ADAGE CAPITAL PARTNERS GP, L.L.C.
Position in SYRE — Spyre Therapeutics, Inc.
CIK 1165408
Boston, MA
Position in SYRE
as of Jun 30, 2026
· filed Aug 14, 2026
Position Value
$152,905,794
+$143,771,100 QoQ
Shares Held
1,722,300
+182.3% QoQ
Ownership
1.95%
of shares outstanding
% of Portfolio
0.22%
of 13F equity value
Holder Rank
#18
of 260 holders
Holding Since
Dec 2023
8 quarters on record
Voting authority
Sole 100%
Shared 0%
None 0%
Common Shares in SYRE Over Time
Shares Held
Position Value (USD)
Position in Biotechnology
Healthcare · as of Jun 30, 2026ADAGE CAPITAL PARTNERS GP, L.L.C. holds $4,240,035,723 across 126 Biotechnology names. SYRE ranks #6 (3.6% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | ROIV |
Roivant Sciences Ltd.
|
10,349,328 | $366,262,717 | |
| 2 | PRAX |
Praxis Precision Medicines, Inc.
|
1,015,480 | $339,972,549 | |
| 3 | VRTX |
Vertex Pharmaceuticals Inc / Ma
|
393,964 | $195,693,737 | |
| 4 | TNGX |
Tango Therapeutics, Inc.
|
5,600,000 | $175,056,000 | |
| 5 | BBIO |
BridgeBio Pharma, Inc.
|
2,252,000 | $167,728,960 | |
| 6 | SYRE |
Spyre Therapeutics, Inc.
This page
|
1,722,300 | $152,905,794 | |
| 7 | TVTX |
Travere Therapeutics, Inc.
|
2,569,356 | $145,965,114 | |
| 8 | RPRX |
Royalty Pharma plc
|
2,500,000 | $140,175,000 |
All Filings in SYRE
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8 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-06-30 | $152,905,794 | 1,722,300 | Shares | Sole | 2026-08-14 | |
| 2025-06-30 | $9,134,694 | 610,200 | Shares | Sole | 2025-08-14 | |
| 2025-03-31 | $12,959,632 | 803,200 | Shares | Sole | 2025-05-15 | |
| 2024-12-31 | $23,978,400 | 1,030,000 | Shares | Sole | 2025-02-14 | |
| 2024-09-30 | $31,027,550 | 1,055,000 | Shares | Sole | 2024-11-14 | |
| 2024-06-30 | $27,093,182 | 1,152,411 | Shares | Sole | 2024-08-14 | |
| 2024-03-31 | $41,920,236 | 1,105,200 | Shares | Sole | 2024-05-15 | |
| 2023-12-31 | $21,520,000 | 1,000,000 | Shares | Sole | 2024-02-14 | |
| No filing history on record for this holder in this stock. | ||||||