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Equibles

D. E. Shaw & Co., Inc.

Position in IONS — Ionis Pharmaceuticals Inc

CIK 1009207 New York, NY
Back to IONS Full portfolio

Position in IONS

as of Jun 30, 2026 · filed Aug 14, 2026
Position Value
$23,552,379
-$8,706,208 QoQ
Shares Held
297,041
-30.9% QoQ
Ownership
0.179%
of shares outstanding
% of Portfolio
0.02%
of 13F equity value
Holder Rank
#77
of 513 holders
Holding Since
Mar 2020
23 quarters on record
Voting authority Sole 89% Shared 0% None 11%

Common Shares in IONS Over Time

Shares Held

Position Value (USD)

Derivatives in IONS

reported options exposure · as of Jun 30, 2026
CallValue
$6,937,875
CallShares
87,500
PutValue
$0
PutShares
0

Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.

Position in Biotechnology

Healthcare · as of Jun 30, 2026

D. E. Shaw & Co., Inc. holds $5,139,216,221 across 217 Biotechnology names. IONS ranks #45 (0.5% of the industry book) .

# Ticker Company Shares Value (USD) Open
1 INSM
INSMED Inc
 5,877,959 $626,707,987
2 ALNY
Alnylam Pharmaceuticals, Inc.
 1,104,109 $332,369,932
3 EXEL
Exelixis, Inc.
 5,551,747 $302,070,554
4 BBIO
BridgeBio Pharma, Inc.
 3,633,007 $270,586,360
5 TGTX
Tg Therapeutics, Inc.
 3,400,808 $186,840,390
6 HALO
Halozyme Therapeutics, Inc.
 2,006,479 $157,047,110
7 AXSM
Axsome Therapeutics, Inc.
 604,753 $148,025,391
8 PTCT
Ptc Therapeutics, Inc.
 1,548,919 $126,345,322

All Filings in IONS

Export CSV
33 filing rows on record
Report Date Value (USD) Shares
2026-06-30 $23,552,379 297,041
2026-06-30 $6,937,875 87,500
2026-03-31 $32,258,587 429,599
2025-12-31 $26,328,045 332,803
2025-09-30 $41,275,963 630,938
2024-12-31 $808,379 23,123
2024-09-30 $5,812,344 145,091
2024-06-30 $9,092,622 190,781
2024-03-31 $6,956,894 160,482
2023-12-31 $6,028,202 119,158
2023-09-30 $16,422,361 362,045
2023-06-30 $8,050,619 196,213
2023-03-31 $3,096,906 86,651
2022-12-31 $11,301,954 299,231
2022-09-30 $9,263,751 209,445
2022-06-30 $4,687,509 126,621
2021-12-31 $4,888,853 160,659
2021-09-30 $4,229,595 126,106
2021-06-30 $355,021 8,900
2021-06-30 $2,978,426 74,666
2021-03-31 $364,445 8,106
2021-03-31 $400,144 8,900
2020-12-31 $503,206 8,900
2020-12-31 $758,597 13,417
2020-12-31 $2,199,406 38,900
2020-09-30 $422,305 8,900
2020-09-30 $10,588,419 223,149
2020-09-30 $1,845,805 38,900
2020-06-30 $524,744 8,900
2020-06-30 $6,654,933 112,872
2020-06-30 $2,293,544 38,900
2020-03-31 $1,181,810 24,996
2020-03-31 $1,839,192 38,900