SYRE · Spyre Therapeutics, Inc.
$87.05
-1.45 (-1.64%)
At close · Sep 2
Going-concern doubt
— flagged Aug 4, 2026
Substantial doubt about the company's ability to continue as a going concern.
“We will need to raise additional capital to continue to fund our operations in the future. If we are unable to raise additional capital when needed, we will not be able to continue as a going concern.”View the 10-Q filed Aug 4, 2026
Market Cap
$7.54B
Shares
88.17M
Registered funds — mutual funds, ETFs and closed-end funds — whose latest Form N-PORT portfolio report holds this stock, matched by the stock's CUSIP. Each row is one fund position with its size, value and weight in that fund.
Funds holding SYRE
289 fund positions| Fund | Ticker | Balance | Value | % of Fund | Side | Reported | Open |
|---|---|---|---|---|---|---|---|
| SMALLCAP World Fund Inc | — | 2,780,536 | $246,855,986 | 0.26% | Long | 2026-06-30 | |
| VANGUARD TOTAL STOCK MARKET INDEX FUND | — | 2,482,298 | $220,378,416 | 0.01% | Long | 2026-06-30 | |
| Fidelity Growth Company Fund | — | 2,576,969 | $189,407,222 | 0.19% | Long | 2026-05-31 | |
| iShares Russell 2000 ETF | IWM | 1,911,678 | $169,718,773 | 0.20% | Long | 2026-06-30 | |
| State Street(R) SPDR(R) S&P(R) Biotech ETF | XBI | 1,326,035 | $117,725,387 | 1.10% | Long | 2026-06-30 | |
| VANGUARD SMALL-CAP INDEX FUND | — | 896,559 | $79,596,508 | 0.04% | Long | 2026-06-30 | |
| VANGUARD EXTENDED MARKET INDEX FUND | — | 886,177 | $78,674,794 | 0.08% | Long | 2026-06-30 | |
| Fidelity Advisor Biotechnology Fund | — | 851,772 | $63,414,425 | 3.33% | Long | 2026-04-30 | |
| T. Rowe Price Health Sciences Fund, Inc. | — | 711,845 | $63,197,599 | 0.53% | Long | 2026-06-30 | |
| iShares Russell 2000 Growth ETF | IWO | 687,511 | $61,037,227 | 0.40% | Long | 2026-06-30 | |
| T. Rowe Price New Horizons Fund, Inc. | — | 673,799 | $59,819,875 | 0.41% | Long | 2026-06-30 | |
| Fidelity Small Cap Growth Fund | — | 777,720 | $57,901,254 | 0.69% | Long | 2026-04-30 | |
| Select Health Care Portfolio | — | 760,000 | $55,860,000 | 0.97% | Long | 2026-05-31 | |
| Fidelity Growth Company K6 Fund | FGKFX | 749,630 | $55,097,805 | 0.20% | Long | 2026-05-31 | |
| Fidelity Small Cap Index Fund | FSSNX | 738,371 | $54,971,721 | 0.17% | Long | 2026-04-30 | |
| VANGUARD SMALL-CAP VALUE INDEX FUND | — | 567,724 | $50,402,537 | 0.07% | Long | 2026-06-30 | |
| Fidelity Series Growth Company Fund | FCGSX | 671,191 | $49,332,539 | 0.20% | Long | 2026-05-31 | |
| iShares Biotechnology ETF | IBB | 547,684 | $48,623,386 | 0.54% | Long | 2026-06-30 | |
| T. Rowe Price Integrated U.S. Small-Cap Growth Equity Fund | — | 509,247 | $45,210,949 | 0.46% | Long | 2026-06-30 | |
| Fidelity Advisor Health Care Fund | — | 410,000 | $30,524,500 | 1.06% | Long | 2026-04-30 | |
| Select Biotechnology Portfolio | FBIOX | 403,153 | $29,631,746 | 0.56% | Long | 2026-05-31 | |
| Janus Henderson Global Life Sciences Fund | — | 328,592 | $29,172,398 | 0.50% | Long | 2026-06-30 | |
| Fidelity Stock Selector Small Cap Fund | — | 383,335 | $28,539,291 | 0.41% | Long | 2026-04-30 | |
| Fidelity Small Cap Growth K6 Fund | FOCSX | 383,326 | $28,538,621 | 0.67% | Long | 2026-04-30 | |
| Fidelity Extended Market Index Fund | FSMAX | 384,291 | $28,245,389 | 0.07% | Long | 2026-05-31 | |
| VANGUARD RUSSELL 2000 INDEX FUND | — | 383,517 | $28,188,500 | 0.16% | Long | 2026-05-31 | |
| Driehaus Small Cap Growth Fund | — | 309,152 | $27,446,515 | 1.70% | Long | 2026-06-30 | |
| Schwab U.S. Small-Cap ETF | SCHA | 360,437 | $26,492,120 | 0.12% | Long | 2026-05-31 | |
| Fidelity Contrafund | — | 295,700 | $26,252,246 | 0.01% | Long | 2026-06-30 | |
| Putnam Small Cap Growth Fund | — | 263,526 | $23,395,838 | 0.69% | Long | 2026-06-30 | |
| JPMorgan Small Cap Growth Fund | — | 261,269 | $23,195,462 | 0.89% | Long | 2026-06-30 | |
| Fidelity Series Small Cap Opportunities Fund | FSOPX | 293,347 | $21,839,684 | 0.43% | Long | 2026-04-30 | |
| Fidelity Small Cap Value Fund | — | 246,764 | $18,371,580 | 0.36% | Long | 2026-04-30 | |
| Victory Pioneer Select Mid Cap Growth Fund | — | 249,308 | $18,324,138 | 0.97% | Long | 2026-05-31 | |
| Eventide Healthcare & Life Sciences Fund | — | 200,000 | $17,756,000 | 0.99% | Long | 2026-06-30 | |
| Franklin Biotechnology Discovery Fund | — | 220,000 | $16,379,000 | 1.58% | Long | 2026-04-30 | |
| Schwab Small-Cap Index Fund | SWSSX | 163,777 | $12,193,198 | 0.17% | Long | 2026-04-30 | |
| Master Small Cap Index Series | — | 137,310 | $12,190,382 | 0.20% | Long | 2026-06-30 | |
| Driehaus Micro Cap Growth Fund | DMCRX | 134,180 | $11,912,500 | 2.00% | Long | 2026-06-30 | |
| SmallCap Growth Fund I | — | 158,331 | $11,787,743 | 0.50% | Long | 2026-04-30 | |
| Franklin Small Cap Growth Fund | — | 155,799 | $11,599,236 | 0.47% | Long | 2026-04-30 | |
| Emerald Growth Fund | — | 153,485 | $11,426,958 | 0.81% | Long | 2026-04-30 | |
| VIP Health Care Portfolio | — | 128,000 | $11,363,840 | 0.98% | Long | 2026-06-30 | |
| VANGUARD HEALTH CARE INDEX FUND | — | 146,746 | $10,785,831 | 0.06% | Long | 2026-05-31 | |
| Fidelity Total Market Index Fund | FSKAX | 141,090 | $10,370,115 | 0.01% | Long | 2026-05-31 | |
| iShares Core S&P Total U.S. Stock Market ETF | ITOT | 102,323 | $9,084,236 | 0.01% | Long | 2026-06-30 | |
| Fidelity Series Total Market Index Fund | FCFMX | 114,368 | $8,406,048 | 0.01% | Long | 2026-05-31 | |
| Franklin Biotechnology Discovery Fund | — | 103,584 | $7,711,829 | 0.74% | Long | 2026-04-30 | |
| Victory RS Small Cap Growth Fund | — | 85,798 | $7,617,146 | 1.87% | Long | 2026-06-30 | |
| JPMorgan Small Cap Blend Fund | — | 83,045 | $7,372,735 | 0.44% | Long | 2026-06-30 |
Showing 1–50 of 289 positions
Key facts
CIK
1636282
CUSIP
00773J202
13F (30d)
237 filings
234 filers
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