Commodore Capital LP

CIK

1831942

Location

NEW YORK, NY

Portfolio Value

Mid $1,728,452,363

Diversification

Diversified

Filing Date

Global Rank

#1,306 / 8,623 ▲ 146 · as of Mar 2026

Top Industry

Biotechnology 85.0%

3Y Alpha vs SPY

+15.5%

Period ended 4 months ago

Filed May 15, 2026 · 3mo

22 quarters · since Dec 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.

Cloned portfolio

+140.0%

SPY

+65.3%

Annualised alpha

+15.6%

Max drawdown

−53.5%

Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 100% of reported value on average across 13 quarters. Past performance does not predict future results.

Portfolio Concentration

36 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

9.8%

−0.0 pts

Top 5

37.8%

+4.4 pts

Top 10

61.3%

+4.2 pts

HHI

493

Diversified+23

Portfolio Trend

22 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	99.7%	$1,723,372,363	35
Financial Services	0.3%	$5,080,000	1

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

7 positions

Ticker	Company	Δ Shares	Shares	Value
PEPG	PepGen Inc.	+1,075,000	4,475,000	$7,920,750
ANRO	Alto Neuroscience, Inc.	+900,000	2,723,196	$61,217,446
COGT	Cogent Biosciences, Inc.	+691,162	2,888,007	$111,159,389
ALKS	Alkermes plc.	+650,000	4,200,000	$148,512,000
NUVL	Nuvalent, Inc.	+283,600	833,600	$85,402,320
CLDX	Celldex Therapeutics, Inc.	+131,616	2,696,616	$85,536,659
PHVS	Pharvaris N.V.	+29,525	1,918,970	$54,210,902
No positions match the current search.

Trimmed

Positions the filer reduced

6 positions

Ticker	Company	Δ Shares	Shares	Value
PALI	Palisade Bio, Inc.	−4,263,938	7,181,062	$12,566,858
ELVN	Enliven Therapeutics, Inc.	−1,417,809	3,275,000	$128,380,000
XENE	Xenon Pharmaceuticals Inc.	−975,000	825,000	$47,973,750
TYRA	Tyra Biosciences, Inc.	−900,000	2,475,000	$94,792,500
SLNO	Soleno Therapeutics Inc	−547,568	652,432	$21,843,423
SYRE	Spyre Therapeutics, Inc.	−475,865	1,912,380	$96,460,447
No positions match the current search.

New Positions

Positions the filer opened this quarter

13 positions

Ticker	Company	Shares	Value
ERAS	Erasca, Inc.	3,175,000	$51,371,500
DMRA	Damora Therapeutics, Inc.	1,939,000	$50,220,100
DFTX	Definium Therapeutics, Inc.	2,000,000	$37,800,000
EYPT	EyePoint, Inc.	2,825,000	$36,414,250
CRVS	Corvus Pharmaceuticals, Inc.	2,258,735	$33,045,293
CATX	Perspective Therapeutics, Inc.	6,336,782	$26,424,380
OCUL	Ocular Therapeutix, Inc	2,575,000	$21,810,250
IPSC	Century Therapeutics, Inc.	8,695,652	$19,652,173
ZURA	Zura Bio Ltd	3,250,000	$19,337,500
KPTI	Karyopharm Therapeutics Inc.	1,950,000	$10,861,500
ANTX	AN2 Therapeutics, Inc.	2,333,713	$7,981,298
HLXC	Helix Acquisition Corp. III	500,000	$5,080,000
RLMD	Relmada Therapeutics, Inc.	633,901	$4,411,950
No positions match the current search.

Sold Out

Positions the filer fully exited

8 positions

Ticker	Company	Shares	Value
TERN	Terns Pharmaceuticals, Inc.	1,475,000	$59,590,000
ORKA	Oruka Therapeutics, Inc.	1,753,054	$53,135,066
PTGX	Protagonist Therapeutics, Inc	450,000	$39,303,000
CTMX	CytomX Therapeutics, Inc.	7,692,300	$32,769,198
CNTA	Centessa Pharmaceuticals plc	1,000,000	$25,010,000
REPL	Replimune Group, Inc.	1,425,000	$13,851,000
CTNM	Contineum Therapeutics, Inc.	816,326	$9,330,606
DRUG	Bright Minds Biosciences Inc.	18,851	$1,471,132
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

36 tracked positions · $1,728,452,363 total · filing declares 36 positions · $1,728,452,370 · as of Mar 31, 2026

All sectors Financial Services Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
RLAY	Relay Therapeutics, Inc. Healthcare	Held	17,000,000	0	$169,150,000	+17.6%	9.79%
ALKS	Alkermes plc. Healthcare	Added	4,200,000	+650,000	$148,512,000	+49.5%	8.59%
ELVN	Enliven Therapeutics, Inc. Healthcare	Reduced	3,275,000	-1,417,809	$128,380,000	+77.6%	7.43%
COGT	Cogent Biosciences, Inc. Healthcare	Added	2,888,007	+691,162	$111,159,389	+42.5%	6.43%
SYRE	Spyre Therapeutics, Inc. Healthcare	Reduced	1,912,380	-475,865	$96,460,447	+23.3%	5.58%
TYRA	Tyra Biosciences, Inc. Healthcare	Reduced	2,475,000	-900,000	$94,792,500	+6.8%	5.48%
CLDX	Celldex Therapeutics, Inc. Healthcare	Added	2,696,616	+131,616	$85,536,659	+22.8%	4.95%
NUVL	Nuvalent, Inc. Healthcare	Added	833,600	+283,600	$85,402,320	+54.4%	4.94%
AMLX	Amylyx Pharmaceuticals, Inc. Healthcare	Held	5,650,000	0	$78,535,000	+15.1%	4.54%
KYMR	Kymera Therapeutics, Inc. Healthcare	Held	750,000	0	$62,467,500	+7.0%	3.61%
ANRO	Alto Neuroscience, Inc. Healthcare	Added	2,723,196	+900,000	$61,217,446	+88.6%	3.54%
PHVS	Pharvaris N.V. Healthcare	Added	1,918,970	+29,525	$54,210,902	+3.4%	3.14%
ERAS	Erasca, Inc. Healthcare	NEW	3,175,000	NEW	$51,371,500	NEW	2.97%
DMRA	Damora Therapeutics, Inc. Healthcare	NEW	1,939,000	NEW	$50,220,100	NEW	2.91%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Reduced	825,000	-975,000	$47,973,750	−40.5%	2.78%
DFTX	Definium Therapeutics, Inc. Healthcare	NEW	2,000,000	NEW	$37,800,000	NEW	2.19%
LBRX	Lb Pharmaceuticals Inc Healthcare	Held	1,500,000	0	$36,990,000	+10.8%	2.14%
EYPT	EyePoint, Inc. Healthcare	NEW	2,825,000	NEW	$36,414,250	NEW	2.11%
NRIX	Nurix Therapeutics, Inc. Healthcare	Held	2,275,000	0	$35,262,500	−18.3%	2.04%
CRVS	Corvus Pharmaceuticals, Inc. Healthcare	NEW	2,258,735	NEW	$33,045,293	NEW	1.91%
ASMB	Assembly Biosciences, Inc. Healthcare	Held	1,000,000	0	$27,750,000	−18.4%	1.61%
CATX	Perspective Therapeutics, Inc. Healthcare	NEW	6,336,782	NEW	$26,424,380	NEW	1.53%
SLNO	Soleno Therapeutics Inc Healthcare	Reduced	652,432	-547,568	$21,843,423	−60.7%	1.26%
OCUL	Ocular Therapeutix, Inc Healthcare	NEW	2,575,000	NEW	$21,810,250	NEW	1.26%
IPSC	Century Therapeutics, Inc. Healthcare	NEW	8,695,652	NEW	$19,652,173	NEW	1.14%
ZURA	Zura Bio Ltd Healthcare	NEW	3,250,000	NEW	$19,337,500	NEW	1.12%
SABS	SAB Biotherapeutics, Inc. Healthcare	Held	4,401,500	0	$16,857,745	+2.4%	0.98%
PALI	Palisade Bio, Inc. Healthcare	Reduced	7,181,062	-4,263,938	$12,566,858	−53.3%	0.73%
KPTI	Karyopharm Therapeutics Inc. Healthcare	NEW	1,950,000	NEW	$10,861,500	NEW	0.63%
IKT	Inhibikase Therapeutics, Inc. Healthcare	Held	5,397,488	0	$9,067,779	−18.0%	0.52%
ANTX	AN2 Therapeutics, Inc. Healthcare	NEW	2,333,713	NEW	$7,981,298	NEW	0.46%
PEPG	PepGen Inc. Healthcare	Added	4,475,000	+1,075,000	$7,920,750	−64.2%	0.46%
AVTX	Avalo Therapeutics, Inc. Healthcare	Held	483,000	0	$7,211,190	−17.8%	0.42%
HLXC	Helix Acquisition Corp. III Financial Services	NEW	500,000	NEW	$5,080,000	NEW	0.29%
LONA	LeonaBio, Inc. Healthcare	Held	464,398	0	$4,774,011	+35.8%	0.28%
RLMD	Relmada Therapeutics, Inc. Healthcare	NEW	633,901	NEW	$4,411,950	NEW	0.26%

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.