D. E. Shaw & Co., Inc.

CIK

1009207

City

New York

State / Country

Stock

AGIO — Agios Pharmaceuticals, Inc.

Top Portfolio Positions

2,759 positions · $152,558,660,408 total · as of Mar 31, 2026

Ticker	Company	Shares	Value (USD)	% of Portfolio
NVDA	Nvidia Corp Technology	22,002,115	$3,837,168,854	2.52%
MSFT	Microsoft Corp Technology	8,119,370	$3,005,547,192	1.97%
TSLA	Tesla, Inc. Consumer Cyclical	7,308,193	$2,716,820,747	1.78%
GOOGL	Alphabet Inc. Communication Services	9,392,969	$2,701,042,165	1.77%
AVGO	Broadcom Inc. Technology	7,833,108	$2,424,425,255	1.59%
AAPL	Apple Inc. Technology	9,246,586	$2,346,691,059	1.54%
MU	Micron Technology Inc Technology	5,815,376	$1,964,666,627	1.29%
META	Meta Platforms, Inc. Communication Services	3,417,924	$1,955,496,857	1.28%
AMZN	Amazon Com Inc Consumer Cyclical	8,037,824	$1,674,037,603	1.10%
BSX	Boston Scientific Corp Healthcare	24,432,352	$1,533,130,087	1.00%

Portfolio Trend

25 quarters · across all stocks

Holdings in AGIO

Compact Export CSV

Shares Held

Position Value (USD)

29 quarters on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$90,703,947	2,681,169	+11025.2%	Shares	Defined	2026-05-15
2025-12-31	$656,002	24,100	-98.7%	Call	Defined	2026-02-17
2025-12-31	$50,008,202	1,837,186	+399.6%	Shares	Defined	2026-02-17
2025-09-30	$14,761,443	367,749	-38.3%	Shares	Defined	2025-11-14
2025-06-30	$19,829,678	596,202	+7.5%	Shares	Defined	2025-08-14
2025-03-31	$16,256,226	554,820	+7.4%	Shares	Defined	2025-05-15
2024-12-31	$16,971,367	516,475	-3.0%	Shares	Defined	2025-02-14
2024-09-30	$23,654,709	532,404	-21.5%	Shares	Defined	2024-11-14
2024-06-30	$29,245,450	678,234	+87.3%	Shares	Defined	2024-08-14
2024-03-31	$10,588,797	362,134	+67.3%	Shares	Defined	2024-05-15
2023-12-31	$4,821,098	216,484	+36.8%	Shares	Defined	2024-02-14
2023-09-30	$3,917,430	158,280	+65.1%	Shares	Defined	2023-11-14
2023-06-30	$2,714,755	95,860	-6.2%	Shares	Defined	2023-08-14
2023-03-31	$2,346,293	102,146	-38.4%	Shares	Defined	2023-05-15
2022-12-31	$4,655,607	165,798	-43.1%	Shares	Defined	2023-02-14
2022-09-30	$8,237,709	291,291	+5.4%	Shares	Defined	2022-11-14
2022-06-30	$6,128,209	276,419	+821.4%	Shares	Defined	2022-08-15
2022-03-31	$873,300	30,000	-40.6%	Put	Defined	2022-05-16
2022-03-31	$1,471,306	50,543	-55.6%	Shares	Defined	2022-05-16
2021-12-31	$3,742,775	113,866	+279.6%	Shares	Defined	2022-02-14
2021-12-31	$986,100	30,000	-78.7%	Put	Defined	2022-02-14
2021-09-30	$6,495,797	140,754	+558.1%	Shares	Defined	2021-11-15
2021-06-30	$1,178,692	21,388	-75.2%	Shares	Defined	2021-08-16
2021-03-31	$4,459,527	86,358	-53.6%	Shares	Defined	2021-05-17
2020-12-31	$8,060,679	186,030	-44.6%	Shares	Defined	2021-02-16
2020-09-30	$11,748,450	335,670	+29.1%	Shares	Defined	2020-11-16
2020-06-30	$13,907,153	260,044	+145.8%	Shares	Defined	2020-08-14
2020-03-31	$3,753,784	105,800	-53.5%	Put	Defined	2020-05-15
2020-03-31	$8,064,710	227,303	—	Shares	Defined	2020-05-15
No 13F history on record for this holder in this stock.