Foresite Capital Management IV, LLC
CIK
1704132
Location
West Hollywood, CA
Portfolio Value
Small
$237,082,218
Diversification
Highly concentrated
Filing Date
Global Rank
#3,863
/ 8,605
▲ 177
· as of Mar 2026
Top Industry
Biotechnology
100.0%
3Y Alpha vs SPY
-2.6%
Period ended 3 months ago
Filed May 15, 2026 · 55d
25 quarters · since Mar 2020
Clone Performance
Jul 2023–Jul 2026 · vs SPYHypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.
Cloned portfolio
+65.2%
SPY
+76.5%
Annualised alpha
-2.6%
Max drawdown
−64.2%
Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.
Portfolio Concentration
8 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025Top Position
56.9%
−0.8 pts
Top 5
90.6%
−3.7 pts
Top 10
100.0%
0.0 pts
HHI
3,608
Highly concentrated−119
Portfolio Trend
25 quarters · across all stocks
Sector Breakdown
As of Mar 31, 2026| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 100.0% | $237,082,218 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
1 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| CYTK | Cytokinetics Inc | +45,000 | 503,295 | $33,172,173 | |
| No positions match the current search. | |||||
Trimmed
Positions the filer reduced
1 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| MAZE | Maze Therapeutics, Inc. | −365,756 | 156,901 | $4,683,494 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
1 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| EIKN | Eikon Therapeutics, Inc. | 1,943,682 | $20,564,155 | |
| No positions match the current search. | ||||
Sold Out
Positions the filer fully exitedNo qualifying positions this quarter.
8 positions ·
$237,082,218 total
· as of Mar 31, 2026
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| PHVS |
Pharvaris N.V.
Healthcare
|
Held | 4,778,581 | $134,994,913 | 56.94% | |
| CYTK |
Cytokinetics Inc
Healthcare
|
Added | 503,295 | $33,172,173 | 13.99% | |
| EIKN |
Eikon Therapeutics, Inc.
Healthcare
|
NEW | 1,943,682 | $20,564,155 | 8.67% | |
| LYEL |
Lyell Immunopharma, Inc.
Healthcare
|
Held | 800,399 | $16,056,003 | 6.77% | |
| RLAY |
Relay Therapeutics, Inc.
Healthcare
|
Held | 1,000,000 | $9,950,000 | 4.20% | |
| XENE |
Xenon Pharmaceuticals Inc.
Healthcare
|
Held | 160,000 | $9,304,000 | 3.92% | |
| ALEC |
Alector, Inc.
Healthcare
|
Held | 3,887,200 | $8,357,480 | 3.53% | |
| MAZE |
Maze Therapeutics, Inc.
Healthcare
|
Reduced | 156,901 | $4,683,494 | 1.98% |