HighVista Strategies LLC

CIK

1335325

Location

BOSTON, MA

Portfolio Value

Small $359,474,418

Diversification

Diversified

Filing Date

Global Rank

#3,133 / 8,622 ▼ 23 · as of Mar 2026

Top Industry

Biotechnology 68.3%

3Y Alpha vs SPY

+9.2%

Period ended 4 months ago

Filed May 15, 2026 · 2mo

25 quarters · since Mar 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.

Cloned portfolio

+111.4%

SPY

+67.9%

Annualised alpha

+9.5%

Max drawdown

−29.0%

Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. It tracks 100% of reported value on average across 13 quarters. Past performance does not predict future results.

Portfolio Concentration

154 tracked positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

8.5%

+2.3 pts

Top 5

18.5%

−0.1 pts

Top 10

27.4%

−1.5 pts

HHI

168

Diversified+5

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	67.4%	$242,385,867	83
Technology	9.1%	$32,616,951	21
Unclassified	8.5%	$30,607,040	1
Industrials	5.5%	$19,810,669	17
Consumer Cyclical	2.9%	$10,478,055	9
Financial Services	2.3%	$8,419,688	8
Utilities	1.7%	$6,148,792	5
Basic Materials	0.9%	$3,064,480	3
Communication Services	0.6%	$2,210,915	3
Consumer Defensive	0.4%	$1,383,251	2
Real Estate	0.3%	$1,184,735	1
Energy	0.3%	$1,163,975	1

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

25 positions

Ticker	Company	Δ Shares	Shares	Value
PALI	Palisade Bio, Inc.	+719,295	2,019,326	$3,533,820
DYN	Dyne Therapeutics, Inc.	+123,286	182,929	$3,316,502
AMLX	Amylyx Pharmaceuticals, Inc.	+113,273	352,085	$4,893,981
OCUL	Ocular Therapeutix, Inc	+97,506	441,573	$3,740,123
TYRA	Tyra Biosciences, Inc.	+96,218	131,304	$5,028,943
CTMX	CytomX Therapeutics, Inc.	+94,116	288,057	$1,353,867
ALKS	Alkermes plc.	+46,788	73,189	$2,587,963
ABVX	Abivax S.A.	+41,069	113,254	$12,610,832
CORZ	Core Scientific, Inc./tx	+39,900	103,412	$1,547,043
CLDX	Celldex Therapeutics, Inc.	+37,592	89,397	$2,835,672
U	Unity Software Inc.	+34,100	62,763	$1,377,020
LBRX	Lb Pharmaceuticals Inc	+33,488	173,595	$4,280,852
SLNO	Soleno Therapeutics Inc	+30,158	165,227	$5,531,799
IMCR	Immunocore Holdings plc	+25,699	58,697	$1,769,714
CPNG	Coupang, Inc.	+21,244	46,036	$869,159
BBD	Bank Bradesco	+18,000	208,264	$760,163
HPE	Hewlett Packard Enterprise Co	+13,800	89,981	$2,142,447
NOK	Nokia Corp	+11,300	70,824	$569,424
PCVX	Vaxcyte, Inc.	+10,598	124,647	$7,243,237
KBR	Kbr, Inc.	+9,400	39,406	$1,452,505
AXSM	Axsome Therapeutics, Inc.	+9,306	20,437	$3,454,261
NVDA	Nvidia Corp	+8,200	22,420	$3,910,048
JANX	Janux Therapeutics, Inc.	+7,940	49,383	$686,423
AMZN	Amazon Com Inc	+5,000	22,397	$4,664,623
XEL	Xcel Energy Inc	+4,500	12,558	$997,607
No positions match the current search.

Trimmed

Positions the filer reduced

25 positions

Ticker	Company	Δ Shares	Shares	Value
VRDN	Viridian Therapeutics, Inc.\DE	−238,243	134,229	$2,625,519
BBOT	BridgeBio Oncology Therapeutics, Inc.	−151,076	78,187	$699,773
COGT	Cogent Biosciences, Inc.	−139,616	197,051	$7,584,492
CMPS	COMPASS Pathways plc	−134,573	364,360	$2,014,910
OLMA	Olema Pharmaceuticals, Inc.	−123,888	117,601	$1,753,430
RLAY	Relay Therapeutics, Inc.	−123,198	421,881	$4,197,715
EWTX	Edgewise Therapeutics, Inc.	−79,206	91,931	$2,895,826
MLYS	Mineralys Therapeutics, Inc.	−77,766	46,778	$1,267,216
MAZE	Maze Therapeutics, Inc.	−70,503	99,850	$2,980,522
GPCR	Structure Therapeutics Inc.	−69,092	123,909	$5,972,413
XOMA	XOMA Royalty Corp	−66,103	46,814	$1,468,555
PHVS	Pharvaris N.V.	−64,504	97,866	$2,764,714
TERN	Terns Pharmaceuticals, Inc.	−61,155	114,307	$6,026,265
LQDA	Liquidia Corp	−56,259	99,744	$3,764,338
CYTK	Cytokinetics Inc	−55,921	58,643	$3,865,160
APGE	Apogee Therapeutics, Inc.	−53,468	35,761	$3,010,003
STOK	Stoke Therapeutics, Inc.	−52,922	62,617	$2,038,809
TRVI	Trevi Therapeutics, Inc.	−52,634	53,525	$638,553
RVMD	Revolution Medicines, Inc.	−50,931	69,309	$6,740,300
RXO	RXO, Inc.	−47,900	43,038	$629,215
SYRE	Spyre Therapeutics, Inc.	−41,942	146,264	$7,377,556
PTGX	Protagonist Therapeutics, Inc	−39,693	33,852	$3,568,000
CNTA	Centessa Pharmaceuticals plc	−38,526	5,964	$236,890
AVTX	Avalo Therapeutics, Inc.	−37,009	58,622	$875,226
QXO	QXO, Inc.	−32,400	26,320	$511,134
No positions match the current search.

New Positions

Positions the filer opened this quarter

25 positions

Ticker	Company	Shares	Value
ORKA	Oruka Therapeutics, Inc.	78,911	$3,870,584
MLTX	MoonLake Immunotherapeutics	193,955	$3,615,321
DFTX	Definium Therapeutics, Inc.	185,856	$3,512,678
NRIX	Nurix Therapeutics, Inc.	226,546	$3,511,463
IVA	Inventiva S.A.	615,666	$3,416,946
ERAS	Erasca, Inc.	181,069	$2,929,696
XENE	Xenon Pharmaceuticals Inc.	49,050	$2,852,257
VERA	Vera Therapeutics, Inc.	69,241	$2,785,565
ALMS	Alumis Inc.	112,929	$2,487,825
EYPT	EyePoint, Inc.	183,037	$2,359,346
TNGX	Tango Therapeutics, Inc.	104,193	$2,179,717
ASMB	Assembly Biosciences, Inc.	74,735	$2,073,896
JAZZ	Jazz Pharmaceuticals plc	10,838	$2,048,923
NATL	NCR Atleos Corp	40,100	$1,747,558
ON	On Semiconductor Corp	28,000	$1,733,760
KOD	Kodiak Sciences Inc.	43,569	$1,660,850
AVTR	Avantor, Inc.	186,500	$1,462,160
MIRM	Mirum Pharmaceuticals, Inc.	15,563	$1,437,709
SVRA	Savara Inc	250,999	$1,370,454
KNX	Knight-Swift Transportation Holdings Inc.	22,900	$1,318,582
MU	Micron Technology Inc	3,800	$1,283,792
BLTE	Belite Bio, Inc	8,033	$1,280,781
JHX	James Hardie Industries plc	65,598	$1,242,426
KRC	Kilroy Realty Corp	41,997	$1,184,735
STX	Seagate Technology Holdings plc	2,900	$1,136,104
No positions match the current search.

Sold Out

Positions the filer fully exited

22 positions

Ticker	Company	Shares	Value
ACLX	Arcellx, Inc.	75,002	$4,890,130
AGIO	Agios Pharmaceuticals, Inc.	147,662	$4,019,359
APLS	Apellis Pharmaceuticals, Inc.	150,776	$3,787,493
SEPN	Septerna, Inc.	78,682	$2,193,654
APP	AppLovin Corp	2,482	$1,672,421
UNF	Unifirst Corp	7,727	$1,490,538
CMPX	Compass Therapeutics, Inc.	245,532	$1,318,506
TMO	Thermo Fisher Scientific Inc.	2,269	$1,314,772
OFIX	Orthofix Medical Inc.	85,049	$1,289,342
ACHC	Acadia Healthcare Company, Inc.	81,630	$1,158,329
SCHW	Schwab Charles Corp	10,601	$1,059,145
SNDK	Sandisk Corp	4,378	$1,039,249
AFRM	Affirm Holdings, Inc.	13,086	$973,990
VST	Vistra Corp.	5,673	$915,225
BVN	Buenaventura Mining Co Inc	29,649	$825,131
ALC	Alcon Inc	10,440	$822,776
FOUR	Shift4 Payments, Inc.	12,982	$817,476
GTLB	Gitlab Inc.	19,305	$724,516
RBLX	Roblox Corp	8,431	$683,163
CNX	CNX Resources Corp	17,624	$648,034
ALV	Autoliv Inc	5,243	$622,344
DBVT	DBV Technologies S.A.	15,877	$304,362
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

154 tracked positions · $359,474,418 total · as of Mar 31, 2026

All sectors Basic Materials Communication Services Consumer Cyclical Consumer Defensive Energy Financial Services Healthcare Industrials Real Estate Technology Utilities

Showing 1–50 of 154 positions by value · page 1 of 4

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
DBC	Invesco DB Commodity Index Tracking Fund	Held	1,057,238	0	$30,607,040	+29.5%	8.51%
ABVX	Abivax S.A. Healthcare	Added	113,254	+41,069	$12,610,832	+29.5%	3.51%
PRAX	Praxis Precision Medicines, Inc. Healthcare	Added	26,323	+482	$8,481,007	+11.4%	2.36%
COGT	Cogent Biosciences, Inc. Healthcare	Reduced	197,051	-139,616	$7,584,492	−36.6%	2.11%
SYRE	Spyre Therapeutics, Inc. Healthcare	Reduced	146,264	-41,942	$7,377,556	+19.7%	2.05%
PCVX	Vaxcyte, Inc. Healthcare	Added	124,647	+10,598	$7,243,237	+37.6%	2.01%
RVMD	Revolution Medicines, Inc. Healthcare	Reduced	69,309	-50,931	$6,740,300	−29.6%	1.88%
TERN	Terns Pharmaceuticals, Inc. Healthcare	Reduced	114,307	-61,155	$6,026,265	−15.0%	1.68%
GPCR	Structure Therapeutics Inc. Healthcare	Reduced	123,909	-69,092	$5,972,413	−55.5%	1.66%
NUVL	Nuvalent, Inc. Healthcare	Reduced	56,602	-16,685	$5,798,874	−21.3%	1.61%
IMVT	Immunovant, Inc. Healthcare	Added	225,139	+3,256	$5,592,452	−0.8%	1.56%
SLNO	Soleno Therapeutics Inc Healthcare	Added	165,227	+30,158	$5,531,799	−11.5%	1.54%
TYRA	Tyra Biosciences, Inc. Healthcare	Added	131,304	+96,218	$5,028,943	+445.2%	1.40%
AMLX	Amylyx Pharmaceuticals, Inc. Healthcare	Added	352,085	+113,273	$4,893,981	+69.6%	1.36%
AMZN	Amazon Com Inc Consumer Cyclical	Added	22,397	+5,000	$4,664,623	+16.2%	1.30%
LBRX	Lb Pharmaceuticals Inc Healthcare	Added	173,595	+33,488	$4,280,852	+37.3%	1.19%
RLAY	Relay Therapeutics, Inc. Healthcare	Reduced	421,881	-123,198	$4,197,715	−9.0%	1.17%
INSM	INSMED Inc Healthcare	Reduced	24,316	-15,084	$3,976,152	−42.0%	1.11%
NVDA	Nvidia Corp Technology	Added	22,420	+8,200	$3,910,048	+47.4%	1.09%
ORKA	Oruka Therapeutics, Inc. Healthcare	NEW	78,911	NEW	$3,870,584	NEW	1.08%
CYTK	Cytokinetics Inc Healthcare	Reduced	58,643	-55,921	$3,865,160	−46.9%	1.08%
LQDA	Liquidia Corp Healthcare	Reduced	99,744	-56,259	$3,764,338	−30.0%	1.05%
OCUL	Ocular Therapeutix, Inc Healthcare	Added	441,573	+97,506	$3,740,123	−10.5%	1.04%
TARS	Tarsus Pharmaceuticals, Inc. Healthcare	Reduced	52,464	-1,100	$3,680,349	−16.1%	1.02%
BBIO	BridgeBio Pharma, Inc. Healthcare	Reduced	49,560	-30,645	$3,680,325	−40.0%	1.02%
MLTX	MoonLake Immunotherapeutics Healthcare	NEW	193,955	NEW	$3,615,321	NEW	1.01%
ARGX	Argenx SE Healthcare	Added	4,918	+1,330	$3,591,369	+19.0%	1.00%
PTGX	Protagonist Therapeutics, Inc Healthcare	Reduced	33,852	-39,693	$3,568,000	−44.5%	0.99%
PALI	Palisade Bio, Inc. Healthcare	Added	2,019,326	+719,295	$3,533,820	+15.7%	0.98%
DFTX	Definium Therapeutics, Inc. Healthcare	NEW	185,856	NEW	$3,512,678	NEW	0.98%
NRIX	Nurix Therapeutics, Inc. Healthcare	NEW	226,546	NEW	$3,511,463	NEW	0.98%
AXSM	Axsome Therapeutics, Inc. Healthcare	Added	20,437	+9,306	$3,454,261	+69.9%	0.96%
IVA	Inventiva S.A. Healthcare	NEW	615,666	NEW	$3,416,946	NEW	0.95%
DYN	Dyne Therapeutics, Inc. Healthcare	Added	182,929	+123,286	$3,316,502	+184.3%	0.92%
APGE	Apogee Therapeutics, Inc. Healthcare	Reduced	35,761	-53,468	$3,010,003	−55.3%	0.84%
GHRS	GH Research PLC Healthcare	Reduced	213,212	-27,312	$2,997,760	−1.9%	0.83%
DNTH	Dianthus Therapeutics, Inc. /DE/ Healthcare	Reduced	35,587	-12,897	$2,986,461	+49.5%	0.83%
MAZE	Maze Therapeutics, Inc. Healthcare	Reduced	99,850	-70,503	$2,980,522	−57.8%	0.83%
ERAS	Erasca, Inc. Healthcare	NEW	181,069	NEW	$2,929,696	NEW	0.81%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Reduced	91,931	-79,206	$2,895,826	−31.8%	0.81%
ELVN	Enliven Therapeutics, Inc. Healthcare	Reduced	73,102	-9,434	$2,865,598	+125.5%	0.80%
XENE	Xenon Pharmaceuticals Inc. Healthcare	NEW	49,050	NEW	$2,852,257	NEW	0.79%
CLDX	Celldex Therapeutics, Inc. Healthcare	Added	89,397	+37,592	$2,835,672	+101.5%	0.79%
VERA	Vera Therapeutics, Inc. Healthcare	NEW	69,241	NEW	$2,785,565	NEW	0.77%
PHVS	Pharvaris N.V. Healthcare	Reduced	97,866	-64,504	$2,764,714	−38.6%	0.77%
VRDN	Viridian Therapeutics, Inc.\DE Healthcare	Reduced	134,229	-238,243	$2,625,519	−77.3%	0.73%
ALKS	Alkermes plc. Healthcare	Added	73,189	+46,788	$2,587,963	+250.3%	0.72%
ALMS	Alumis Inc. Healthcare	NEW	112,929	NEW	$2,487,825	NEW	0.69%
MSFT	Microsoft Corp Technology	Reduced	6,457	-80	$2,390,187	−24.4%	0.66%
EYPT	EyePoint, Inc. Healthcare	NEW	183,037	NEW	$2,359,346	NEW	0.66%

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.