SUSQUEHANNA INTERNATIONAL GROUP, LLP
Position in SYRE — Spyre Therapeutics, Inc.
CIK 1446194
BALA CYNWYD, PA
Position in SYRE
as of Mar 31, 2026
· filed May 15, 2026
Position Value
$1,460,843
+$1,260,647 QoQ
Shares Held
28,962
+373.9% QoQ
Ownership
0.033%
of shares outstanding
% of Portfolio
0.00%
of 13F equity value
Holder Rank
—
not a current holder
Holding Since
Mar 2024
7 quarters on record
Voting authority
Sole 100%
Shared 0%
None 0%
Common Shares in SYRE Over Time
Shares Held
Position Value (USD)
Derivatives in SYRE
reported options exposure · as of Mar 31, 2026CallValue
$4,358,016
CallShares
86,400
PutValue
$660,764
PutShares
13,100
Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.
Position in Biotechnology
Healthcare · as of Mar 31, 2026SUSQUEHANNA INTERNATIONAL GROUP, LLP holds $1,162,367,415 across 355 Biotechnology names. SYRE ranks #135 (0.1% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | CYTK |
Cytokinetics Inc
|
898,951 | $59,249,860 | |
| 2 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
174,268 | $57,660,053 | |
| 3 | AGIO |
Agios Pharmaceuticals, Inc.
|
1,344,953 | $45,499,759 | |
| 4 | ABVX |
Abivax S.A.
|
381,282 | $42,455,750 | |
| 5 | BBIO |
BridgeBio Pharma, Inc.
|
398,943 | $29,625,507 | |
| 6 | INSM |
INSMED Inc
|
173,630 | $28,391,977 | |
| 7 | CRSP |
CRISPR Therapeutics AG
|
593,406 | $28,228,323 | |
| 8 | TERN |
Terns Pharmaceuticals, Inc.
|
521,571 | $27,497,223 |
All Filings in SYRE
Export CSV
13 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-03-31 | $4,358,016 | 86,400 | Call | Other | 2026-05-15 | |
| 2026-03-31 | $1,460,843 | 28,962 | Shares | Other | 2026-05-15 | |
| 2026-03-31 | $660,764 | 13,100 | Put | Other | 2026-05-15 | |
| 2025-12-31 | $255,528 | 7,800 | Put | Other | 2026-02-17 | |
| 2025-12-31 | $458,640 | 14,000 | Call | Other | 2026-02-17 | |
| 2025-12-31 | $200,196 | 6,111 | Shares | Other | 2026-02-17 | |
| 2025-06-30 | $895,445 | 59,816 | Shares | Other | 2025-08-14 | |
| 2025-03-31 | $374,332 | 23,200 | Put | Other | 2025-05-14 | |
| 2025-03-31 | $758,345 | 47,000 | Call | Other | 2025-05-14 | |
| 2025-03-31 | $947,059 | 58,696 | Shares | Other | 2025-05-14 | |
| 2024-12-31 | $537,511 | 23,089 | Shares | Other | 2025-02-14 | |
| 2024-09-30 | $388,153 | 13,198 | Shares | Defined | 2024-11-14 | |
| 2024-03-31 | $3,850,008 | 101,503 | Shares | Defined | 2024-05-07 | |
| No filing history on record for this holder in this stock. | ||||||