NTLA · Intellia Therapeutics, Inc.
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AI Brief
Q2 FY26 earnings call · Aug 6, 2026TL;DR. Intellia reported positive Phase 3 HAELO data for lonvo-z in HAE supporting a potential first-half 2027 U.S. launch, resumed enrollment in nex-z Phase 3 ATTR trials and identified an HLA allele linked to liver transaminase elevations, and ended Q2 with $628.4M in cash (runway into 2028) but a wider net loss of $106.6M.
- + Expects FDA BLA acceptance for lonvo-z in 2H 2026 with a planned U.S. launch in 1H 2027, supported by completed commercial team hiring.
- + Resumed enrollment/dosing in both nex-z Phase 3 trials in Q2 with Magnitude-2 enrollment expected to complete in 2H 2026.
- + Identified HLA C0501 allele linked to severe liver transaminase elevations, enabling mitigation and patient selection, with management framing it as confidence-building.
- + Cash position strengthened to $628.4M with runway expected at least into 2028, following a $195M equity raise.
- − Collaboration revenue fell to $7.7M from $14.2M, driven by reduced revenue from Regeneron.
- − G&A expenses rose to $37.8M from $27.2M as commercial infrastructure and legal costs increased.
- − Disappointing competitor CardioTransform data raises uncertainty for combination ATTR strategy and may require Magnitude trial design changes.
AI-generated from the earnings call and 8-K · may contain errors · not investment advice
Equibles Rating
blended score · not investment adviceBlended from price, momentum, positioning, fundamentals & volatility · daily-close · not investment advice. Market backdrop is context, not part of the score.
Technicals
trend & momentum for long-term holders SellIllustrative technical + ownership context — a signal mix, not investment advice.
Key metrics
the company's own KPIs, from written earnings releases and filings| Metric | Latest | Period | YoY |
|---|---|---|---|
| all-cause mortality rate for matched NAC ATTR-CM cohort | 12.7 | the three months ended June 30, 2026 filing | — |
| all-cause mortality rate for nex-z treated ATTR-CM patients (post-hoc analysis) | 3.9 | the three months ended June 30, 2026 filing | — |
| mean monthly attack rate in the lonvo-z arm (HAELO, weeks 5 to 28) | 0.26 | the three months ended June 30, 2026 filing | — |
| mean monthly attack rate in the placebo arm (HAELO, weeks 5 to 28) | 2.1 | the three months ended June 30, 2026 filing | — |
| NAC matched ATTR-CM cohort size (post-hoc analysis) | 1,792 | the three months ended June 30, 2026 filing | — |
| patients enrolled in HAELO Phase 3 trial | 80 | the three months ended June 30, 2026 filing | — |
| patients entirely attack free and therapy free in the lonvo-z arm (HAELO, weeks 5 to 28) | 62% | the three months ended June 30, 2026 filing | — |
| patients entirely attack free and therapy free in the placebo arm (HAELO, weeks 5 to 28) | 11% | the three months ended June 30, 2026 filing | — |
| patients in MAGNITUDE Phase 3 trial | 1,200 | the three months ended June 30, 2026 filing | — |
| patients in MAGNITUDE-2 Phase 3 trial | 50 | the three months ended June 30, 2026 filing | — |
| Phase 1 ATTRv-PN patients reaching 36 months of follow-up | 12 | the three months ended June 30, 2026 filing | — |
| Phase 1 ATTRv-PN patients receiving a one-time dose of 0.3 mg/kg or higher | 33 | the three months ended June 30, 2026 filing | — |
Figures exactly as the company stated them in writing · click a metric with a to chart its history · period links open the stating document · "filing" marks figures stated in the 10-K/10-Q · YoY needs an exactly comparable prior-year period
Versus peers
Biotechnology — same industry group| Company | Mkt cap | YTD | Rev growth Y/Y | P/E | Short % shares |
|---|---|---|---|---|---|
|
NTLA
this stock
Intellia Therapeutics, Inc.
|
$1.65B | +34.1% | +16.9% | — | 33.3% |
|
VRTX
Vertex Pharmaceuticals Inc / Ma
|
$133.37B | +15.3% | +46.2% | 30.7 | 1.9% |
|
REGN
Regeneron Pharmaceuticals, Inc.
|
$81.13B | -1.8% | +20.8% | 19.5 | 2.5% |
|
MRNA
Moderna, Inc.
|
$79.40B | +553.0% | +4.3% | — | 8.2% |
|
CSLLY
Csl Ltd
|
$61.25B | — | — | — | 0.0% |
Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding
At a glance
key data from every sectionPerformance
| 5D | 20D | 120D | MTD | YTD | |
|---|---|---|---|---|---|
| NTLA | -2.2% | -4.9% | -12.8% | -5.3% | +34.2% |
| SPY | -0.7% | +0.1% | +12.2% | -0.6% | +11.8% |
| vs SPY | -1.5% | -5.0% | -25.0% | -4.7% | +22.3% |