Opaleye Management Inc.
Filing Date
Global Rank
#2,103
/ 8,622
▲ 45
· as of Mar 2026
Top Industry
Biotechnology
57.5%
3Y Alpha vs SPY
+27.6%
Period ended 4 months ago
Filed May 15, 2026 · 2mo
25 quarters · since Mar 2020
Clone Performance
Jul 2023–Jul 2026 · vs SPYHypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.
Cloned portfolio
+214.2%
SPY
+67.9%
Annualised alpha
+27.6%
Max drawdown
−42.1%
Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 100% of reported value on average across 13 quarters. Past performance does not predict future results.
Portfolio Concentration
53 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025Top Position
13.4%
−12.1 pts
Top 5
45.6%
−6.3 pts
Top 10
61.6%
−4.6 pts
HHI
593
Diversified−353
Portfolio Trend
25 quarters · across all stocks
Sector Breakdown
As of Mar 31, 2026| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 100.0% | $743,833,828 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
18 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| CATX | Perspective Therapeutics, Inc. | +3,490,500 | 4,675,000 | $19,494,750 | |
| MGTX | MeiraGTx Holdings plc | +1,732,415 | 2,123,259 | $18,387,422 | |
| URGN | UroGen Pharma Ltd. | +1,161,577 | 1,430,000 | $25,711,400 | |
| QTTB | Q32 Bio Inc. | +1,042,865 | 1,256,228 | $8,064,983 | |
| ACOG | Alpha Cognition Inc. | +491,166 | 2,561,950 | $14,065,105 | |
| CABA | Cabaletta Bio, Inc. | +480,000 | 1,380,000 | $3,712,200 | |
| IRON | Disc Medicine, Inc. | +221,000 | 421,000 | $26,918,740 | |
| AVIR | Atea Pharmaceuticals, Inc. | +142,785 | 322,600 | $1,735,588 | |
| CBIO | Crescent Biopharma, Inc. | +134,315 | 1,312,615 | $24,112,737 | |
| LQDA | Liquidia Corp | +110,000 | 2,545,000 | $96,048,300 | |
| ENTA | Enanta Pharmaceuticals Inc | +50,000 | 125,000 | $1,578,750 | |
| SLGL | Sol-Gel Technologies Ltd. | +46,261 | 500,000 | $39,610,000 | |
| ALMS | Alumis Inc. | +15,000 | 550,000 | $12,116,500 | |
| RZLT | Rezolute, Inc. | +12,844 | 6,300,000 | $19,215,000 | |
| ZNTL | Zentalis Pharmaceuticals, Inc. | +11,750 | 1,412,656 | $3,305,615 | |
| XOMA | XOMA Royalty Corp | +7,410 | 300,000 | $9,411,000 | |
| STOK | Stoke Therapeutics, Inc. | +5,000 | 700,000 | $22,792,000 | |
| APGE | Apogee Therapeutics, Inc. | +1,743 | 390,000 | $32,826,300 | |
| No positions match the current search. | |||||
Trimmed
Positions the filer reduced
12 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| PLX | Protalix BioTherapeutics, Inc. | −2,138,176 | 340,000 | $737,800 | |
| HROW | Harrow, Inc. | −1,072,770 | 2,832,230 | $99,864,429 | |
| OCUL | Ocular Therapeutix, Inc | −995,000 | 600,000 | $5,082,000 | |
| CGON | CG Oncology, Inc. | −315,200 | 94,800 | $6,416,064 | |
| ANNX | Annexon, Inc. | −268,239 | 2,331,761 | $12,917,955 | |
| RYTM | Rhythm Pharmaceuticals, Inc. | −207,000 | 123,000 | $10,697,310 | |
| TECX | Tectonic Therapeutic, Inc. | −91,747 | 123,000 | $3,801,930 | |
| FBIO | Fortress Biotech, Inc. | −48,000 | 1,042,000 | $2,907,180 | |
| VYGR | Voyager Therapeutics, Inc. | −46,904 | 1,150,000 | $4,439,000 | |
| DERM | Journey Medical Corp | −15,000 | 960,000 | $4,502,400 | |
| PTGX | Protagonist Therapeutics, Inc | −5,000 | 100,000 | $10,540,000 | |
| CDXS | Codexis, Inc. | −4,738 | 6,785,000 | $11,059,550 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
9 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| ASRT | Assertio Holdings, Inc. | 265,707 | $5,064,375 | |
| EDIT | Editas Medicine, Inc. | 1,926,997 | $4,759,682 | |
| BDSX | Biodesix Inc | 238,047 | $3,451,681 | |
| NTLA | Intellia Therapeutics, Inc. | 245,000 | $3,140,900 | |
| LYEL | Lyell Immunopharma, Inc. | 79,097 | $1,586,685 | |
| NXTC | NextCure, Inc. | 141,181 | $1,507,813 | |
| FDMT | 4D Molecular Therapeutics, Inc. | 112,291 | $1,045,429 | |
| BBOT | BridgeBio Oncology Therapeutics, Inc. | 53,282 | $476,873 | |
| LBRX | Lb Pharmaceuticals Inc | 14,506 | $357,717 | |
| No positions match the current search. | ||||
Sold Out
Positions the filer fully exited
6 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| ALKS | Alkermes plc. | 490,000 | $13,710,200 | |
| GOSS | Gossamer Bio, Inc. | 2,720,000 | $8,432,000 | |
| KPTI | Karyopharm Therapeutics Inc. | 930,000 | $6,844,800 | |
| ZYME | Zymeworks Inc. | 108,929 | $2,868,100 | |
| BBIO | BridgeBio Pharma, Inc. | 18,319 | $1,401,220 | |
| SLN | Silence Therapeutics plc | 78,926 | $479,870 | |
| No positions match the current search. | ||||
53 tracked positions ·
$743,833,828 total
· as of Mar 31, 2026
Showing 1–50
of 53 positions by value
· page 1 of 2
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| HROW |
Harrow, Inc.
Healthcare
|
Reduced | 2,832,230 | $99,864,429 | 13.43% | |
| LQDA |
Liquidia Corp
Healthcare
|
Added | 2,545,000 | $96,048,300 | 12.91% | |
| ETON |
Eton Pharmaceuticals, Inc.
Healthcare
|
Held | 2,860,000 | $70,584,800 | 9.49% | |
| SLGL |
Sol-Gel Technologies Ltd.
Healthcare
|
Added | 500,000 | $39,610,000 | 5.33% | |
| APGE |
Apogee Therapeutics, Inc.
Healthcare
|
Added | 390,000 | $32,826,300 | 4.41% | |
| IRON |
Disc Medicine, Inc.
Healthcare
|
Added | 421,000 | $26,918,740 | 3.62% | |
| URGN |
UroGen Pharma Ltd.
Healthcare
|
Added | 1,430,000 | $25,711,400 | 3.46% | |
| CBIO |
Crescent Biopharma, Inc.
Healthcare
|
Added | 1,312,615 | $24,112,737 | 3.24% | |
| STOK |
Stoke Therapeutics, Inc.
Healthcare
|
Added | 700,000 | $22,792,000 | 3.06% | |
| CATX |
Perspective Therapeutics, Inc.
Healthcare
|
Added | 4,675,000 | $19,494,750 | 2.62% | |
| RZLT |
Rezolute, Inc.
Healthcare
|
Added | 6,300,000 | $19,215,000 | 2.58% | |
| MGTX |
MeiraGTx Holdings plc
Healthcare
|
Added | 2,123,259 | $18,387,422 | 2.47% | |
| TGTX |
Tg Therapeutics, Inc.
Healthcare
|
Held | 535,000 | $17,772,700 | 2.39% | |
| SNWV |
SANUWAVE Health, Inc.
Healthcare
|
Held | 981,267 | $16,966,106 | 2.28% | |
| EWTX |
Edgewise Therapeutics, Inc.
Healthcare
|
Held | 500,000 | $15,750,000 | 2.12% | |
| ACOG |
Alpha Cognition Inc.
Healthcare
|
Reduced | 2,561,950 | $14,065,105 | 1.89% | |
| ANNX |
Annexon, Inc.
Healthcare
|
Reduced | 2,331,761 | $12,917,955 | 1.74% | |
| ALMS |
Alumis Inc.
Healthcare
|
Added | 550,000 | $12,116,500 | 1.63% | |
| CDXS |
Codexis, Inc.
Healthcare
|
Reduced | 6,785,000 | $11,059,550 | 1.49% | |
| RYTM |
Rhythm Pharmaceuticals, Inc.
Healthcare
|
Reduced | 123,000 | $10,697,310 | 1.44% | |
| PTGX |
Protagonist Therapeutics, Inc
Healthcare
|
Reduced | 100,000 | $10,540,000 | 1.42% | |
| RVMD |
Revolution Medicines, Inc.
Healthcare
|
Held | 100,000 | $9,725,000 | 1.31% | |
| XOMA |
XOMA Royalty Corp
Healthcare
|
Added | 300,000 | $9,411,000 | 1.27% | |
| QTTB |
Q32 Bio Inc.
Healthcare
|
Added | 1,256,228 | $8,064,983 | 1.08% | |
| MBX |
MBX Biosciences, Inc.
Healthcare
|
Held | 260,000 | $7,761,000 | 1.04% | |
| RLMD |
Relmada Therapeutics, Inc.
Healthcare
|
Held | 935,000 | $6,507,600 | 0.87% | |
| CGON |
CG Oncology, Inc.
Healthcare
|
Reduced | 94,800 | $6,416,064 | 0.86% | |
| JBIO |
Jade Biosciences, Inc.
Healthcare
|
Held | 427,608 | $6,007,892 | 0.81% | |
| IRD |
Opus Genetics, Inc.
Healthcare
|
Held | 1,120,000 | $5,096,000 | 0.69% | |
| OCUL |
Ocular Therapeutix, Inc
Healthcare
|
Reduced | 600,000 | $5,082,000 | 0.68% | |
| ASRT |
Assertio Holdings, Inc.
Healthcare
|
NEW | 265,707 | $5,064,375 | 0.68% | |
| EDIT |
Editas Medicine, Inc.
Healthcare
|
NEW | 1,926,997 | $4,759,682 | 0.64% | |
| STRO |
Sutro Biopharma, Inc.
Healthcare
|
Held | 190,671 | $4,749,614 | 0.64% | |
| DERM |
Journey Medical Corp
Healthcare
|
Reduced | 960,000 | $4,502,400 | 0.61% | |
| VYGR |
Voyager Therapeutics, Inc.
Healthcare
|
Reduced | 1,150,000 | $4,439,000 | 0.60% | |
| TRVI |
Trevi Therapeutics, Inc.
Healthcare
|
Held | 345,100 | $4,117,043 | 0.55% | |
| TECX |
Tectonic Therapeutic, Inc.
Healthcare
|
Reduced | 123,000 | $3,801,930 | 0.51% | |
| CABA |
Cabaletta Bio, Inc.
Healthcare
|
Added | 1,380,000 | $3,712,200 | 0.50% | |
| BDSX |
Biodesix Inc
Healthcare
|
NEW | 238,047 | $3,451,681 | 0.46% | |
| RCKT |
Rocket Pharmaceuticals, Inc.
Healthcare
|
Held | 955,000 | $3,418,900 | 0.46% | |
| ZNTL |
Zentalis Pharmaceuticals, Inc.
Healthcare
|
Added | 1,412,656 | $3,305,615 | 0.44% | |
| NTLA |
Intellia Therapeutics, Inc.
Healthcare
|
NEW | 245,000 | $3,140,900 | 0.42% | |
| FBIO |
Fortress Biotech, Inc.
Healthcare
|
Reduced | 1,042,000 | $2,907,180 | 0.39% | |
| RIGL |
Rigel Pharmaceuticals Inc
Healthcare
|
Held | 70,000 | $1,892,800 | 0.25% | |
| AVIR |
Atea Pharmaceuticals, Inc.
Healthcare
|
Added | 322,600 | $1,735,588 | 0.23% | |
| LYEL |
Lyell Immunopharma, Inc.
Healthcare
|
NEW | 79,097 | $1,586,685 | 0.21% | |
| ENTA |
Enanta Pharmaceuticals Inc
Healthcare
|
Added | 125,000 | $1,578,750 | 0.21% | |
| NXTC |
NextCure, Inc.
Healthcare
|
NEW | 141,181 | $1,507,813 | 0.20% | |
| FDMT |
4D Molecular Therapeutics, Inc.
Healthcare
|
NEW | 112,291 | $1,045,429 | 0.14% | |
| PLX |
Protalix BioTherapeutics, Inc.
Healthcare
|
Reduced | 340,000 | $737,800 | 0.10% |
Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.