HighVista Strategies LLC

CIK

1335325

Location

BOSTON, MA

Portfolio Value

Small $359,474,418

Diversification

Diversified

Filing Date

Global Rank

#2,819 / 8,232 ▲ 75

Top Industry

Biotechnology 68.3%

3Y Alpha vs SPY

+3.1%

Period ended 2 months ago

Filed May 15, 2026 · 30d

25 quarters · since Mar 2020

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+90.1%

SPY

+76.3%

Annualised alpha

+3.1%

Max drawdown

−29.2%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

154 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

8.5%

+2.3 pts

Top 5

18.5%

−0.1 pts

Top 10

27.4%

−1.5 pts

HHI

168

Diversified+5

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	67.4%	$242,385,867	83
Technology	9.1%	$32,616,951	21
Unclassified	8.5%	$30,607,040	1
Industrials	5.5%	$19,810,669	17
Consumer Cyclical	2.9%	$10,478,055	9
Financial Services	2.3%	$8,419,688	8
Utilities	1.7%	$6,148,792	5
Basic Materials	0.9%	$3,064,480	3
Communication Services	0.6%	$2,210,915	3
Consumer Defensive	0.4%	$1,383,251	2
Real Estate	0.3%	$1,184,735	1
Energy	0.3%	$1,163,975	1

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

25 positions

Ticker	Company	Δ Shares	Shares	Value
PALI	Palisade Bio, Inc.	+719,295	2,019,326	$3,533,820
DYN	Dyne Therapeutics, Inc.	+123,286	182,929	$3,316,502
AMLX	Amylyx Pharmaceuticals, Inc.	+113,273	352,085	$4,893,981
OCUL	Ocular Therapeutix, Inc	+97,506	441,573	$3,740,123
TYRA	Tyra Biosciences, Inc.	+96,218	131,304	$5,028,943
CTMX	CytomX Therapeutics, Inc.	+94,116	288,057	$1,353,867
ALKS	Alkermes plc.	+46,788	73,189	$2,587,963
ABVX	Abivax S.A.	+41,069	113,254	$12,610,832
CORZ	Core Scientific, Inc./tx	+39,900	103,412	$1,547,043
CLDX	Celldex Therapeutics, Inc.	+37,592	89,397	$2,835,672
U	Unity Software Inc.	+34,100	62,763	$1,377,020
LBRX	Lb Pharmaceuticals Inc	+33,488	173,595	$4,280,852
SLNO	Soleno Therapeutics Inc	+30,158	165,227	$5,531,799
IMCR	Immunocore Holdings plc	+25,699	58,697	$1,769,714
CPNG	Coupang, Inc.	+21,244	46,036	$869,159
BBD	Bank Bradesco	+18,000	208,264	$760,163
HPE	Hewlett Packard Enterprise Co	+13,800	89,981	$2,142,447
NOK	Nokia Corp	+11,300	70,824	$569,424
PCVX	Vaxcyte, Inc.	+10,598	124,647	$7,243,237
KBR	Kbr, Inc.	+9,400	39,406	$1,452,505
AXSM	Axsome Therapeutics, Inc.	+9,306	20,437	$3,454,261
NVDA	Nvidia Corp	+8,200	22,420	$3,910,048
JANX	Janux Therapeutics, Inc.	+7,940	49,383	$686,423
AMZN	Amazon Com Inc	+5,000	22,397	$4,664,623
XEL	Xcel Energy Inc	+4,500	12,558	$997,607
No positions match the current search.

Trimmed

Positions the filer reduced

25 positions

Ticker	Company	Δ Shares	Shares	Value
VRDN	Viridian Therapeutics, Inc.DE	−238,243	134,229	$2,625,519
BBOT	BridgeBio Oncology Therapeutics, Inc.	−151,076	78,187	$699,773
COGT	Cogent Biosciences, Inc.	−139,616	197,051	$7,584,492
CMPS	COMPASS Pathways plc	−134,573	364,360	$2,014,910
OLMA	Olema Pharmaceuticals, Inc.	−123,888	117,601	$1,753,430
RLAY	Relay Therapeutics, Inc.	−123,198	421,881	$4,197,715
EWTX	Edgewise Therapeutics, Inc.	−79,206	91,931	$2,895,826
MLYS	Mineralys Therapeutics, Inc.	−77,766	46,778	$1,267,216
MAZE	Maze Therapeutics, Inc.	−70,503	99,850	$2,980,522
GPCR	Structure Therapeutics Inc.	−69,092	123,909	$5,972,413
XOMA	XOMA Royalty Corp	−66,103	46,814	$1,468,555
PHVS	Pharvaris N.V.	−64,504	97,866	$2,764,714
TERN	Terns Pharmaceuticals, Inc.	−61,155	114,307	$6,026,265
LQDA	Liquidia Corp	−56,259	99,744	$3,764,338
CYTK	Cytokinetics Inc	−55,921	58,643	$3,865,160
APGE	Apogee Therapeutics, Inc.	−53,468	35,761	$3,010,003
STOK	Stoke Therapeutics, Inc.	−52,922	62,617	$2,038,809
TRVI	Trevi Therapeutics, Inc.	−52,634	53,525	$638,553
RVMD	Revolution Medicines, Inc.	−50,931	69,309	$6,740,300
RXO	RXO, Inc.	−47,900	43,038	$629,215
SYRE	Spyre Therapeutics, Inc.	−41,942	146,264	$7,377,556
PTGX	Protagonist Therapeutics, Inc	−39,693	33,852	$3,568,000
CNTA	Centessa Pharmaceuticals plc	−38,526	5,964	$236,890
AVTX	Avalo Therapeutics, Inc.	−37,009	58,622	$875,226
QXO	QXO, Inc.	−32,400	26,320	$511,134
No positions match the current search.

New Positions

Positions the filer opened this quarter

25 positions

Ticker	Company	Shares	Value
ORKA	Oruka Therapeutics, Inc.	78,911	$3,870,584
MLTX	MoonLake Immunotherapeutics	193,955	$3,615,321
DFTX	Definium Therapeutics, Inc.	185,856	$3,512,678
NRIX	Nurix Therapeutics, Inc.	226,546	$3,511,463
IVA	Inventiva S.A.	615,666	$3,416,946
ERAS	Erasca, Inc.	181,069	$2,929,696
XENE	Xenon Pharmaceuticals Inc.	49,050	$2,852,257
VERA	Vera Therapeutics, Inc.	69,241	$2,785,565
ALMS	Alumis Inc.	112,929	$2,487,825
EYPT	EyePoint, Inc.	183,037	$2,359,346
TNGX	Tango Therapeutics, Inc.	104,193	$2,179,717
ASMB	Assembly Biosciences, Inc.	74,735	$2,073,896
JAZZ	Jazz Pharmaceuticals plc	10,838	$2,048,923
NATL	NCR Atleos Corp	40,100	$1,747,558
ON	On Semiconductor Corp	28,000	$1,733,760
KOD	Kodiak Sciences Inc.	43,569	$1,660,850
AVTR	Avantor, Inc.	186,500	$1,462,160
MIRM	Mirum Pharmaceuticals, Inc.	15,563	$1,437,709
SVRA	Savara Inc	250,999	$1,370,454
KNX	Knight-Swift Transportation Holdings Inc.	22,900	$1,318,582
MU	Micron Technology Inc	3,800	$1,283,792
BLTE	Belite Bio, Inc	8,033	$1,280,781
JHX	James Hardie Industries plc	65,598	$1,242,426
KRC	Kilroy Realty Corp	41,997	$1,184,735
STX	Seagate Technology Holdings plc	2,900	$1,136,104
No positions match the current search.

Sold Out

Positions the filer fully exited

22 positions

Ticker	Company	Shares	Value
ACLX	Arcellx, Inc.	75,002	$4,890,130
AGIO	Agios Pharmaceuticals, Inc.	147,662	$4,019,359
APLS	Apellis Pharmaceuticals, Inc.	150,776	$3,787,493
SEPN	Septerna, Inc.	78,682	$2,193,654
APP	AppLovin Corp	2,482	$1,672,421
UNF	Unifirst Corp	7,727	$1,490,538
CMPX	Compass Therapeutics, Inc.	245,532	$1,318,506
TMO	Thermo Fisher Scientific Inc.	2,269	$1,314,772
OFIX	Orthofix Medical Inc.	85,049	$1,289,342
ACHC	Acadia Healthcare Company, Inc.	81,630	$1,158,329
SCHW	Schwab Charles Corp	10,601	$1,059,145
SNDK	Sandisk Corp	4,378	$1,039,249
AFRM	Affirm Holdings, Inc.	13,086	$973,990
VST	Vistra Corp.	5,673	$915,225
BVN	Buenaventura Mining Co Inc	29,649	$825,131
ALC	Alcon Inc	10,440	$822,776
FOUR	Shift4 Payments, Inc.	12,982	$817,476
GTLB	Gitlab Inc.	19,305	$724,516
RBLX	Roblox Corp	8,431	$683,163
CNX	CNX Resources Corp	17,624	$648,034
ALV	Autoliv Inc	5,243	$622,344
DBVT	DBV Technologies S.A.	15,877	$304,362
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

154 positions · $359,474,418 total · as of Mar 31, 2026

All sectors Basic Materials Communication Services Consumer Cyclical Consumer Defensive Energy Financial Services Healthcare Industrials Real Estate Technology Utilities

Showing 1–50 of 154 positions by value · page 1 of 4

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
DBC	Invesco DB Commodity Index Tracking Fund	Held	1,057,238	0	$30,607,040	+29.5%	8.51%
ABVX	Abivax S.A. Healthcare	Added	113,254	+41,069	$12,610,832	+29.5%	3.51%
PRAX	Praxis Precision Medicines, Inc. Healthcare	Added	26,323	+482	$8,481,007	+11.4%	2.36%
COGT	Cogent Biosciences, Inc. Healthcare	Reduced	197,051	-139,616	$7,584,492	−36.6%	2.11%
SYRE	Spyre Therapeutics, Inc. Healthcare	Reduced	146,264	-41,942	$7,377,556	+19.7%	2.05%
PCVX	Vaxcyte, Inc. Healthcare	Added	124,647	+10,598	$7,243,237	+37.6%	2.01%
RVMD	Revolution Medicines, Inc. Healthcare	Reduced	69,309	-50,931	$6,740,300	−29.6%	1.88%
TERN	Terns Pharmaceuticals, Inc. Healthcare	Reduced	114,307	-61,155	$6,026,265	−15.0%	1.68%
GPCR	Structure Therapeutics Inc. Healthcare	Reduced	123,909	-69,092	$5,972,413	−55.5%	1.66%
NUVL	Nuvalent, Inc. Healthcare	Reduced	56,602	-16,685	$5,798,874	−21.3%	1.61%
IMVT	Immunovant, Inc. Healthcare	Added	225,139	+3,256	$5,592,452	−0.8%	1.56%
SLNO	Soleno Therapeutics Inc Healthcare	Added	165,227	+30,158	$5,531,799	−11.5%	1.54%
TYRA	Tyra Biosciences, Inc. Healthcare	Added	131,304	+96,218	$5,028,943	+445.2%	1.40%
AMLX	Amylyx Pharmaceuticals, Inc. Healthcare	Added	352,085	+113,273	$4,893,981	+69.6%	1.36%
AMZN	Amazon Com Inc Consumer Cyclical	Added	22,397	+5,000	$4,664,623	+16.2%	1.30%
LBRX	Lb Pharmaceuticals Inc Healthcare	Added	173,595	+33,488	$4,280,852	+37.3%	1.19%
RLAY	Relay Therapeutics, Inc. Healthcare	Reduced	421,881	-123,198	$4,197,715	−9.0%	1.17%
INSM	INSMED Inc Healthcare	Reduced	24,316	-15,084	$3,976,152	−42.0%	1.11%
NVDA	Nvidia Corp Technology	Added	22,420	+8,200	$3,910,048	+47.4%	1.09%
ORKA	Oruka Therapeutics, Inc. Healthcare	NEW	78,911	NEW	$3,870,584	NEW	1.08%
CYTK	Cytokinetics Inc Healthcare	Reduced	58,643	-55,921	$3,865,160	−46.9%	1.08%
LQDA	Liquidia Corp Healthcare	Reduced	99,744	-56,259	$3,764,338	−30.0%	1.05%
OCUL	Ocular Therapeutix, Inc Healthcare	Added	441,573	+97,506	$3,740,123	−10.5%	1.04%
TARS	Tarsus Pharmaceuticals, Inc. Healthcare	Reduced	52,464	-1,100	$3,680,349	−16.1%	1.02%
BBIO	BridgeBio Pharma, Inc. Healthcare	Reduced	49,560	-30,645	$3,680,325	−40.0%	1.02%
MLTX	MoonLake Immunotherapeutics Healthcare	NEW	193,955	NEW	$3,615,321	NEW	1.01%
ARGX	Argenx SE Healthcare	Added	4,918	+1,330	$3,591,369	+19.0%	1.00%
PTGX	Protagonist Therapeutics, Inc Healthcare	Reduced	33,852	-39,693	$3,568,000	−44.5%	0.99%
PALI	Palisade Bio, Inc. Healthcare	Added	2,019,326	+719,295	$3,533,820	+15.7%	0.98%
DFTX	Definium Therapeutics, Inc. Healthcare	NEW	185,856	NEW	$3,512,678	NEW	0.98%
NRIX	Nurix Therapeutics, Inc. Healthcare	NEW	226,546	NEW	$3,511,463	NEW	0.98%
AXSM	Axsome Therapeutics, Inc. Healthcare	Added	20,437	+9,306	$3,454,261	+69.9%	0.96%
IVA	Inventiva S.A. Healthcare	NEW	615,666	NEW	$3,416,946	NEW	0.95%
DYN	Dyne Therapeutics, Inc. Healthcare	Added	182,929	+123,286	$3,316,502	+184.3%	0.92%
APGE	Apogee Therapeutics, Inc. Healthcare	Reduced	35,761	-53,468	$3,010,003	−55.3%	0.84%
GHRS	GH Research PLC Healthcare	Reduced	213,212	-27,312	$2,997,760	−1.9%	0.83%
DNTH	Dianthus Therapeutics, Inc. /DE/ Healthcare	Reduced	35,587	-12,897	$2,986,461	+49.5%	0.83%
MAZE	Maze Therapeutics, Inc. Healthcare	Reduced	99,850	-70,503	$2,980,522	−57.8%	0.83%
ERAS	Erasca, Inc. Healthcare	NEW	181,069	NEW	$2,929,696	NEW	0.81%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Reduced	91,931	-79,206	$2,895,826	−31.8%	0.81%
ELVN	Enliven Therapeutics, Inc. Healthcare	Reduced	73,102	-9,434	$2,865,598	+125.5%	0.80%
XENE	Xenon Pharmaceuticals Inc. Healthcare	NEW	49,050	NEW	$2,852,257	NEW	0.79%
CLDX	Celldex Therapeutics, Inc. Healthcare	Added	89,397	+37,592	$2,835,672	+101.5%	0.79%
VERA	Vera Therapeutics, Inc. Healthcare	NEW	69,241	NEW	$2,785,565	NEW	0.77%
PHVS	Pharvaris N.V. Healthcare	Reduced	97,866	-64,504	$2,764,714	−38.6%	0.77%
VRDN	Viridian Therapeutics, Inc.DE Healthcare	Reduced	134,229	-238,243	$2,625,519	−77.3%	0.73%
ALKS	Alkermes plc. Healthcare	Added	73,189	+46,788	$2,587,963	+250.3%	0.72%
ALMS	Alumis Inc. Healthcare	NEW	112,929	NEW	$2,487,825	NEW	0.69%
MSFT	Microsoft Corp Technology	Reduced	6,457	-80	$2,390,187	−24.4%	0.66%
EYPT	EyePoint, Inc. Healthcare	NEW	183,037	NEW	$2,359,346	NEW	0.66%