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Equibles

PERCEPTIVE ADVISORS LLC

Position in SYRE — Spyre Therapeutics, Inc.

CIK 1224962 NEW YORK, NY
Back to SYRE Full portfolio

Position in SYRE

as of Jun 30, 2026 · filed Aug 14, 2026
Position Value
$383,484,854
+$192,658,985 QoQ
Shares Held
4,319,496
+14.2% QoQ
Ownership
4.90%
of shares outstanding
% of Portfolio
6.18%
of 13F equity value
Holder Rank
#3
of 266 holders
Holding Since
Sep 2023
12 quarters on record
Voting authority Sole 100% Shared 0% None 0%

Common Shares in SYRE Over Time

Shares Held

Position Value (USD)

Position in Biotechnology

Healthcare · as of Jun 30, 2026

PERCEPTIVE ADVISORS LLC holds $5,490,398,452 across 69 Biotechnology names. SYRE ranks #2 (7.0% of the industry book) .

# Ticker Company Shares Value (USD) Open
1 PRAX
Praxis Precision Medicines, Inc.
 2,035,986 $681,627,752
2 SYRE
Spyre Therapeutics, Inc.
This page 		4,319,496 $383,484,854
3 CELC
Celcuity Inc.
 3,197,200 $334,491,064
4 ASND
Ascendis Pharma A/S
 1,163,721 $310,387,665
5 RYTM
Rhythm Pharmaceuticals, Inc.
 2,586,295 $287,156,333
6 ROIV
Roivant Sciences Ltd.
 8,085,461 $286,144,464
7 RLAY
Relay Therapeutics, Inc.
 14,106,187 $263,926,758
8 TVTX
Travere Therapeutics, Inc.
 3,752,574 $213,183,728

All Filings in SYRE

Export CSV
12 filing rows on record
Report Date Value (USD) Shares
2026-06-30 $383,484,854 4,319,496
2026-03-31 $190,825,869 3,783,225
2025-12-31 $100,547,811 3,069,225
2025-09-30 $20,605,498 1,229,445
2025-06-30 $22,895,791 1,529,445
2025-03-31 $37,324,643 2,313,272
2024-12-31 $59,939,551 2,574,723
2024-09-30 $84,481,607 2,872,547
2024-06-30 $71,259,233 3,031,018
2024-03-31 $96,974,834 2,556,679
2023-12-31 $56,095,732 2,606,679
2023-09-30 $993,671 81,116