AMLX · Amylyx Pharmaceuticals, Inc. · Shareholders & Ownership

$28.77 +1.44 (+5.27%)

Russell 2000 member Rebalance outlook locked

Market Cap

$3.22B

111.42M

Volume · Oct 20 1.61M Avg daily vol (3M) 2.32M

Every disclosed holder of AMLX in one list: 13F institutions, Schedule 13D and 13G filers, insiders (Forms 3, 4 and 5) and registered funds, each from its own latest filing. Holders nest by CIK and SEC reporting links, never by name, and each is summed once.

How the holder list picks a filing →

Who Owns AMLX

13F quarter Sep 30, 2026, combined view: filers that have not filed yet carry their Jun 30, 2026 positions

No chart: the summed disclosures exceed shares outstanding, so they are not parts of one whole.

Holder group	Holders	Shares	% Out	Summed
Institutional (13F)	209	115,017,164	103.23%	Yes
Insiders (Forms 3, 4, 5)	8	8,878,487	7.97%	Yes
13D/G-only blocks	4	12,608,003	11.32%	Yes
Remaining	—	25,080,606	-22.51%	Negative
Registered funds (N-PORT, not summed)	189	37,699,183	33.83%	No

Shares outstanding: 111,423,048, the issuer's latest cover-page count restated onto today's split basis.

Remaining is negative: the summed disclosures exceed shares outstanding, as when filings are dated at different times or holders that do not disclose their links count the same shares. It is flagged, not clipped.

13D/G-only counts each filer's latest 13D or 13G that no 13F report of the listing contains, that names no 13F filer and that no counted insider files. Funds are never summed: their shares sit inside their advisers' 13F reports.

Holders of AMLX

One row per holder Every filing By ultimate parent

All 13F Funds Insiders 13D/G Non-US

#	Holder	Shares	% Out	Change	As of	Notes
1	FMR LLC 13F CIK 315066 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	16,727,909	15.01%	+97,368	Jun 30, 2026	carried, not yet filed for the newest quarter
1.1	Fidelity Advisor Biotechnology Fund Fund S000005321 · Registered fund · Jul 31, 2026 Fidelity Advisor Series VII, not summed	2,433,200	2.18%	0	Jul 31, 2026	Fidelity Advisor Series VII, not summed
1.2	Fidelity Small Cap Growth Fund Fund S000007193 · Registered fund · Jul 31, 2026 Fidelity Securities Fund, not summed	2,115,961	1.90%	0	Jul 31, 2026	Fidelity Securities Fund, not summed
1.3	Select Health Care Portfolio Fund S000007466 · Registered fund · May 31, 2026 Fidelity Select Portfolios, not summed	1,420,000	1.27%	0	May 31, 2026	Fidelity Select Portfolios, not summed
1.4	Fidelity Stock Selector Small Cap Fund Fund S000005453 · Registered fund · Jul 31, 2026 Fidelity Capital Trust, not summed	1,257,800	1.13%	+9,017	Jul 31, 2026	Fidelity Capital Trust, not summed
1.5	Strategic Advisers Fidelity U.S. Total Stock Fund Fund S000061481 · Registered fund · May 31, 2026 Fidelity Rutland Square Trust II, not summed	1,138,109	1.02%	0	May 31, 2026	Fidelity Rutland Square Trust II, not summed
2	BlackRock, Inc. 13F CIK 2012383 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	8,827,085	7.92%	-1,751	Jun 30, 2026	carried, not yet filed for the newest quarter
2.1	iShares Russell 2000 ETF Fund S000004344 · Registered fund · Jun 30, 2026 iShares Trust, not summed	2,360,386	2.12%	+131,510	Jun 30, 2026	iShares Trust, not summed
2.2	iShares Russell 2000 Growth ETF Fund S000004343 · Registered fund · Jun 30, 2026 iShares Trust, not summed	848,854	0.76%	+275,604	Jun 30, 2026	iShares Trust, not summed
2.3	iShares Biotechnology ETF Fund S000004350 · Registered fund · Jun 30, 2026 iShares Trust, not summed	658,481	0.59%	-29,055	Jun 30, 2026	iShares Trust, not summed
2.4	BlackRock Advantage Small Cap Core Fund Fund S000039982 · Registered fund · May 29, 2026 BlackRock Funds, not summed	307,235	0.28%	-3,792	May 29, 2026	BlackRock Funds, not summed
2.5	iShares U.S. Pharmaceuticals ETF Fund S000009417 · Registered fund · Jun 30, 2026 iShares Trust, not summed	219,612	0.20%	-13,668	Jun 30, 2026	iShares Trust, not summed
3	PERCEPTIVE ADVISORS LLC 13F CIK 1224962 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	8,334,882	7.48%	+50,000	Jun 30, 2026	carried, not yet filed for the newest quarter
4	TCG Crossover Management, LLC 13F CIK 1839948 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	6,243,812	5.60%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
5	Commodore Capital LP 13F CIK 1831942 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	5,650,000	5.07%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
6	Jupiter Topco LLC 13F CIK 2146052 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	5,236,102	4.70%	+250,029	Jun 30, 2026	carried, not yet filed for the newest quarter
7	TCG Crossover GP II, LLC 13G CIK 1969280 · Unknown · Aug 14, 2024 Rule 13d-1(c), passive investor	4,643,812	4.17%	—	Aug 14, 2024	Rule 13d-1(c), passive investor
8	Saturn V Capital Management LP 13F CIK 1964437 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	4,624,101	4.15%	+274,216	Jun 30, 2026	carried, not yet filed for the newest quarter
9	VANGUARD CAPITAL MANAGEMENT LLC 13F CIK 2100119 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	4,224,224	3.79%	+82,649	Jun 30, 2026	carried, not yet filed for the newest quarter
10	Cohen Joshua B Insider CIK 1898644 · Sep 10, 2026 Director, Co-Chief Executive Officer, issuer-wide	3,613,123	3.24%	-30,464	Sep 10, 2026	Director, Co-Chief Executive Officer, issuer-wide
11	Klee Justin B. Insider CIK 1898314 · Sep 10, 2026 Director, Co-Chief Executive Officer, issuer-wide	3,613,056	3.24%	-30,464	Sep 10, 2026	Director, Co-Chief Executive Officer, issuer-wide
12	VANGUARD TOTAL STOCK MARKET INDEX FUND Fund S000002848 · Registered fund · Jun 30, 2026 VANGUARD INDEX FUNDS, not summed	3,154,723	2.83%	+50,808	Jun 30, 2026	VANGUARD INDEX FUNDS, not summed
13	MORGAN STANLEY 13F CIK 895421 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	3,130,808	2.81%	+955,261	Jun 30, 2026	carried, not yet filed for the newest quarter
14	Driehaus Capital Management LLC 13F CIK 938206 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	3,036,970	2.73%	+49,823	Jun 30, 2026	carried, not yet filed for the newest quarter
14.1	Driehaus Micro Cap Growth Fund Fund S000042829 · Registered fund · Jun 30, 2026 Driehaus Mutual Funds, not summed	279,810	0.25%	+44,623	Jun 30, 2026	Driehaus Mutual Funds, not summed
15	First Light Asset Management, LLC 13F CIK 1600004 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	3,023,256	2.71%	-167,389	Jun 30, 2026	carried, not yet filed for the newest quarter
16	VIKING GLOBAL INVESTORS LP 13G CIK 1103804 · Registered investment adviser · Dec 31, 2023 Rule 13d-1(c), passive investor	2,962,555	2.66%	—	Dec 31, 2023	Rule 13d-1(c), passive investor
17	FRANKLIN RESOURCES INC 13F CIK 38777 · Investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	2,950,225	2.65%	+688,656	Jun 30, 2026	carried, not yet filed for the newest quarter
17.1	Franklin Biotechnology Discovery Fund Fund S000006882 · Registered fund · Jul 31, 2026 Franklin Strategic Series, not summed	752,824	0.68%	+103,565	Jul 31, 2026	Franklin Strategic Series, not summed
17.2	Franklin Small Cap Growth Fund Fund S000006889 · Registered fund · Jul 31, 2026 Franklin Strategic Series, not summed	743,983	0.67%	-7,262	Jul 31, 2026	Franklin Strategic Series, not summed
18	GOLDMAN SACHS GROUP INC 13F CIK 886982 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	2,858,239	2.57%	+232,248	Jun 30, 2026	carried, not yet filed for the newest quarter
18.1	Goldman Sachs ActiveBeta(R) U.S. Small Cap Equity ETF Fund S000048296 · Registered fund · May 31, 2026 Goldman Sachs ETF Trust, not summed	43,655	0.04%	-3,705	May 31, 2026	Goldman Sachs ETF Trust, not summed
18.2	Goldman Sachs Absolute Return Tracker Fund Fund S000020314 · Registered fund · Jun 30, 2026 GOLDMAN SACHS TRUST, not summed	10,801	0.01%	+3,269	Jun 30, 2026	GOLDMAN SACHS TRUST, not summed
19	Point72 Asset Management, L.P. 13G CIK 1603466 · Registered investment adviser · Sep 30, 2025 Rule 13d-1(c), passive investor	2,801,636	2.51%	-1,916,073	Sep 30, 2025	Rule 13d-1(c), passive investor
20	STATE STREET CORP 13F CIK 93751 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	2,603,337	2.34%	+240,176	Jun 30, 2026	carried, not yet filed for the newest quarter
20.1	State Street(R) SPDR(R) S&P(R) Pharmaceuticals ETF Fund S000012321 · Registered fund · Jun 30, 2026 SPDR SERIES TRUST, not summed	485,721	0.44%	+90,308	Jun 30, 2026	SPDR SERIES TRUST, not summed
20.2	STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO Fund S000050332 · Registered fund · Jun 30, 2026 STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed	33,100	0.03%	+1,900	Jun 30, 2026	STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
20.3	State Street Total Return V.I.S. Fund Fund S000001637 · Registered fund · Jun 30, 2026 STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed	2,321	0.00%	+236	Jun 30, 2026	STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed
20.4	State Street Balanced Index Fund Fund S000082802 · Registered fund · Jun 30, 2026 STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed	575	0.00%	0	Jun 30, 2026	STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
21	GEODE CAPITAL MANAGEMENT, LLC 13F CIK 1214717 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	2,335,315	2.10%	+124,383	Jun 30, 2026	carried, not yet filed for the newest quarter
22	Panacea Venture Healthcare Fund II, L.P. 13G CIK 2010692 · Unknown · Dec 31, 2024 Rule 13d-1(c), passive investor	2,200,000	1.97%	-2,000,000	Dec 31, 2024	Rule 13d-1(c), passive investor
23	ADAGE CAPITAL PARTNERS GP, L.L.C. 13F CIK 1165408 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,900,000	1.71%	-1,660,764	Jun 30, 2026	carried, not yet filed for the newest quarter
24	JPMORGAN CHASE & CO 13F CIK 19617 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	1,863,650	1.67%	+1,703,987	Jun 30, 2026	carried, not yet filed for the newest quarter
25	Siren, L.L.C. 13F CIK 2005245 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	1,480,586	1.33%	+250,586	Jun 30, 2026	carried, not yet filed for the newest quarter
26	EVENTIDE ASSET MANAGEMENT, LLC 13F CIK 1442891 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,327,536	1.19%	-186,422	Jun 30, 2026	carried, not yet filed for the newest quarter
26.1	Eventide Healthcare & Life Sciences Fund Fund S000039514 · Registered fund · Jun 30, 2026 MUTUAL FUND SERIES TRUST, not summed	1,324,994	1.19%	-187,450	Jun 30, 2026	MUTUAL FUND SERIES TRUST, not summed
26.2	Eventide Small Cap ETF Fund S000095403 · Registered fund · Jul 31, 2026 Strategy Shares, not summed	3,189	0.00%	+1,587	Jul 31, 2026	Strategy Shares, not summed
27	683 Capital Management, LLC 13F CIK 1404574 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,279,512	1.15%	-250,488	Jun 30, 2026	carried, not yet filed for the newest quarter
28	VANGUARD PORTFOLIO MANAGEMENT LLC 13F CIK 2100121 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,061,534	0.95%	+116,753	Jun 30, 2026	carried, not yet filed for the newest quarter
29	Alyeska Investment Group, L.P. 13F CIK 1453072 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,053,015	0.95%	+1,053,015	Jun 30, 2026	carried, not yet filed for the newest quarter
30	Almitas Capital LLC 13F CIK 1596468 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	974,881	0.87%	-1,147,716	Jun 30, 2026	carried, not yet filed for the newest quarter
31	VANGUARD EXTENDED MARKET INDEX FUND Fund S000002841 · Registered fund · Jun 30, 2026 VANGUARD INDEX FUNDS, not summed	963,188	0.86%	+31,582	Jun 30, 2026	VANGUARD INDEX FUNDS, not summed
32	DIMENSIONAL FUND ADVISORS LP 13F CIK 354204 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	902,463	0.81%	-729	Jun 30, 2026	carried, not yet filed for the newest quarter
32.1	U.S. MICRO CAP PORTFOLIO Fund S000000948 · Registered fund · Jul 31, 2026 DFA INVESTMENT DIMENSIONS GROUP INC, not summed	245,512	0.22%	0	Jul 31, 2026	DFA INVESTMENT DIMENSIONS GROUP INC, not summed
32.2	U.S. SMALL CAP PORTFOLIO Fund S000000971 · Registered fund · Jul 31, 2026 DFA INVESTMENT DIMENSIONS GROUP INC, not summed	198,730	0.18%	-2,059	Jul 31, 2026	DFA INVESTMENT DIMENSIONS GROUP INC, not summed
32.3	Dimensional U.S. Small Cap ETF Fund S000070906 · Registered fund · Jul 31, 2026 Dimensional ETF Trust, not summed	148,485	0.13%	-1,926	Jul 31, 2026	Dimensional ETF Trust, not summed
32.4	Dimensional U.S. Core Equity 2 ETF Fund S000070903 · Registered fund · Jul 31, 2026 Dimensional ETF Trust, not summed	54,057	0.05%	0	Jul 31, 2026	Dimensional ETF Trust, not summed
32.5	U.S. CORE EQUITY 2 PORTFOLIO Fund S000000980 · Registered fund · Jul 31, 2026 DFA INVESTMENT DIMENSIONS GROUP INC, not summed	27,931	0.03%	0	Jul 31, 2026	DFA INVESTMENT DIMENSIONS GROUP INC, not summed
33	Jones Hill Capital LP 13F CIK 2102314 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	894,058	0.80%	-704,736	Jun 30, 2026	carried, not yet filed for the newest quarter
34	Woodline Partners LP 13F CIK 1784547 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	846,387	0.76%	+587	Jun 30, 2026	carried, not yet filed for the newest quarter
35	NORTHERN TRUST CORP 13F CIK 73124 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	831,740	0.75%	+51,832	Jun 30, 2026	carried, not yet filed for the newest quarter
35.1	Small Cap Index Fund Fund S000001245 · Registered fund · Jun 30, 2026 Northern Funds, not summed	46,462	0.04%	+4,971	Jun 30, 2026	Northern Funds, not summed
35.2	Small Cap Core Fund Fund S000001244 · Registered fund · Jun 30, 2026 Northern Funds, not summed	17,592	0.02%	-501	Jun 30, 2026	Northern Funds, not summed
36	BANK OF AMERICA CORP /DE/ 13F CIK 70858 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	821,841	0.74%	-508,848	Jun 30, 2026	carried, not yet filed for the newest quarter
37	Boxer Capital Management, LLC 13F CIK 2018299 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	800,000	0.72%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
38	JPMorgan Small Cap Growth Fund Fund S000003859 · Registered fund · Jun 30, 2026 JPMorgan Trust II, not summed	799,066	0.72%	—	Jun 30, 2026	JPMorgan Trust II, not summed
39	MILNE GEORGE M JR Insider CIK 1179552 · Oct 5, 2026 Director, issuer-wide	782,881	0.70%	-30,000	Oct 5, 2026	Director, issuer-wide
40	Aberdeen Group plc 13F CIK 1716774 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	737,670	0.66%	+737,670	Jun 30, 2026	carried, not yet filed for the newest quarter
41	CHARLES SCHWAB INVESTMENT MANAGEMENT INC 13F CIK 884546 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	725,030	0.65%	+8,805	Jun 30, 2026	carried, not yet filed for the newest quarter
41.1	Schwab U.S. Small-Cap ETF Fund S000026636 · Registered fund · May 31, 2026 SCHWAB STRATEGIC TRUST, not summed	402,853	0.36%	-6,621	May 31, 2026	SCHWAB STRATEGIC TRUST, not summed
41.2	Schwab Small-Cap Index Fund Fund S000005912 · Registered fund · Jul 31, 2026 SCHWAB CAPITAL TRUST, not summed	223,339	0.20%	+22,626	Jul 31, 2026	SCHWAB CAPITAL TRUST, not summed
41.3	Schwab U.S. Broad Market ETF Fund S000026631 · Registered fund · May 31, 2026 SCHWAB STRATEGIC TRUST, not summed	58,783	0.05%	+479	May 31, 2026	SCHWAB STRATEGIC TRUST, not summed
41.4	Schwab Total Stock Market Index Fund Fund S000005913 · Registered fund · Jul 31, 2026 SCHWAB CAPITAL TRUST, not summed	50,499	0.05%	0	Jul 31, 2026	SCHWAB CAPITAL TRUST, not summed
42	Connor, Clark & Lunn Investment Management Ltd. 13F CIK 1596800 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	721,002	0.65%	-147,323	Jun 30, 2026	carried, not yet filed for the newest quarter
43	GREAT POINT PARTNERS LLC 13F CIK 1281446 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	700,000	0.63%	-1,050,000	Jun 30, 2026	carried, not yet filed for the newest quarter
44	Balyasny Asset Management L.P. 13F CIK 1218710 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	684,974	0.61%	-422,297	Jun 30, 2026	carried, not yet filed for the newest quarter
45	Qube Research & Technologies Ltd 13F CIK 1729829 · Exempt reporting adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	681,389	0.61%	-20,847	Jun 30, 2026	carried, not yet filed for the newest quarter
46	VANGUARD FIDUCIARY TRUST CO 13F CIK 933478 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	623,078	0.56%	+36,926	Jun 30, 2026	carried, not yet filed for the newest quarter
47	TWO SIGMA INVESTMENTS, LP 13F CIK 1179392 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	593,435	0.53%	+431,490	Jun 30, 2026	carried, not yet filed for the newest quarter
48	DEUTSCHE BANK AG\ 13F CIK 948046 · Non-US institution · Jun 30, 2026 carried, not yet filed for the newest quarter	557,937	0.50%	-709,848	Jun 30, 2026	carried, not yet filed for the newest quarter
48.1	DWS Small Cap Index VIP Fund S000006223 · Registered fund · Jun 30, 2026 DEUTSCHE DWS INVESTMENTS VIT FUNDS, not summed	14,453	0.01%	+1,703	Jun 30, 2026	DEUTSCHE DWS INVESTMENTS VIT FUNDS, not summed
49	Rock Springs Capital Management LP 13F CIK 1595725 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	499,764	0.45%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
50	ADAR1 Capital Management, LLC 13F CIK 1940272 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	494,378	0.44%	-506,226	Jun 30, 2026	carried, not yet filed for the newest quarter

51 more nested rows are not shown here; Every filing lists them all.

Shares are restated onto today's split basis. Change compares each row with the same holder's previous filing in the same source; a dash means there is none to compare. Nested 13D/G, insider and fund rows are not summed, since a 13F report already holds them.

Showing 1–50 of 285 holders

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Key facts CIK 1658551 CUSIP 03237H101 13F (30d) 13 filings 13 filers Visit website Investor relations