Commodore Capital LP

CIK

1831942

Location

NEW YORK, NY

Portfolio Value

Mid $1,622,545,162

Diversification

Diversified

Filing Date

Global Rank

#1,331 / 7,976 ▲ 229

Top Industry

Biotechnology 90.4%

3Y Alpha vs SPY

+1.2%

Period ended 9 months ago

Filed Nov 14, 2025 · 7mo

20 quarters · since Dec 2020

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+81.6%

SPY

+76.3%

Annualised alpha

+1.2%

Max drawdown

−53.5%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

34 positions · as of Sep 30, 2025 · Δ vs Jun 30, 2025

Top Position

7.5%

−1.7 pts

Top 5

32.3%

−6.4 pts

Top 10

58.2%

−6.8 pts

HHI

456

Diversified−81

Portfolio Trend

20 quarters · across all stocks

Sector Breakdown

As of Sep 30, 2025

Sector	% Portfolio	Value	Positions
Healthcare	99.5%	$1,614,595,162	33
Financial Services	0.5%	$7,950,000	1

Last Quarter's Activity

Export CSV

Sep 30, 2025 vs Jun 30, 2025

Added To

Positions the filer increased

9 positions

Ticker	Company	Δ Shares	Shares	Value
COGT	Cogent Biosciences, Inc.	+4,938,836	7,250,000	$104,110,000
RLAY	Relay Therapeutics, Inc.	+3,650,000	17,000,000	$88,740,000
SLNO	Soleno Therapeutics Inc	+740,000	1,350,000	$91,260,000
ALKS	Alkermes plc.	+646,754	3,096,754	$92,902,620
PHVS	Pharvaris N.V.	+507,043	2,418,476	$60,340,976
ORKA	Oruka Therapeutics, Inc.	+333,340	1,753,054	$33,711,228
TYRA	Tyra Biosciences, Inc.	+275,000	3,375,000	$47,216,250
NUVL	Nuvalent, Inc.	+25,000	1,400,000	$121,072,000
AGIO	Agios Pharmaceuticals, Inc.	+13,287	2,338,287	$93,858,840
No positions match the current search.

Trimmed

Positions the filer reduced

7 positions

Ticker	Company	Δ Shares	Shares	Value
VRDN	Viridian Therapeutics, Inc.DE	−1,675,000	3,200,000	$69,056,000
CNTA	Centessa Pharmaceuticals plc	−448,289	2,850,000	$69,112,500
CLDX	Celldex Therapeutics, Inc.	−421,665	3,028,335	$78,343,026
XENE	Xenon Pharmaceuticals Inc.	−325,000	2,700,000	$108,405,000
NRIX	Nurix Therapeutics, Inc.	−168,598	3,780,055	$34,927,708
PTGX	Protagonist Therapeutics, Inc	−50,000	1,025,000	$68,090,750
CBIO	Crescent Biopharma, Inc.	−2,857	450,829	$5,360,356
No positions match the current search.

New Positions

Positions the filer opened this quarter

7 positions

Ticker	Company	Shares	Value
AMLX	Amylyx Pharmaceuticals, Inc.	4,075,478	$55,385,746
TERN	Terns Pharmaceuticals, Inc.	5,700,000	$42,807,000
ASMB	Assembly Biosciences, Inc.	1,000,000	$25,600,000
LBRX	Lb Pharmaceuticals Inc	1,500,000	$23,685,000
PEPG	PepGen Inc.	2,357,319	$10,890,813
ENTA	Enanta Pharmaceuticals Inc	800,000	$9,576,000
SABS	SAB Biotherapeutics, Inc.	4,401,500	$8,847,015
No positions match the current search.

Sold Out

Positions the filer fully exited

3 positions

Ticker	Company	Shares	Value
SRRK	Scholar Rock Holding Corp	1,450,000	$51,359,000
VERA	Vera Therapeutics, Inc.	800,000	$18,848,000
NGNE	Neurogene Inc.	427,866	$6,396,596
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

34 positions · $1,622,545,162 total · as of Sep 30, 2025

All sectors Financial Services Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
NUVL	Nuvalent, Inc. Healthcare	Added	1,400,000	+25,000	$121,072,000	+15.4%	7.46%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Reduced	2,700,000	-325,000	$108,405,000	+14.5%	6.68%
COGT	Cogent Biosciences, Inc. Healthcare	Added	7,250,000	+4,938,836	$104,110,000	+527.4%	6.42%
ELVN	Enliven Therapeutics, Inc. Healthcare	Held	4,692,809	0	$96,061,800	+2.0%	5.92%
AGIO	Agios Pharmaceuticals, Inc. Healthcare	Added	2,338,287	+13,287	$93,858,840	+21.4%	5.78%
ALKS	Alkermes plc. Healthcare	Added	3,096,754	+646,754	$92,902,620	+32.5%	5.73%
SLNO	Soleno Therapeutics Inc Healthcare	Added	1,350,000	+740,000	$91,260,000	+78.6%	5.62%
RLAY	Relay Therapeutics, Inc. Healthcare	Added	17,000,000	+3,650,000	$88,740,000	+92.1%	5.47%
CLDX	Celldex Therapeutics, Inc. Healthcare	Reduced	3,028,335	-421,665	$78,343,026	+11.6%	4.83%
CNTA	Centessa Pharmaceuticals plc Healthcare	Reduced	2,850,000	-448,289	$69,112,500	+59.5%	4.26%
VRDN	Viridian Therapeutics, Inc.DE Healthcare	Reduced	3,200,000	-1,675,000	$69,056,000	+1.3%	4.26%
PTGX	Protagonist Therapeutics, Inc Healthcare	Reduced	1,025,000	-50,000	$68,090,750	+14.6%	4.20%
PHVS	Pharvaris N.V. Healthcare	Added	2,418,476	+507,043	$60,340,976	+79.4%	3.72%
AMLX	Amylyx Pharmaceuticals, Inc. Healthcare	NEW	4,075,478	NEW	$55,385,746	NEW	3.41%
TYRA	Tyra Biosciences, Inc. Healthcare	Added	3,375,000	+275,000	$47,216,250	+59.2%	2.91%
TERN	Terns Pharmaceuticals, Inc. Healthcare	NEW	5,700,000	NEW	$42,807,000	NEW	2.64%
KYMR	Kymera Therapeutics, Inc. Healthcare	Held	750,000	0	$42,450,000	+29.7%	2.62%
NRIX	Nurix Therapeutics, Inc. Healthcare	Reduced	3,780,055	-168,598	$34,927,708	−22.3%	2.15%
ORKA	Oruka Therapeutics, Inc. Healthcare	Added	1,753,054	+333,340	$33,711,228	+111.8%	2.08%
SYRE	Spyre Therapeutics, Inc. Healthcare	Held	1,988,084	0	$33,320,287	+12.0%	2.05%
DRUG	Bright Minds Biosciences Inc. Healthcare	Held	500,000	0	$30,330,000	+132.3%	1.87%
ASMB	Assembly Biosciences, Inc. Healthcare	NEW	1,000,000	NEW	$25,600,000	NEW	1.58%
CTMX	CytomX Therapeutics, Inc. Healthcare	Held	7,692,300	0	$24,538,437	+40.5%	1.51%
LBRX	Lb Pharmaceuticals Inc Healthcare	NEW	1,500,000	NEW	$23,685,000	NEW	1.46%
TNGX	Tango Therapeutics, Inc. Healthcare	Held	1,500,000	0	$12,600,000	+64.1%	0.78%
APGE	Apogee Therapeutics, Inc. Healthcare	Held	290,000	0	$11,521,700	−8.5%	0.71%
PEPG	PepGen Inc. Healthcare	NEW	2,357,319	NEW	$10,890,813	NEW	0.67%
ENTA	Enanta Pharmaceuticals Inc Healthcare	NEW	800,000	NEW	$9,576,000	NEW	0.59%
SABS	SAB Biotherapeutics, Inc. Healthcare	NEW	4,401,500	NEW	$8,847,015	NEW	0.55%
IKT	Inhibikase Therapeutics, Inc. Healthcare	Held	5,397,488	0	$8,743,930	−16.9%	0.54%
PCSC	Perceptive Capital Solutions Corp Financial Services	Held	750,000	0	$7,950,000	−0.2%	0.49%
AVTX	Avalo Therapeutics, Inc. Healthcare	Held	483,000	0	$6,138,930	+154.7%	0.38%
VTGN	Vistagen Therapeutics, Inc. Healthcare	Held	1,575,000	0	$5,591,250	+77.5%	0.34%
CBIO	Crescent Biopharma, Inc. Healthcare	Reduced	450,829	-2,857	$5,360,356	−26.8%	0.33%