HighVista Strategies LLC

Position in SYRE — Spyre Therapeutics, Inc.

CIK 1335325 BOSTON, MA

Position in SYRE

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$6,907,705

-$469,851 QoQ

Shares Held

77,807

-46.8% QoQ

Ownership

0.088%

of shares outstanding

% of Portfolio

1.57%

of 13F equity value

Holder Rank

#87

of 266 holders

Holding Since

Dec 2023

11 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Jun 30, 2026

HighVista Strategies LLC holds $278,365,756 across 70 Biotechnology names. SYRE ranks #12 (2.5% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ABVX	Abivax S.A.	113,031	$15,062,511
2	RVMD	Revolution Medicines, Inc.	66,983	$12,544,576
3	DFTX	Definium Therapeutics, Inc.	242,884	$11,425,263
4	IMVT	Immunovant, Inc.	277,873	$10,706,446
5	PRAX	Praxis Precision Medicines, Inc.	30,210	$10,114,005
6	RLAY	Relay Therapeutics, Inc.	506,235	$9,471,656
7	PCVX	Vaxcyte, Inc.	149,739	$8,704,328
8	TNGX	Tango Therapeutics, Inc.	260,070	$8,129,788

11 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$6,907,705	77,807	-46.8%	Shares	Sole	2026-08-14
2026-03-31	$7,377,556	146,264	-22.3%	Shares	Sole	2026-05-15
2025-12-31	$6,165,628	188,206	-12.8%	Shares	Sole	2026-02-17
2025-09-30	$3,615,902	215,746	+91.3%	Shares	Sole	2025-11-14
2025-06-30	$1,688,690	112,805	+18.5%	Shares	Sole	2025-08-14
2025-03-31	$1,535,390	95,159	0.0%	Shares	Sole	2025-05-15
2024-12-31	$2,215,301	95,159	-9.7%	Shares	Sole	2025-02-14
2024-09-30	$3,098,372	105,351	-7.2%	Shares	Sole	2024-11-14
2024-06-30	$2,669,560	113,550	-26.4%	Shares	Sole	2024-08-14
2024-03-31	$5,855,671	154,381	-73.3%	Shares	Sole	2024-05-15
2023-12-31	$12,430,296	577,616	—	Shares	Sole	2024-02-14
No filing history on record for this holder in this stock.