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Equibles

GEODE CAPITAL MANAGEMENT, LLC

Position in SYRE — Spyre Therapeutics, Inc.

CIK 1214717 BOSTON, MA
Back to SYRE Full portfolio

Position in SYRE

as of Jun 30, 2026 · filed Aug 12, 2026
Position Value
$227,477,886
+$140,675,086 QoQ
Shares Held
2,562,265
+48.9% QoQ
Ownership
2.91%
of shares outstanding
% of Portfolio
0.01%
of 13F equity value
Holder Rank
#11
of 266 holders
Holding Since
Sep 2023
12 quarters on record
Voting authority Sole 100% Shared 0% None 0%

Common Shares in SYRE Over Time

Shares Held

Position Value (USD)

Position in Biotechnology

Healthcare · as of Jun 30, 2026

GEODE CAPITAL MANAGEMENT, LLC holds $22,039,427,018 across 520 Biotechnology names. SYRE ranks #20 (1.0% of the industry book) .

# Ticker Company Shares Value (USD) Open
1 VRTX
Vertex Pharmaceuticals Inc / Ma
 6,017,848 $2,989,245,636
2 REGN
Regeneron Pharmaceuticals, Inc.
 2,625,810 $1,637,297,566
3 ALNY
Alnylam Pharmaceuticals, Inc.
 2,635,840 $793,466,914
4 RVMD
Revolution Medicines, Inc.
 3,942,676 $738,384,360
5 MRNA
Moderna, Inc.
 9,710,335 $680,014,759
6 INCY
Incyte Corp
 4,750,735 $538,543,319
7 RPRX
Royalty Pharma plc
 8,058,048 $451,814,751
8 INSM
INSMED Inc
 4,220,155 $449,952,925

All Filings in SYRE

Export CSV
12 filing rows on record
Report Date Value (USD) Shares
2026-06-30 $227,477,886 2,562,265
2026-03-31 $86,802,800 1,720,912
2025-12-31 $54,353,425 1,659,140
2025-09-30 $20,533,564 1,225,153
2025-06-30 $18,371,662 1,227,232
2025-03-31 $17,096,048 1,059,563
2024-12-31 $22,491,482 966,129
2024-09-30 $26,205,721 891,048
2024-06-30 $18,004,756 765,834
2024-03-31 $12,525,434 330,225
2023-12-31 $652,615 30,326
2023-09-30 $328,300 26,800