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Equibles

Polar Capital Holdings Plc

Position in SYRE — Spyre Therapeutics, Inc.

CIK 1837309 London, X0
Back to SYRE Full portfolio

Position in SYRE

as of Jun 30, 2026 · filed Aug 14, 2026
Position Value
$87,715,439
+$47,724,237 QoQ
Shares Held
988,009
+24.6% QoQ
Ownership
1.12%
of shares outstanding
% of Portfolio
0.25%
of 13F equity value
Holder Rank
#27
of 266 holders
Holding Since
Sep 2023
12 quarters on record
Voting authority Sole 100% Shared 0% None 0%

Common Shares in SYRE Over Time

Shares Held

Position Value (USD)

Position in Biotechnology

Healthcare · as of Jun 30, 2026

Polar Capital Holdings Plc holds $3,774,805,029 across 41 Biotechnology names. SYRE ranks #20 (2.3% of the industry book) .

# Ticker Company Shares Value (USD) Open
1 ELVN
Enliven Therapeutics, Inc.
 6,430,636 $326,354,777
2 XENE
Xenon Pharmaceuticals Inc.
 4,570,556 $275,878,760
3 CYTK
Cytokinetics Inc
 2,253,649 $191,988,358
4 RYTM
Rhythm Pharmaceuticals, Inc.
 1,663,632 $184,713,060
5 ARQT
Arcutis Biotherapeutics, Inc.
 6,606,945 $173,234,097
6 ASND
Ascendis Pharma A/S
 616,908 $164,541,701
7 BBIO
BridgeBio Pharma, Inc.
 2,063,609 $153,697,598
8 ALNY
Alnylam Pharmaceuticals, Inc.
 482,751 $145,322,533

All Filings in SYRE

Export CSV
12 filing rows on record
Report Date Value (USD) Shares
2026-06-30 $87,715,439 988,009
2026-03-31 $39,991,202 792,847
2025-12-31 $24,253,079 740,326
2025-09-30 $13,220,086 788,788
2025-06-30 $11,152,650 745,000
2025-03-31 $13,311,375 825,000
2024-12-31 $17,460,000 750,000
2024-09-30 $14,705,000 500,000
2024-06-30 $11,755,000 500,000
2024-03-31 $18,965,000 500,000
2023-12-31 $10,760,000 500,000
2023-09-30 $3,675,000 300,000