	403,048	-1,307,036	$15,211,031	−74.2%	0.43%
OCUL	Ocular Therapeutix, Inc Healthcare	Reduced	1,647,752	-4,092,479	$13,956,459	−80.0%	0.40%
AVTX	Avalo Therapeutics, Inc. Healthcare	Added	738,383	+255,383	$11,024,058	+25.7%	0.31%
URGN	UroGen Pharma Ltd. Healthcare	Reduced	405,365	-311,982	$7,288,462	−56.6%	0.21%
MNPR	Monopar Therapeutics Healthcare	Reduced	132,103	-9,812	$7,237,923	−21.9%	0.21%
CNTX	Context Therapeutics Inc. Healthcare	NEW	2,682,696	NEW	$7,028,663	NEW	0.20%
GPCR	Structure Therapeutics Inc. Healthcare	Reduced	140,411	-780,446	$6,767,810	−89.4%	0.19%
CGEM	Cullinan Therapeutics, Inc. Healthcare	NEW	406,786	NEW	$5,780,429	NEW	0.17%
LONA	LeonaBio, Inc. Healthcare	Held	464,398	0	$4,774,011	+35.8%	0.14%
KRRO	Korro Bio, Inc. Healthcare	Held	416,301	0	$4,712,527	+41.3%	0.13%
UPB	Upstream Bio, Inc. Healthcare	Reduced	181,063	-562,823	$1,629,567	−91.9%	0.05%
VTGN	Vistagen Therapeutics, Inc. Healthcare	Held	2,676,580	0	$1,525,650	−13.6%	0.04%