SYRE · Spyre Therapeutics, Inc. · Held by Funds
$89.22
+4.50 (+5.31%)
At close · Oct 20
Return incl. dividend (before tax)
Going-concern doubt
— flagged Aug 4, 2026
Substantial doubt about the company's ability to continue as a going concern.
“We will need to raise additional capital to continue to fund our operations in the future. If we are unable to raise additional capital when needed, we will not be able to continue as a going concern.”View the 10-Q filed Aug 4, 2026
Market Cap
$7.47B
Shares
88.17M
Volume · Oct 20
210.18K
Avg daily vol (3M)
1.2M
Registered funds — mutual funds, ETFs and closed-end funds — whose latest Form N-PORT portfolio report holds this exact listed security, matched by CUSIP. Each row is one fund position with its size, value and weight in that fund.
Funds holding SYRE
309 fund positions| Fund | Ticker | Balance | Value | % of Fund | Side | Reported | Open |
|---|---|---|---|---|---|---|---|
| SMALLCAP World Fund Inc | — | 2,780,536 | $246,855,986 | 0.26% | Long | 2026-06-30 | |
| VANGUARD TOTAL STOCK MARKET INDEX FUND | — | 2,482,298 | $220,378,416 | 0.01% | Long | 2026-06-30 | |
| Fidelity Growth Company Fund | — | 2,576,969 | $189,407,222 | 0.19% | Long | 2026-05-31 | |
| iShares Russell 2000 ETF | IWM | 1,911,678 | $169,718,773 | 0.20% | Long | 2026-06-30 | |
| State Street(R) SPDR(R) S&P(R) Biotech ETF | XBI | 1,326,035 | $117,725,387 | 1.10% | Long | 2026-06-30 | |
| Fidelity Advisor Biotechnology Fund | — | 857,347 | $84,302,931 | 3.83% | Long | 2026-07-31 | |
| Fidelity Small Cap Index Fund | FSSNX | 814,290 | $80,069,136 | 0.24% | Long | 2026-07-31 | |
| VANGUARD SMALL-CAP INDEX FUND | — | 896,559 | $79,596,508 | 0.04% | Long | 2026-06-30 | |
| VANGUARD EXTENDED MARKET INDEX FUND | — | 886,177 | $78,674,794 | 0.08% | Long | 2026-06-30 | |
| Fidelity Small Cap Growth Fund | — | 777,720 | $76,473,208 | 0.87% | Long | 2026-07-31 | |
| T. Rowe Price Health Sciences Fund, Inc. | — | 711,845 | $63,197,599 | 0.53% | Long | 2026-06-30 | |
| iShares Russell 2000 Growth ETF | IWO | 687,511 | $61,037,227 | 0.40% | Long | 2026-06-30 | |
| T. Rowe Price New Horizons Fund, Inc. | — | 673,799 | $59,819,875 | 0.41% | Long | 2026-06-30 | |
| Select Health Care Portfolio | — | 760,000 | $55,860,000 | 0.97% | Long | 2026-05-31 | |
| Fidelity Growth Company K6 Fund | FGKFX | 749,630 | $55,097,805 | 0.20% | Long | 2026-05-31 | |
| VANGUARD SMALL-CAP VALUE INDEX FUND | — | 567,724 | $50,402,537 | 0.07% | Long | 2026-06-30 | |
| Fidelity Series Growth Company Fund | FCGSX | 671,191 | $49,332,539 | 0.20% | Long | 2026-05-31 | |
| iShares Biotechnology ETF | IBB | 547,684 | $48,623,386 | 0.54% | Long | 2026-06-30 | |
| VANGUARD EXPLORER FUND | — | 489,165 | $48,099,594 | 0.22% | Long | 2026-07-31 | |
| T. Rowe Price Integrated U.S. Small-Cap Growth Equity Fund | — | 509,247 | $45,210,949 | 0.46% | Long | 2026-06-30 | |
| Fidelity Stock Selector Small Cap Fund | — | 383,335 | $37,693,331 | 0.51% | Long | 2026-07-31 | |
| Fidelity Small Cap Growth K6 Fund | FOCSX | 383,326 | $37,692,446 | 0.82% | Long | 2026-07-31 | |
| Fidelity Advisor Health Care Fund | — | 340,000 | $33,432,200 | 1.07% | Long | 2026-07-31 | |
| Select Biotechnology Portfolio | FBIOX | 403,153 | $29,631,746 | 0.56% | Long | 2026-05-31 | |
| Janus Henderson Global Life Sciences Fund | — | 328,592 | $29,172,398 | 0.50% | Long | 2026-06-30 | |
| Fidelity Series Small Cap Opportunities Fund | FSOPX | 293,347 | $28,844,811 | 0.61% | Long | 2026-07-31 | |
| Fidelity Extended Market Index Fund | FSMAX | 384,291 | $28,245,389 | 0.07% | Long | 2026-05-31 | |
| VANGUARD RUSSELL 2000 INDEX FUND | — | 383,517 | $28,188,500 | 0.16% | Long | 2026-05-31 | |
| Driehaus Small Cap Growth Fund | — | 309,152 | $27,446,515 | 1.70% | Long | 2026-06-30 | |
| Schwab U.S. Small-Cap ETF | SCHA | 360,437 | $26,492,120 | 0.12% | Long | 2026-05-31 | |
| Fidelity Contrafund | — | 295,700 | $26,252,246 | 0.01% | Long | 2026-06-30 | |
| Putnam Small Cap Growth Fund | — | 263,526 | $23,395,838 | 0.69% | Long | 2026-06-30 | |
| JPMorgan Small Cap Growth Fund | — | 261,269 | $23,195,462 | 0.89% | Long | 2026-06-30 | |
| Franklin Biotechnology Discovery Fund | — | 220,000 | $21,632,600 | 1.87% | Long | 2026-07-31 | |
| ClearBridge Small Cap Growth Fund | — | 209,500 | $20,600,135 | 1.08% | Long | 2026-07-31 | |
| Fidelity SAI Small-Mid Cap Momentum Index Fund | FZFLX | 208,605 | $20,512,130 | 0.49% | Long | 2026-07-31 | |
| Franklin Small Cap Growth Fund | — | 195,293 | $19,203,161 | 0.78% | Long | 2026-07-31 | |
| Victory Pioneer Select Mid Cap Growth Fund | — | 249,308 | $18,324,138 | 0.97% | Long | 2026-05-31 | |
| Schwab Small-Cap Index Fund | SWSSX | 180,878 | $17,785,734 | 0.24% | Long | 2026-07-31 | |
| Eventide Healthcare & Life Sciences Fund | — | 200,000 | $17,756,000 | 0.99% | Long | 2026-06-30 | |
| SmallCap Growth Fund I | — | 161,595 | $15,889,636 | 0.64% | Long | 2026-07-31 | |
| Emerald Growth Fund | — | 153,485 | $15,092,180 | 1.02% | Long | 2026-07-31 | |
| Fidelity Small Cap Value Fund | — | 137,664 | $13,536,501 | 0.25% | Long | 2026-07-31 | |
| Master Small Cap Index Series | — | 137,310 | $12,190,382 | 0.20% | Long | 2026-06-30 | |
| Driehaus Micro Cap Growth Fund | DMCRX | 134,180 | $11,912,500 | 2.00% | Long | 2026-06-30 | |
| Emerald Growth Fund | — | 153,485 | $11,426,958 | 0.81% | Long | 2026-04-30 | |
| VIP Health Care Portfolio | — | 128,000 | $11,363,840 | 0.98% | Long | 2026-06-30 | |
| VANGUARD HEALTH CARE INDEX FUND | — | 146,746 | $10,785,831 | 0.06% | Long | 2026-05-31 | |
| Fidelity Total Market Index Fund | FSKAX | 141,090 | $10,370,115 | 0.01% | Long | 2026-05-31 | |
| Calamos Timpani Small Cap Growth Fund | — | 104,841 | $10,309,016 | 1.35% | Long | 2026-07-31 |
Showing 1–50 of 309 positions
Key facts
CIK
1636282
CUSIP
00773J202
13F (30d)
12 filings
12 filers
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