Opaleye Management Inc.

Registered adviser

CIK

1595855

Location

Boston, MA

Portfolio Value

Mid $1,089,799,211

Diversification

Diversified

Filing Date

Global Rank

#2,367 / 8,817 ▲ 437

Top Industry

Biotechnology 62.3%

Period ended 4 months ago

Filed Aug 14, 2026 · 2mo

26 quarters · since Mar 2020

Regulatory profile

From Form ADV, the SEC filer profile, 13D/13G type codes and N-CEN, never from the name.

Holder type

Registered adviser

Form ADV roster, Oct 1, 2026

Form ADV adviser

CRD 124513

Roster of Oct 1, 2026

Regulatory AUM

$802,773,181

Main clients

Pooled investment vehicles (98% of AUM)

Private funds

1 fund · Hedge funds

Focus by fund count, roster of Oct 1, 2026

$789,221,306 gross assets

Private funds on Schedule D 7.B.(1)

As filed Mar 26, 2024; SEC's bulk Form ADV archive ends with 2024 filings.

$421,822,670 gross assets in 1 fund Hedge funds $421,822,670 (1)

Form ADV history

Monthly rosters from Dec 2019; each row is a run with the same figures, newest first.

Rosters	Regulatory AUM	Main clients
Mar 2026 to Oct 2026	$802,773,181	Pooled investment vehicles (98%)
Apr 2025 to Feb 2026	$639,571,499	Pooled investment vehicles (97%)
Apr 2024 to Mar 2025	$432,480,569	Pooled investment vehicles (98%)
May 2023 to Mar 2024	$421,979,116	Pooled investment vehicles (96%)
Apr 2023	$421,979,116	Pooled investment vehicles (96%)
Nov 2022 to Mar 2023	$597,658,928	Pooled investment vehicles (96%)

4 earlier changes not shown.

Portfolio style

Measured from the filed 13F common-share book for Jun 30, 2026, never from the firm's own description.

Style

Concentrated

The top 10 positions are 65.6% of the book (60%+)

Turnover

Medium turnover

48.1% over the last four quarters (30% to under 100%)

Horizon

Horizon unknown

The value-weighted holding period is at least 11.9 quarters, but 11.4% of the book was already held when coverage starts

Closest benchmark: the Russell 2000 as of 2026-06-30, active share 97.8%; sector active share 90.9% against the combined 13F book's sector weights.

Over time 26 measured quarters

How the bands are measured

Style bands measure the filed 13F common-share book each closed quarter, tested in this order. Unknown: under $10,000,000 of valued equity or 5 stocks. Index-like (100+ stocks): active share of 20% or less against the closest benchmark, which is the S&P 500, S&P MidCap 400, S&P SmallCap 600, Russell 1000, Russell 2000, Nasdaq-100 or Dow Jones Industrial Average (weighted by an index-tracking fund's reported holdings or the index's constituents nearest the quarter end, over the names resolved to companies, and only when those are 90%+ of its weight) or every 13F filer's combined book, or index series holding 80%+ of the registered fund assets it advises (N-CEN) and equal to 50%+ of its book. Systematic-like: 500+ stocks, 100%+ annual turnover and a top 10 weight of 25% or less. Concentrated: a top 10 weight of 60%+ or 12 or fewer effective positions. Diversified active: none of these. Turnover is the smaller of buys and sells over average equity value, summed over four quarters: low under 30%, high 100%+. Horizon is the value-weighted number of quarters each position has been held: short under 4, long 12+.

Clone Performance

Build a hypothetical price-return history from this filer's public 13F holdings.

View clone backtest

Portfolio Concentration

58 tracked positions · as of Jun 30, 2026 · Δ vs Mar 31, 2026

Top Position

17.9%

+4.2 pts

Top 5

47.4%

+0.9 pts

Top 10

65.6%

+2.8 pts

HHI

670

Diversified+55

Portfolio Trend

26 quarters · across all stocks

Sector Breakdown

As of Jun 30, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$1,089,799,211	58

Last Quarter's Activity

Export CSV

Jun 30, 2026 vs Mar 31, 2026

Added To

Positions the filer increased

15 positions

Ticker	Company	Δ Shares	Shares	Value
CABA	Cabaletta Bio, Inc.	+2,483,800	3,863,800	$12,016,418
EDIT	Editas Medicine, Inc.	+1,934,933	3,861,930	$12,512,653
MGTX	MeiraGTx Holdings plc	+1,426,741	3,550,000	$47,960,500
BBOT	BridgeBio Oncology Therapeutics, Inc.	+646,718	700,000	$5,334,000
IRON	Disc Medicine, Inc.	+434,000	855,000	$62,534,700
ACOG	Alpha Cognition Inc.	+333,517	2,895,467	$20,905,271
LYEL	Lyell Immunopharma, Inc.	+264,928	344,025	$4,833,551
FDMT	4D Molecular Therapeutics, Inc.	+222,146	334,437	$4,448,012
RCKT	Rocket Pharmaceuticals, Inc.	+45,000	1,000,000	$3,420,000
—		+38,374	338,374	$0
VYGR	Voyager Therapeutics, Inc.	+35,000	1,185,000	$4,147,500
URGN	UroGen Pharma Ltd.	+9,996	1,439,996	$52,991,852
CBIO	Crescent Biopharma, Inc.	+6,736	1,319,351	$23,748,318
NTLA	Intellia Therapeutics, Inc.	+5,000	250,000	$4,230,000
IRD	Opus Genetics, Inc.	+5,000	1,125,000	$4,623,750
No positions match the current search.

Trimmed

Positions the filer reduced

13 positions

Ticker	Company	Δ Shares	Shares	Value
SNWV	SANUWAVE Health, Inc.	−675,127	306,140	$3,061,400
ANNX	Annexon, Inc.	−617,310	1,714,451	$9,789,515
DERM	Journey Medical Corp	−610,000	350,000	$2,478,000
HROW	Harrow, Inc.	−432,230	2,400,000	$101,928,000
QTTB	Q32 Bio Inc.	−325,228	931,000	$11,860,940
JBIO	Jade Biosciences, Inc.	−282,608	145,000	$3,221,900
FBIO	Fortress Biotech, Inc.	−152,000	890,000	$2,723,400
LQDA	Liquidia Corp	−97,500	2,447,500	$195,139,175
AVIR	Atea Pharmaceuticals, Inc.	−87,600	235,000	$1,092,750
CGON	CG Oncology, Inc.	−77,011	17,789	$1,263,908
BDSX	Biodesix Inc	−58,047	180,000	$4,059,000
TRVI	Trevi Therapeutics, Inc.	−35,100	310,000	$5,781,500
RYTM	Rhythm Pharmaceuticals, Inc.	−500	122,500	$13,601,175
No positions match the current search.

New Positions

Positions the filer opened this quarter

13 positions

Ticker	Company	Shares	Value
IMMX	Immix Biopharma, Inc.	2,345,000	$24,176,950
GLUE	Monte Rosa Therapeutics, Inc.	745,000	$18,029,000
REPL	Replimune Group, Inc.	1,384,993	$15,331,872
VSTM	Verastem, Inc.	1,800,000	$6,876,000
PHAT	Phathom Pharmaceuticals, Inc.	185,589	$2,013,640
INBX	Inhibrx Biosciences, Inc.	20,291	$1,922,572
COAG	Hemab Therapeutics Holdings, Inc.	47,652	$1,750,257
TRAX	First Tracks Biotherapeutics, Inc.	65,000	$1,307,800
BHVN	Biohaven Ltd.	77,915	$1,159,375
KTTA	Pasithea Therapeutics Corp.	2,050,000	$1,055,750
ADCT	ADC Therapeutics SA	700,000	$749,000
OKYO	OKYO Pharma Ltd	375,204	$562,806
PTN	Palatin Technologies Inc	20,500	$221,195
No positions match the current search.

Sold Out

Positions the filer fully exited

8 positions

Ticker	Company	Shares	Value
CATX	Perspective Therapeutics, Inc.	4,675,000	$19,494,750
STRO	Sutro Biopharma, Inc.	190,671	$4,749,614
TECX	Tectonic Therapeutic, Inc.	123,000	$3,801,930
RIGL	Rigel Pharmaceuticals Inc	70,000	$1,892,800
NXTC	NextCure, Inc.	141,181	$1,507,813
PLX	Protalix BioTherapeutics, Inc.	340,000	$737,800
LBRX	Lb Pharmaceuticals Inc	14,506	$357,717
—		265,707	$0
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

58 tracked positions · $1,089,799,211 total · filing declares 58 positions · $1,104,182,260 · as of Jun 30, 2026

All sectors Healthcare

Showing 1–50 of 58 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	Held (qtrs)	Est. cost/share	% of Portfolio
LQDA	Liquidia Corp Healthcare	Reduced	2,447,500	-97,500	$195,139,175	+103.2%	19	$13.02	17.91%
ETON	Eton Pharmaceuticals, Inc. Healthcare	Held	2,860,000	0	$103,532,000	+46.7%	26+	before history	9.50%
HROW	Harrow, Inc. Healthcare	Reduced	2,400,000	-432,230	$101,928,000	+2.1%	25	$6.44	9.35%
IRON	Disc Medicine, Inc. Healthcare	Added	855,000	+434,000	$62,534,700	+132.3%	6	$65.04	5.74%
URGN	UroGen Pharma Ltd. Healthcare	Added	1,439,996	+9,996	$52,991,852	+106.1%	3	$20.40	4.86%
		Held	390,000	0	$51,764,700	+57.7%	4	$39.93	4.75%
MGTX	MeiraGTx Holdings plc Healthcare	Added	3,550,000	+1,426,741	$47,960,500	+160.8%	3	$8.62	4.40%
SLGL	Sol-Gel Technologies Ltd. Healthcare	Held	500,000	0	$37,070,000	−6.4%	4	$33.21	3.40%
RZLT	Rezolute, Inc. Healthcare	Held	6,300,000	0	$32,760,000	+70.5%	8	$7.30	3.01%
TGTX	Tg Therapeutics, Inc. Healthcare	Held	535,000	0	$29,392,900	+65.4%	12	$13.67	2.70%
IMMX	Immix Biopharma, Inc. Healthcare	NEW	2,345,000	NEW	$24,176,950	NEW	1	$9.28	2.22%
CBIO	Crescent Biopharma, Inc. Healthcare	Added	1,319,351	+6,736	$23,748,318	−1.5%	3	$12.65	2.18%
STOK	Stoke Therapeutics, Inc. Healthcare	Held	700,000	0	$22,904,000	+0.5%	7	$11.38	2.10%
ACOG	Alpha Cognition Inc. Healthcare	Added	2,895,467	+333,517	$20,905,271	+48.6%	4	$6.31	1.92%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Held	500,000	0	$20,315,000	+29.0%	18	$11.02	1.86%
RVMD	Revolution Medicines, Inc. Healthcare	Held	100,000	0	$18,728,000	+92.6%	5	$38.42	1.72%
GLUE	Monte Rosa Therapeutics, Inc. Healthcare	NEW	745,000	NEW	$18,029,000	NEW	1	$18.89	1.65%
ALMS	Alumis Inc. Healthcare	Held	550,000	0	$15,477,000	+27.7%	5	$5.28	1.42%
CDXS	Codexis, Inc. Healthcare	Held	6,785,000	0	$15,334,100	+38.7%	26+	before history	1.41%
REPL	Replimune Group, Inc. Healthcare	NEW	1,384,993	NEW	$15,331,872	NEW	1	$6.12	1.41%
MBX	MBX Biosciences, Inc. Healthcare	Held	260,000	0	$14,352,000	+84.9%	6	$11.09	1.32%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	Reduced	122,500	-500	$13,601,175	+27.1%	17	$12.73	1.25%
EDIT	Editas Medicine, Inc. Healthcare	Added	3,861,930	+1,934,933	$12,512,653	+162.9%	2	$2.52	1.15%
PTGX	Protagonist Therapeutics, Inc Healthcare	Held	100,000	0	$12,258,000	+16.3%	11	$17.50	1.12%
CABA	Cabaletta Bio, Inc. Healthcare	Added	3,863,800	+2,483,800	$12,016,418	+223.7%	4	$2.88	1.10%
QTTB	Q32 Bio Inc. Healthcare	Reduced	931,000	-325,228	$11,860,940	+47.1%	3	$4.42	1.09%
ANNX	Annexon, Inc. Healthcare	Reduced	1,714,451	-617,310	$9,789,515	−24.2%	4	$2.48	0.90%
VSTM	Verastem, Inc. Healthcare	NEW	1,800,000	NEW	$6,876,000	NEW	1	$4.84	0.63%
ZNTL	Zentalis Pharmaceuticals, Inc. Healthcare	Held	1,412,656	0	$6,851,381	+107.3%	8	$1.88	0.63%
RLMD	Relmada Therapeutics, Inc. Healthcare	Held	935,000	0	$6,470,200	−0.6%	3	$3.35	0.59%
OCUL	Ocular Therapeutix, Inc Healthcare	Held	600,000	0	$5,892,000	+15.9%	26+	before history	0.54%
TRVI	Trevi Therapeutics, Inc. Healthcare	Reduced	310,000	-35,100	$5,781,500	+40.4%	15	$2.06	0.53%
BBOT	BridgeBio Oncology Therapeutics, Inc. Healthcare	Added	700,000	+646,718	$5,334,000	+1018.5%	2	$8.53	0.49%
LYEL	Lyell Immunopharma, Inc. Healthcare	Added	344,025	+264,928	$4,833,551	+204.6%	2	$19.31	0.44%
IRD	Opus Genetics, Inc. Healthcare	Added	1,125,000	+5,000	$4,623,750	−9.3%	6	$1.14	0.42%
FDMT	4D Molecular Therapeutics, Inc. Healthcare	Added	334,437	+222,146	$4,448,012	+325.5%	2	$9.39	0.41%
NTLA	Intellia Therapeutics, Inc. Healthcare	Added	250,000	+5,000	$4,230,000	+34.7%	2	$12.76	0.39%
VYGR	Voyager Therapeutics, Inc. Healthcare	Added	1,185,000	+35,000	$4,147,500	−6.6%	3	$4.40	0.38%
BDSX	Biodesix Inc Healthcare	Reduced	180,000	-58,047	$4,059,000	+17.6%	2	$12.39	0.37%
RCKT	Rocket Pharmaceuticals, Inc. Healthcare	Added	1,000,000	+45,000	$3,420,000	+0.0%	3	$3.42	0.31%
JBIO	Jade Biosciences, Inc. Healthcare	Reduced	145,000	-282,608	$3,221,900	−46.4%	3	$11.73	0.30%
SNWV	SANUWAVE Health, Inc. Healthcare	Reduced	306,140	-675,127	$3,061,400	−82.0%	6	$28.51	0.28%
FBIO	Fortress Biotech, Inc. Healthcare	Reduced	890,000	-152,000	$2,723,400	−6.3%	3	$2.85	0.25%
DERM	Journey Medical Corp Healthcare	Reduced	350,000	-610,000	$2,478,000	−45.0%	6	$7.08	0.23%
PHAT	Phathom Pharmaceuticals, Inc. Healthcare	NEW	185,589	NEW	$2,013,640	NEW	1	$11.41	0.18%
INBX	Inhibrx Biosciences, Inc. Healthcare	NEW	20,291	NEW	$1,922,572	NEW	1	$100.20	0.18%
ENTA	Enanta Pharmaceuticals Inc Healthcare	Held	125,000	0	$1,822,500	+15.4%	3	$12.98	0.17%
COAG	Hemab Therapeutics Holdings, Inc. Healthcare	NEW	47,652	NEW	$1,750,257	NEW	1	$27.59	0.16%
TRAX	First Tracks Biotherapeutics, Inc. Healthcare	NEW	65,000	NEW	$1,307,800	NEW	1	$18.70	0.12%
CGON	CG Oncology, Inc. Healthcare	Reduced	17,789	-77,011	$1,263,908	−80.3%	6	$27.46	0.12%

Showing the top 50 of 58 positions. Create a free account to see every position, past quarters, search, filters and CSV export.

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.