HighVista Strategies LLC

Position in SYRE — Spyre Therapeutics, Inc.

CIK 1335325 BOSTON, MA

Position in SYRE

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$7,377,556

+$1,211,928 QoQ

Shares Held

146,264

-22.3% QoQ

Ownership

0.168%

of shares outstanding

% of Portfolio

2.06%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Dec 2023

10 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Mar 31, 2026

HighVista Strategies LLC holds $224,607,258 across 76 Biotechnology names. SYRE ranks #4 (3.3% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ABVX	Abivax S.A.	113,254	$12,610,832
2	PRAX	Praxis Precision Medicines, Inc.	26,323	$8,481,007
3	COGT	Cogent Biosciences, Inc.	197,051	$7,584,492
4	SYRE	Spyre Therapeutics, Inc. This page	146,264	$7,377,556
5	PCVX	Vaxcyte, Inc.	124,647	$7,243,237
6	RVMD	Revolution Medicines, Inc.	69,309	$6,740,300
7	TERN	Terns Pharmaceuticals, Inc.	114,307	$6,026,265
8	GPCR	Structure Therapeutics Inc.	123,909	$5,972,413

10 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$7,377,556	146,264	-22.3%	Shares	Sole	2026-05-15
2025-12-31	$6,165,628	188,206	-12.8%	Shares	Sole	2026-02-17
2025-09-30	$3,615,902	215,746	+91.3%	Shares	Sole	2025-11-14
2025-06-30	$1,688,690	112,805	+18.5%	Shares	Sole	2025-08-14
2025-03-31	$1,535,390	95,159	0.0%	Shares	Sole	2025-05-15
2024-12-31	$2,215,301	95,159	-9.7%	Shares	Sole	2025-02-14
2024-09-30	$3,098,372	105,351	-7.2%	Shares	Sole	2024-11-14
2024-06-30	$2,669,560	113,550	-26.4%	Shares	Sole	2024-08-14
2024-03-31	$5,855,671	154,381	-73.3%	Shares	Sole	2024-05-15
2023-12-31	$12,430,296	577,616	—	Shares	Sole	2024-02-14
No filing history on record for this holder in this stock.