RENAISSANCE TECHNOLOGIES LLC

Position in IONS — Ionis Pharmaceuticals Inc

CIK 1037389 NEW YORK, NY

Position in IONS

as of Mar 31, 2026 · filed May 14, 2026 Compact

Position Value

$22,943,674

+$5,254,125 QoQ

Shares Held

305,549

+36.6% QoQ

Ownership

0.185%

of shares outstanding

% of Portfolio

0.04%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Mar 2020

25 quarters on record

Voting authority Sole 100.ToString("F0")% Shared 0.ToString("F0")% None 0.ToString("F0")%

Healthcare · as of Mar 31, 2026

RENAISSANCE TECHNOLOGIES LLC holds $3,467,670,450 across 330 Biotechnology names. IONS ranks #31 (0.7% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	EXEL	Exelixis, Inc.	13,726,993	$588,750,729
2	INCY	Incyte Corp	3,651,532	$343,682,191
3	CORT	Corcept Therapeutics Inc	5,682,783	$229,072,982
4	VRTX	Vertex Pharmaceuticals Inc / Ma	421,688	$188,300,559
5	JAZZ	Jazz Pharmaceuticals plc	819,374	$154,902,654
6	GMAB	Genmab A/S	4,414,550	$118,442,376
7	INVA	Innoviva, Inc.	4,055,632	$94,496,225
8	ARWR	Arrowhead Pharmaceuticals, Inc.	1,036,495	$64,988,236

25 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$22,943,674	305,549	+36.6%	Shares	Sole	2026-05-14
2025-12-31	$17,689,549	223,607	-54.1%	Shares	Sole	2026-02-12
2025-09-30	$31,840,829	486,714	+79.8%	Shares	Sole	2025-11-13
2025-06-30	$10,695,910	270,714	+76.3%	Shares	Sole	2025-08-13
2025-03-31	$4,631,517	153,514	-25.3%	Shares	Sole	2025-05-14
2024-12-31	$7,184,769	205,514	+7.9%	Shares	Sole	2025-02-13
2024-09-30	$7,631,990	190,514	-23.6%	Shares	Sole	2024-11-13
2024-06-30	$11,891,837	249,514	+38.8%	Shares	Sole	2024-08-09
2024-03-31	$7,790,601	179,714	+59.9%	Shares	Sole	2024-05-13
2023-12-31	$5,687,024	112,414	-58.3%	Shares	Sole	2024-02-13
2023-09-30	$12,238,128	269,800	-27.2%	Shares	Sole	2023-11-14
2023-06-30	$15,201,615	370,500	-41.8%	Shares	Sole	2023-08-11
2023-03-31	$22,741,862	636,314	-46.0%	Shares	Sole	2023-05-12
2022-12-31	$44,523,804	1,178,814	+35.9%	Shares	Sole	2023-02-13
2022-09-30	$38,378,990	867,714	+41.1%	Shares	Sole	2022-11-14
2022-06-30	$22,760,414	614,814	+355.7%	Shares	Sole	2022-08-12
2022-03-31	$4,997,214	134,914	-41.5%	Shares	Sole	2022-05-13
2021-12-31	$7,023,670	230,814	+136.2%	Shares	Sole	2022-02-11
2021-09-30	$3,277,327	97,714	-87.4%	Shares	Sole	2021-11-12
2021-06-30	$30,971,154	776,414	+32.2%	Shares	Sole	2021-08-13
2021-03-31	$26,410,133	587,414	-21.2%	Shares	Sole	2021-05-13
2020-12-31	$42,141,975	745,348	-49.2%	Shares	Sole	2021-02-10
2020-09-30	$69,617,074	1,467,167	-16.3%	Shares	Sole	2020-11-13
2020-06-30	$103,349,038	1,752,867	+3.8%	Shares	Sole	2020-08-13
2020-03-31	$79,828,072	1,688,411	—	Shares	Sole	2020-05-14
No filing history on record for this holder in this stock.