CBIO · Crescent Biopharma, Inc.

$16.23 -1.09 (-6.29%) At close · Aug 20

Market Cap

$602.85M

37.14M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Quarter:

Holders: 79

Total Value: $524,043,378

Total Shares: 29,113,521

Institutional Ownership Trend

5 quarters

Holder Concentration

Across 79 13F filers · Δ vs Mar 31, 2026

Top Holder

14.2%

−2.3 pts

Top 5

46.9%

−6.6 pts

Top 10

72.9%

−5.6 pts

HHI

654

Broadly held−126

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +19

Institutional value: +13.6%

Shares held: +15.9%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mid Logos Global Management LP	+1,417,500	1,900,000
Mega BlackRock, Inc.	+1,156,037	1,271,762
Mega GEODE CAPITAL MANAGEMENT, LLC	+280,355	384,576
Mega STATE STREET CORP	+276,520	315,587
Mega JENNISON ASSOCIATES LLC	+225,533	378,507

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Small SILVERARC CAPITAL MANAGEMENT, LLC	−71,396	59,104
Small Stonepine Capital Management, LLC	−45,000	40,000
Mega VANGUARD CAPITAL MANAGEMENT LLC	−33,640	767,755
Mid ADAR1 Capital Management, LLC	−31,998	18,275
Mega JPMORGAN CHASE & CO	−31,984	9,020

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Small Remedium Capital Partners, LLC	361,250	$6,502,500
Mega AMERIPRISE FINANCIAL INC	302,568	$5,446,224
Mega VANGUARD PORTFOLIO MANAGEMENT LLC	188,803	$3,398,454
Small STEMPOINT CAPITAL LP	182,382	$3,282,876
Small SECTORAL ASSET MANAGEMENT INC	121,300	$2,183,400

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mid Deep Track Capital, LP	453,686	$8,334,211
Large Alyeska Investment Group, L.P.	264,000	$4,849,680
Mega GOLDMAN SACHS GROUP INC	228,475	$4,197,085
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP	213,635	$3,924,474
Large Hudson Bay Capital Management LP	88,867	$1,632,486

Filter: New 31 Increased 17 Reduced 14 Sold out 12 Unchanged 17

Showing 79 of 79

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

FMR LLC

$74,403,252

14.20%

4,133,514

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	2,833,972	$51,011,496	68.6%	Defined
FIDELITY MANAGEMENT TRUST CO	1,299,542	$23,391,756	31.4%	Defined

BVF INC/IL

$49,477,734

9.44%

2,748,763

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BVF PARTNERS L P/IL	2,748,763	$49,477,734	100.0%	Defined

Fairmount Funds Management LLC

$49,461,588

9.44%

2,747,866

Venrock Adviser, LLC

$38,404,368

7.33%

2,133,576

Logos Global Management LP

$34,200,000

6.53%

1,900,000

FCPM III SERVICES B.V.

$30,201,336

5.76%

1,677,852

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Forbion Growth Management III B.V.	1,677,852	$30,201,336	100.0%	Defined

Balyasny Asset Management L.P.

$29,932,506

5.71%

1,662,917

Vestal Point Capital, LP

$29,340,000

5.60%

1,630,000

Opaleye Management Inc.

$23,748,318

4.53%

1,319,351

BlackRock, Inc.

$22,891,716

4.37%

1,271,762

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	6,638	$119,484	0.5%	Sole
BlackRock Investment Management, LLC	62,438	$1,123,884	4.9%	Sole
BLACKROCK ADVISORS LLC	46,324	$833,832	3.6%	Sole
BlackRock Fund Advisors	791,288	$14,243,184	62.2%	Sole
BlackRock Institutional Trust Company, N.A.	357,876	$6,441,768	28.1%	Sole
BlackRock Investment Management (UK) Ltd.	78	$1,404	0.0%	Sole
Aperio Group, LLC	7,120	$128,160	0.6%	Sole

TANG CAPITAL MANAGEMENT LLC

$20,880,000

3.98%

1,160,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TANG KEVIN	1,160,000	$20,880,000	100.0%	Other

VANGUARD CAPITAL MANAGEMENT LLC

$13,819,590

2.64%

767,755

MILLENNIUM MANAGEMENT LLC

$7,269,462

1.39%

403,859

GEODE CAPITAL MANAGEMENT, LLC

$6,922,368

1.32%

384,576

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	48,165	$866,970	12.5%	Defined
Held directly	336,411	$6,055,398	87.5%	Defined

JENNISON ASSOCIATES LLC

$6,813,126

1.30%

378,507

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Prudential Financial Inc	378,507	$6,813,126	100.0%	Defined

RTW INVESTMENTS, LP

$6,711,408

1.28%

372,856

NEXTBio Capital Management LP

$6,711,408

1.28%

372,856

Remedium Capital Partners, LLC

$6,502,500

1.24%

361,250

STATE STREET CORP

$5,680,566

1.08%

315,587

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	315,587	$5,680,566	100.0%	Defined

AMERIPRISE FINANCIAL INC

$5,446,224

1.04%

302,568

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	302,568	$5,446,224	100.0%	Defined

Point72 Asset Management, L.P.

$5,400,000

1.03%

300,000

PRICE T ROWE ASSOCIATES INC /MD/

$4,960,458

0.95%

275,581

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	26,269	$472,842	9.5%	Defined
Held directly	249,312	$4,487,616	90.5%	Sole

MARSHALL WACE, LLP

$3,857,400

0.74%

214,300

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	214,300	$3,857,400	100.0%	Other

PERCEPTIVE ADVISORS LLC

$3,724,956

0.71%

206,942

VANGUARD PORTFOLIO MANAGEMENT LLC

$3,398,454

0.65%

188,803

TWO SIGMA INVESTMENTS, LP

$3,363,732

0.64%

186,874

STEMPOINT CAPITAL LP

$3,282,876

0.63%

182,382

UBS Group AG

$3,153,276

0.60%

175,182

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS AG	170,093	$3,061,674	97.1%	Defined
UBS Securities LLC	5,089	$91,602	2.9%	Defined

NORTHERN TRUST CORP

$2,498,004

0.48%

138,778

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	135,382	$2,436,876	97.6%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	3,396	$61,128	2.4%	Other

Exome Asset Management LLC

$2,299,842

0.44%

127,769

SECTORAL ASSET MANAGEMENT INC

$2,183,400

0.42%

121,300

Woodline Partners LP

$1,700,784

0.32%

94,488

VANGUARD FIDUCIARY TRUST CO

$1,354,050

0.26%

75,225

Burkehill Global Management, LP

$1,332,000

0.25%

74,000

Blackstone Inc.

$1,127,646

0.22%

62,647

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Blackstone Alternative Asset Management L.P.	62,647	$1,127,646	100.0%	Other

SILVERARC CAPITAL MANAGEMENT, LLC

$1,063,872

0.20%

59,104

Y-Intercept (Hong Kong) Ltd

$914,832

0.17%

50,824

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$904,644

0.17%

50,258

Nuveen, LLC

$857,322

0.16%

47,629

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TEACHERS ADVISORS, LLC joint	47,629	$857,322	100.0%	Defined

Bank of New York Mellon Corp

$824,004

0.16%

45,778

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	12,494	$224,892	27.3%	Defined
The Bank of New York Mellon	33,283	$599,094	72.7%	Defined
Held directly	1	$18	0.0%	Defined

Stonepine Capital Management, LLC

$720,000

0.14%

40,000

BANK OF AMERICA CORP /DE/

$464,778

0.09%

25,821

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	12,414	$223,452	48.1%	Defined
BOFA SECURITIES, INC.	13,407	$241,326	51.9%	Defined

RHUMBLINE ADVISERS

$458,766

0.09%

25,487

MOORE CAPITAL MANAGEMENT, LP

$450,000

0.09%

25,000

Squarepoint Ops LLC

$434,988

0.08%

24,166

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	24,166	$434,988	100.0%	Defined

AMERICAN CENTURY COMPANIES INC

$410,490

0.08%

22,805

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	22,805	$410,490	100.0%	Defined

WELLS FARGO & COMPANY/MN

$354,600

0.07%

19,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	19,700	$354,600	100.0%	Defined

ADAR1 Capital Management, LLC

$328,950

0.06%

18,275

Virtus Investment Advisers, LLC

$328,644

0.06%

18,258

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$319,590

0.06%

17,755

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	17,755	$319,590	100.0%	Defined

MORGAN STANLEY

$318,564

0.06%

17,698

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO. LLC	15,442	$277,956	87.3%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	2,205	$39,690	12.5%	Defined
MORGAN STANLEY SMITH BARNEY LLC	7	$126	0.0%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	44	$792	0.2%	Defined

WELLINGTON MANAGEMENT GROUP LLP

$262,800

0.05%

14,600

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	4,700	$84,600	32.2%	Defined
Wellington Trust Company, NA joint	9,900	$178,200	67.8%	Defined

BANK OF MONTREAL /CAN/

$247,824

0.05%

13,768

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BMO Asset Management Inc.	13,767	$247,806	100.0%	Defined
BMO NESBITT BURNS INC.	1	$18	0.0%	Defined

MetLife Investment Management, LLC

$230,040

0.04%

12,780

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	12,780	$230,040	100.0%	Defined

Invesco Ltd.

$211,158

0.04%

11,731

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	3,121	$56,178	26.6%	Defined
Invesco Trust Co joint	8,610	$154,980	73.4%	Defined

Persistent Asset Partners Ltd

$197,424

0.04%

10,968

XTX Topco Ltd

$190,152

0.04%

10,564

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	10,564	$190,152	100.0%	Defined

CITIGROUP INC

$182,538

0.03%

10,141

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	10,141	$182,538	100.0%	Defined

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$178,218

0.03%

9,901

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	9,901	$178,218	100.0%	Defined

JPMORGAN CHASE & CO

$162,360

0.03%

9,020

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	9,019	$162,342	100.0%	Defined
J.P. Morgan Investment Management Inc.	1	$18	0.0%	Defined

NEW YORK STATE COMMON RETIREMENT FUND

$136,800

0.03%

7,600

Police & Firemen's Retirement System of New Jersey

$114,642

0.02%

6,369

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	6,369	$114,642	100.0%	Defined

BARCLAYS PLC

$80,316

0.02%

4,462

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	3,036	$54,648	68.0%	Defined
BARCLAYS CAPITAL INC.	1,426	$25,668	32.0%	Defined

BNP PARIBAS ARBITRAGE, SA

$59,454

0.01%

3,303

Vanguard Global Advisers, LLC

$48,852

0.01%

2,714

Legal & General Group Plc

$37,746

0.01%

2,097

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	2,097	$37,746	100.0%	Defined

Tower Research Capital LLC (TRC)

$31,698

0.01%

1,761

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Tower Research Capital Investments LLC	11	$198	0.6%	Other
Latour Trading LLC (Latour)	1,750	$31,500	99.4%	Defined

Russell Investments Group, Ltd.

$31,068

0.01%

1,726

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	1,726	$31,068	100.0%	Defined

ROYAL BANK OF CANADA

$12,258

0.00%

681

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC CMA LTD.	661	$11,898	97.1%	Defined
RBC Dominion Securities Inc.	20	$360	2.9%	Defined

US BANCORP \DE\

$7,254

0.00%

403

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
US BANK NATIONAL ASSOCIATION	403	$7,254	100.0%	Defined

Parallel Advisors, LLC

$4,752

0.00%

264

Allworth Financial LP

$2,898

0.00%

161

Sterling Capital Management LLC

$1,368

0.00%

SBI Securities Co., Ltd.

$1,224

0.00%

Fortitude Family Office, LLC

$720

0.00%

Quarry LP

$522

0.00%

OSAIC HOLDINGS, INC.

$468

0.00%

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
OSAIC WEALTH, INC.	26	$468	100.0%	Defined

Caitong International Asset Management Co., Ltd

$378

0.00%

NATIONAL BANK OF CANADA /FI/

$54

0.00%

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
National Bank Financial Inc.	3	$54	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	228,475	$4,197,085	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	213,635	$3,924,474	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Hudson Bay Capital UK LLP	7,036	$129,251	7.9%	Defined
Held directly	81,831	$1,503,235	92.1%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
North Rock Capital Management, LLC	25,000	$459,250	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brevan Howard US Investment Management, LP	19,530	$358,766	100.0%	Defined

Key facts CIK 1253689 CUSIP G2545C104 13F (30d) 77 filings 77 filers Visit website Investor relations