Driehaus Capital Management LLC

Position in SYRE — Spyre Therapeutics, Inc.

CIK 938206 Chicago, IL

Position in SYRE

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$248,509,957

+$107,742,762 QoQ

Shares Held

2,799,166

+0.3% QoQ

Ownership

3.17%

of shares outstanding

% of Portfolio

1.44%

of 13F equity value

Holder Rank

#10

of 260 holders

Holding Since

Sep 2023

12 quarters on record

Voting authority Sole 81% Shared 0% None 19%

Healthcare · as of Jun 30, 2026

Driehaus Capital Management LLC holds $3,602,052,293 across 59 Biotechnology names. SYRE ranks #4 (6.9% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	DFTX	Definium Therapeutics, Inc.	6,845,276	$322,001,783
2	PRAX	Praxis Precision Medicines, Inc.	959,048	$321,079,679
3	XENE	Xenon Pharmaceuticals Inc.	4,418,557	$266,704,100
4	SYRE	Spyre Therapeutics, Inc. This page	2,799,166	$248,509,957
5	CRNX	Crinetics Pharmaceuticals, Inc.	6,463,551	$241,866,078
6	APGE	Apogee Therapeutics, Inc.	1,740,101	$230,963,605
7	EWTX	Edgewise Therapeutics, Inc.	4,728,623	$192,123,952
8	SEPN	Septerna, Inc.	4,433,058	$148,463,112

12 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$248,509,957	2,799,166	+0.3%	Shares	Sole	2026-08-14
2026-03-31	$140,767,195	2,790,785	-3.2%	Shares	Sole	2026-05-15
2025-12-31	$94,428,079	2,882,420	+39.9%	Shares	Sole	2026-02-17
2025-09-30	$34,531,885	2,060,375	-1.2%	Shares	Sole	2025-11-14
2025-06-30	$31,221,282	2,085,590	-23.2%	Shares	Sole	2025-08-14
2025-03-31	$43,843,829	2,717,312	-3.1%	Shares	Sole	2025-05-15
2024-12-31	$65,269,088	2,803,655	+308.1%	Shares	Sole	2025-02-14
2024-09-30	$20,207,022	687,080	0.0%	Shares	Sole	2024-11-14
2024-06-30	$16,153,250	687,080	0.0%	Shares	Sole	2024-08-15
2024-03-31	$26,060,944	687,080	-11.0%	Shares	Sole	2024-05-15
2023-12-31	$16,611,331	771,902	-3.6%	Shares	Sole	2024-02-14
2023-09-30	$9,810,449	800,853	—	Shares	Sole	2023-11-14
No filing history on record for this holder in this stock.