KPTI · Karyopharm Therapeutics Inc. · Shareholders & Ownership
$0.48
-0.04 (-6.84%)
At close · Oct 26
Return incl. dividend (before tax)
Going-concern doubt
— flagged Aug 13, 2026
Substantial doubt about the company's ability to continue as a going concern.
“Based on our current business plan and current capital resources, combined with the uncertainty regarding the availability of additional funding or other strategic alternatives and considering our debt service obligations and financial covenant to maintain minimum liquidity, we have concluded that there is substantial doubt regarding our ability to continue as a going concern within one year after the date the accompanying condensed consolidated financial statements are issued.”View the 10-Q filed Aug 13, 2026
Market Cap
$11.74M
Shares
22.68M
Volume · Oct 26
1.37M
Avg daily vol (3M)
1.94M
Every disclosed holder of KPTI in one list: 13F institutions, Schedule 13D and 13G filers, insiders (Forms 3, 4 and 5) and registered funds, each from its own latest filing. Holders nest by CIK and SEC reporting links, never by name, and each is summed once.
Who Owns KPTI
13F quarter Sep 30, 2026, combined view: filers that have not filed yet carry their Jun 30, 2026 positionsNo chart: the summed disclosures exceed shares outstanding, so they are not parts of one whole.
| Holder group | Shares | % Out |
|---|---|---|
| Institutional (13F) | 21,148,454 | 93.24% |
| Insiders (Forms 3, 4, 5) | 824,231 | 3.63% |
| 13D/G-only blocks | 4,928,892 | 21.73% |
| Remaining | 4,220,117 | -18.61% |
| Registered funds (N-PORT, not summed) | 3,061,770 | 13.50% |
Shares outstanding: 22,681,460, the issuer's latest cover-page count restated onto today's split basis.
Remaining is negative: the summed disclosures exceed shares outstanding, as when filings are dated at different times or holders that do not disclose their links count the same shares. It is flagged, not clipped.
13D/G-only counts each filer's latest 13D or 13G that no 13F report of the listing contains, that names no 13F filer and that no counted insider files. Funds are never summed: their shares sit inside their advisers' 13F reports.
Holders of KPTI
| # | Holder | Shares | As of | Notes |
|---|---|---|---|---|
| 1 |
RA CAPITAL MANAGEMENT, L.P.
13F
CIK 1346824 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,917,354 | ||
| 1.1 |
RA CAPITAL MANAGEMENT, L.P.
13G
CIK 1346824 · Registered investment adviser · Jun 30, 2026
Rule 13d-1(c), passive investor, not summed
|
2,302,504 | ||
| 2 |
ADAGE CAPITAL PARTNERS GP, L.L.C.
13F
CIK 1165408 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,521,322 | ||
| 2.1 |
Adage Capital Management, L.P.
13G
CIK 1535978 · Investment adviser · Jun 30, 2026
Rule 13d-1(b), qualified institution, not summed
|
1,536,736 | ||
| 3 |
ACORN CAPITAL ADVISORS, LLC
13F
CIK 2054410 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,518,113 | ||
| 4 |
GOLDMAN SACHS GROUP INC
13F
CIK 886982 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,424,658 | ||
| 4.1 |
GOLDMAN SACHS GROUP INC
13G
CIK 886982 · Holding company · Jun 30, 2026
Rule 13d-1(b), qualified institution, not summed
|
1,429,197 | ||
| 4.2 |
Goldman Sachs Absolute Return Tracker Fund
Fund
S000020314 · Registered fund · Aug 31, 2026
GOLDMAN SACHS TRUST, not summed
|
4 | ||
| 5 |
BlackRock, Inc.
13F
CIK 2012383 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,418,799 | ||
| 5.1 |
BlackRock, Inc.
13G
CIK 2012383 · Holding company · Jun 30, 2026
Rule 13d-1(b), qualified institution, not summed
|
1,266,084 | ||
| 5.2 |
iShares Russell 2000 ETF
Fund
S000004344 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
490,317 | ||
| 5.3 |
iShares Russell 2000 Value ETF
Fund
S000004342 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
153,539 | ||
| 5.4 |
iShares Russell 2000 Growth ETF
Fund
S000004343 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
81,441 | ||
| 5.5 |
iShares Micro-Cap ETF
Fund
S000004439 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
66,938 | ||
| 6 |
|
1,297,297 | ||
| 7 |
|
1,021,668 | ||
| 8 |
J. Wood Capital Advisors LLC
13G
CIK 1586446 · Unknown · Oct 14, 2025
Rule 13d-1(c), passive investor
|
1,000,708 | ||
| 9 |
VANGUARD CAPITAL MANAGEMENT LLC
13F
CIK 2100119 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
958,979 | ||
| 10 |
Catalio Capital Management, LP
13F
CIK 1958125 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
940,855 | ||
| 11 |
Avidity Partners Management LP
13F
CIK 1791827 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
924,487 | ||
| 12 |
T. Rowe Price Investment Management, Inc.
13F
CIK 1897612 · Investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
786,309 | ||
| 13 |
TWO SIGMA INVESTMENTS, LP
13F
CIK 1179392 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
695,264 | ||
| 14 |
Kalehua Capital Management LLC
13F
CIK 2106181 · Exempt reporting adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
685,644 | ||
| 15 |
VANGUARD TOTAL STOCK MARKET INDEX FUND
Fund
S000002848 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
|
677,729 | ||
| 16 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC
13G
CIK 919185 · Registered investment adviser · Sep 30, 2025
Rule 13d-1(b), qualified institution
|
649,984 | ||
| 17 |
Opaleye Management Inc.
13G
CIK 1595855 · Registered investment adviser · Mar 31, 2026
Rule 13d-1(c), passive investor
|
619,089 | ||
| 18 |
NEA Management Company, LLC
13F
CIK 1512848 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
576,780 | ||
| 19 |
GEODE CAPITAL MANAGEMENT, LLC
13F
CIK 1214717 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
531,231 | ||
| 20 |
Ghisallo Capital Management LLC
13F
CIK 1825214 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
500,000 | ||
| 21 |
Soleus Capital Management, L.P.
13F
CIK 1802630 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
440,000 | ||
| 22 |
|
353,545 | ||
| 23 |
Palo Alto Investors LP
13G
CIK 1306923 · Registered investment adviser · Dec 31, 2023
Rule 13d-1(b), qualified institution
|
340,146 | ||
| 24 |
|
325,991 | ||
| 24.1 |
STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO
Fund
S000050332 · Registered fund · Jun 30, 2026
STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
|
6,800 | ||
| 24.2 |
State Street Total Return V.I.S. Fund
Fund
S000001637 · Registered fund · Jun 30, 2026
STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed
|
503 | ||
| 25 |
Affinity Asset Advisors, LLC
13F
CIK 1773195 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
312,500 | ||
| 26 |
Brevan Howard Capital Management LP
13F
CIK 1512857 · Exempt reporting adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
309,817 | ||
| 27 |
MILLENNIUM MANAGEMENT LLC
13F
CIK 1273087 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
305,676 | ||
| 28 |
Boxer Capital Management, LLC
13F
CIK 2018299 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
302,536 | ||
| 29 |
Davidson Kempner Capital Management LP
13F
CIK 1595082 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
300,000 | ||
| 30 |
ACADIAN ASSET MANAGEMENT LLC
13F
CIK 916542 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
298,997 | ||
| 31 |
SILVERARC CAPITAL MANAGEMENT, LLC
13F
CIK 1816307 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
297,460 | ||
| 32 |
Eversept Partners, LP
13F
CIK 1697013 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
276,174 | ||
| 33 |
|
269,747 | ||
| 34 |
VANGUARD EXTENDED MARKET INDEX FUND
Fund
S000002841 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
|
263,084 | ||
| 35 |
JPMORGAN CHASE & CO
13F
CIK 19617 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
|
207,609 | ||
| 36 |
MORGAN STANLEY
13F
CIK 895421 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
202,506 | ||
| 37 |
Trexquant Investment LP
13F
CIK 1633445 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
188,368 | ||
| 38 |
BNP PARIBAS ARBITRAGE, SA
13F
CIK 1166588 · Non-US institution · Jun 30, 2026
carried, not yet filed for the newest quarter
|
188,038 | ||
| 39 |
|
165,904 | ||
| 40 |
NORTHERN TRUST CORP
13F
CIK 73124 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
|
160,006 | ||
| 40.1 |
Small Cap Index Fund
Fund
S000001245 · Registered fund · Jun 30, 2026
Northern Funds, not summed
|
10,410 | ||
| 41 |
VANGUARD FIDUCIARY TRUST CO
13F
CIK 933478 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
145,401 | ||
| 42 |
VANGUARD PORTFOLIO MANAGEMENT LLC
13F
CIK 2100121 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
134,818 | ||
| 43 |
MARSHALL WACE, LLP
13F
CIK 1318757 · Exempt reporting adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
128,451 | ||
| 44 |
RENAISSANCE TECHNOLOGIES LLC
13F
CIK 1037389 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
108,214 | ||
| 45 |
|
107,940 | ||
| 46 |
C WorldWide Group Holding A/S
13F
CIK 1625244 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
100,000 | ||
| 47 |
|
94,632 | ||
| 48 |
|
94,398 | ||
| 49 |
Jump Financial, LLC
13F
CIK 1831577 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
94,000 | ||
| 50 |
Invesco Ltd.
13F
CIK 914208 · Investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
90,304 | ||
| 50.1 |
Invesco RAFI US 1500 Small-Mid ETF
Fund
S000013120 · Registered fund · Jul 31, 2026
Invesco Exchange-Traded Fund Trust, not summed
|
32,185 |
5 more nested rows are not shown here; Every filing lists them all.
Shares are restated onto today's split basis. Change compares each row with the same holder's previous filing in the same source; a dash means there is none to compare. Nested 13D/G, insider and fund rows are not summed, since a 13F report already holds them.
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Key facts
CIK
1503802
CUSIP
48576U205
13F (30d)
10 filings
10 filers
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