Avidity Partners Management LP
Filing Date
Global Rank
#3,052
/ 8,420
▼ 256
Top Industry
Biotechnology
65.4%
3Y Alpha vs SPY
-0.2%
Period ended 6 months ago
Filed Feb 17, 2026 · 4mo
24 quarters · since Mar 2020
Clone Performance
Jun 2023–Jun 2026 · vs SPYHypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.
Cloned portfolio
+75.6%
SPY
+76.3%
Annualised alpha
-0.2%
Max drawdown
−37.9%
Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.
Portfolio Concentration
39 positions · as of Dec 31, 2025 · Δ vs Sep 30, 2025Top Position
25.0%
−4.3 pts
Top 5
58.4%
+3.2 pts
Top 10
71.9%
+4.0 pts
HHI
1,095
Diversified−105
Portfolio Trend
24 quarters · across all stocks
Sector Breakdown
As of Dec 31, 2025| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 98.8% | $342,677,779 |
| Consumer Defensive | 1.2% | $4,015,800 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
5 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| JBIO | Jade Biosciences, Inc. | +273,522 | 1,400,708 | $21,612,924 | |
| CATX | Perspective Therapeutics, Inc. | +216,700 | 3,210,733 | $8,829,515 | |
| RGEN | Repligen Corp | +27,000 | 50,300 | $8,242,158 | |
| INSM | INSMED Inc | +6,100 | 17,700 | $3,080,508 | |
| MCK | Mckesson Corp | +3,720 | 9,520 | $7,809,160 | |
| No positions match the current search. | |||||
Trimmed
Positions the filer reduced
19 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| CNTX | Context Therapeutics Inc. | −3,477,000 | 5,504,855 | $8,092,136 | |
| SCYX | Scynexis Inc | −1,268,868 | 2,081,660 | $1,315,609 | |
| DNTH | Dianthus Therapeutics, Inc. /DE/ | −1,100,000 | 2,104,184 | $86,713,422 | |
| PFE | Pfizer Inc | −162,800 | 203,600 | $5,069,640 | |
| GMAB | Genmab A/S | −156,100 | 92,000 | $2,833,600 | |
| CGON | CG Oncology, Inc. | −128,200 | 1,472,699 | $61,146,462 | |
| PHAT | Phathom Pharmaceuticals, Inc. | −99,924 | 206,076 | $3,418,800 | |
| TEVA | Teva Pharmaceutical Industries Ltd | −92,700 | 417,300 | $13,023,933 | |
| MDT | Medtronic plc | −83,000 | 107,600 | $10,336,056 | |
| NTRA | Natera, Inc. | −58,600 | 11,800 | $2,703,262 | |
| BSX | Boston Scientific Corp | −49,800 | 114,500 | $10,917,575 | |
| DHR | Danaher Corp /De/ | −37,700 | 17,000 | $3,891,640 | |
| ACAD | Acadia Pharmaceuticals Inc | −37,100 | 106,900 | $2,855,299 | |
| KVUE | Kenvue Inc. | −32,400 | 232,800 | $4,015,800 | |
| TMO | Thermo Fisher Scientific Inc. | −12,200 | 6,700 | $3,882,315 | |
| EHC | Encompass Health Corp | −10,300 | 31,600 | $3,354,024 | |
| COR | Cencora, Inc. | −9,600 | 9,400 | $3,174,850 | |
| HQY | Healthequity, Inc. | −8,400 | 16,900 | $1,548,209 | |
| CI | Cigna Group | −5,000 | 11,600 | $3,192,668 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
11 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| ALNY | Alnylam Pharmaceuticals, Inc. | 21,000 | $8,350,650 | |
| ICLR | Icon PLC | 33,100 | $6,031,482 | |
| A | Agilent Technologies, Inc. | 41,500 | $5,646,905 | |
| CNC | Centene Corp | 119,400 | $4,913,310 | |
| NVO | Novo Nordisk A S | 67,300 | $3,424,224 | |
| WAT | Waters Corp /De/ | 8,100 | $3,076,623 | |
| ACHC | Acadia Healthcare Company, Inc. | 169,000 | $2,398,110 | |
| ITGR | Integer Holdings Corp | 29,800 | $2,337,214 | |
| PVLA | Palvella Therapeutics, Inc. | 19,300 | $2,020,131 | |
| IQV | Iqvia Holdings Inc. | 4,400 | $991,804 | |
| CORT | Corcept Therapeutics Inc | 22,000 | $765,600 | |
| No positions match the current search. | ||||
Sold Out
Positions the filer fully exited
13 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| BMY | Bristol Myers Squibb Co | 257,600 | $11,617,760 | |
| UNH | Unitedhealth Group Inc | 17,800 | $6,146,340 | |
| ARVN | Arvinas, Inc. | 698,363 | $5,950,052 | |
| JNJ | Johnson & Johnson | 26,800 | $4,969,256 | |
| ABBV | AbbVie Inc. | 19,800 | $4,584,492 | |
| CARL | Carlsmed, Inc. | 321,912 | $4,310,401 | |
| ARQT | Arcutis Biotherapeutics, Inc. | 214,400 | $4,041,440 | |
| EXAS | EXACT SCIENCES CORP | 73,600 | $4,026,656 | |
| ASND | Ascendis Pharma A/S | 14,500 | $2,882,745 | |
| BEAM | Beam Therapeutics Inc. | 112,000 | $2,718,240 | |
| WVE | Wave Life Sciences Ltd. | 297,500 | $2,177,700 | |
| XENE | Xenon Pharmaceuticals Inc. | 53,400 | $2,144,010 | |
| IMRX | Immuneering Corp | 90,900 | $636,300 | |
| No positions match the current search. | ||||
39 positions ·
$346,693,579 total
· as of Dec 31, 2025
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| DNTH |
Dianthus Therapeutics, Inc. /DE/
Healthcare
|
Reduced | 2,104,184 | $86,713,422 | 25.01% | |
| CGON |
CG Oncology, Inc.
Healthcare
|
Reduced | 1,472,699 | $61,146,462 | 17.64% | |
| JBIO |
Jade Biosciences, Inc.
Healthcare
|
Added | 1,400,708 | $21,612,924 | 6.23% | |
| ORKA |
Oruka Therapeutics, Inc.
Healthcare
|
Held | 660,424 | $20,017,451 | 5.77% | |
| TEVA |
Teva Pharmaceutical Industries Ltd
Healthcare
|
Reduced | 417,300 | $13,023,933 | 3.76% | |
| BSX |
Boston Scientific Corp
Healthcare
|
Reduced | 114,500 | $10,917,575 | 3.15% | |
| MDT |
Medtronic plc
Healthcare
|
Reduced | 107,600 | $10,336,056 | 2.98% | |
| CATX |
Perspective Therapeutics, Inc.
Healthcare
|
Added | 3,210,733 | $8,829,515 | 2.55% | |
| ALNY |
Alnylam Pharmaceuticals, Inc.
Healthcare
|
NEW | 21,000 | $8,350,650 | 2.41% | |
| RGEN |
Repligen Corp
Healthcare
|
Added | 50,300 | $8,242,158 | 2.38% | |
| CNTX |
Context Therapeutics Inc.
Healthcare
|
Reduced | 5,504,855 | $8,092,136 | 2.33% | |
| MCK |
Mckesson Corp
Healthcare
|
Added | 9,520 | $7,809,160 | 2.25% | |
| ICLR |
Icon PLC
Healthcare
|
NEW | 33,100 | $6,031,482 | 1.74% | |
| A |
Agilent Technologies, Inc.
Healthcare
|
NEW | 41,500 | $5,646,905 | 1.63% | |
| PFE |
Pfizer Inc
Healthcare
|
Reduced | 203,600 | $5,069,640 | 1.46% | |
| CNC |
Centene Corp
Healthcare
|
NEW | 119,400 | $4,913,310 | 1.42% | |
| KVUE |
Kenvue Inc.
Consumer Defensive
|
Reduced | 232,800 | $4,015,800 | 1.16% | |
| DHR |
Danaher Corp /De/
Healthcare
|
Reduced | 17,000 | $3,891,640 | 1.12% | |
| TMO |
Thermo Fisher Scientific Inc.
Healthcare
|
Reduced | 6,700 | $3,882,315 | 1.12% | |
| NVO |
Novo Nordisk A S
Healthcare
|
NEW | 67,300 | $3,424,224 | 0.99% | |
| PHAT |
Phathom Pharmaceuticals, Inc.
Healthcare
|
Reduced | 206,076 | $3,418,800 | 0.99% | |
| EHC |
Encompass Health Corp
Healthcare
|
Reduced | 31,600 | $3,354,024 | 0.97% | |
| CI |
Cigna Group
Healthcare
|
Reduced | 11,600 | $3,192,668 | 0.92% | |
| COR |
Cencora, Inc.
Healthcare
|
Reduced | 9,400 | $3,174,850 | 0.92% | |
| INSM |
INSMED Inc
Healthcare
|
Added | 17,700 | $3,080,508 | 0.89% | |
| WAT |
Waters Corp /De/
Healthcare
|
NEW | 8,100 | $3,076,623 | 0.89% | |
| ACAD |
Acadia Pharmaceuticals Inc
Healthcare
|
Reduced | 106,900 | $2,855,299 | 0.82% | |
| GMAB |
Genmab A/S
Healthcare
|
Reduced | 92,000 | $2,833,600 | 0.82% | |
| NTRA |
Natera, Inc.
Healthcare
|
Reduced | 11,800 | $2,703,262 | 0.78% | |
| IMUX |
Immunic, Inc.
Healthcare
|
Held | 4,699,411 | $2,509,485 | 0.72% | |
| ACHC |
Acadia Healthcare Company, Inc.
Healthcare
|
NEW | 169,000 | $2,398,110 | 0.69% | |
| ITGR |
Integer Holdings Corp
Healthcare
|
NEW | 29,800 | $2,337,214 | 0.67% | |
| ELVN |
Enliven Therapeutics, Inc.
Healthcare
|
Held | 140,300 | $2,160,620 | 0.62% | |
| PVLA |
Palvella Therapeutics, Inc.
Healthcare
|
NEW | 19,300 | $2,020,131 | 0.58% | |
| HQY |
Healthequity, Inc.
Healthcare
|
Reduced | 16,900 | $1,548,209 | 0.45% | |
| SCYX |
Scynexis Inc
Healthcare
|
Reduced | 2,081,660 | $1,315,609 | 0.38% | |
| IQV |
Iqvia Holdings Inc.
Healthcare
|
NEW | 4,400 | $991,804 | 0.29% | |
| KPTI |
Karyopharm Therapeutics Inc.
Healthcare
|
Held | 134,566 | $990,405 | 0.29% | |
| CORT |
Corcept Therapeutics Inc
Healthcare
|
NEW | 22,000 | $765,600 | 0.22% |