TCG Crossover Management, LLC

CIK

1839948

Location

PALO ALTO, CA

Portfolio Value

Mid $3,501,388,578

Diversification

Diversified

Filing Date

Global Rank

#839 / 8,622 ▲ 120 · as of Mar 2026

Top Industry

Biotechnology 91.9%

3Y Alpha vs SPY

+33.3%

Period ended 4 months ago

Filed May 15, 2026 · 2mo

18 quarters · since Dec 2021

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.

Cloned portfolio

+245.3%

SPY

+67.9%

Annualised alpha

+32.3%

Max drawdown

−57.4%

Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 100% of reported value on average across 13 quarters. Past performance does not predict future results.

Portfolio Concentration

49 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

20.6%

−12.1 pts

Top 5

44.3%

−8.2 pts

Top 10

60.9%

−4.9 pts

HHI

688

Diversified−578

Portfolio Trend

18 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$3,501,388,578	49

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

8 positions

Ticker	Company	Δ Shares	Shares	Value
IMVT	Immunovant, Inc.	+2,797,055	4,457,988	$110,736,421
RLAY	Relay Therapeutics, Inc.	+1,053,170	4,273,356	$42,519,892
MIRM	Mirum Pharmaceuticals, Inc.	+1,000,000	1,062,049	$98,112,086
TYRA	Tyra Biosciences, Inc.	+350,877	3,248,980	$124,435,934
AVTX	Avalo Therapeutics, Inc.	+255,383	738,383	$11,024,058
TRDA	Entrada Therapeutics, Inc.	+199,108	2,287,500	$28,868,250
RVMD	Revolution Medicines, Inc.	+140,000	576,473	$56,061,999
LBRX	Lb Pharmaceuticals Inc	+94,474	1,839,489	$45,361,798
No positions match the current search.

Trimmed

Positions the filer reduced

10 positions

Ticker	Company	Δ Shares	Shares	Value
OCUL	Ocular Therapeutix, Inc	−4,092,479	1,647,752	$13,956,459
TNGX	Tango Therapeutics, Inc.	−2,231,023	10,531,071	$220,310,005
LQDA	Liquidia Corp	−1,307,036	403,048	$15,211,031
COGT	Cogent Biosciences, Inc.	−921,268	4,946,894	$190,405,950
GPCR	Structure Therapeutics Inc.	−780,446	140,411	$6,767,810
ABVX	Abivax S.A.	−630,511	6,481,085	$721,668,814
UPB	Upstream Bio, Inc.	−562,823	181,063	$1,629,567
URGN	UroGen Pharma Ltd.	−311,982	405,365	$7,288,462
ARVN	Arvinas, Inc.	−278,755	2,387,461	$25,307,086
MNPR	Monopar Therapeutics	−9,812	132,103	$7,237,923
No positions match the current search.

New Positions

Positions the filer opened this quarter

11 positions

Ticker	Company	Shares	Value
BCRX	Biocryst Pharmaceuticals Inc	11,020,968	$104,919,615
VOR	Vor Biopharma Inc.	5,673,078	$101,207,711
IRON	Disc Medicine, Inc.	1,341,862	$85,798,656
SRZN	Surrozen, Inc./DE	1,473,101	$42,911,432
IPSC	Century Therapeutics, Inc.	17,754,430	$40,125,011
TECX	Tectonic Therapeutic, Inc.	1,204,891	$37,243,180
CATX	Perspective Therapeutics, Inc.	7,915,567	$33,007,914
ALXO	Alx Oncology Holdings Inc	13,011,849	$26,088,757
AGMB	Agomab Therapeutics NV	2,053,233	$21,538,414
CNTX	Context Therapeutics Inc.	2,682,696	$7,028,663
CGEM	Cullinan Therapeutics, Inc.	406,786	$5,780,429
No positions match the current search.

Sold Out

Positions the filer fully exited

3 positions

Ticker	Company	Shares	Value
EYPT	EyePoint, Inc.	3,572,335	$65,266,560
AGIO	Agios Pharmaceuticals, Inc.	1,181,841	$32,169,712
MAZE	Maze Therapeutics, Inc.	173,816	$7,201,196
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

49 tracked positions · $3,501,388,578 total · filing declares 49 positions · $3,495,390,908 · as of Mar 31, 2026

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
ABVX	Abivax S.A. Healthcare	Reduced	6,481,085	-630,511	$721,668,814	−24.8%	20.61%
CGON	CG Oncology, Inc. Healthcare	Held	3,670,206	0	$248,399,542	+63.0%	7.09%
TNGX	Tango Therapeutics, Inc. Healthcare	Reduced	10,531,071	-2,231,023	$220,310,005	+94.8%	6.29%
COGT	Cogent Biosciences, Inc. Healthcare	Reduced	4,946,894	-921,268	$190,405,950	−8.7%	5.44%
CNTA	Centessa Pharmaceuticals plc Healthcare	Held	4,286,480	0	$170,258,985	+58.8%	4.86%
DNTH	Dianthus Therapeutics, Inc. /DE/ Healthcare	Held	1,676,624	0	$140,702,286	+103.6%	4.02%
TYRA	Tyra Biosciences, Inc. Healthcare	Added	3,248,980	+350,877	$124,435,934	+63.3%	3.55%
IMVT	Immunovant, Inc. Healthcare	Added	4,457,988	+2,797,055	$110,736,421	+162.3%	3.16%
BCRX	Biocryst Pharmaceuticals Inc Healthcare	NEW	11,020,968	NEW	$104,919,615	NEW	3.00%
VOR	Vor Biopharma Inc. Healthcare	NEW	5,673,078	NEW	$101,207,711	NEW	2.89%
MIRM	Mirum Pharmaceuticals, Inc. Healthcare	Added	1,062,049	+1,000,000	$98,112,086	+1901.8%	2.80%
SYRE	Spyre Therapeutics, Inc. Healthcare	Held	1,900,582	0	$95,865,356	+54.0%	2.74%
AMLX	Amylyx Pharmaceuticals, Inc. Healthcare	Held	6,243,812	0	$86,788,986	+15.1%	2.48%
IRON	Disc Medicine, Inc. Healthcare	NEW	1,341,862	NEW	$85,798,656	NEW	2.45%
DYN	Dyne Therapeutics, Inc. Healthcare	Held	4,615,144	0	$83,672,560	−7.3%	2.39%
GLUE	Monte Rosa Therapeutics, Inc. Healthcare	Held	4,622,151	0	$76,034,383	+4.9%	2.17%
SVRA	Savara Inc Healthcare	Held	12,362,205	0	$67,497,639	−9.5%	1.93%
RVMD	Revolution Medicines, Inc. Healthcare	Added	576,473	+140,000	$56,061,999	+61.3%	1.60%
KOD	Kodiak Sciences Inc. Healthcare	Held	1,445,538	0	$55,103,908	+36.3%	1.57%
LBRX	Lb Pharmaceuticals Inc Healthcare	Added	1,839,489	+94,474	$45,361,798	+16.8%	1.30%
SRZN	Surrozen, Inc./DE Healthcare	NEW	1,473,101	NEW	$42,911,432	NEW	1.23%
ADCT	ADC Therapeutics SA Healthcare	Held	11,390,175	0	$42,713,156	+6.2%	1.22%
RLAY	Relay Therapeutics, Inc. Healthcare	Added	4,273,356	+1,053,170	$42,519,892	+56.1%	1.21%
FULC	Fulcrum Therapeutics, Inc. Healthcare	Held	5,250,000	0	$40,267,500	−32.2%	1.15%
IPSC	Century Therapeutics, Inc. Healthcare	NEW	17,754,430	NEW	$40,125,011	NEW	1.15%
BHVN	Biohaven Ltd. Healthcare	Held	4,631,317	0	$39,180,941	−25.1%	1.12%
TECX	Tectonic Therapeutic, Inc. Healthcare	NEW	1,204,891	NEW	$37,243,180	NEW	1.06%
CATX	Perspective Therapeutics, Inc. Healthcare	NEW	7,915,567	NEW	$33,007,914	NEW	0.94%
XNCR	Xencor Inc Healthcare	Held	2,452,138	0	$29,572,784	−21.2%	0.84%
TRDA	Entrada Therapeutics, Inc. Healthcare	Added	2,287,500	+199,108	$28,868,250	+34.5%	0.82%
ALXO	Alx Oncology Holdings Inc Healthcare	NEW	13,011,849	NEW	$26,088,757	NEW	0.75%
ARVN	Arvinas, Inc. Healthcare	Reduced	2,387,461	-278,755	$25,307,086	−20.0%	0.72%
JANX	Janux Therapeutics, Inc. Healthcare	Held	1,789,617	0	$24,875,676	+0.7%	0.71%
AGMB	Agomab Therapeutics NV Healthcare	NEW	2,053,233	NEW	$21,538,414	NEW	0.62%
ALEC	Alector, Inc. Healthcare	Held	10,000,000	0	$21,500,000	+37.8%	0.61%
MBX	MBX Biosciences, Inc. Healthcare	Held	650,000	0	$19,402,500	−5.4%	0.55%
SLN	Silence Therapeutics plc Healthcare	Held	3,033,560	0	$15,986,861	−13.3%	0.46%
LQDA	Liquidia Corp Healthcare	Reduced	403,048	-1,307,036	$15,211,031	−74.2%	0.43%
OCUL	Ocular Therapeutix, Inc Healthcare	Reduced	1,647,752	-4,092,479	$13,956,459	−80.0%	0.40%
AVTX	Avalo Therapeutics, Inc. Healthcare	Added	738,383	+255,383	$11,024,058	+25.7%	0.31%
URGN	UroGen Pharma Ltd. Healthcare	Reduced	405,365	-311,982	$7,288,462	−56.6%	0.21%
MNPR	Monopar Therapeutics Healthcare	Reduced	132,103	-9,812	$7,237,923	−21.9%	0.21%
CNTX	Context Therapeutics Inc. Healthcare	NEW	2,682,696	NEW	$7,028,663	NEW	0.20%
GPCR	Structure Therapeutics Inc. Healthcare	Reduced	140,411	-780,446	$6,767,810	−89.4%	0.19%
CGEM	Cullinan Therapeutics, Inc. Healthcare	NEW	406,786	NEW	$5,780,429	NEW	0.17%
LONA	LeonaBio, Inc. Healthcare	Held	464,398	0	$4,774,011	+35.8%	0.14%
KRRO	Korro Bio, Inc. Healthcare	Held	416,301	0	$4,712,527	+41.3%	0.13%
UPB	Upstream Bio, Inc. Healthcare	Reduced	181,063	-562,823	$1,629,567	−91.9%	0.05%
VTGN	Vistagen Therapeutics, Inc. Healthcare	Held	2,676,580	0	$1,525,650	−13.6%	0.04%

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.