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AXSM · Axsome Therapeutics, Inc.

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$141.69 -2.68 (-1.86%) At close · Nov 13
Market Cap
$7.45B
Shares
52.60M
Volume · Nov 13 973.14K Avg daily vol (3M) 847.81K

Price & Indicators

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20d MA 50d MA 200d MA Earnings Filing Insider Congress Investor day
Close$141.69 Open$143.74 Day$136.63–145.29 52W close$129.80–255.17 Avg vol 30d1.1M Short int3.3M · 6.2% of shares · 3.4d Short vol27% Last earningsNov 2, 2026 DataJan 2020–Nov 2026 Filing10-Q · Nov 2

Up next

Feb 22, 2027 Est · unconfirmed · in 14 wks

Latest documents

2026
Nov 9
Investor event
Quarterly revenue reaches $260 million; cash flow turns positive

Axsome Therapeutics reported $260 million in quarterly revenue and its first cash-flow-positive quarter; Avality prescriptions continued rising, and AXS-12 remained on track for a May 1st PDUFA date.

4 source passages
revenue for the quarter was $260 million, surpassing on a run rate, annualized run rate, a billion dollars for the first time ever. this quarter, we were actually cash flow positive for the first time. much of the focus outside the company is on the performance of Avality. We have a PDUFA date for AXS-12. That's riboxetine. For cataplexy and narcolepsy, that is May 1st. Open the document at this passage
Nov 2
Quarterly report 10-Q FY2026 Q3, ended Sep 30
Quarterly report for FY2026 Q3

Axsome Therapeutics reported $259.7 million of revenue and a $12.9 million net loss for the three months ended September 30, 2026. AUVELITY received FDA approval for agitation associated with Alzheimer’s disease in April 2026 and launched in June 2026.

Revenue $259.69M ▲ 51.9% Net loss $12.88M Diluted EPS -$0.25
Read from the MD&A section
Nov 2
Earnings call
Q3 2026 earnings call

Axsome Therapeutics reported third-quarter revenue of $259.7 million, up 52% year-over-year and 19% sequentially, while net loss narrowed to $12.9 million, or $0.25 per share. Its AXS-12 narcolepsy NDA remains under FDA review with a May 1, 2027 action date.

Nov 2
Current report 8-K
Financial results, Other events

Axsome reported 3Q 2026 net product revenue of $259.7 million, up 52% year-over-year, and a net loss of $12.9 million; it initiated the SUMMIT Phase 3 trial of AXS-05 for smoking cessation.

All documents

Metrics snapshot

Useful current figures from the complete screener profile.

Revenue (TTM)
$865.27M
Trailing 12 months
Net income (TTM)
−$157.29M
Trailing 12 months
Revenue growth YoY
+51.9%
Year over year
Operating margin
-17.5%
Trailing 12 months
P / E (TTM)
—
Trailing earnings
FCF yield
-1.1%
TTM · current market cap
Return on invested capital
—
Trailing 12 months
Net cash
$125.79M
Latest balance sheet
Dividend yield
—
Trailing 12 months
Shares change YoY
+4.8%
Year over year · more shares
Price change (1Y)
+3.1%
Trailing year
Short interest
6.2%
Latest settlement · 3.4 days to cover
View all 125 metrics

AI Brief

Q2 FY26 earnings call · Aug 10, 2026
Q2 FY26

TL;DR. Axsome delivered 46% YoY revenue growth to $218.4M led by Auvelity (+51%) and Sunosi (+20%), launched Auvelity in Alzheimer's disease agitation with early NBRx +126% in 65+ patients, and advanced its pipeline with FDA acceptance of the AXS-12 NDA (PDUFA May 1, 2027) and initiation of two ADHD Phase 3 trials.

Bullish
  • + Total net product revenue grew 46% YoY to $218.4M with Auvelity up 51% and Sunosi up 20%.
  • + Auvelity launched in Alzheimer's disease agitation in June 2026 with new-to-brand prescriptions up 126% in patients 65+ in the first eight weeks.
  • + FDA accepted the AXS-12 NDA for cataplexy in narcolepsy with a PDUFA target action date of May 1, 2027.
  • + Initiated FOCUS-2 and FOCUS-3 Phase 3 trials of solriamfetol in children and adolescents with ADHD.
  • + Payer coverage for Auvelity reached ~89% of lives (~82% commercial, ~100% government), supporting continued access expansion.
Bearish
  • − Symbravo net sales declined $1.8M QoQ due to a prior period adjustment and elevated gross-to-net discounts in the high 80% range.
  • − SG&A expenses surged 60% YoY to $208.1M driven by Auvelity sales force expansion and Symbravo launch activities.
  • − Net loss widened to $51.3M ($0.99/share) versus a $48.0M loss a year ago, including $27.1M of stock-based compensation.
  • − Auvelity gross-to-net discounts remain elevated at ~50% as Medicare scripts grow as a higher proportion of mix.

AI-generated from the earnings call and 8-K · may contain errors · not investment advice

Equibles Rating

blended score · not investment advice
Overall
Sell
SellHoldBuy
Technical Sell Momentum Very Weak Sentiment Neutral Fundamentals Strong Quant / Vol Very High
Market backdrop VIX 19.3 · elevated Equity put/call 0.63
Technical
price trend
Sell
50 / 200-day cross No cross
Price vs 200-day avg −28%
below
Price vs 50-day avg −17%
below
RSI (14) 41
neutral
MACD trend Positive
52-week position 9%
near low
Volume (OBV) Confirms
volume backs price
Momentum
relative strength
Very Weak
1-month return −10%
trailing
6-month return −40%
trailing
YTD return −22%
this year
Relative strength −40%
vs S&P · 6-mo
Sentiment
smart money
Neutral
Trend (MA cross) No cross
50d $171 › 200d $197 — 200d above 50d
Institutional flow Accumulating
418 of 514 funds reported for Sep 30 · net +740.6K sh shares · +42 new
Insider flow Flat
No net insider activity over 90 days
Short interest Rising
6.20% of shares out · ▲ +4.9% MoM · 3.4 days cover
Volume signal Normal
Volume near normal
Institution breadth Multi-yr high
514 holders — near 3-yr high, broad support
Squeeze score 66
elevated · 0–100
Fundamentals
Strong
EPS growth +39%
Y/Y
Free cash flow $-93.9M
Balance sheet $135.2M
net cash
Quant / Vol
risk profile
Very High
Volatility 46%
annualized · 1-yr
Max drawdown −49%
past year
ATR 5.5%
of price · 14-day

Blended from price, momentum, positioning, fundamentals & volatility · daily-close · not investment advice. Market backdrop is context, not part of the score.

Guidance & track record

Latest guidance · from the Earnings Call filed May 4, 2026
at peak
Annual revenue at peak at least $8B
peak
Peak sales for Avaldi at least $8B
Peak sales for Synose $300M – $500M
Peak sales for SunBravo $500M – $1B
Previous outlook earlier release · from the Earnings Call filed Mar 31, 2026

Still-open targets the latest release did not restate under the same label.

Peak sales for AUVELITY · peak at least $8B
Peak sales for SUNOSI · peak $300M – $500M
Peak sales for SYMBRAVO · peak $500M – $1B
AUVELITY peak sales · peak $8B
SUNOSI peak sales · peak $300M – $500M
SYMBRAVO peak sales · peak $500M – $1B

Guidance from company 8-Ks · delivered figures from as-reported statements · no analyst estimates involved.

Technicals

trend & momentum for long-term holders Sell
3 · 3 · 1
50 / 200-day cross
No cross Neutral
Price vs 200-day avg
−28% Bearish
Price vs 50-day avg
−17% Bearish
RSI (14)
41 Neutral
MACD trend
Positive Bullish
52-week position
9% Bearish
Volume (OBV)
Confirms Neutral
Market signals — smart money & positioning
Bullish · 2 of 6
Trend (MA cross) No cross
50d $171 › 200d $197 — 200d above 50d
Institutional flow Accumulating
418 of 514 funds reported for Sep 30 · net +740.6K sh shares · +42 new
Insider flow Flat
No net insider activity over 90 days
Short interest Rising
6.20% of shares out · ▲ +4.9% MoM · 3.4 days cover
Volume signal Normal
Volume near normal
Institution breadth Multi-yr high
514 holders — near 3-yr high, broad support
Price context
position in its 52-week range
Range low $130 Now $142 · 9% Range high $255
vs 200-day avg -28% vs 50-day avg -17%

Illustrative technical + ownership context — a signal mix, not investment advice.

Key metrics

the company's own KPIs, from written earnings releases and filings
Metric Latest Period YoY
AUVELITY net product sales $180.3M Q2 2026 —
AUVELITY payer coverage 89% Q2 2026 —
AUVELITY total prescriptions 266,000 Q2 2026 —
Commercial covered lives (AUVELITY) 82% 2Q 2026 —
Commercial covered lives (SUNOSI) 96% 2Q 2026 —
Commercial covered lives (SYMBRAVO) 56% 2Q 2026 —
Patients treated since launch (AUVELITY) 350,000 2Q 2026 —
Patients treated since launch (SUNOSI) 109,000 2Q 2026 —
Patients treated since launch (SYMBRAVO) 19,500 2Q 2026 —
QoQ growth in activated new writers (AUVELITY) 21% 2Q 2026 —
Sales force representatives 630 2Q 2026 —
SUNOSI net product revenue $35.8M Q2 2026 —
SUNOSI payer coverage 82% Q2 2026 —
SUNOSI prescriptions 61,000 Q2 2026 —
SYMBRAVO net product sales $2.3M Q2 2026 —
SYMBRAVO payer coverage 57% Q2 2026 —
SYMBRAVO prescriptions 23,500 Q2 2026 —
Unique writers since launch (AUVELITY) 69,000 2Q 2026 —
Unique writers since launch (SUNOSI) 17,000 2Q 2026 —
Unique writers since launch (SYMBRAVO) 4,700 2Q 2026 —

Figures exactly as the company stated them in writing · click a metric with a to chart its history · period links open the stating document · "filing" marks figures stated in the 10-K/10-Q · YoY needs an exactly comparable prior-year period

Versus peers

Biotechnology — same industry group
Open screener →
Company Mkt cap YTD Rev growth Y/Y P/E Short % shares
AXSM
Axsome Therapeutics, Inc.
this stock
$7.45B -22.4% +65.5% — 6.2%
VRTX
Vertex Pharmaceuticals Inc
$136.56B +18.8% +46.2% 34.7 1.9%
REGN
Regeneron Pharmaceuticals, Inc.
$98.84B +23.8% +20.8% 21.1 2.1%
MRNA
Moderna, Inc.
$90.38B +657.4% +4.3% — 8.2%
CSLLY
Csl Ltd
$66.05B — — — 0.0%

Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding

At a glance

key data from every section
Ownership
Institutional Holders Accumulating
Holders
491
% held
77.6%
Reported
418 of 514
Top holder
BlackRock, Inc.
Held Float
View
Held by Funds
Fund positions
422
View
Short & Settlement
Short Interest Rising
Shares short
3.3M
Days to cover
3.4d
Change
+151.5K sh
View
Short Volume
Short vol %
27%
As of
Nov 13, 2026
Short Total
View
Fails to Deliver
FTD shares
649
Value
$107.7K
As of
Oct 13, 2026
View
Off-Exchange
Off-exchange %
50.8%
Week of
Oct 5, 2026
Off-exch Lit
View
Smart Money
Congressional Trades Buy
Member
Christopher L. Jacobs
Amount
$15.0K–$50.0K
Traded
Jun 16, 2022
View
Financials
Financials
Revenue (FY)
$638.5M
Net income (FY)
$-183.2M
EPS diluted
$-3.68
View
Filings
SEC Filings
Latest
Investor Event Transcript
Filed
Nov 9, 2026
This year
30

Axsome Therapeutics reported $260 million in quarterly revenue and its first cash-flow-positive quarter; Avality prescriptions continued rising, and AXS-12 remained on track for a May 1st PDUFA date.

View
Proposed Sales
Value
$71.2K
Shares
286
Filed
Jun 11, 2026
View
Earnings & Events
Webcasts Upcoming
Next webcast
Nov 16, 2026
Last webcast
Nov 9, 2026
View
Investor Relations
Latest news
Axsome Therapeutics to Participat…
Published
Nov 3, 2026
Upcoming events
1
View

Performance

5D 20D 120D MTD YTD
AXSM +7.0% -9.8% -39.5% -1.9% -22.4%
SPY +2.6% -1.2% +0.5% -0.2% +10.6%
vs SPY +4.5% -8.7% -40.0% -1.7% -33.0%
Key facts CIK 1579428 CUSIP 05464T104 13F (30d) 362 filings 326 filers Visit website Investor relations