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XENE · Xenon Pharmaceuticals Inc.

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$40.48 -0.52 (-1.26%) At close · Nov 13
Market Cap
$3.98B
Shares
98.28M
Volume · Nov 13 607.68K Avg daily vol (3M) 1.62M

Price & Indicators

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20d MA 50d MA 200d MA Earnings Filing Insider Congress Investor day
Close$40.48 Open$40.89 Day$39.84–41.20 52W close$33.49–70.96 Avg vol 30d1.4M Short int7.4M · 7.5% of shares · 6.4d Short vol62% Last earningsNov 9, 2026 DataJan 2020–Nov 2026 Filing10-Q · Nov 9

Up next

Mar 8, 2027 Est · unconfirmed · in 16 wks

Latest documents

2026
Nov 10
Investor event
NDA filed for Zetucandler ahead of December depression readout

Xenon filed its NDA in September for U.S. commercialization of Zetucandler in focal seizures, moved the major depressive disorder readout to December, and reported a billion two in cash and cash into 2029.

4 source passages
things at Xenon are going incredibly well right now. We filed our NDA in September, and we look forward to commercializing in the U.S. the drug called Zetucandler for focal seizures. We've got ongoing studies in major depressive disorder, one of which we announced last night on the Q3 earnings call. We've been able to move up the readout for that study into December of this year We have a billion two in cash and cash into 2029. Open the document at this passage
Nov 9
Quarterly report 10-Q FY2026 Q3, ended Sep 30
Azetukalner NDA submitted; nine-month net loss reached $323.5 million

Xenon Pharmaceuticals Inc. submitted azetukalner’s NDA for focal seizures to the U.S. Food & Drug Administration in September 2026. Net loss was $323.5 million for the nine months ended September 30, 2026, while cash and marketable securities totaled $1,153.5 million.

Revenue $0 Net loss $110.44M Diluted EPS -$1.11
Read from the MD&A section
4 source passages
Xenon Pharmaceuticals Inc. We submitted our New Drug Application (NDA) for azetukalner in FS to the U.S. Food & Drug Administration (FDA) in September 2026. We had a net loss of $323.5 million and $240.6 million for the nine months ended September 30, 2026 and 2025, respectively. As of September 30, 2026, we had cash and cash equivalents and marketable securities of $1,153.5 million. Open the document at this passage
Nov 9
Current report 8-K
Azetukalner NDA submitted for focal seizures

Xenon Pharmaceuticals Inc. submitted azetukalner’s drug application for focal seizures to the FDA in September 2026, reported $1.2 billion in cash, cash equivalents and marketable securities with cash runway into 2029, and expects X-NOVA2 results in December 2026.

Financial results, Regulation FD disclosure
4 source passages
Xenon Pharmaceuticals Inc. (Nasdaq: XENE), a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need, today reported financial results for the third quarter ended September 30, 2026 and provided a business update. Xenon submitted its New Drug Application (NDA) for azetukalner in FS to the U.S. Food & Drug Administration (FDA) in September 2026. Cash, cash equivalents and marketable securities of $1.2 billion with cash runway into 2029 Enrollment in Phase 3 X-NOVA2 study of azetukalner in MDD completed with topline data readout now expected in December 2026 Open the document at this passage
All documents

Metrics snapshot

Useful current figures from the complete screener profile.

Revenue (TTM)
$0
Trailing 12 months
Net income (TTM)
−$428.73M
Trailing 12 months
Revenue growth YoY
—
Year over year
Operating margin
—
Trailing 12 months
P / E (TTM)
—
Trailing earnings
FCF yield
-9.0%
TTM · current market cap
Return on invested capital
—
Trailing 12 months
Net cash
$950.80M
Latest balance sheet
Dividend yield
—
Trailing 12 months
Shares change YoY
+25.9%
Year over year · more shares
Price change (1Y)
+1.1%
Trailing year
Short interest
7.5%
Latest settlement · 6.4 days to cover
View all 125 metrics

AI Brief

Q3 FY26 earnings call · Nov 9, 2026
Q3 FY26

TL;DR. Xenon submitted the focal-seizure NDA, plans X-FIRST and additional epilepsy studies, moved X-NOVA2 data to December 2026, received positive Phase 1 support for pain Phase 2 studies planned for H1 2027, and ended the quarter with $1,153.5 million of cash and marketable securities and runway into 2029. Q3 net loss increased to $110.4 million, while neuropsychiatric adverse events prompted a voluntary enrollment pause in MDD and bipolar depression studies.

Bullish
  • + All four azetukalner doses produced statistically significant seizure reductions in the pivotal studies, while X-TOLE2 achieved a 42.7% placebo-adjusted median percent change. new
  • + Positive Phase 1 results support planned Phase 2 proof-of-concept studies for XEN1701 and XEN1120 in acute pain, with initiation expected in the first half of 2027. new
  • + Cash, cash equivalents and marketable securities increased to $1,153.5 million at September 30, 2026 from $586.0 million at December 31, 2025, with cash runway into 2029. new
  • + Enrollment in the Phase 3 X-NOVA2 MDD study was completed, with topline data accelerated to December 2026 from Q1 2027. new
  • + Xenon submitted the azetukalner NDA for focal seizures to the FDA in September 2026. new
Bearish
  • − Q3 net loss increased to $110.4 million from $90.9 million in the prior-year quarter. new
  • − Q3 research and development expense rose to $95.6 million from $77.1 million in the prior-year quarter. new
  • − Q3 general and administrative expense increased to $24.4 million from $19.3 million in the prior-year quarter. new
  • − Broad payer coverage for azetukalner is expected to take time following commercial availability. new
  • − The clinical-stage pipeline remains subject to development, regulatory and commercialization risks. new

AI-generated from the earnings call and 8-K · may contain errors · not investment advice

Equibles Rating

blended score · not investment advice
Overall
Sell
SellHoldBuy
Technical Neutral Momentum Weak Sentiment Bullish Fundamentals Weak Quant / Vol Very High
Market backdrop VIX 19.3 · elevated Equity put/call 0.63
Technical
price trend
Neutral
50 / 200-day cross No cross
Price vs 200-day avg −23%
below
Price vs 50-day avg −2%
below
RSI (14) 55
neutral
MACD trend Positive
52-week position 19%
mid-range
Volume (OBV) Confirms
volume backs price
Momentum
relative strength
Weak
1-month return +21%
trailing
6-month return −25%
trailing
YTD return −10%
this year
Relative strength −26%
vs S&P · 6-mo
Sentiment
smart money
Bullish
Trend (MA cross) No cross
50d $41 › 200d $52 — 200d above 50d
Institutional flow Accumulating
228 of 319 funds reported for Sep 30 · net +404.6K sh shares · +23 new
Insider flow Accumulating
Net +$1.7M over 90 days · 0% sells
Short interest Rising
7.49% of shares out · ▲ +0.2% MoM · 6.4 days cover
Volume signal Normal
Volume near normal
Institution breadth Multi-yr high
319 holders — near 3-yr high, broad support
Squeeze score 72
high risk · 0–100
Fundamentals
Weak
Revenue growth −83%
Y/Y
EPS growth −45%
Y/Y
Free cash flow $-279.9M
Balance sheet $199.2M
net cash
Quant / Vol
risk profile
Very High
Volatility 68%
annualized · 1-yr
Max drawdown −53%
past year
ATR 3.7%
of price · 14-day

Blended from price, momentum, positioning, fundamentals & volatility · daily-close · not investment advice. Market backdrop is context, not part of the score.

Guidance & track record

Latest guidance · from the Earnings Call filed May 21, 2020
FDA acceptance of IND for NBI-921352 Phase 2 trial
Milestone payment $25M
through the initiation of a Phase 2 proof-of-concept clinical tr
Milestone payments up to $9M

Guidance from company 8-Ks · delivered figures from as-reported statements · no analyst estimates involved.

Technicals

trend & momentum for long-term holders Neutral
1 · 5 · 1
50 / 200-day cross
No cross Neutral
Price vs 200-day avg
−23% Bearish
Price vs 50-day avg
−2% Neutral
RSI (14)
55 Neutral
MACD trend
Positive Bullish
52-week position
19% Neutral
Volume (OBV)
Confirms Neutral
Market signals — smart money & positioning
Bullish · 3 of 6
Trend (MA cross) No cross
50d $41 › 200d $52 — 200d above 50d
Institutional flow Accumulating
228 of 319 funds reported for Sep 30 · net +404.6K sh shares · +23 new
Insider flow Accumulating
Net +$1.7M over 90 days · 0% sells
Short interest Rising
7.49% of shares out · ▲ +0.2% MoM · 6.4 days cover
Volume signal Normal
Volume near normal
Institution breadth Multi-yr high
319 holders — near 3-yr high, broad support
Price context
position in its 52-week range
Range low $33 Now $40 · 19% Range high $71
vs 200-day avg -23% vs 50-day avg -2%

Illustrative technical + ownership context — a signal mix, not investment advice.

Key metrics

the company's own KPIs, from written earnings releases and filings
Metric Latest Period YoY
Direct external costs - Azetukalner 55.76M the three months ended June 30, 2026 filing —
Direct external costs - Pain programs 5.58M the three months ended June 30, 2026 filing —
Direct external costs - Pre-clinical, discovery and other programs 4.68M the three months ended June 30, 2026 filing —
Indirect costs - Other unallocated expenses 4.64M the three months ended June 30, 2026 filing —
Indirect costs - Personnel-related (including stock-based compensation) 28.56M the three months ended June 30, 2026 filing —
Other G&A expenses 2.69M the three months ended June 30, 2026 filing —
Personnel-related expenses (including stock-based compensation) - G&A 15.91M the three months ended June 30, 2026 filing —
Professional and consulting fees - G&A 5.34M the three months ended June 30, 2026 filing —

Figures exactly as the company stated them in writing · click a metric with a to chart its history · period links open the stating document · "filing" marks figures stated in the 10-K/10-Q · YoY needs an exactly comparable prior-year period

Versus peers

Biotechnology — same industry group
Open screener →
Company Mkt cap YTD Rev growth Y/Y P/E Short % shares
XENE
Xenon Pharmaceuticals Inc.
this stock
$3.98B -9.7% -82.8% — 7.5%
VRTX
Vertex Pharmaceuticals Inc
$136.56B +18.8% +46.2% 34.7 1.9%
REGN
Regeneron Pharmaceuticals, Inc.
$98.84B +23.8% +20.8% 21.1 2.1%
MRNA
Moderna, Inc.
$90.38B +657.4% +4.3% — 8.2%
CSLLY
Csl Ltd
$66.05B — — — 0.0%

Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding

At a glance

key data from every section
Ownership
Institutional Holders Accumulating
Holders
312
% held
104.4%
Reported
228 of 319
Top holder
FMR LLC
Held Float
View
Held by Funds
Fund positions
338
View
Short & Settlement
Short Interest Rising
Shares short
7.4M
Days to cover
6.4d
Change
+14.8K sh
View
Short Volume
Short vol %
62%
As of
Nov 13, 2026
Short Total
View
Fails to Deliver
FTD shares
44.1K
Value
$1.6M
As of
Oct 8, 2026
View
Off-Exchange
Off-exchange %
43.3%
Week of
Oct 5, 2026
Off-exch Lit
View
Smart Money
Insider Trades Net buying
Net (90d)
+$1.7M
Buyers / Sellers
2 / 0
Buyers Sellers
View
Financials
Financials
Revenue (FY)
$311.0K
Net income (FY)
$-345.9M
EPS diluted
$-4.36
View
Filings
SEC Filings
Latest
Investor Event Transcript
Filed
Nov 10, 2026
This year
23

Xenon filed its NDA in September for U.S. commercialization of Zetucandler in focal seizures, moved the major depressive disorder readout to December, and reported a billion two in cash and cash into 2029.

View
Proposed Sales
Value
$437.7K
Shares
7.1K
Filed
Aug 28, 2026
View
Earnings & Events
Webcasts Upcoming
Next webcast
Nov 18, 2026
Last webcast
Nov 11, 2026
View
Investor Relations
Latest news
Xenon Reports Q3 2026 Financial R…
Published
Nov 9, 2026
Upcoming events
2
View

Performance

5D 20D 120D MTD YTD
XENE +3.3% +20.9% -25.0% +8.2% -9.7%
SPY +2.6% -1.2% +0.5% -0.2% +10.6%
vs SPY +0.8% +22.0% -25.5% +8.4% -20.3%
Key facts CIK 1582313 CUSIP 98420N105 13F (30d) 230 filings 192 filers Visit website Investor relations