SYRE

Spyre Therapeutics, Inc.

Company with tickers: SYRE

CIK

1636282

CUSIP

00773J202

Shares Outstanding

86,841,253

13F Activity (30d)

153 filings 151 filers

Trades by corporate insiders — officers, directors and holders of more than 10% of the shares — disclosed to the SEC on Forms 3, 4 and 5. Form 4 must be filed within two business days of the trade.

Date	Insider	Role	Type	Shares	Price	Value	After
2026-06-03	Sloan Sheldon	Chief Medical Officer	Sell	8,333	$75.00	$624,975	0
2026-06-03	Sloan Sheldon	Chief Medical Officer	Convert	8,333	$27.46	$228,824	8,333
2026-06-03	Sloan Sheldon	Chief Medical Officer	Convert	8,333	—	—	313,334
2026-06-01	Burrows Scott L	Chief Financial Officer	Convert	7,500	$14.50	$108,750	105,494
2026-06-01	Burrows Scott L	Chief Financial Officer	Sell	1,801	$69.75	$125,620	103,693
2026-06-01	Turtle Cameron	Director	Sell	8,149	$70.50	$574,505	600,834
2026-06-01	Turtle Cameron	Director	Sell	3,557	$69.40	$246,856	608,983
2026-06-01	Turtle Cameron	Director	Sell	3,294	$71.38	$235,126	597,540
2026-06-01	Burrows Scott L	Chief Financial Officer	Convert	7,500	—	—	374,857
2026-06-01	Burrows Scott L	Chief Financial Officer	Sell	2,599	$70.77	$183,931	101,094
2026-06-01	Burrows Scott L	Chief Financial Officer	Sell	3,100	$72.06	$223,386	97,994
2026-05-27	Albers Jeffrey W.	Director	Award	8,026	—	—	8,026
2026-05-27	McKenna Mark C.	Director	Award	8,026	—	—	8,026
2026-05-27	Fairmount Funds Management LLC	Director	Award	8,026	—	—	8,026
2026-05-27	HENDERSON MICHAEL THOMAS	Chief Business Officer	Award	8,026	—	—	8,026
2026-05-27	Milligan Sandra	Interim CEO & President	Award	8,026	—	—	8,026
2026-05-27	Stelzer Laurie	Director	Award	8,026	—	—	8,026
2026-05-08	HENDERSON MICHAEL THOMAS	Chief Business Officer	Sell	2,404	$72.57	$174,458	166,202
2026-05-08	HENDERSON MICHAEL THOMAS	Chief Business Officer	Sell	19,269	$75.35	$1,451,919	88,606
2026-05-08	HENDERSON MICHAEL THOMAS	Chief Business Officer	Sell	24,814	$74.76	$1,855,095	107,875
2026-05-08	HENDERSON MICHAEL THOMAS	Chief Business Officer	Sell	33,513	$73.72	$2,470,578	132,689
2026-05-01	Sloan Sheldon	Chief Medical Officer	Sell	19,656	$70.61	$1,387,910	37,371
2026-05-01	Turtle Cameron	Director	Sell	300	$74.96	$22,488	612,540
2026-05-01	Sloan Sheldon	Chief Medical Officer	Sell	12,777	$72.94	$931,954	15,817
2026-05-01	Burrows Scott L	Chief Financial Officer	Sell	12,500	$71.37	$892,125	97,994
2026-05-01	Sloan Sheldon	Chief Medical Officer	Sell	5,059	$74.60	$377,401	400
2026-05-01	Turtle Cameron	Director	Sell	3,600	$70.77	$254,772	618,640
2026-05-01	Sloan Sheldon	Chief Medical Officer	Sell	400	$75.37	$30,148	0
2026-05-01	Sloan Sheldon	Chief Medical Officer	Convert	78,333	$27.46	$2,151,024	78,333
2026-05-01	Burrows Scott L	Chief Financial Officer	Convert	12,500	$14.50	$181,250	110,494
2026-05-01	Sloan Sheldon	Chief Medical Officer	Sell	10,358	$73.74	$763,799	5,459
2026-05-01	Burrows Scott L	Chief Financial Officer	Convert	12,500	—	—	382,357
2026-05-01	Sloan Sheldon	Chief Medical Officer	Sell	8,777	$71.56	$628,082	28,594
2026-05-01	Turtle Cameron	Director	Sell	1,000	$71.76	$71,760	617,640
2026-05-01	Sloan Sheldon	Chief Medical Officer	Sell	21,306	$69.53	$1,481,406	57,027
2026-05-01	Turtle Cameron	Director	Sell	3,100	$73.14	$226,734	614,540
2026-05-01	Turtle Cameron	Director	Sell	1,700	$74.23	$126,191	612,840
2026-05-01	Sloan Sheldon	Chief Medical Officer	Convert	78,333	—	—	321,667
2026-05-01	Turtle Cameron	Director	Sell	5,300	$69.54	$368,562	622,240
2026-04-01	Burrows Scott L	Chief Financial Officer	Sell	1,300	$49.98	$64,974	97,994
2026-04-01	Burrows Scott L	Chief Financial Officer	Convert	7,500	—	—	394,857
2026-04-01	Sloan Sheldon	Chief Medical Officer	Sell	7,958	$50.00	$397,900	0
2026-04-01	Turtle Cameron	Director	Sell	12,344	$49.20	$607,325	630,196
2026-04-01	Sloan Sheldon	Chief Medical Officer	Convert	7,958	—	—	87,542
2026-04-01	Turtle Cameron	Director	Sell	2,656	$49.92	$132,588	627,540
2026-04-01	Burrows Scott L	Chief Financial Officer	Convert	7,500	$14.50	$108,750	105,494
2026-04-01	Sloan Sheldon	Chief Medical Officer	Convert	7,958	$21.66	$172,370	7,958
2026-04-01	Burrows Scott L	Chief Financial Officer	Sell	6,200	$49.21	$305,102	99,294
2026-03-03	Burrows Scott L	Chief Financial Officer	Sell	2,300	$40.56	$93,288	98,194
2026-03-03	Burrows Scott L	Chief Financial Officer	Convert	2,500	—	—	402,357

Showing 1–50 of 242 transactions