D. E. Shaw & Co., Inc.

Position in VRTX — Vertex Pharmaceuticals Inc / Ma

CIK 1009207 New York, NY

Back to VRTX Full portfolio

Position in VRTX

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$1,542,346

-$109,628,252 QoQ

Shares Held

3,105

-98.8% QoQ

Ownership

0.001%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

#738

of 1,735 holders

Holding Since

Mar 2020

26 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Common Shares in VRTX Over Time

Shares Held

Position Value (USD)

Derivatives in VRTX

reported options exposure · as of Jun 30, 2026

CallValue

$4,967,300

CallShares

10,000

PutValue

$2,533,323

PutShares

5,100

Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.

Position in Biotechnology

Healthcare · as of Jun 30, 2026

D. E. Shaw & Co., Inc. holds $5,017,559,982 across 217 Biotechnology names. VRTX ranks #140 (0.0% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	INSM	INSMED Inc	5,877,959	$626,707,987
2	ALNY	Alnylam Pharmaceuticals, Inc.	1,104,109	$332,369,932
3	EXEL	Exelixis, Inc.	5,551,747	$302,070,554
4	BBIO	BridgeBio Pharma, Inc.	3,633,007	$270,586,360
5	TGTX	Tg Therapeutics, Inc.	3,400,808	$186,840,390
6	HALO	Halozyme Therapeutics, Inc.	2,006,479	$157,047,110
7	AXSM	Axsome Therapeutics, Inc.	604,753	$148,025,391
8	PTCT	Ptc Therapeutics, Inc.	1,548,919	$126,345,322

All Filings in VRTX

Export CSV

50 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$1,542,346	3,105	-98.8%	Shares	Defined	2026-08-14
2026-06-30	$4,967,300	10,000	-69.8%	Call	Defined	2026-08-14
2026-06-30	$2,533,323	5,100	-45.7%	Put	Defined	2026-08-14
2026-03-31	$111,170,598	248,960	+7347.2%	Shares	Defined	2026-05-15
2025-12-31	$4,261,584	9,400	-24.2%	Put	Defined	2026-02-17
2025-12-31	$15,006,216	33,100	-7.0%	Call	Defined	2026-02-17
2025-09-30	$1,309,251	3,343	-83.4%	Shares	Defined	2025-11-14
2025-09-30	$4,856,336	12,400	+148.0%	Put	Defined	2025-11-14
2025-09-30	$13,942,384	35,600	+888.9%	Call	Defined	2025-11-14
2025-06-30	$2,226,000	5,000	+127.3%	Put	Defined	2025-08-14
2025-06-30	$8,940,060	20,081	-72.1%	Shares	Defined	2025-08-14
2025-06-30	$1,602,720	3,600	-71.9%	Call	Defined	2025-08-14
2025-03-31	$6,205,696	12,800	-9.2%	Call	Defined	2025-05-15
2025-03-31	$34,874,556	71,933	-72.9%	Shares	Defined	2025-05-15
2025-03-31	$1,066,604	2,200	+57.1%	Put	Defined	2025-05-15
2024-12-31	$106,990,946	265,684	+92.0%	Shares	Defined	2025-02-14
2024-09-30	$6,557,628	14,100	+182.0%	Call	Defined	2024-11-14
2024-09-30	$64,370,792	138,408	-18.6%	Shares	Defined	2024-11-14
2024-06-30	$2,343,600	5,000	-43.8%	Call	Defined	2024-08-14
2024-06-30	$79,711,928	170,063	-52.2%	Shares	Defined	2024-08-14
2024-03-31	$3,720,289	8,900	-36.0%	Call	Defined	2024-05-15
2024-03-31	$148,584,998	355,458	+66.9%	Shares	Defined	2024-05-15
2023-12-31	$86,659,838	212,981	-17.1%	Shares	Defined	2024-02-14
2023-09-30	$486,836	1,400	-82.5%	Put	Defined	2023-11-14
2023-09-30	$89,366,745	256,993	+2.1%	Shares	Defined	2023-11-14
2023-06-30	$88,596,157	251,758	+22.8%	Shares	Defined	2023-08-14
2023-03-31	$64,567,925	204,932	+85.4%	Shares	Defined	2023-05-15
2022-12-31	$31,919,719	110,533	-6.5%	Shares	Defined	2023-02-14
2022-12-31	$2,310,240	8,000	0.0%	Put	Defined	2023-02-14
2022-09-30	$2,316,320	8,000	-55.6%	Put	Defined	2022-11-14
2022-09-30	$34,238,973	118,253	-57.6%	Shares	Defined	2022-11-14
2022-06-30	$5,072,220	18,000	-11.8%	Put	Defined	2022-08-15
2022-06-30	$78,547,271	278,744	-62.5%	Shares	Defined	2022-08-15
2022-03-31	$5,323,788	20,400	-59.9%	Put	Defined	2022-05-16
2022-03-31	$194,226,399	744,248	-27.1%	Shares	Defined	2022-05-16
2021-12-31	$224,282,530	1,021,323	-40.4%	Shares	Defined	2022-02-14
2021-12-31	$11,177,640	50,900	-48.7%	Put	Defined	2022-02-14
2021-09-30	$311,017,460	1,714,634	+120.7%	Shares	Defined	2021-11-15
2021-09-30	$17,993,888	99,200	+68.1%	Put	Defined	2021-11-15
2021-06-30	$156,669,533	777,015	+42.1%	Shares	Defined	2021-08-16
2021-06-30	$11,896,170	59,000	+145.8%	Put	Defined	2021-08-16
2021-03-31	$117,464,031	546,624	-37.5%	Shares	Defined	2021-05-17
2021-03-31	$5,157,360	24,000	—	Put	Defined	2021-05-17
2020-12-31	$206,643,406	874,348	+149.0%	Shares	Defined	2021-02-16
2020-12-31	$3,285,126	13,900	0.0%	Call	Defined	2021-02-16
2020-09-30	$3,782,468	13,900	-4.1%	Call	Defined	2020-11-16
2020-09-30	$95,551,672	351,138	+137.5%	Shares	Defined	2020-11-16
2020-06-30	$42,916,526	147,830	—	Shares	Defined	2020-08-14
2020-06-30	$4,209,495	14,500	-3.3%	Call	Defined	2020-08-14
2020-03-31	$3,569,250	15,000	—	Call	Defined	2020-05-15
No filing history on record for this holder in this stock.